KEGG   PATHWAY: opi00590
Entry
opi00590                    Pathway                                
Name
Arachidonic acid metabolism - Ochotona princeps (American pika)
Class
Metabolism; Lipid metabolism
Pathway map
opi00590  Arachidonic acid metabolism
opi00590

Other DBs
GO: 0019369
Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101523511  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
101530469  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101523457  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101532712  PLA2G3; LOW QUALITY PROTEIN: group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101536606  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
101516043  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101523219  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101523458  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101523706  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
101523952  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
101524190  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
101520582  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101522976  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101523982  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101524217  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101524453  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101524927  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
101520966  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101517442  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
101526582  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
101527047  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101524436  phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101536794  phospholipase A and acyltransferase 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101534818  PTGS1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
101536557  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101525058  PTGES; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
101523695  PTGES3; prostaglandin E synthase 3 isoform X1 [KO:K15730] [EC:5.3.99.3]
101524741  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
101525632  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
101536607  carbonyl reductase [NADPH] 2-like [KO:K00081] [EC:1.1.1.184]
101524267  carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
101536727  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X3 [KO:K00069] [EC:1.1.1.141]
101534820  TBXAS1; thromboxane-A synthase [KO:K01832] [EC:5.3.99.5]
101527586  PTGDS; prostaglandin-H2 D-isomerase [KO:K01830] [EC:5.3.99.2]
101519374  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
101524567  estradiol 17 beta-dehydrogenase 5-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101526664  aldo-keto reductase family 1 member C3 homolog isoform X2 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101525842  aldo-keto reductase family 1 member C15-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101526901  aldo-keto reductase family 1 member C15-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101527313  aldo-keto reductase family 1 member C15-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101527569  aldo-keto reductase family 1 member C15-like isoform X2 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101527977  aldo-keto reductase family 1 member C3-like isoform X2 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101516658  PTGIS; prostacyclin synthase [KO:K01831] [EC:5.3.99.4]
101534185  ALOX5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
101516579  LTA4H; leukotriene A-4 hydrolase [KO:K01254] [EC:3.3.2.6]
101532024  ZADH2; prostaglandin reductase 3 [KO:K07119] [EC:1.3.1.48]
101517239  PTGR2; prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]
101525583  PTGR1; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
101526783  LTC4S; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
101532226  GGT5; glutathione hydrolase 5 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
101530962  GPX4; phospholipid hydroperoxide glutathione peroxidase [KO:K05361] [EC:1.11.1.12]
101532509  cytochrome P450 2E1 isoform X1 [KO:K07415] [EC:1.14.14.-]
101531516  cytochrome P450 2J1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101531357  cytochrome P450 2J1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101525859  cytochrome P450 2U1 [KO:K07422] [EC:1.14.14.80]
101530008  cytochrome P450 4A5-like [KO:K07425] [EC:1.14.14.80]
101530261  cytochrome P450 4A7-like [KO:K07425] [EC:1.14.14.80]
101518253  ALOX12; polyunsaturated fatty acid lipoxygenase ALOX12 [KO:K00458] [EC:1.13.11.31]
101524657  ALOXE3; hydroperoxide isomerase ALOXE3 isoform X1 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
101524903  ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
101525136  ALOX15B; polyunsaturated fatty acid lipoxygenase ALOX15B isoform X1 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
101530662  cytochrome P450 2B4 [KO:K07412] [EC:1.14.14.1]
101519910  cytochrome P450 2C18-like [KO:K07413] [EC:1.14.14.1]
101525811  cytochrome P450 2C5-like isoform X1 [KO:K07413] [EC:1.14.14.1]
101526220  cytochrome P450 2C15-like isoform X2 [KO:K07413] [EC:1.14.14.1]
101526786  cytochrome P450 2C5-like isoform X1 [KO:K07413] [EC:1.14.14.1]
101527195  cytochrome P450 2C2 isoform X1 [KO:K07413] [EC:1.14.14.1]
101527783  cytochrome P450 2C14-like isoform X1 [KO:K07413] [EC:1.14.14.1]
101528381  cytochrome P450 2C14-like isoform X1 [KO:K07413] [EC:1.14.14.1]
101528927  cytochrome P450 2C14-like isoform X1 [KO:K07413] [EC:1.14.14.1]
101529516  cytochrome P450 2C1-like isoform X2 [KO:K07413] [EC:1.14.14.1]
101529922  cytochrome P450 2C1-like isoform X1 [KO:K07413] [EC:1.14.14.1]
101520157  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
101520641  LOW QUALITY PROTEIN: cytochrome P450 2C3-like [KO:K07413] [EC:1.14.14.1]
101519662  cytochrome P450 2C31-like [KO:K07413] [EC:1.14.14.1]
101524854  cytochrome P450 2C30-like isoform X2 [KO:K07413] [EC:1.14.14.1]
101526632  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
101518498  ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
opi00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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