KEGG   PATHWAY: ogo04114
Entry
ogo04114                    Pathway                                
Name
Oocyte meiosis - Oncorhynchus gorbuscha (pink salmon)
Description
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segregate to opposite poles, while the sister chromatids segregate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (prophase of meiosis I). The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B. In PI-arrested oocytes, MPF is initially inactive and is activated by the dual-specificity CDC25C phosphatase as the result of new synthesis of Mos induced by progesterone. MPF activation mediates the transition from the PI arrest to MI. The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos. CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs. Fertilization triggers a transient increase in cytosolic free Ca2+, which leads to CSF inactivation and cyclin B destruction through the APC. Then eggs are released from MII into the first embryonic cell cycle.
Class
Cellular Processes; Cell growth and death
Pathway map
ogo04114  Oocyte meiosis
ogo04114

Other DBs
GO: 0051321
Organism
Oncorhynchus gorbuscha (pink salmon) [GN:ogo]
Gene
123995144  insulin-like [KO:K04526]
124000570  insulin [KO:K04526]
123994489  insulin-like growth factor I isoform X1 [KO:K05459]
124013790  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
124036813  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
124000795  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
123992448  pgr; progesterone receptor [KO:K08556]
123993663  androgen receptor-like [KO:K08557]
124011430  androgen receptor-like [KO:K08557]
123999303  androgen receptor-like isoform X1 [KO:K08557]
124008847  androgen receptor-like isoform X1 [KO:K08557]
123997178  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
124010162  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
124041773  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
124043321  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
124027005  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
123995167  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
123997492  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
124005714  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
124043989  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
124017844  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
124031731  adcy6a; LOW QUALITY PROTEIN: adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
124046119  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
124032309  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
124033586  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
124035566  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
124009784  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
124045363  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
123999196  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
124016520  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
123994965  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
124002772  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
124003154  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
124041764  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
124027026  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
124009569  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
124002931  aurka; aurora kinase A [KO:K11481] [EC:2.7.11.1]
123996843  cytoplasmic polyadenylation element-binding protein 2-like isoform X1 [KO:K02602]
124018109  cpeb1b; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
124040143  cpeb1a; cytoplasmic polyadenylation element-binding protein 1a isoform X1 [KO:K02602]
124010853  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
124041413  LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 3-like [KO:K02602]
123998709  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
124014213  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
124037834  cytoplasmic polyadenylation element-binding protein 2-like isoform X1 [KO:K02602]
124038137  cpeb3; LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 3 [KO:K02602]
124039165  mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
124037367  map2k1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124037445  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
124034739  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
124036684  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124037950  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124000779  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
123991286  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
123993785  rps6kal; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
124040368  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
124006725  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
124007012  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
124001147  ribosomal protein S6 kinase 2 alpha-like isoform X1 [KO:K04373] [EC:2.7.11.1]
124038420  ribosomal protein S6 kinase alpha-2-like isoform X1 [KO:K04373] [EC:2.7.11.1]
124046261  rps6ka1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
124039520  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
124048497  pkmyt1; LOW QUALITY PROTEIN: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
123990608  14-3-3 protein zeta-like [KO:K16197]
123994871  14-3-3 protein zeta-like [KO:K16197]
124003263  14-3-3 protein beta/alpha-1-like [KO:K16197]
124022322  14-3-3 protein beta/alpha-A-like [KO:K16197]
124026228  14-3-3 protein beta/alpha-A-like [KO:K16197]
124008166  14-3-3 protein beta/alpha-1 [KO:K16197]
124045643  14-3-3 protein beta/alpha-2 [KO:K16197]
124001369  14-3-3 protein beta/alpha-1-like [KO:K16197]
124031666  14-3-3 protein beta/alpha-2-like [KO:K16197]
124046306  14-3-3 protein beta/alpha-1-like [KO:K16197]
123992982  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
123998749  14-3-3 protein epsilon isoform X1 [KO:K06630]
124005576  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
124012747  14-3-3 protein epsilon-like [KO:K06630]
123992755  ywhag2; 14-3-3 protein gamma-2 [KO:K16198]
124048867  ywhah; LOW QUALITY PROTEIN: 14-3-3 protein eta [KO:K16198]
124005799  14-3-3 protein gamma-2-like [KO:K16198]
124000591  14-3-3 protein gamma-1 [KO:K16198]
124007390  14-3-3 protein eta-like [KO:K16198]
124014729  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
124035953  spdya; speedy protein A [KO:K08694]
124041195  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
124038297  cyclin-dependent kinase 1-like isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
124003072  cyclin-dependent kinase 2-like isoform X1 [KO:K02206] [EC:2.7.11.22]
124031195  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
123994513  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
123994514  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
124002691  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
124002932  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
124034927  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
124013918  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
124013993  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
124031636  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
124031849  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
124046141  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
124046145  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
124032327  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
124032336  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
123990935  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
123995345  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
124048508  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
124034415  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A-like [KO:K06269] [EC:3.1.3.16]
124036188  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
123999459  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
124013950  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like isoform X1 [KO:K06269] [EC:3.1.3.16]
124015411  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
124008535  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
124004058  STE20-like serine/threonine-protein kinase isoform X1 [KO:K08836] [EC:2.7.11.1]
124041247  slka; STE20-like serine/threonine-protein kinase isoform X1 [KO:K08836] [EC:2.7.11.1]
124015200  STE20-like serine/threonine-protein kinase isoform X1 [KO:K08836] [EC:2.7.11.1]
124030332  si:dkey-81j8.6; serine/threonine-protein kinase 10 isoform X1 [KO:K08836] [EC:2.7.11.1]
124021791  serine/threonine-protein kinase PLK1-like isoform X1 [KO:K06631] [EC:2.7.11.21]
124022872  serine/threonine-protein kinase PLK1-like isoform X1 [KO:K06631] [EC:2.7.11.21]
124007279  M-phase inducer phosphatase 1-B-like [KO:K05867] [EC:3.1.3.48]
123993890  cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770]
124033750  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
124035731  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
124014433  mRNA decay activator protein ZFP36L2-B-like [KO:K13056]
124000287  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
124015661  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
123991258  cul1b; cullin-1b [KO:K03347]
124009652  cullin-1 [KO:K03347]
124041817  cullin-1-like [KO:K03347]
124013717  S-phase kinase-associated protein 1 [KO:K03094]
124000513  S-phase kinase-associated protein 1-like [KO:K03094]
123993303  fbxw11a; F-box and WD repeat domain-containing 11-A isoform X1 [KO:K03362]
124010761  F-box and WD repeat domain-containing 11-B isoform X1 [KO:K03362]
124008249  F-box and WD repeat domain-containing 11-B-like [KO:K03362]
124017534  F-box and WD repeat domain-containing 11-B-like [KO:K03362]
124041157  fbxo5; F-box only protein 5 [KO:K10292]
124037254  F-box only protein 5-like [KO:K10292]
124038324  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 1-like [KO:K03348]
124048986  anapc2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
124007131  anaphase-promoting complex subunit 2-like [KO:K03349]
123999378  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
124015543  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
123997078  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
124035186  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
124041402  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
124043740  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
124034419  anaphase-promoting complex subunit 7-like isoform X1 [KO:K03354]
124036184  anaphase-promoting complex subunit 7 [KO:K03354]
124006436  cell division cycle protein 23 homolog [KO:K03355]
124007161  cell division cycle protein 23 homolog isoform X1 [KO:K03355]
124008444  anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
124003794  anaphase-promoting complex subunit 11 [KO:K03358]
124016146  anaphase-promoting complex subunit 11 [KO:K03358]
124047696  anaphase-promoting complex subunit CDC26-like [KO:K03359]
124042259  anaphase-promoting complex subunit CDC26-like [KO:K03359]
124006939  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
123998727  anapc13; anaphase-promoting complex subunit 13 isoform X1 [KO:K12456]
123993881  anaphase-promoting complex subunit 15-like [KO:K25228]
124006344  anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
124041087  anaphase-promoting complex subunit 16-like [KO:K25229]
124041088  anaphase-promoting complex subunit 16-like [KO:K25229]
124034715  cell division cycle protein 20 homolog B-like [KO:K03363]
124041801  cell division cycle protein 20 homolog [KO:K03363]
124017624  F-box only protein 43-like [KO:K10318]
124017629  F-box only protein 43-like [KO:K10318]
124017647  F-box only protein 43-like [KO:K10318]
124011536  pttg1; securin isoform X1 [KO:K06635]
124003497  espl1; separin [KO:K02365] [EC:3.4.22.49]
123998032  meiotic recombination protein REC8 homolog isoform X1 [KO:K13054]
124039154  rec8b; REC8 meiotic recombination protein b isoform X1 [KO:K13054]
123997775  smc1b; structural maintenance of chromosomes protein 1B [KO:K06636]
124046108  structural maintenance of chromosomes protein 1A [KO:K06636]
124032292  structural maintenance of chromosomes protein 1A-like [KO:K06636]
124015302  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
124047880  G2/mitotic-specific cyclin-B1-like [KO:K05868]
124035070  G2/mitotic-specific cyclin-B1-like [KO:K05868]
124007134  G2/mitotic-specific cyclin-B1-like [KO:K05868]
123990647  mitotic checkpoint serine/threonine-protein kinase BUB1-like isoform X1 [KO:K02178] [EC:2.7.11.1]
123995640  mitotic checkpoint serine/threonine-protein kinase BUB1-like isoform X1 [KO:K02178] [EC:2.7.11.1]
124014475  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
124008407  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
124045084  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
124022339  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
124024619  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
123996660  G1/S-specific cyclin-E2-like isoform X1 [KO:K06626]
124033162  G1/S-specific cyclin-E1-like [KO:K06626]
124035086  G1/S-specific cyclin-E1-like [KO:K06626]
124005573  G1/S-specific cyclin-E2-like [KO:K06626]
124013201  sgo1; shugoshin 1 isoform X1 [KO:K11580]
123990583  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform-like [KO:K11584]
123990967  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
123994854  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform-like isoform X1 [KO:K11584]
123995312  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
124041352  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform-like isoform X1 [KO:K11584]
124014488  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like [KO:K11584]
124001142  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
124038185  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
124001311  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
124046206  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
124046529  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform-like isoform X1 [KO:K11584]
124017503  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like [KO:K11584]
123993117  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
124004833  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
123989480  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
123993708  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
124010911  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
124033974  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
124013707  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
123999690  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
124016626  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
123995794  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1-like [KO:K05861] [EC:3.1.4.11]
124003822  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
124003962  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
124031230  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
124031497  itpr1b; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
124035132  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
124002508  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
124045536  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
124031940  inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
123990895  calmodulin-A isoform X1 [KO:K02183]
123993069  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
123995385  calmodulin-1 [KO:K02183]
124017992  calm1a; calmodulin-1a [KO:K02183]
124011142  calml4b; calmodulin-like protein 4 isoform X1 [KO:K02183]
124041381  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
124005296  calmodulin-1 [KO:K02183]
124035491  calmodulin-like protein 4 [KO:K02183]
124022801  calmodulin-like protein 4 [KO:K02183]
124025548  calmodulin-like protein 4 [KO:K02183]
124006994  calmodulin-1 [KO:K02183]
124007773  calmodulin-1 [KO:K02183]
124001270  calmodulin-1 [KO:K02183]
124038162  calmodulin-1 [KO:K02183]
124017156  calglandulin-like [KO:K02183]
123993586  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124034144  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
124011241  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
124048714  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
123999177  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
124006395  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
124036504  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
124007488  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124014618  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124007866  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
124040442  calcineurin subunit B type 1-like isoform X1 [KO:K06268]
124048080  calcineurin subunit B type 1-like [KO:K06268]
124003478  calcineurin subunit B type 1 isoform X1 [KO:K06268]
124015906  calcineurin subunit B type 1 [KO:K06268]
123989345  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
124040066  calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
124048133  calcium/calmodulin-dependent protein kinase type II subunit delta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
124034029  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
124041281  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
124005769  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
124036602  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
124006676  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
124006684  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
124026272  calcium/calmodulin-dependent protein kinase type II delta 2 chain-like [KO:K04515] [EC:2.7.11.17]
124027516  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
124014458  calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
124008153  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
Compound
C00076  Calcium cation
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:16760654
  Authors
Haccard O, Jessus C
  Title
Oocyte maturation, Mos and cyclins--a matter of synthesis: two functionally redundant ways to induce meiotic maturation.
  Journal
Cell Cycle 5:1152-9 (2006)
DOI:10.4161/cc.5.11.2800
Reference
PMID:15182704
  Authors
Crane R, Gadea B, Littlepage L, Wu H, Ruderman JV
  Title
Aurora A, meiosis and mitosis.
  Journal
Biol Cell 96:215-29 (2004)
DOI:10.1016/j.biolcel.2003.09.008
Reference
PMID:15136768
  Authors
Perdiguero E, Nebreda AR
  Title
Regulation of Cdc25C activity during the meiotic G2/M transition.
  Journal
Cell Cycle 3:733-7 (2004)
DOI:10.4161/cc.3.6.906
Reference
PMID:17480229
  Authors
Perry JA, Kornbluth S
  Title
Cdc25 and Wee1: analogous opposites?
  Journal
Cell Div 2:12 (2007)
DOI:10.1186/1747-1028-2-12
Reference
PMID:15182701
  Authors
Jessus C, Ozon R
  Title
How does Xenopus oocyte acquire its competence to undergo meiotic maturation?
  Journal
Biol Cell 96:187-92 (2004)
DOI:10.1016/j.biolcel.2003.12.007
Reference
PMID:16518630
  Authors
Revenkova E, Jessberger R
  Title
Shaping meiotic prophase chromosomes: cohesins and synaptonemal complex proteins.
  Journal
Chromosoma 115:235-40 (2006)
DOI:10.1007/s00412-006-0060-x
Reference
PMID:18631137
  Authors
Belloc E, Pique M, Mendez R
  Title
Sequential waves of polyadenylation and deadenylation define a translation circuit that drives meiotic progression.
  Journal
Biochem Soc Trans 36:665-70 (2008)
DOI:10.1042/BST0360665
Reference
PMID:18598214
  Authors
Pesin JA, Orr-Weaver TL
  Title
Regulation of APC/C activators in mitosis and meiosis.
  Journal
Annu Rev Cell Dev Biol 24:475-99 (2008)
DOI:10.1146/annurev.cellbio.041408.115949
Reference
PMID:18550795
  Authors
Tang W, Wu JQ, Guo Y, Hansen DV, Perry JA, Freel CD, Nutt L, Jackson PK, Kornbluth S
  Title
Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.
  Journal
Mol Biol Cell 19:3536-43 (2008)
DOI:10.1091/mbc.E08-04-0417
Reference
PMID:18946022
  Authors
Wu JQ, Kornbluth S
  Title
Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era.
  Journal
J Cell Sci 121:3509-14 (2008)
DOI:10.1242/jcs.036855
Reference
PMID:16554437
  Authors
Schmidt A, Rauh NR, Nigg EA, Mayer TU
  Title
Cytostatic factor: an activity that puts the cell cycle on hold.
  Journal
J Cell Sci 119:1213-8 (2006)
DOI:10.1242/jcs.02919
Reference
PMID:18096427
  Authors
Vogt E, Kirsch-Volders M, Parry J, Eichenlaub-Ritter U
  Title
Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error.
  Journal
Mutat Res 651:14-29 (2008)
DOI:10.1016/j.mrgentox.2007.10.015
Reference
PMID:18311174
  Authors
Perry AC, Verlhac MH
  Title
Second meiotic arrest and exit in frogs and mice.
  Journal
EMBO Rep 9:246-51 (2008)
DOI:10.1038/embor.2008.22
Reference
PMID:14691134
  Authors
Tunquist BJ, Eyers PA, Chen LG, Lewellyn AL, Maller JL
  Title
Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest.
  Journal
J Cell Biol 163:1231-42 (2003)
DOI:10.1083/jcb.200306153
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Related
pathway
ogo04010  MAPK signaling pathway
ogo04120  Ubiquitin mediated proteolysis
ogo04914  Progesterone-mediated oocyte maturation
KO pathway
ko04114   
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