KEGG   PATHWAY: pmac03040
Entry
pmac03040                   Pathway                                
Name
Spliceosome - Papilio machaon (common yellow swallowtail)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
pmac03040  Spliceosome
pmac03040

Other DBs
GO: 0005681
Organism
Papilio machaon (common yellow swallowtail) [GN:pmac]
Gene
106720910  probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
106721752  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
106719785  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
106718954  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
106720362  pre-mRNA-processing factor 17 [KO:K12816]
106718406  ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
106709567  pre-mRNA-splicing factor Slu7 [KO:K12819]
106709225  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [KO:K12820] [EC:5.6.2.6]
106713304  small nuclear ribonucleoprotein-associated protein B [KO:K11086]
106709397  probable small nuclear ribonucleoprotein Sm D1 [KO:K11087]
106716021  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
106712613  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
106718916  probable small nuclear ribonucleoprotein E [KO:K11097]
106713769  small nuclear ribonucleoprotein F [KO:K11098]
106716837  LOW QUALITY PROTEIN: probable small nuclear ribonucleoprotein G [KO:K11099]
106710864  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
106720250  U1 small nuclear ribonucleoprotein C [KO:K11095]
106714120  LOW QUALITY PROTEIN: pre-mRNA-processing factor 40 homolog A [KO:K12821]
106711753  LOW QUALITY PROTEIN: RNA-binding protein 25-like [KO:K12822]
106708836  ATP-dependent RNA helicase DBP2-like [KO:K12823] [EC:5.6.2.7]
106711656  ATP-dependent RNA helicase p62-like [KO:K12823] [EC:5.6.2.7]
106711674  ATP-dependent RNA helicase p62-like isoform X1 [KO:K12823] [EC:5.6.2.7]
106708488  ATP-dependent RNA helicase DBP2-like [KO:K12823] [EC:5.6.2.7]
106709151  ATP-dependent RNA helicase dbp2-like isoform X1 [KO:K12823] [EC:5.6.2.7]
106720861  transcription elongation regulator 1-like [KO:K12824]
106720369  RNA-binding protein cabeza-like [KO:K13098]
106714890  U2 small nuclear ribonucleoprotein A' [KO:K11092]
106718941  LOW QUALITY PROTEIN: U1 small nuclear ribonucleoprotein A [KO:K11094]
106712903  splicing factor 3A subunit 1 [KO:K12825]
106708750  splicing factor 3A subunit 2 [KO:K12826]
106717998  splicing factor 3A subunit 3 [KO:K12827]
106709061  splicing factor 3B subunit 1 [KO:K12828]
106712042  splicing factor 3B subunit 2 [KO:K12829]
106713817  splicing factor 3B subunit 3 isoform X1 [KO:K12830]
106714497  splicing factor 3B subunit 4-like [KO:K12831]
106721237  splicing factor 3B subunit 4-like [KO:K12831]
106718794  probable splicing factor 3B subunit 5 [KO:K12832]
106709026  splicing factor 3B subunit 6 [KO:K12833]
106719320  PHD finger-like domain-containing protein 5A [KO:K12834]
106719303  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
106714112  splicing factor U2af 38 kDa subunit [KO:K12836]
106717538  splicing factor U2AF 50 kDa subunit isoform X1 [KO:K12837]
106720642  poly(U)-binding-splicing factor half pint [KO:K12838]
106709002  survival of motor neuron-related-splicing factor 30 [KO:K12839]
106709003  splicing factor 45 [KO:K12840]
106716741  LOW QUALITY PROTEIN: calcium homeostasis endoplasmic reticulum protein [KO:K12841]
106719017  U2 snRNP-associated SURP motif-containing protein [KO:K12842]
106708320  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
106721042  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
106711941  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
106713233  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
106713274  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
106713275  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
106721060  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
106718753  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
106720865  U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
106720866  U4/U6 small nuclear ribonucleoprotein Prp4-like [KO:K12662]
106720233  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
106718439  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
106720749  NHP2-like protein 1 [KO:K12845]
106709366  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
106719550  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
106712683  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
106714893  zinc finger matrin-type protein 2 [KO:K12848]
106711004  pre-mRNA-splicing factor 38A [KO:K12849]
106711942  pre-mRNA-splicing factor 38B [KO:K12850]
106711638  LOW QUALITY PROTEIN: 116 kDa U5 small nuclear ribonucleoprotein component-like [KO:K12852]
106709494  pre-mRNA-processing factor 6-like [KO:K12855]
106720931  pre-mRNA-processing factor 6 [KO:K12855]
106717755  pre-mRNA-processing-splicing factor 8 [KO:K12856]
106713171  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
106707869  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
106711164  thioredoxin-like protein 4A isoform X1 [KO:K12859]
106718989  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
106720590  cell division cycle 5-related protein [KO:K12860]
106719482  pre-mRNA-splicing factor SPF27 [KO:K12861]
106709710  LOW QUALITY PROTEIN: pleiotropic regulator 1 [KO:K12862]
106707284  pleiotropic regulator 1-like [KO:K12862]
106710811  protein CWC15 homolog [KO:K12863]
106712320  beta-catenin-like protein 1 [KO:K12864]
106708062  LOW QUALITY PROTEIN: heat shock protein 68-like [KO:K03283]
106712862  heat shock protein 68-like [KO:K03283]
106720294  heat shock 70 kDa protein cognate 4 isoform X1 [KO:K03283]
106713054  heat shock protein 68-like [KO:K03283]
106721548  polyglutamine-binding protein 1 [KO:K12865]
106713702  WW domain-binding protein 11 [KO:K12866]
106712203  puff-specific protein Bx42 isoform X1 [KO:K06063]
106713728  pre-mRNA-splicing factor SYF1 [KO:K12867]
106720978  pre-mRNA-splicing factor Syf2 [KO:K12868]
106720054  protein crooked neck [KO:K12869]
106714957  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
106708310  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
106707842  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
106717434  coiled-coil domain-containing protein 12 [KO:K12871]
106709191  pre-mRNA-splicing factor RBM22 [KO:K12872]
106713357  protein BUD31 homolog [KO:K12873]
106721618  intron-binding protein aquarius [KO:K12874]
106712050  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
106715288  RNA-binding protein 8A [KO:K12876]
106707846  protein mago nashi [KO:K12877]
106713738  THO complex subunit 1 [KO:K12878]
106708860  LOW QUALITY PROTEIN: THO complex subunit 2 [KO:K12879]
106719339  THO complex subunit 3 [KO:K12880]
106717812  THO complex subunit 4 [KO:K12881]
106710046  LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 1 [KO:K12882]
106712354  nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
106711516  heterogeneous nuclear ribonucleoprotein 87F-like isoform X1 [KO:K12741]
106711401  heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog [KO:K12741]
106713644  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein K-like [KO:K12886]
106712626  serine/arginine-rich splicing factor 1A isoform X1 [KO:K12890]
106718242  serine/arginine-rich splicing factor 2 [KO:K12891]
106707716  serine-arginine protein 55 isoform X1 [KO:K12893]
106714816  serine/arginine-rich splicing factor 7-like [KO:K12896]
106711425  RNA-binding protein 1 [KO:K12896]
106719332  transformer-2 protein homolog alpha isoform X1 [KO:K12897]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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