KEGG   PATHWAY: nle04530
Entry
nle04530                    Pathway                                
Name
Tight junction - Nomascus leucogenys (northern white-cheeked gibbon)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
nle04530  Tight junction
nle04530

Other DBs
GO: 0005923
Organism
Nomascus leucogenys (northern white-cheeked gibbon) [GN:nle]
Gene
100594803  CRB3; protein crumbs homolog 3 isoform X2 [KO:K06090]
100606879  CLDN34; claudin-34 [KO:K06087]
100598950  CLDN20; claudin-20 [KO:K06087]
100581619  CLDN23; claudin-23 [KO:K06087]
100596925  CLDN10; claudin-10 isoform X1 [KO:K06087]
100588826  CLDN7; claudin-7 isoform X1 [KO:K06087]
100579352  CLDN2; claudin-2 [KO:K06087]
100590243  CLDN3; claudin-3 [KO:K06087]
100597091  CLDN14; claudin-14 [KO:K06087]
100600203  CLDN16; claudin-16 [KO:K06087]
100580330  CLDN1; claudin-1 [KO:K06087]
100582745  putative claudin-24 [KO:K06087]
100583701  CLDN5; claudin-5 [KO:K06087]
100582068  CLDN22; claudin-22 [KO:K06087]
100606792  CLDN18; claudin-18 isoform X2 [KO:K06087]
101176801  claudin-6-like [KO:K06087]
100586632  CLDN6; claudin-6 [KO:K06087]
100586289  CLDN9; claudin-9 [KO:K06087]
100591337  CLDN25; LOW QUALITY PROTEIN: putative claudin-25 [KO:K06087]
100588998  CLDN4; claudin-4 [KO:K06087]
100600877  CLDN11; claudin-11 [KO:K06087]
100596588  CLDN15; claudin-15 isoform X1 [KO:K06087]
100597536  CLDN8; claudin-8 [KO:K06087]
100597196  CLDN17; claudin-17 [KO:K06087]
100601876  CLDN12; claudin-12 [KO:K06087]
100583496  OCLN; occludin [KO:K06088]
100596378  F11R; junctional adhesion molecule A [KO:K06089]
100585596  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
100583594  JAM3; junctional adhesion molecule C isoform X1 [KO:K06785]
100582667  BVES; blood vessel epicardial substance [KO:K21108]
100605245  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100586482  PARD6A; partitioning defective 6 homolog alpha isoform X6 [KO:K06093]
100597121  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
100588054  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
100584751  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
100587466  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
100591308  PATJ; inaD-like protein [KO:K06092]
100589141  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
100585698  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
100599635  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
100599109  AMOT; angiomotin isoform X2 [KO:K16819]
100596553  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
100596184  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
100581241  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
100604516  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100599082  NF2; merlin isoform X1 [KO:K16684]
101179420  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
100594687  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
100603856  DLG1; disks large homolog 1 isoform X20 [KO:K12076]
100607109  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
100596525  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100585393  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100605248  PPP2R1B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
100598916  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100584267  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
100585667  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100583131  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X5 [KO:K04354]
100583311  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
100592712  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100605316  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100589256  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
100596645  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
100590895  DLG2; disks large homolog 2 isoform X18 [KO:K12075]
100583755  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
100600829  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
100589832  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
100597281  CGN; cingulin [KO:K06102]
100605225  CGNL1; cingulin-like protein 1 isoform X2 [KO:K21110]
100601565  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X10 [KO:K12791]
100607291  RHOA; transforming protein RhoA [KO:K04513]
100602105  GATA4; transcription factor GATA-4 isoform X2 [KO:K09183]
100581916  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
100606554  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100581677  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100605285  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100602081  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
100586501  JUN; transcription factor AP-1 [KO:K04448]
100599192  CD1B; T-cell surface glycoprotein CD1b [KO:K06448]
100597833  CD1D; antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
100598860  CD1C; T-cell surface glycoprotein CD1c [KO:K06448]
100598522  CD1A; T-cell surface glycoprotein CD1a isoform X1 [KO:K06448]
100599526  CD1E; T-cell surface glycoprotein CD1e, membrane-associated isoform X1 [KO:K06448]
100601480  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
100594967  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100586942  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
100599532  SYMPK; symplekin isoform X1 [KO:K06100]
100591168  PCNA; proliferating cell nuclear antigen [KO:K04802]
100605736  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100601700  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100594110  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
100602925  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
100606650  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
100581958  EZR; ezrin isoform X1 [KO:K08007]
100601297  RDX; radixin isoform X2 [KO:K05762]
100601428  MSN; moesin [KO:K05763]
100606298  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
100598167  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100598411  ACTB; actin, cytoplasmic 1 [KO:K05692]
100600997  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100587332  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
100587140  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100602214  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100600009  CTTN; src substrate cortactin isoform X1 [KO:K06106]
100598393  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
100587384  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
100587269  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
100606041  ACTR3; actin-related protein 3 [KO:K18584]
100584005  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
100589804  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
100597015  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
100601579  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
100596861  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X2 [KO:K05755]
100598106  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
100581707  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X2 [KO:K05754]
100581937  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
100598058  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
100597154  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100583577  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X8 [KO:K04345] [EC:2.7.11.11]
100579779  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100607741  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100598193  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
100581805  rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
100586590  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
100585294  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
100590389  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100586019  EPB41L4B; band 4.1-like protein 4B isoform X4 [KO:K21111]
100602473  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
100582042  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
100595096  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
100600676  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
100597131  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
100598921  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X3 [KO:K07200]
100607037  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
100606474  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
100585776  MYH10; myosin-10 isoform X1 [KO:K10352]
100589070  myosin-14 isoform X1 [KO:K10352]
100591092  MYH9; myosin-9 isoform X1 [KO:K10352]
100601489  MYH11; myosin-11 isoform X1 [KO:K10352]
100597763  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
100598109  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
100593242  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100586474  MYL12A; myosin regulatory light chain 12A isoform X1 [KO:K12757]
100585479  MYL12B; myosin regulatory light chain 12B [KO:K12757]
100601137  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
100581639  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
100591761  SYNPO; synaptopodin [KO:K21112]
100588862  ACTN4; alpha-actinin-4 isoform X2 [KO:K05699]
100596303  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
100595017  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
100593627  RAB8A; ras-related protein Rab-8A [KO:K07901]
100594472  RAB8B; ras-related protein Rab-8B [KO:K07902]
100591273  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X2 [KO:K08020]
100603891  RAP1A; ras-related protein Rap-1A [KO:K04353]
100595108  ITGB1; integrin beta-1 [KO:K05719]
100592208  AFDN; afadin isoform X1 [KO:K05702]
100579261  tight junction protein ZO-2 isoform X1 [KO:K06098]
100594311  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X12 [KO:K08018]
105738102  RAP2C; ras-related protein Rap-2c isoform X1 [KO:K07839]
100582164  MARVELD2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
100602904  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
100582452  TUBA8; tubulin alpha-8 chain [KO:K07374]
100585215  tubulin alpha-3 chain [KO:K07374]
100587604  tubulin alpha-3 chain [KO:K07374]
100599731  TUBA4B; putative tubulin-like protein alpha-4B [KO:K07374]
100602647  tubulin alpha-1C chain isoform X1 [KO:K07374]
100583522  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
100592992  TUBA3E; tubulin alpha-3E chain [KO:K07374]
100585634  tubulin alpha-1A chain [KO:K07374]
100604350  tubulin alpha-1B chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
nle04520  Adherens junction
nle04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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