KEGG   PATHWAY: ogo04120
Entry
ogo04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Oncorhynchus gorbuscha (pink salmon)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ogo04120  Ubiquitin mediated proteolysis
ogo04120

Other DBs
GO: 0016567
Organism
Oncorhynchus gorbuscha (pink salmon) [GN:ogo]
Gene
123989496  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
123990307  [KO:K03872]
123990657  [KO:K10578] [EC:2.3.2.23]
123991105  [KO:K10589] [EC:2.3.2.26]
123991148  [KO:K03870]
123991159  [KO:K05633] [EC:2.3.2.26]
123991258  cul1b; cullin-1b [KO:K03347]
123991444  ube2wb; probable ubiquitin-conjugating enzyme E2 W-B [KO:K10688] [EC:2.3.2.23 2.3.2.25]
123991981  [KO:K10571]
123992832  [KO:K10612]
123992881  [KO:K10590] [EC:2.3.2.26]
123992895  [KO:K10611]
123992902  [KO:K10684] [EC:6.2.1.45]
123993104  [KO:K04707] [EC:2.3.2.27]
123993123  [KO:K03869]
123993303  fbxw11a; F-box and WD repeat domain-containing 11-A isoform X1 [KO:K03362]
123993308  [KO:K04649] [EC:2.3.2.23]
123993317  [KO:K06689] [EC:2.3.2.23]
123993537  [KO:K10609]
123993548  [KO:K10573] [EC:2.3.2.23]
123993587  ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
123993741  [KO:K10601] [EC:2.3.2.27]
123993881  [KO:K25228]
123994057  [KO:K10599] [EC:2.3.2.27]
123994181  [KO:K04725] [EC:2.3.2.27]
123994337  ube2h; ubiquitin-conjugating enzyme E2 H isoform X1 [KO:K10576] [EC:2.3.2.23]
123994407  [KO:K10580] [EC:2.3.2.23]
123994761  cblb; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
123994920  ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
123995172  [KO:K10575] [EC:2.3.2.23]
123996513  herc2; E3 ubiquitin-protein ligase HERC2 [KO:K10595] [EC:2.3.2.26]
123996516  [KO:K10587] [EC:2.3.2.26]
123996931  [KO:K03364]
123997051  [KO:K02207] [EC:2.3.2.23]
123997078  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
123997081  [KO:K16065] [EC:2.3.2.27]
123997202  [KO:K02927]
123997682  [KO:K20217] [EC:2.3.2.23]
123997683  [KO:K20217] [EC:2.3.2.23]
123997908  [KO:K10593] [EC:2.3.2.26]
123998021  [KO:K02927]
123998048  [KO:K22518] [EC:2.3.2.27]
123998150  ube2s; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
123998705  [KO:K04678] [EC:2.3.2.26]
123998727  anapc13; anaphase-promoting complex subunit 13 isoform X1 [KO:K12456]
123998754  ubb; polyubiquitin-B isoform X1 [KO:K08770]
123998864  [KO:K10579] [EC:2.3.2.34]
123998916  [KO:K10612]
123998926  [KO:K04707] [EC:2.3.2.27]
123999122  [KO:K03873]
123999147  [KO:K10604] [EC:2.3.2.27]
123999206  [KO:K10577]
123999307  [KO:K10585] [EC:2.3.2.23]
123999323  [KO:K10574] [EC:2.3.2.23]
123999378  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
123999389  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
123999393  [KO:K10608] [EC:2.3.2.27]
123999589  [KO:K10685] [EC:6.2.1.45]
123999595  [KO:K03875]
123999859  [KO:K10594] [EC:2.3.2.26]
123999927  [KO:K05630] [EC:2.3.2.26]
124000221  [KO:K10577]
124000279  [KO:K04506] [EC:2.3.2.27]
124000287  [KO:K03868] [EC:2.3.2.32]
124000476  [KO:K10575] [EC:2.3.2.23]
124000513  [KO:K03094]
124000628  [KO:K04552] [EC:2.3.2.23]
124001233  [KO:K10260]
124001521  [KO:K10599] [EC:2.3.2.27]
124001774  [KO:K06689] [EC:2.3.2.23]
124001869  [KO:K10576] [EC:2.3.2.23]
124002549  [KO:K10580] [EC:2.3.2.23]
124002677  [KO:K02207] [EC:2.3.2.23]
124002684  uba7; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
124003033  [KO:K04678] [EC:2.3.2.26]
124003088  [KO:K05632] [EC:2.3.2.26]
124003432  vhl; von Hippel-Lindau disease tumor suppressor [KO:K03871]
124003588  [KO:K10581] [EC:2.3.2.24]
124003794  [KO:K03358]
124004691  [KO:K10590] [EC:2.3.2.26]
124004753  [KO:K10593] [EC:2.3.2.26]
124005190  [KO:K20217] [EC:2.3.2.23]
124005191  [KO:K20217] [EC:2.3.2.23]
124005536  [KO:K10612]
124005631  [KO:K10611]
124005722  [KO:K03869]
124005958  [KO:K04707] [EC:2.3.2.27]
124006001  ube4a; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
124006266  [KO:K10583] [EC:2.3.2.23]
124006344  [KO:K25228]
124006385  [KO:K06689] [EC:2.3.2.23]
124006413  [KO:K10684] [EC:6.2.1.45]
124006436  [KO:K03355]
124006939  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
124006977  [KO:K10575] [EC:2.3.2.23]
124006988  [KO:K16060]
124007026  trim32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
124007098  [KO:K10447]
124007131  [KO:K03349]
124007161  [KO:K03355]
124007184  [KO:K06689] [EC:2.3.2.23]
124007312  [KO:K10447]
124007424  [KO:K04551]
124008249  [KO:K03362]
124008377  [KO:K08285] [EC:2.3.2.27]
124008444  anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
124008909  [KO:K10260]
124009101  fzr1b; fizzy-related protein homolog [KO:K03364]
124009410  [KO:K02207] [EC:2.3.2.23]
124009543  [KO:K02927]
124009558  [KO:K03869]
124009603  [KO:K10143] [EC:2.3.2.27]
124009652  [KO:K03347]
124009768  [KO:K03364]
124009971  pias4b; E3 SUMO-protein ligase PIAS4b isoform X1 [KO:K16065] [EC:2.3.2.27]
124010245  aire; autoimmune regulator [KO:K10603]
124010604  [KO:K06689] [EC:2.3.2.23]
124010761  [KO:K03362]
124010867  [KO:K04649] [EC:2.3.2.23]
124010880  [KO:K10573] [EC:2.3.2.23]
124011193  [KO:K10608] [EC:2.3.2.27]
124011196  [KO:K10601] [EC:2.3.2.27]
124011275  keap1a; LOW QUALITY PROTEIN: kelch-like ECH-associated protein 1A [KO:K10456]
124011372  [KO:K04707] [EC:2.3.2.27]
124011389  [KO:K04725] [EC:2.3.2.27]
124011437  [KO:K08285] [EC:2.3.2.27]
124011516  [KO:K06689] [EC:2.3.2.23]
124011679  [KO:K10609]
124012671  [KO:K10599] [EC:2.3.2.27]
124012673  [KO:K10612]
124012764  [KO:K20217] [EC:2.3.2.23]
124012791  [KO:K10614] [EC:2.3.2.26]
124012798  [KO:K20217] [EC:2.3.2.23]
124012881  [KO:K10582] [EC:2.3.2.23]
124013403  [KO:K10260]
124013653  [KO:K10574] [EC:2.3.2.23]
124013717  [KO:K03094]
124014117  [KO:K10580] [EC:2.3.2.23]
124014287  [KO:K10260]
124015158  [KO:K03873]
124015161  keap1b; kelch-like ECH-associated protein 1B [KO:K10456]
124015174  [KO:K04678] [EC:2.3.2.26]
124015183  [KO:K10579] [EC:2.3.2.34]
124015224  [KO:K10604] [EC:2.3.2.27]
124015318  [KO:K04678] [EC:2.3.2.26]
124015436  [KO:K10585] [EC:2.3.2.23]
124015543  [KO:K03350]
124015645  ube2ia; SUMO-conjugating enzyme UBC9-B [KO:K10577]
124015661  [KO:K03868] [EC:2.3.2.32]
124015734  [KO:K16060]
124016130  [KO:K10577]
124016146  [KO:K03358]
124016542  [KO:K10581] [EC:2.3.2.24]
124017534  [KO:K03362]
124017937  [KO:K22518] [EC:2.3.2.27]
124018750  [KO:K06643] [EC:2.3.2.27]
124018751  [KO:K06643] [EC:2.3.2.27]
124019177  [KO:K04694]
124019997  [KO:K04696]
124020280  [KO:K03871]
124020441  [KO:K07868]
124020547  uba6; ubiquitin-like modifier-activating enzyme 6 [KO:K10699] [EC:6.2.1.45]
124020637  [KO:K09561] [EC:2.3.2.27]
124020844  fancl; E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
124020948  [KO:K06689] [EC:2.3.2.23]
124021787  [KO:K10596] [EC:2.3.2.27]
124021898  [KO:K04649] [EC:2.3.2.23]
124021909  [KO:K10602] [EC:2.3.2.27]
124022366  [KO:K10587] [EC:2.3.2.26]
124023335  [KO:K07868]
124023381  [KO:K10609]
124023650  [KO:K07868]
124024521  [KO:K04706] [EC:2.3.2.-]
124025288  ube2j2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
124026074  [KO:K06689] [EC:2.3.2.23]
124026207  ube2c; ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
124026329  [KO:K05632] [EC:2.3.2.26]
124026357  [KO:K03175] [EC:2.3.2.27]
124027388  [KO:K04678] [EC:2.3.2.26]
124027666  [KO:K03871]
124027691  [KO:K02207] [EC:2.3.2.23]
124027860  [KO:K03175] [EC:2.3.2.27]
124027918  [KO:K06689] [EC:2.3.2.23]
124028190  [KO:K03871]
124028669  [KO:K04694]
124028727  [KO:K10609]
124029060  [KO:K03872]
124029997  [KO:K16060]
124030245  [KO:K16063] [EC:2.3.2.-]
124031351  fbxo2; F-box only protein 2 [KO:K10099]
124031431  [KO:K10686] [EC:6.2.1.64]
124031512  [KO:K04706] [EC:2.3.2.-]
124031976  ube4b; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
124032014  [KO:K10582] [EC:2.3.2.23]
124032034  [KO:K10686] [EC:6.2.1.64]
124032074  [KO:K05632] [EC:2.3.2.26]
124032295  [KO:K10592] [EC:2.3.2.26]
124032427  [KO:K03178] [EC:6.2.1.45]
124033071  [KO:K03175] [EC:2.3.2.27]
124033380  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
124033733  [KO:K10591] [EC:2.3.2.26]
124033805  [KO:K10582] [EC:2.3.2.23]
124033937  [KO:K10610]
124034047  fbxw8; F-box/WD repeat-containing protein 8 isoform X1 [KO:K10264]
124034079  fbxo4; F-box only protein 4 [KO:K10291]
124034092  [KO:K10600] [EC:2.3.2.27]
124034314  [KO:K06689] [EC:2.3.2.23]
124034339  [KO:K07868]
124034417  [KO:K10575] [EC:2.3.2.23]
124034419  [KO:K03354]
124034532  [KO:K02207] [EC:2.3.2.23]
124034561  ube3b; ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
124034611  rhobtb4; LOW QUALITY PROTEIN: rho related BTB domain containing 4 [KO:K07868]
124034695  ube2l3b; ubiquitin-conjugating enzyme E2 L3b [KO:K04552] [EC:2.3.2.23]
124034732  [KO:K16063] [EC:2.3.2.-]
124035073  [KO:K10580] [EC:2.3.2.23]
124035157  [KO:K10144] [EC:2.3.2.27]
124035186  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
124035260  ercc8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
124035310  [KO:K04552] [EC:2.3.2.23]
124035701  ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
124035717  [KO:K10591] [EC:2.3.2.26]
124035784  [KO:K10582] [EC:2.3.2.23]
124035858  [KO:K10576] [EC:2.3.2.23]
124035910  [KO:K10610]
124036043  [KO:K10588] [EC:2.3.2.26]
124036073  [KO:K02207] [EC:2.3.2.23]
124036184  [KO:K03354]
124036185  [KO:K10575] [EC:2.3.2.23]
124036280  rhobtb2a; rho-related BTB domain-containing protein 2 isoform X1 [KO:K07868]
124036310  [KO:K06689] [EC:2.3.2.23]
124036561  [KO:K10600] [EC:2.3.2.27]
124036682  ppil2; RING-type E3 ubiquitin-protein ligase PPIL2 [KO:K10598] [EC:5.2.1.8]
124036968  ddb2; DNA damage-binding protein 2 [KO:K10140]
124037504  [KO:K10582] [EC:2.3.2.23]
124037557  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
124037666  [KO:K16065] [EC:2.3.2.27]
124037692  [KO:K02207] [EC:2.3.2.23]
124037839  [KO:K05630] [EC:2.3.2.26]
124038073  [KO:K10685] [EC:6.2.1.45]
124038112  [KO:K10571]
124038225  [KO:K10586] [EC:2.3.2.23]
124038289  [KO:K06689] [EC:2.3.2.23]
124038314  [KO:K02977]
124038324  [KO:K03348]
124038438  [KO:K04696]
124039085  [KO:K03872]
124039447  [KO:K10688] [EC:2.3.2.23 2.3.2.25]
124039820  ube3c; ubiquitin-protein ligase E3C isoform X1 [KO:K10589] [EC:2.3.2.26]
124039856  [KO:K03870]
124039895  [KO:K10577]
124041015  [KO:K10584] [EC:2.3.2.23]
124041087  [KO:K25229]
124041088  [KO:K25229]
124041176  [KO:K02977]
124041203  [KO:K06689] [EC:2.3.2.23]
124041292  [KO:K10586] [EC:2.3.2.23]
124041364  prkn; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
124041402  [KO:K03353]
124041449  herc4; probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
124041520  [KO:K03364]
124041532  [KO:K02207] [EC:2.3.2.23]
124041642  [KO:K03869]
124041680  [KO:K16061]
124041801  [KO:K03363]
124041817  [KO:K03347]
124041870  [KO:K10143] [EC:2.3.2.27]
124042004  [KO:K02927]
124042259  [KO:K03359]
124043324  [KO:K10582] [EC:2.3.2.23]
124043364  [KO:K20217] [EC:2.3.2.23]
124043365  [KO:K20217] [EC:2.3.2.23]
124043555  [KO:K08285] [EC:2.3.2.27]
124043740  [KO:K03353]
124043955  [KO:K10687] [EC:2.3.2.34]
124044031  [KO:K20217] [EC:2.3.2.23]
124044102  si:rp71-68n21.9; kelch-like protein 9 [KO:K10447]
124044165  [KO:K10573] [EC:2.3.2.23]
124044257  [KO:K08285] [EC:2.3.2.27]
124045447  [KO:K03178] [EC:6.2.1.45]
124045554  [KO:K10573] [EC:2.3.2.23]
124045614  [KO:K16061]
124045849  [KO:K05632] [EC:2.3.2.26]
124045894  [KO:K10686] [EC:6.2.1.64]
124046072  [KO:K10447]
124046110  huwe1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HUWE1 [KO:K10592] [EC:2.3.2.26]
124046902  [KO:K10597] [EC:2.3.2.27]
124046979  [KO:K20217] [EC:2.3.2.23]
124047696  [KO:K03359]
124048340  ube2ib; SUMO-conjugating enzyme UBC9-A isoform X1 [KO:K10577]
124048367  [KO:K09561] [EC:2.3.2.27]
124048392  [KO:K10687] [EC:2.3.2.34]
124048417  [KO:K10605] [EC:2.3.2.27]
124048708  [KO:K04552] [EC:2.3.2.23]
124048986  anapc2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
124049026  [KO:K10575] [EC:2.3.2.23]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
ogo03050  Proteasome
KO pathway
ko04120   

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