KEGG   PATHWAY: mgp03410
mgp03410                    Pathway                                

Base excision repair - Meleagris gallopavo (turkey)
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Genetic Information Processing; Replication and repair
Pathway map
mgp03410  Base excision repair

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Meleagris gallopavo (turkey) [GN:mgp]
100542597  OGG1; N-glycosylase/DNA lyase isoform X1 [KO:K03660] [EC:3.2.2.-]
100550099  NTHL1; endonuclease III-like protein 1 [KO:K10773] [EC:]
100545517  NEIL2; endonuclease 8-like 2 isoform X1 [KO:K10568] [EC:3.2.2.-]
100548485  NEIL3; endonuclease 8-like 3 isoform X1 [KO:K10569]
100549740  UNG; uracil-DNA glycosylase [KO:K03648] [EC:]
104916790  SMUG1; single-strand selective monofunctional uracil DNA glycosylase [KO:K10800] [EC:3.2.2.-]
100548655  MUTYH; adenine DNA glycosylase [KO:K03575] [EC:]
100550768  MPG; DNA-3-methyladenine glycosylase isoform X1 [KO:K03652] [EC:]
100545227  MBD4; methyl-CpG-binding domain protein 4 [KO:K10801] [EC:3.2.2.-]
100545972  TDG; G/T mismatch-specific thymine DNA glycosylase [KO:K20813] [EC:]
104915812  APEX1; DNA-(apurinic or apyrimidinic site) lyase [KO:K10771] [EC:]
100549334  POLB; DNA polymerase beta isoform X1 [KO:K02330] [EC: 4.2.99.-]
100545174  POLL; DNA polymerase lambda isoform X1 [KO:K03512] [EC: 4.2.99.-]
100543659  HMGB1; high mobility group protein B1 [KO:K10802]
100542455  XRCC1; DNA repair protein XRCC1 isoform X1 [KO:K10803]
100551390  PCNA; proliferating cell nuclear antigen [KO:K04802]
100543187  POLD2; DNA polymerase delta subunit 2 [KO:K02328]
104909450  DNA polymerase delta subunit 3 [KO:K03504]
100551403  DNA polymerase delta subunit 3-like [KO:K03504]
100546821  POLE; DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:]
100539609  POLE2; DNA polymerase epsilon subunit 2 [KO:K02325] [EC:]
100549999  POLE3; DNA polymerase epsilon subunit 3 [KO:K02326] [EC:]
104914653  POLE4; DNA polymerase epsilon subunit 4 [KO:K03506] [EC:]
100550112  LIG1; LOW QUALITY PROTEIN: DNA ligase 1 [KO:K10747] [EC:]
100549287  LIG3; DNA ligase 3 [KO:K10776] [EC:]
100540164  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:]
100549659  PARP4; LOW QUALITY PROTEIN: protein mono-ADP-ribosyltransferase PARP4 [KO:K10798] [EC:]
100551477  PARP3; LOW QUALITY PROTEIN: protein mono-ADP-ribosyltransferase PARP3 [KO:K10798] [EC:]
104917598  protein mono-ADP-ribosyltransferase PARP4-like [KO:K10798] [EC:]
100544808  FEN1; flap endonuclease 1 [KO:K04799] [EC:3.-.-.-]
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
Acta Biochim Pol 54:413-34 (2007)
Almeida KH, Sobol RW.
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
DNA Repair (Amst) 6:695-711 (2007)
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
J Bacteriol 193:4495-508 (2011)
Ikeda S, Seki S.
[Base excision repair: DNA glycosylase and AP endonuclease] Japanese
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway

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