Entry
Name
GABAergic synapse - Neogale vison (American mink)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Neogale vison (American mink) [GN:
nvs ]
Gene
122891431 SLC38A1; sodium-coupled neutral amino acid transporter 1 [KO:K14990 ]
122891429 SLC38A2; sodium-coupled neutral amino acid transporter 2 isoform X1 [KO:K14207 ]
122889380 GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175 ]
122889496 GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175 ]
122897152 GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175 ]
122893240 GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175 ]
122901965 GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175 ]
122893724 GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 isoform X1 [KO:K05175 ]
122890521 GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181 ]
122893248 GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181 ]
122893530 GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181 ]
122889525 GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 isoform X1 [KO:K05186 ]
122893215 GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186 ]
122894391 GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 isoform X1 [KO:K05186 ]
122899349 GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184 ]
122897320 GABRE; gamma-aminobutyric acid receptor subunit epsilon isoform X1 [KO:K05185 ]
122897350 GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192 ]
122907318 HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647 ]
122891208 GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
122911227 GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
122902192 TRAK2; trafficking kinesin-binding protein 2 isoform X1 [KO:K15374 ]
122902159 PLCL1; inactive phospholipase C-like protein 1 isoform X1 [KO:K15375 ]
122916016 SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967 ]
122904689 GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190 ]
122898673 GABRR1; gamma-aminobutyric acid receptor subunit rho-1 isoform X1 [KO:K05190 ]
122910375 GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190 ]
122909666 CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344 ]
122917048 CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849 ]
122892214 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850 ]
122909338 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
122897554 CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853 ]
122918773 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
122915043 GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615 ]
122917419 GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615 ]
122904758 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630 ]
122900295 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
122909406 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
122911436 GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534 ]
122899348 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
122896086 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
122892610 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
122908715 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
122892946 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
122893048 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
122913015 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
122898876 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541 ]
122906945 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
122900135 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
122901985 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
122909910 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
122913893 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
122917352 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
122904822 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
122900073 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
122909693 GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347 ]
122895413 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
122904821 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
122906603 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
122908293 KCNJ6; G protein-activated inward rectifier potassium channel 2 isoform X1 [KO:K05000 ]
122909204 SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034 ]
122891805 SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046 ]
122909205 SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044 ]
122891878 SLC6A12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045 ]
122909407 SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576 ]
122897233 SLC38A5; sodium-coupled neutral amino acid transporter 5 [KO:K14992 ]
Compound
Reference
Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
Title
Neuropsychopharmacology: The fifth generation of progress
Journal
Reference
Authors
Farrant M, Kaila K
Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
Journal
Reference
Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
Journal
Reference
Authors
Pinard A, Seddik R, Bettler B
Title
GABAB receptors: physiological functions and mechanisms of diversity.
Journal
Reference
Authors
Chalifoux JR, Carter AG
Title
GABAB receptor modulation of synaptic function.
Journal
Reference
Authors
Padgett CL, Slesinger PA
Title
GABAB receptor coupling to G-proteins and ion channels.
Journal
Reference
Authors
Emson PC
Title
GABA(B) receptors: structure and function.
Journal
Reference
Authors
Kornau HC
Title
GABA(B) receptors and synaptic modulation.
Journal
Reference
Authors
Jacob TC, Moss SJ, Jurd R
Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
Journal
Reference
Authors
Kneussel M
Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
Journal
Reference
Authors
Luscher B, Fuchs T, Kilpatrick CL
Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
Journal
Reference
Authors
Arancibia-Carcamo IL, Kittler JT
Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
Journal
Reference
Authors
Bak LK, Schousboe A, Waagepetersen HS
Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
Journal
Reference
Authors
Conti F, Minelli A, Melone M
Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
Journal
Reference
Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
Title
GABAergic dysfunction in mood disorders.
Journal
Reference
Authors
Chebib M, Johnston GA
Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
Journal
Related pathway
nvs00250 Alanine, aspartate and glutamate metabolism
KO pathway
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