KEGG   PATHWAY: oga04310
Entry
oga04310                    Pathway                                
Name
Wnt signaling pathway - Otolemur garnettii (small-eared galago)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
oga04310  Wnt signaling pathway
oga04310

Other DBs
GO: 0016055
Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100953924  PORCN; protein-serine O-palmitoleoyltransferase porcupine [KO:K00181] [EC:2.3.1.250]
100943890  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100946400  WNT2; protein Wnt-2 [KO:K00182]
100960603  WNT2B; protein Wnt-2b [KO:K00182]
100964130  WNT3A; protein Wnt-3a [KO:K00312]
100954489  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100950370  WNT4; protein Wnt-4 [KO:K00408]
100962307  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100950006  WNT5B; protein Wnt-5b [KO:K00444]
100947622  WNT6; protein Wnt-6 [KO:K00445]
100959243  WNT7A; protein Wnt-7a [KO:K00572]
100943606  WNT7B; protein Wnt-7b [KO:K00572]
100947970  WNT8B; protein Wnt-8b [KO:K00714]
100963978  WNT8A; protein Wnt-8a [KO:K00714]
100957093  WNT9A; protein Wnt-9a [KO:K01064]
100954800  WNT9B; protein Wnt-9b [KO:K01064]
100943567  WNT10B; protein Wnt-10b [KO:K01357]
100947304  WNT10A; protein Wnt-10a [KO:K01357]
100954223  WNT11; protein Wnt-11 [KO:K01384]
100959119  WNT16; protein Wnt-16 [KO:K01558]
100965250  CER1; cerberus [KO:K01645]
100948896  NOTUM; palmitoleoyl-protein carboxylesterase NOTUM [KO:K19882] [EC:3.1.1.98]
100941390  WIF1; wnt inhibitory factor 1 [KO:K01691]
100945552  SOST; sclerostin [KO:K16834]
100956836  DKK2; dickkopf-related protein 2 [KO:K02165]
100951312  DKK4; dickkopf-related protein 4 [KO:K02165]
100955497  DKK1; dickkopf-related protein 1 [KO:K02165]
100955912  SERPINF1; pigment epithelium-derived factor [KO:K19614]
100948261  SFRP1; secreted frizzled-related protein 1 [KO:K02166]
100964361  SFRP2; secreted frizzled-related protein 2 [KO:K02176]
100952733  FRZB; secreted frizzled-related protein 3 [KO:K25481]
100944184  SFRP4; secreted frizzled-related protein 4 [KO:K02185]
100956792  SFRP5; secreted frizzled-related protein 5 [KO:K02222]
100964353  RSPO1; R-spondin-1 [KO:K19471]
100950467  RSPO2; R-spondin-2 isoform X1 [KO:K23097]
100947917  RSPO3; R-spondin-3 [KO:K23098]
100957706  RSPO4; R-spondin-4 [KO:K23099]
100957559  LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1 [KO:K04309]
100950967  LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1 [KO:K04308]
100960170  LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399]
100966696  RNF43; E3 ubiquitin-protein ligase RNF43 [KO:K15694] [EC:2.3.2.27]
100961217  ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [KO:K16273] [EC:2.3.2.27]
100963272  FZD7; frizzled-7 [KO:K02432]
100948251  FZD1; frizzled-1 [KO:K02432]
100963711  FZD2; frizzled-2 [KO:K02235]
100956711  FZD3; frizzled-3 [KO:K02329]
100964395  FZD4; frizzled-4 [KO:K02354]
100947964  FZD8; frizzled-8 [KO:K02375]
100963379  FZD5; frizzled-5 [KO:K02375]
100955382  FZD6; frizzled-6 isoform X2 [KO:K02376]
100943205  FZD10; frizzled-10 [KO:K02842]
100943348  FZD9; frizzled-9 [KO:K02842]
100961774  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
100960349  BAMBI; BMP and activin membrane-bound inhibitor homolog isoform X1 [KO:K10162]
100960527  APCDD1; protein APCDD1 [KO:K25812]
100952610  APCDD1L; protein APCDD1-like [KO:K25812]
100948365  CSNK1E; casein kinase I isoform X3 [KO:K08960] [EC:2.7.11.1]
100950509  protein Daple [KO:K25811]
100940907  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100947881  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100961331  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
100960572  FRAT1; proto-oncogene FRAT1 [KO:K03069]
100967077  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
100949419  CSNK2A1; LOW QUALITY PROTEIN: casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
100950929  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
100964744  NKD2; protein naked cuticle homolog 2 [KO:K03213]
100957233  NKD1; protein naked cuticle homolog 1 [KO:K03213]
100964172  CXXC4; CXXC-type zinc finger protein 4 [KO:K03344]
100963944  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
100952751  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
100966689  CTNNB1; catenin beta-1 [KO:K02105]
100964150  AXIN1; axin-1 isoform X2 [KO:K02157]
100964757  AXIN2; axin-2 [KO:K04385]
100950293  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100966348  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
100961078  casein kinase I-like isoform X1 [KO:K08957] [EC:2.7.11.1]
100942799  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
100963051  casein kinase I-like isoform X1 [KO:K08957] [EC:2.7.11.1]
100964686  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
100953920  CSNK1A1; casein kinase I isoform X3 [KO:K08957] [EC:2.7.11.1]
100947392  TCF7; transcription factor 7 isoform X1 [KO:K02620]
100940553  TCF7L1; transcription factor 7-like 1 [KO:K04490]
100943434  TCF7L2; transcription factor 7-like 2 isoform X11 [KO:K04491]
100958411  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
100944072  LZTS2; leucine zipper putative tumor suppressor 2 [KO:K26471]
100953685  CTNNBIP1; beta-catenin-interacting protein 1 [KO:K04493]
100946045  CBY1; protein chibby homolog 1 [KO:K23402]
100961087  CHD8; chromodomain-helicase-DNA-binding protein 8 isoform X2 [KO:K04494] [EC:5.6.2.-]
100949017  MCC; colorectal mutant cancer protein isoform X1 [KO:K26734]
100940731  CCAR2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816]
100966528  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
100954105  SOX17; transcription factor SOX-17 [KO:K04495]
100960121  CTBP1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
100949153  CTBP2; C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
100941634  TLE3; transducin-like enhancer protein 3 [KO:K04497]
100949071  TLE1; transducin-like enhancer protein 1 isoform X4 [KO:K04497]
100949232  TLE2; transducin-like enhancer protein 2 [KO:K04497]
100948918  TLE6; transducin-like enhancer protein 6 [KO:K04497]
100948361  transducin-like enhancer protein 4 isoform X2 [KO:K04497]
100965189  CTNND2; catenin delta-2 isoform X1 [KO:K23491]
100943144  CREBBP; CREB-binding protein isoform X3 [KO:K04498] [EC:2.3.1.48]
100963040  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
100953578  RUVBL1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
100955502  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
100962223  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
100962907  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100956941  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
100952981  MYC; myc proto-oncogene protein [KO:K04377]
100965098  JUN; transcription factor AP-1 [KO:K04448]
100962923  FOSL1; fos-related antigen 1 isoform X1 [KO:K04502]
100958947  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100962188  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100945148  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
100954940  WISP1; WNT1-inducible-signaling pathway protein 1 [KO:K22471]
100951033  PPARD; peroxisome proliferator-activated receptor delta isoform X2 [KO:K04504]
100952024  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
100964083  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100966533  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100963622  TP53; cellular tumor antigen p53 [KO:K04451]
100962144  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
100951173  E3 ubiquitin-protein ligase Siah1-like [KO:K04506] [EC:2.3.2.27]
100945306  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
100949715  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
100943948  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
100943149  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
100945371  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
100959034  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X2 [KO:K04506] [EC:2.3.2.27]
100944326  calcyclin-binding protein-like isoform X1 [KO:K04507]
100959800  calcyclin-binding protein-like [KO:K04507]
100946060  CACYBP; calcyclin-binding protein [KO:K04507]
100947924  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
100951462  TBL1X; F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
100963535  TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
100942812  BTRC; F-box/WD repeat-containing protein 1A [KO:K03362]
100946977  FBXW11; F-box/WD repeat-containing protein 11 isoform X2 [KO:K03362]
100962270  CUL1; cullin-1 [KO:K03347]
100963359  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
100947369  GPC4; glypican-4 [KO:K08110]
100941889  ROR1; inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:2.7.10.1]
100967002  ROR2; tyrosine-protein kinase transmembrane receptor ROR2 isoform X1 [KO:K05123] [EC:2.7.10.1]
100941759  RYK; tyrosine-protein kinase RYK [KO:K05128] [EC:2.7.10.1]
100943027  VANGL1; vang-like protein 1 [KO:K04510]
100950542  VANGL2; vang-like protein 2 [KO:K04510]
100943540  PRICKLE4; prickle-like protein 4 [KO:K04511]
100951298  PRICKLE3; prickle planar cell polarity protein 3 [KO:K04511]
100952266  PRICKLE2; prickle-like protein 2 [KO:K04511]
100955346  PRICKLE1; prickle-like protein 1 [KO:K04511]
100954889  INVS; inversin isoform X1 [KO:K19626]
100951140  DAAM2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
100963217  DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512]
100954771  RHOA; transforming protein RhoA [KO:K04513]
100953342  ROCK2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
100951369  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100957182  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100948274  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
100957169  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100967053  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100960275  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100966029  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100966182  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858] [EC:3.1.4.11]
100953462  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858] [EC:3.1.4.11]
100951857  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
100941825  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
100955681  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515] [EC:2.7.11.17]
100956846  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
100950655  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100961754  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100961025  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
100945846  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
105886540  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105887331  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100965377  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100943579  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100956877  PRKCG; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100940498  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100955220  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
100966615  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
100950273  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
oga04010  MAPK signaling pathway
oga04110  Cell cycle
oga04115  p53 signaling pathway
oga04120  Ubiquitin mediated proteolysis
oga04350  TGF-beta signaling pathway
oga04510  Focal adhesion
oga04520  Adherens junction
oga05010  Alzheimer disease
KO pathway
ko04310   
LinkDB

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