KEGG   PATHWAY: mmf04020
Entry
mmf04020                    Pathway                                
Name
Calcium signaling pathway - Molossus molossus (Pallas's mastiff bat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mmf04020  Calcium signaling pathway
mmf04020

Other DBs
GO: 0019722
Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118615118  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
118615300  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118615314  ADRB2; beta-2 adrenergic receptor isoform X1 [KO:K04142]
118615351  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
118615360  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
118615375  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
118615386  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
118615394  [KO:K15041]
118615449  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
118615466  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
118615480  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
118615621  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
118615645  DRD1; D(1A) dopamine receptor [KO:K04144]
118615652  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
118615653  TBXA2R; thromboxane A2 receptor [KO:K04264]
118615793  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118615801  PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
118615824  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
118615876  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
118615891  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
118615931  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
118615941  FGF18; fibroblast growth factor 18 [KO:K04358]
118616022  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
118616042  FGF2; fibroblast growth factor 2 [KO:K18497]
118616063  HRH2; histamine H2 receptor [KO:K04150]
118616075  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
118616081  FGF1; fibroblast growth factor 1 [KO:K18496]
118616546  FGF22; fibroblast growth factor 22 [KO:K04358]
118616784  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
118616835  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
118617212  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
118617533  AGTR1; type-1 angiotensin II receptor [KO:K04166]
118617946  CALM1; calmodulin-1 [KO:K02183]
118618219  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
118618225  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
118618293  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
118618299  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
118618303  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
118618304  [KO:K04632]
118618547  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
118618649  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118618746  TNNC2; troponin C, skeletal muscle [KO:K12042]
118618784  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
118618999  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
118619155  DRD5; D(1B) dopamine receptor [KO:K05840]
118619157  NTSR1; neurotensin receptor type 1 [KO:K04211]
118619531  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
118619605  [KO:K02183]
118619714  [KO:K10785]
118619834  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
118619859  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
118620018  [KO:K05863]
118620067  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
118620077  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118620123  RYR3; ryanodine receptor 3 [KO:K04963]
118620164  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
118620177  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
118620202  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
118620241  HTR5A; 5-hydroxytryptamine receptor 5A isoform X1 [KO:K04161]
118620747  [KO:K23449]
118620981  TFEB; transcription factor EB [KO:K15590]
118621078  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
118621105  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
118621173  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
118621273  PLN; cardiac phospholamban [KO:K05852]
118621540  [KO:K23449]
118622250  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
118622324  ADRB3; beta-3 adrenergic receptor [KO:K04143]
118622548  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
118622563  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
118622599  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
118622697  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118622736  EDNRB; endothelin receptor type B [KO:K04198]
118622757  FGF20; fibroblast growth factor 20 [KO:K04358]
118622788  VEGFC; vascular endothelial growth factor C [KO:K05449]
118623363  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
118623451  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118623513  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
118623517  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
118623540  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
118623804  FGF23; fibroblast growth factor 23 [KO:K22428]
118623871  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
118623942  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
118623957  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
118624129  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
118624192  AVPR1A; vasopressin V1a receptor [KO:K04226]
118624255  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118624257  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
118624310  FGF9; fibroblast growth factor 9 [KO:K04358]
118624552  FGF6; fibroblast growth factor 6 [KO:K04358]
118625095  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
118625188  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
118625195  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
118625406  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
118625794  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
118626130  FGF7; fibroblast growth factor 7 [KO:K04358]
118626159  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
118626166  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118626305  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
118626405  MCOLN3; mucolipin-3 [KO:K04994]
118626504  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
118626541  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
118626702  PTAFR; platelet-activating factor receptor isoform X1 [KO:K04279]
118627077  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
118627279  [KO:K04633]
118627560  [KO:K02183]
118627704  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
118627722  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
118627890  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
118627971  [KO:K05862]
118628000  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
118628169  [KO:K02183]
118628259  FGF19; fibroblast growth factor 19 [KO:K22603]
118628260  FGF4; fibroblast growth factor 4 [KO:K04358]
118628278  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118628294  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
118628437  P2RX3; P2X purinoceptor 3 [KO:K05217]
118628445  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
118628761  FGF3; fibroblast growth factor 3 [KO:K04358]
118628832  SLN; sarcolipin [KO:K22642]
118629013  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
118629069  PDGFD; platelet-derived growth factor D [KO:K05450]
118629438  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
118629502  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
118629607  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
118629634  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
118629696  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
118629754  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
118630484  CALM2; calmodulin-2 [KO:K02183]
118630645  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
118630701  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
118630745  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
118630900  TACR1; substance-P receptor [KO:K04222]
118631038  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
118631388  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
118631458  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
118631528  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
118631719  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
118631897  [KO:K02183]
118632082  TACR2; substance-K receptor [KO:K04223]
118632108  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
118632151  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
118632179  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118632183  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
118632238  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
118632260  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118632270  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
118632298  MRLN; myoregulin [KO:K22643]
118632322  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
118632329  ADRB1; beta-1 adrenergic receptor [KO:K04141]
118632332  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
118632384  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
118632500  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
118632878  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118632910  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
118632979  MST1; hepatocyte growth factor-like protein [KO:K23441]
118633142  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
118633182  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
118633270  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
118633310  OXTR; oxytocin receptor [KO:K04229]
118633330  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
118633382  HRH1; histamine H1 receptor [KO:K04149]
118633430  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
118633780  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
118633781  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
118633812  SMIM6; small integral membrane protein 6 [KO:K26468]
118633856  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118633872  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118633888  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118633936  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
118634176  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
118634219  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
118634287  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
118634494  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
118634564  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
118634685  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118634857  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
118635452  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
118635594  GRPR; gastrin-releasing peptide receptor [KO:K04169]
118635603  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
118635608  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
118635695  [KO:K15041]
118635789  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
118635791  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
118635912  [KO:K05096] [EC:2.7.10.1]
118636051  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
118636086  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
118636313  [KO:K02183]
118636328  VEGFD; vascular endothelial growth factor D [KO:K05449]
118636454  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
118636475  FGF16; fibroblast growth factor 16 [KO:K04358]
118636611  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
118637108  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
118637205  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
118637308  CASQ2; calsequestrin-2 [KO:K23445]
118637345  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
118637403  CASQ1; calsequestrin-1 [KO:K23468]
118637529  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
118637713  NGF; beta-nerve growth factor [KO:K02582]
118637921  AVPR1B; vasopressin V1b receptor [KO:K04227]
118638191  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
118638252  CALM3; calmodulin-3 [KO:K02183]
118638266  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
118638404  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
118638710  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
118638998  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
118639040  ITPKC; inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
118639222  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
118639281  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
118639385  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118639510  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
118639620  FGF21; fibroblast growth factor 21 [KO:K22429]
118639621  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
118639622  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
118639624  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118639809  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
118639832  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
118639904  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
118640000  ADORA2A; adenosine receptor A2a [KO:K04266]
118640019  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
118640024  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
118640087  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
118640095  [KO:K02183]
118640121  FGF5; fibroblast growth factor 5 [KO:K04358]
118640172  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
118640204  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
118640233  P2RX4; P2X purinoceptor 4 [KO:K05218]
118640543  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
118640549  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
118640583  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
118640735  RYR2; ryanodine receptor 2 [KO:K04962]
118640787  TACR3; neuromedin-K receptor [KO:K04224]
118640838  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
118640961  NTRK3; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
118641158  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
118641173  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
118641247  CCKAR; cholecystokinin receptor type A [KO:K04194]
118641250  ADORA2B; adenosine receptor A2b [KO:K04267]
118641341  BDKRB2; B2 bradykinin receptor [KO:K03916]
118641345  BDKRB1; B1 bradykinin receptor [KO:K03915]
118641370  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118641419  ORAI2; protein orai-2 [KO:K16057]
118641608  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
118641660  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
118641796  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
118641943  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
118642159  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
118642221  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
118642281  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
118642446  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
118642448  FGF10; fibroblast growth factor 10 [KO:K04358]
118642548  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
118642748  ORAI3; protein orai-3 isoform X1 [KO:K16058]
118642779  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
118642780  F2R; proteinase-activated receptor 1 [KO:K03914]
118643424  CALML6; calmodulin-like protein 6 [KO:K02183]
118643595  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118643618  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
118643683  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
118643768  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
118643921  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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Reference
PMID:11413485
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The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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Reference
PMID:15111104
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Wang MC, Dolphin A, Kitmitto A.
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L-type voltage-gated calcium channels: understanding function through structure.
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FEBS Lett 564:245-50 (2004)
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Reference
PMID:11299192
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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Reference
PMID:11698232
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Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
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Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
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Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
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Yakel JL.
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Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
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Reference
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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Neurosci Res 38:3-17 (2000)
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Reference
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
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Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
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Reference
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Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
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Reference
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
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Mol Cell Biol 23:7068-81 (2003)
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Reference
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Hutchins JR, Dikovskaya D, Clarke PR.
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
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Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Reference
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Baba Y, Kurosaki T
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[Regulation of store-operated calcium entry by STIM1].
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Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
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Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
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Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mmf04010  MAPK signaling pathway
mmf04070  Phosphatidylinositol signaling system
mmf04210  Apoptosis
mmf04720  Long-term potentiation
mmf04730  Long-term depression
KO pathway
ko04020   

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