KEGG   PATHWAY: msam03440
Entry
msam03440                   Pathway                                
Name
Homologous recombination - Micropterus salmoides (largemouth bass)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
msam03440  Homologous recombination
msam03440

Other DBs
GO: 0000724
Organism
Micropterus salmoides (largemouth bass) [GN:msam]
Gene
119918177  ssbp1; single-stranded DNA-binding protein, mitochondrial [KO:K03111]
119895172  rad50; DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
119882603  mre11a; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
119897623  nbn; nibrin isoform X1 [KO:K10867]
119882548  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
119916150  breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
119903973  bard1; BRCA1-associated RING domain protein 1 [KO:K10683]
119907359  rbbp8; DNA endonuclease RBBP8 isoform X1 [KO:K20773] [EC:3.1.-.-]
119883109  brip1; Fanconi anemia group J protein [KO:K15362] [EC:5.6.2.3]
119911854  topbp1; DNA topoisomerase 2-binding protein 1 [KO:K10728]
119914111  abraxas1; BRCA1-A complex subunit Abraxas 1 isoform X1 [KO:K20774]
119895021  uimc1; BRCA1-A complex subunit RAP80 [KO:K20775]
119900456  babam1; BRISC and BRCA1-A complex member 1 isoform X1 [KO:K20776]
119909823  babam2; BRISC and BRCA1-A complex member 2 [KO:K12173]
119914758  brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
119898698  palb2; LOW QUALITY PROTEIN: partner and localizer of BRCA2 [KO:K10897]
119883039  brca2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein [KO:K08775]
119898899  sem1; 26S proteasome complex subunit SEM1 [KO:K10881]
119894368  sycp3; synaptonemal complex protein 3 isoform X1 [KO:K19528]
119895247  replication protein A 70 kDa DNA-binding subunit-like isoform X1 [KO:K07466]
119882687  rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
119897303  rpa2; replication protein A 32 kDa subunit isoform X1 [KO:K10739]
119907149  replication protein A 32 kDa subunit-like isoform X1 [KO:K10739]
119907146  rpa3; replication protein A 14 kDa subunit [KO:K10740]
119908665  rad51; DNA repair protein RAD51 homolog 1 [KO:K04482]
119915282  rad52; DNA repair protein RAD52 homolog [KO:K10873]
119905543  rad51c; DNA repair protein RAD51 homolog 3 [KO:K10870]
119895024  rad51d; DNA repair protein RAD51 homolog 4 isoform X1 [KO:K10871]
119897554  LOW QUALITY PROTEIN: DNA repair protein XRCC2-like [KO:K10879]
119897577  DNA repair protein XRCC2-like [KO:K10879]
119909070  xrcc3; DNA repair protein XRCC3 isoform X1 [KO:K10880]
119901275  rad54l; DNA repair and recombination protein RAD54-like isoform X1 [KO:K10875] [EC:5.6.2.-]
119897659  rad54b; DNA repair and recombination protein RAD54B isoform X1 [KO:K10877] [EC:5.6.2.-]
119886637  pold1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
119891127  pold2; DNA polymerase delta subunit 2 [KO:K02328]
119901721  pold3; DNA polymerase delta subunit 3 [KO:K03504]
119899853  pold4; DNA polymerase delta subunit 4 [KO:K03505]
119893867  blm; Bloom syndrome protein homolog isoform X1 [KO:K10901] [EC:5.6.2.4]
119881858  top3a; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
119891435  top3b; DNA topoisomerase 3-beta-1 isoform X1 [KO:K03165] [EC:5.6.2.1]
119911796  mus81; crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
119915789  eme1; crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
LinkDB

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