KEGG   PATHWAY: mmf04972
Entry
mmf04972                    Pathway                                
Name
Pancreatic secretion - Molossus molossus (Pallas's mastiff bat)
Description
The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
Class
Organismal Systems; Digestive system
Pathway map
mmf04972  Pancreatic secretion
mmf04972

Other DBs
GO: 0030157
Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118640583  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
118633601  CCK; cholecystokinin [KO:K05226]
118641247  CCKAR; cholecystokinin receptor type A [KO:K04194]
118629502  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
118618293  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
118618784  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
118628278  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118632151  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
118633872  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118641370  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118638191  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
118615978  RAB3D; ras-related protein Rab-3D isoform X1 [KO:K07884]
118615433  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
118640930  RAB11A; ras-related protein Rab-11A [KO:K07904]
118618867  RAB27B; ras-related protein Rab-27B isoform X1 [KO:K07886]
118637043  RAP1A; ras-related protein Rap-1A [KO:K04353]
118624733  RAP1B; ras-related protein Rap-1b [KO:K07836]
118632939  RHOA; transforming protein RhoA [KO:K04513]
118616519  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
118637103  pancreatic alpha-amylase [KO:K01176] [EC:3.2.1.1]
118620046  cationic trypsin [KO:K01312] [EC:3.4.21.4]
118639088  chymotrypsinogen B isoform X1 [KO:K01310] [EC:3.4.21.1]
118639268  chymotrypsinogen 2 [KO:K01310] [EC:3.4.21.1]
118638457  CTRL; chymotrypsin-like protease CTRL-1 [KO:K09632] [EC:3.4.21.-]
118626829  chymotrypsin-like elastase family member 2A [KO:K01346] [EC:3.4.21.71]
118626695  CELA3B; chymotrypsin-like elastase family member 3B [KO:K01345] [EC:3.4.21.70]
118620031  CPA1; carboxypeptidase A1 [KO:K08779] [EC:3.4.17.1]
118619976  CPA2; carboxypeptidase A2 [KO:K01298] [EC:3.4.17.15]
118617282  CPA3; mast cell carboxypeptidase A [KO:K08780] [EC:3.4.17.1]
118617487  CPB1; carboxypeptidase B [KO:K01291] [EC:3.4.17.2]
118622819  CPB2; carboxypeptidase B2 [KO:K01300] [EC:3.4.17.20]
118632241  pancreatic triacylglycerol lipase isoform X1 [KO:K14073] [EC:3.1.1.3]
118632257  PNLIPRP1; inactive pancreatic lipase-related protein 1 [KO:K14074] [EC:3.1.1.3]
118632290  pancreatic lipase-related protein 2-like isoform X1 [KO:K14075] [EC:3.1.1.3]
118629983  CEL; bile salt-activated lipase [KO:K12298] [EC:3.1.1.13 3.1.1.3]
118640229  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118640414  PLA2G3; LOW QUALITY PROTEIN: group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118626499  group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118626618  phospholipase A2 group V-like [KO:K01047] [EC:3.1.1.4]
118626821  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118626975  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
118627023  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118642127  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
118632582  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
118639782  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118632878  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118623451  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118621173  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
118640735  RYR2; ryanodine receptor 2 [KO:K04962]
118641660  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
118615378  BST1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 [KO:K18152] [EC:3.2.2.6 2.4.99.20]
118629013  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
118640019  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
118633780  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
118642281  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
118626465  CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027]
118626677  calcium-activated chloride channel regulator 2-like [KO:K05028]
118626562  CLCA4; calcium-activated chloride channel regulator 4 isoform X1 [KO:K05030]
118626730  LOW QUALITY PROTEIN: calcium-activated chloride channel regulator 1-like [KO:K05030]
118617139  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
118641926  SLC12A2; solute carrier family 12 member 2 [KO:K10951]
118636912  sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
118637061  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
118637940  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
118638724  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
118633048  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
118634933  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
118636327  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
118637584  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
118643207  KCNQ1; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926]
118633330  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
118635789  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
118637529  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
118623540  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
118626285  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
118619782  SLC4A2; anion exchange protein 2 isoform X1 [KO:K13855]
118643140  SCT; secretin [KO:K05263]
118625511  SCTR; secretin receptor [KO:K04588]
118618303  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
118618304  neuroendocrine secretory protein 55-like [KO:K04632]
118620164  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
118642779  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
118630645  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
118631458  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
118617134  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
118623920  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
118639510  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
118631528  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
118642221  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
118619948  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
118619849  SLC26A3; chloride anion exchanger [KO:K14078]
118631993  SLC4A4; electrogenic sodium bicarbonate cotransporter 1 isoform X1 [KO:K13575]
118631896  CA2; carbonic anhydrase 2 isoform X1 [KO:K18245] [EC:4.2.1.1]
Compound
C00001  H2O
C00011  CO2
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00288  HCO3-
C00575  3',5'-Cyclic AMP
C00698  Cl-
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01353  Carbonic acid
C01996  Acetylcholine
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:17850212
  Authors
Petersen OH, Tepikin AV
  Title
Polarized calcium signaling in exocrine gland cells.
  Journal
Annu Rev Physiol 70:273-99 (2008)
DOI:10.1146/annurev.physiol.70.113006.100618
Reference
PMID:20625287
  Authors
Williams JA
  Title
Regulation of acinar cell function in the pancreas.
  Journal
Curr Opin Gastroenterol 26:478-83 (2010)
DOI:10.1097/MOG.0b013e32833d11c6
Reference
PMID:16891880
  Authors
Williams JA
  Title
Regulation of pancreatic acinar cell function.
  Journal
Curr Opin Gastroenterol 22:498-504 (2006)
DOI:10.1097/01.mog.0000239863.96833.c0
Reference
PMID:15689674
  Authors
Bi Y, Williams JA
  Title
Receptor biology and signal transduction in pancreatic acinar cells.
  Journal
Curr Opin Gastroenterol 20:427-34 (2004)
DOI:10.1097/00001574-200409000-00002
Reference
PMID:14660554
  Authors
Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A
  Title
Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
  Journal
J Biol Chem 279:7234-40 (2004)
DOI:10.1074/jbc.M311088200
Reference
PMID:9548666
  Authors
Kanno T
  Title
Ca2+ signaling in the pancreatic acinus.
  Journal
Pancreas 16:273-6 (1998)
Reference
PMID:18626068
  Authors
Heitzmann D, Warth R
  Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
  Journal
Physiol Rev 88:1119-82 (2008)
DOI:10.1152/physrev.00020.2007
Reference
PMID:14637169
  Authors
Konturek SJ, Zabielski R, Konturek JW, Czarnecki J
  Title
Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion.
  Journal
Eur J Pharmacol 481:1-14 (2003)
DOI:10.1016/j.ejphar.2003.08.042
Reference
PMID:16888148
  Authors
Chu JY, Yung WH, Chow BK
  Title
Secretin: a pleiotrophic hormone.
  Journal
Ann N Y Acad Sci 1070:27-50 (2006)
DOI:10.1196/annals.1317.013
Reference
PMID:16930743
  Authors
Siu FK, Lam IP, Chu JY, Chow BK
  Title
Signaling mechanisms of secretin receptor.
  Journal
Regul Pept 137:95-104 (2006)
DOI:10.1016/j.regpep.2006.02.011
Reference
PMID:15709963
  Authors
Steward MC, Ishiguro H, Case RM
  Title
Mechanisms of bicarbonate secretion in the pancreatic duct.
  Journal
Annu Rev Physiol 67:377-409 (2005)
DOI:10.1146/annurev.physiol.67.031103.153247
Reference
PMID:20224219
  Authors
Kim D, Steward MC
  Title
The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia.
  Journal
J Med Invest 56 Suppl:336-42 (2009)
DOI:10.2152/jmi.56.336
Reference
PMID:17205399
  Authors
Whitcomb DC, Lowe ME
  Title
Human pancreatic digestive enzymes.
  Journal
Dig Dis Sci 52:1-17 (2007)
DOI:10.1007/s10620-006-9589-z
Reference
PMID:10835353
  Authors
Cancela JM, Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH
  Title
Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
  Journal
EMBO J 19:2549-57 (2000)
DOI:10.1093/emboj/19.11.2549
Reference
PMID:10078532
  Authors
Cancela JM, Churchill GC, Galione A
  Title
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
  Journal
Nature 398:74-6 (1999)
DOI:10.1038/18032
Reference
PMID:11087843
  Authors
Parekh AB
  Title
Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.
  Journal
Proc Natl Acad Sci U S A 97:12933-4 (2000)
DOI:10.1073/pnas.97.24.12933
Reference
PMID:19088252
  Authors
Williams JA, Chen X, Sabbatini ME
  Title
Small G proteins as key regulators of pancreatic digestive enzyme secretion.
  Journal
Am J Physiol Endocrinol Metab 296:E405-14 (2009)
DOI:10.1152/ajpendo.90874.2008
Related
pathway
mmf04020  Calcium signaling pathway
mmf04530  Tight junction
mmf04973  Carbohydrate digestion and absorption
mmf04974  Protein digestion and absorption
mmf04975  Fat digestion and absorption
mmf04977  Vitamin digestion and absorption
KO pathway
ko04972   
LinkDB

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