KEGG   PATHWAY: pdic04120
Entry
pdic04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Phyllostomus discolor (pale spear-nosed bat)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
pdic04120  Ubiquitin mediated proteolysis
pdic04120

Other DBs
GO: 0016567
Organism
Phyllostomus discolor (pale spear-nosed bat) [GN:pdic]
Gene
114515031  UBB; polyubiquitin-B isoform X2 [KO:K04551]
114510445  UBC; polyubiquitin-C [KO:K08770]
114512124  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
114496160  ubiquitin-like [KO:K02927]
114502682  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
114499520  LOW QUALITY PROTEIN: uncharacterized protein LOC114499520 [KO:K02927]
114513188  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
114497783  ubiquitin-like [KO:K02977]
114499254  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
114504530  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
114510989  SAE1; SUMO-activating enzyme subunit 1 isoform X2 [KO:K10684] [EC:6.2.1.45]
114510900  UBA2; SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
114501565  UBA3; LOW QUALITY PROTEIN: NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
114501402  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
114491750  UBA6; ubiquitin-like modifier-activating enzyme 6 [KO:K10699] [EC:6.2.1.45]
114504703  UBE2A; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
114509520  UBE2B; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
114510364  ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
114493443  ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
114506741  UBE2C; ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
114496516  UBE2D1; ubiquitin-conjugating enzyme E2 D1 isoform X1 [KO:K06689] [EC:2.3.2.23]
114490239  UBE2D4; ubiquitin-conjugating enzyme E2 D4 isoform X3 [KO:K06689] [EC:2.3.2.23]
114491755  UBE2D3; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
114504753  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
114504766  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
114504788  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
114505198  ubiquitin-conjugating enzyme E2 2-like [KO:K06689] [EC:2.3.2.23]
114505202  ubiquitin-conjugating enzyme E2 D3-like isoform X1 [KO:K06689] [EC:2.3.2.23]
114505237  ubiquitin-conjugating enzyme E2 D3-like isoform X1 [KO:K06689] [EC:2.3.2.23]
114505261  ubiquitin-conjugating enzyme E2 D3-like [KO:K06689] [EC:2.3.2.23]
114505269  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
114505290  ubiquitin-conjugating enzyme E2 2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
114505295  ubiquitin-conjugating enzyme E2 D3-like [KO:K06689] [EC:2.3.2.23]
114509111  UBE2D2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
114494107  UBE2E3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
114501533  UBE2E1; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 E1 [KO:K20217] [EC:2.3.2.23]
114501818  ubiquitin-conjugating enzyme E2 E2 [KO:K20217] [EC:2.3.2.23]
114494741  UBE2F; NEDD8-conjugating enzyme UBE2F isoform X1 [KO:K10687] [EC:2.3.2.34]
114514969  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
114490571  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X2 [KO:K04555] [EC:2.3.2.23]
114507529  UBE2H; ubiquitin-conjugating enzyme E2 H isoform X1 [KO:K10576] [EC:2.3.2.23]
114495109  LOW QUALITY PROTEIN: SUMO-conjugating enzyme UBC9-like [KO:K10577]
114498189  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
114494308  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X2 [KO:K10578] [EC:2.3.2.23]
114496560  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
114492997  UBE2K; ubiquitin-conjugating enzyme E2 K isoform X1 [KO:K04649] [EC:2.3.2.23]
114509302  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
114490924  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
114492528  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
114500835  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
114511699  UBE2M; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
114497384  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
114512763  UBE2N; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
114501925  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
114503034  UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme [KO:K10581] [EC:2.3.2.24]
114488550  UBE2Q2; ubiquitin-conjugating enzyme E2 Q2 isoform X2 [KO:K10582] [EC:2.3.2.23]
114488863  UBE2Q1; ubiquitin-conjugating enzyme E2 Q1 isoform X2 [KO:K10582] [EC:2.3.2.23]
114511990  UBE2QL1; ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
114496388  UBE2R2; ubiquitin-conjugating enzyme E2 R2 isoform X1 [KO:K02207] [EC:2.3.2.23]
114503438  CDC34; ubiquitin-conjugating enzyme E2 R1 isoform X1 [KO:K02207] [EC:2.3.2.23]
114510940  UBE2S; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
114496963  UBE2U; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 U [KO:K10584] [EC:2.3.2.23]
114501297  UBE2W; ubiquitin-conjugating enzyme E2 W isoform X3 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
114503992  UBE2Z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
114498432  BIRC6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
114489794  UBE3A; ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
114509206  UBE3B; ubiquitin-protein ligase E3B isoform X2 [KO:K10588] [EC:2.3.2.26]
114507708  UBE3C; LOW QUALITY PROTEIN: ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
114502376  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X2 [KO:K04678] [EC:2.3.2.26]
114509284  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
114506905  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
114501274  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3 [KO:K05633] [EC:2.3.2.26]
114515494  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
114493815  TRIP12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
114492503  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
114506304  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X14 [KO:K13305] [EC:2.3.2.26]
114504763  HUWE1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
114514411  UBR5; E3 ubiquitin-protein ligase UBR5 isoform X3 [KO:K10593] [EC:2.3.2.26]
114492811  HERC1; probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
114489804  HERC2; E3 ubiquitin-protein ligase HERC2 isoform X1 [KO:K10595] [EC:2.3.2.26]
114491381  HERC3; probable E3 ubiquitin-protein ligase HERC3 isoform X1 [KO:K10614] [EC:2.3.2.26]
114498118  HERC4; probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
114500577  UBE4A; ubiquitin conjugation factor E4 A isoform X1 [KO:K10596] [EC:2.3.2.27]
114496851  UBE4B; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
114494788  STUB1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
114509851  PPIL2; RING-type E3 ubiquitin-protein ligase PPIL2 isoform X4 [KO:K10598] [EC:5.2.1.8]
114499968  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
114506359  UBOX5; RING finger protein 37 isoform X1 [KO:K10600]
114513642  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114499969  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
114489417  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
114511452  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
114490084  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
114488135  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
114493028  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
114500758  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
114512339  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
114512138  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
114492248  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
114498544  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
114500581  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
114504538  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
114506156  BIRC7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
114493041  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X2 [KO:K04706] [EC:2.3.2.-]
114506232  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X2 [KO:K16063] [EC:2.3.2.-]
114488802  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
114502266  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X1 [KO:K16065] [EC:2.3.2.27]
114499322  SYVN1; E3 ubiquitin-protein ligase synoviolin isoform X3 [KO:K10601] [EC:2.3.2.27]
114497227  NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
114491147  AIRE; autoimmune regulator [KO:K10603]
114497804  MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
114502888  BRCA1; breast cancer type 1 susceptibility protein isoform X2 [KO:K10605] [EC:2.3.2.27]
114499281  FANCL; E3 ubiquitin-protein ligase FANCL isoform X2 [KO:K10606] [EC:2.3.2.27]
114504633  MID1; E3 ubiquitin-protein ligase Midline-1 isoform X1 [KO:K08285] [EC:2.3.2.27]
114494186  TRIM32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
114502590  TRIM37; E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
114513192  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
114508034  CUL1; cullin-1 [KO:K03347]
114509558  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
114508802  LOW QUALITY PROTEIN: S-phase kinase-associated protein 1-like [KO:K03094]
114496409  BTRC; F-box/WD repeat-containing protein 1A isoform X3 [KO:K03362]
114509949  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
114497743  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
114502341  FBXW7; F-box/WD repeat-containing protein 7 isoform X2 [KO:K10260]
114497437  FBXO2; F-box only protein 2 [KO:K10099]
114502408  FBXO4; F-box only protein 4 [KO:K10291]
114491700  CUL2; LOW QUALITY PROTEIN: cullin-2 [KO:K03870]
114506818  LOW QUALITY PROTEIN: cullin-2-like [KO:K03870]
114498733  LOW QUALITY PROTEIN: elongin-C-like [KO:K03872]
114501631  ELOC; elongin-C [KO:K03872]
114495631  ELOB; elongin-B isoform X1 [KO:K03873]
114501672  VHL; von Hippel-Lindau disease tumor suppressor [KO:K03871]
114501724  von Hippel-Lindau disease tumor suppressor-like [KO:K03871]
114495682  CUL3; cullin-3 isoform X1 [KO:K03869]
114502426  KEAP1; kelch-like ECH-associated protein 1 isoform X1 [KO:K10456]
114504720  KLHL13; kelch-like protein 13 isoform X2 [KO:K10447]
114493517  KLHL9; kelch-like protein 9 [KO:K10447]
114502636  RHOBTB2; rho-related BTB domain-containing protein 2 [KO:K07868]
114496452  RHOBTB1; rho-related BTB domain-containing protein 1 [KO:K07868]
114505306  CUL4B; cullin-4B isoform X7 [KO:K10609]
114508469  CUL4A; cullin-4A [KO:K10609]
114500273  DDB1; DNA damage-binding protein 1 [KO:K10610]
114499000  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
114509409  ERCC8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
114488562  DET1; DET1 homolog isoform X1 [KO:K10571]
114502116  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
114493325  RING-box protein 2-like [KO:K10611]
114498538  CUL5; cullin-5 [KO:K10612]
114500939  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
114503090  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
114494617  CUL7; cullin-7 isoform X1 [KO:K10613]
114509748  FBXW8; LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 8 [KO:K10264]
114502686  ANAPC11; anaphase-promoting complex subunit 11 isoform X2 [KO:K03358]
114501613  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
114497762  CDC20; cell division cycle protein 20 homolog [KO:K03363]
114502383  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
114498619  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
114504176  CDC27; cell division cycle protein 27 homolog isoform X3 [KO:K03350]
114492243  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
114509269  ANAPC5; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 5 [KO:K03352]
114508686  CDC16; cell division cycle protein 16 homolog isoform X2 [KO:K03353]
114509765  ANAPC7; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 7 [KO:K03354]
114509196  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
114503015  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
114503201  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
114515301  anaphase-promoting complex subunit 13-like [KO:K12456]
114501562  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
114498645  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
114496111  ANAPC16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
pdic03050  Proteasome
KO pathway
ko04120   
LinkDB

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