Entry Name Long-term potentiation - Mus musculus (house mouse)
Description Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII) . Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsynaptic Ca2+ increases generated through NMDA receptors activate several signal transduction pathways including the Erk/MAP kinase and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptional pathway may increase expression of a family of genes required for late-phase LTP (L-LTP).
Class Organismal Systems; Nervous systemBRITE hierarchy
Pathway map Other DBs Organism Mus musculus (house mouse) [GN:
mmu ]
Gene 108058 Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2 [KO:K04515 ] [EC:2.7.11.17 ]
108071 Grm5; metabotropic glutamate receptor 5 isoform b precursor [KO:K04604 ]
11911 Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
12288 Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform 2 [KO:K04850 ]
12322 Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2 [KO:K04515 ] [EC:2.7.11.17 ]
12323 Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2 [KO:K04515 ] [EC:2.7.11.17 ]
12325 Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 1 [KO:K04515 ] [EC:2.7.11.17 ]
14682 Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
14799 Gria1; glutamate receptor 1 isoform 1 precursor [KO:K05197 ]
14800 Gria2; glutamate receptor 2 isoform 1 precursor [KO:K05198 ]
14810 Grin1; glutamate receptor ionotropic, NMDA 1 isoform 1 precursor [KO:K05208 ]
14811 Grin2a; glutamate receptor ionotropic, NMDA 2A precursor [KO:K05209 ]
14812 Grin2b; glutamate receptor ionotropic, NMDA 2B precursor [KO:K05210 ]
14813 Grin2c; glutamate receptor ionotropic, NMDA 2C precursor [KO:K05211 ]
14814 Grin2d; glutamate receptor ionotropic, NMDA 2D precursor [KO:K05212 ]
14816 Grm1; metabotropic glutamate receptor 1 isoform alpha precursor [KO:K04603 ]
16438 Itpr1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958 ]
16439 Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform 1 [KO:K04959 ]
16440 Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960 ]
18747 Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform 1 [KO:K04345 ] [EC:2.7.11.11 ]
18749 Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform 1 [KO:K04345 ] [EC:2.7.11.11 ]
18795 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 1 [KO:K05858 ] [EC:3.1.4.11 ]
18796 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform a [KO:K05858 ] [EC:3.1.4.11 ]
18797 Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform a [KO:K05858 ] [EC:3.1.4.11 ]
18798 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a [KO:K05858 ] [EC:3.1.4.11 ]
19045 Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
19046 Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
19047 Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1 [KO:K06269 ] [EC:3.1.3.16 ]
19055 Ppp3ca; protein phosphatase 3 catalytic subunit alpha isoform 1 [KO:K04348 ] [EC:3.1.3.16 ]
19056 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform 1 [KO:K04348 ] [EC:3.1.3.16 ]
19057 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2 [KO:K04348 ] [EC:3.1.3.16 ]
223864 Rapgef3; rap guanine nucleotide exchange factor 3 isoform 2 [KO:K08014 ]
26395 Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform 1 [KO:K04368 ] [EC:2.7.12.2 ]
26396 Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform 1 [KO:K04369 ] [EC:2.7.12.2 ]
58200 Ppp1r1a; protein phosphatase 1 regulatory subunit 1A [KO:K08050 ]
75600 Calml4; calmodulin-like protein 4 isoform a [KO:K02183 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Blitzer RD, Iyengar R, Landau EM.
Title Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity.
Journal Reference Authors Soderling TR, Derkach VA.
Title Postsynaptic protein phosphorylation and LTP.
Journal Reference Authors Poser S, Storm DR.
Title Role of Ca2+-stimulated adenylyl cyclases in LTP and memory formation.
Journal Reference Authors Xia Z, Storm DR.
Title The role of calmodulin as a signal integrator for synaptic plasticity.
Journal Reference Authors Purves D, Augustine GJ (ed).
Title Neuroscience
Journal Sunderland, Mass.:Sinauer Associates (2004)
Reference Authors Lynch MA.
Title Long-term potentiation and memory.
Journal Reference Authors Kelly PT, Mackinnon RL 2nd, Dietz RV, Maher BJ, Wang J.
Title Postsynaptic IP3 receptor-mediated Ca2+ release modulates synaptic transmission in hippocampal neurons.
Journal Reference Authors Berridge MJ.
Title Neuronal calcium signaling.
Journal Related KO pathway
