KEGG   PATHWAY: mun04727
Entry
mun04727                    Pathway                                
Name
GABAergic synapse - Meriones unguiculatus (Mongolian gerbil)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
mun04727  GABAergic synapse
mun04727

Other DBs
GO: 0051932
Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110546171  Slc38a1; sodium-coupled neutral amino acid symporter 1 [KO:K14990]
110546176  Slc38a2; sodium-coupled neutral amino acid symporter 2 isoform X1 [KO:K14207]
110552022  Gls; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
110548970  Gls2; glutaminase liver isoform, mitochondrial isoform X3 [KO:K01425] [EC:3.5.1.2]
110549838  Gad1; glutamate decarboxylase 1 [KO:K01580] [EC:4.1.1.15]
110565931  Gad2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
110565877  Slc32a1; vesicular inhibitory amino acid transporter [KO:K15015]
110553199  Abat; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
110566282  Gabra2; gamma-aminobutyric acid receptor subunit alpha-2 [KO:K05175]
110541491  Gabra6; gamma-aminobutyric acid receptor subunit alpha-6 isoform X1 [KO:K05175]
110555457  Gabra5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
110563007  Gabra4; gamma-aminobutyric acid receptor subunit alpha-4 isoform X1 [KO:K05175]
110555027  Gabra1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
132651450  Gabra3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
110555450  Gabrb3; gamma-aminobutyric acid receptor subunit beta-3 isoform X3 [KO:K05181]
110562924  Gabrb2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181]
110563008  Gabrb1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
110541160  Gabrg1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
110563227  Gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
110566366  Gabrg3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
110560563  Gabrd; gamma-aminobutyric acid receptor subunit delta isoform X1 [KO:K05184]
110542528  Gabre; gamma-aminobutyric acid receptor subunit epsilon isoform X1 [KO:K05185]
110557315  Gabrp; gamma-aminobutyric acid receptor subunit pi [KO:K05189]
110545842  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110555016  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110566227  Src; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
110555335  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110559612  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110556016  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110563576  Hap1; huntingtin-associated protein 1 isoform X1 [KO:K04647]
110559712  Gabarapl1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
110555154  Gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
110554748  Gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
110548318  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
110545640  Nsf; vesicle-fusing ATPase isoform X1 [KO:K06027] [EC:3.6.4.6]
110557656  Trak2; trafficking kinesin-binding protein 2 [KO:K15374]
110556959  Plcl1; inactive phospholipase C-like protein 1 isoform X3 [KO:K15375]
110557050  Gphn; gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
110549296  Slc12a5; solute carrier family 12 member 5 isoform X3 [KO:K23967]
110547374  Gabrr1; gamma-aminobutyric acid receptor subunit rho-1 isoform X2 [KO:K05190]
110547376  Gabrr2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
110563476  Gabrr3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
110545836  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
110563057  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
110541273  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
110547567  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110561910  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
110548425  Cacna1s; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
110551130  Gabbr2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
110563047  Gabbr1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
110539607  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
110545517  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
110564775  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
110561150  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
110559917  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
110556769  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
110548560  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
110556251  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
110545481  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
110557636  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
110557460  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
110558140  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
110540240  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
110555606  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
110552633  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
110557441  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
110565823  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
110545821  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
110558424  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110548730  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
110565822  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
110553430  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
110555169  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110550962  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
110555185  Adcy3; adenylate cyclase type 3 isoform X3 [KO:K08043] [EC:4.6.1.1]
110556521  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
110547229  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
110559444  Adcy6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
110560723  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
110561696  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110545944  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
110566853  Kcnj6; G protein-activated inward rectifier potassium channel 2 isoform X1 [KO:K05000]
110548920  Slc6a1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
110546058  Slc6a13; sodium- and chloride-dependent GABA transporter 2 isoform X2 [KO:K05046]
110548942  Slc6a11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
110546069  sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045]
110546187  Glul; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
110564785  Slc38a3; sodium-coupled neutral amino acid transporter 3 [KO:K13576]
110565608  Slc38a5; sodium-coupled neutral amino acid transporter 5 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
mun00020  Citrate cycle (TCA cycle)
mun00250  Alanine, aspartate and glutamate metabolism
mun04144  Endocytosis
mun04721  Synaptic vesicle cycle
KO pathway
ko04727   
LinkDB

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