Entry
Name
Intestinal immune network for IgA production - Phascolarctos cinereus (koala)
Description
The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
pcw04672 Intestinal immune network for IgA production
Ortholog table
Other DBs
Organism
Phascolarctos cinereus (koala) [GN:
pcw ]
Gene
110208066 CD80; T-lymphocyte activation antigen CD80 isoform X1 [KO:K05412 ]
110203296 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
110201282 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
110204537 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
110199338 rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752 ]
110199339 HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752 ]
110199388 H-2 class II histocompatibility antigen, A-R alpha chain-like [KO:K06752 ]
110199389 mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752 ]
110199403 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
110199459 HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752 ]
110199460 HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752 ]
110196708 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
110223182 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150 ]
110202341 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
110205852 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
110193707 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
110223337 MADCAM1; LOW QUALITY PROTEIN: mucosal addressin cell adhesion molecule 1 [KO:K06779 ]
110213833 LTBR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
Compound
Reference
Authors
Fagarasan S, Honjo T
Title
Intestinal IgA synthesis: regulation of front-line body defences.
Journal
Reference
Authors
Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P
Title
The immune geography of IgA induction and function.
Journal
Reference
Authors
Kunisawa J, Kiyono H
Title
A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.
Journal
Reference
Authors
Cerutti A, Rescigno M
Title
The biology of intestinal immunoglobulin A responses.
Journal
Reference
Authors
Tsuji M, Suzuki K, Kinoshita K, Fagarasan S
Title
Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis.
Journal
Reference
Authors
Corthesy B
Title
Roundtrip ticket for secretory IgA: role in mucosal homeostasis?
Journal
Reference
Authors
Suzuki K, Fagarasan S
Title
How host-bacterial interactions lead to IgA synthesis in the gut.
Journal
Reference
Authors
Mora JR, von Andrian UH
Title
Differentiation and homing of IgA-secreting cells.
Journal
Reference
Authors
Suzuki K, Ha SA, Tsuji M, Fagarasan S
Title
Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.
Journal
Reference
Authors
Cerutti A
Title
The regulation of IgA class switching.
Journal
Related pathway
pcw04612 Antigen processing and presentation
pcw04660 T cell receptor signaling pathway
pcw04662 B cell receptor signaling pathway
pcw04670 Leukocyte transendothelial migration
KO pathway
LinkDB
All DBs