KEGG   PATHWAY: mni04914
Entry
mni04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Macaca nemestrina (pig-tailed macaque)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
mni04914  Progesterone-mediated oocyte maturation
mni04914

Other DBs
GO: 0001556
Organism
Macaca nemestrina (pig-tailed macaque) [GN:mni]
Gene
105466499  PGR; progesterone receptor isoform X1 [KO:K08556]
105475205  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105488082  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105494953  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105478978  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105489973  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105469947  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105486663  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105479668  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105484084  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
105474512  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105474514  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
105489757  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105489758  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105475385  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
105479273  GNAI3; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105480474  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
105494232  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105489474  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105479810  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
105477872  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
105470270  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105492900  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
105492251  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
105492815  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105467851  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
105498103  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105491778  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
105482741  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105470630  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
105487916  CPEB2; LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 2 [KO:K02602]
105497484  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
105480288  CPEB3; cytoplasmic polyadenylation element-binding protein 3 [KO:K02602]
105480900  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
105474139  SPDYE4; speedy protein E4 [KO:K08694]
105476830  speedy protein E2B isoform X1 [KO:K08694]
105479726  SPDYA; speedy protein A isoform X1 [KO:K08694]
105499860  putative speedy protein E7 [KO:K08694]
105469558  SPDYC; speedy protein C isoform X1 [KO:K08694]
105498010  putative speedy protein E7 [KO:K08694]
105474169  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105466181  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
105486045  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
105486148  CCNA2; cyclin-A2 [KO:K06627]
105482274  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
105466741  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
105467389  heat shock protein HSP 90-alpha [KO:K04079]
105489542  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
105488275  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105480656  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105482882  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105478207  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
105487633  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
105483642  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
105494511  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105467897  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
105475199  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
105489522  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
105493944  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
105480952  STK10; LOW QUALITY PROTEIN: serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
105485025  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
105480393  CDC25A; M-phase inducer phosphatase 1 isoform X2 [KO:K06645] [EC:3.1.3.48]
105481578  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
105467080  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
105469786  INS; insulin isoform X1 [KO:K04526]
105493817  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
105479398  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
105474669  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105489842  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105495343  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105486928  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
105492133  KRAS; GTPase KRas isoform X1 [KO:K07827]
105463916  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
105471274  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105477727  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105471819  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
105483405  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
105486164  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
105473160  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
105485530  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
105471971  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
105483066  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
105487829  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
105495493  ANAPC5; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 5 [KO:K03352]
105485230  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
105493734  ANAPC7; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 7 [KO:K03354]
105467082  CDC23; cell division cycle protein 23 homolog [KO:K03355]
105463406  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
105469391  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
105487050  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
105469896  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
105468690  ANAPC15; anaphase-promoting complex subunit 15 isoform X2 [KO:K25228]
105466048  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
105482905  KIF22; kinesin-like protein KIF22 isoform X1 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
mni04010  MAPK signaling pathway
mni04110  Cell cycle
KO pathway
ko04914   
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