KEGG   PATHWAY: pmoa04145
Entry
pmoa04145                   Pathway                                
Name
Phagosome - Passer montanus (Eurasian tree sparrow)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
pmoa04145  Phagosome
pmoa04145

Other DBs
GO: 0045335
Organism
Passer montanus (Eurasian tree sparrow) [GN:pmoa]
Gene
120511038  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
120511733  STX12; syntaxin-12 [KO:K13813]
120501344  STX7; syntaxin-7 [KO:K08488]
120504844  actin [KO:K05692]
120505418  ACTG1; actin, cytoplasmic 2 [KO:K05692]
120513236  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
120511581  STX18; syntaxin-18 [KO:K08492]
120497592  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
120503610  LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
120501837  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
120508255  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
120513627  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
120508801  LOW QUALITY PROTEIN: class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
120503615  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
120510395  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
120506311  class II histocompatibility antigen, M alpha chain isoform X1 [KO:K06752]
120506313  class II histocompatibility antigen, M beta 1 chain [KO:K06752]
120496088  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
120507907  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
120496854  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
120503502  RAB5A; ras-related protein Rab-5A [KO:K07887]
120496557  RAB5C; ras-related protein Rab-5C [KO:K07889]
120499793  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
120497697  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
120504400  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
120505560  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
120506364  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
120506538  LOW QUALITY PROTEIN: V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
120509618  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
120505615  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
120505271  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
120500803  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
120500218  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
120501638  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
120500102  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
120510462  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
120507379  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
120498462  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
120501975  V-type proton ATPase subunit e 2 [KO:K02153]
120503653  TCIRG1; V-type proton ATPase 116 kDa subunit a3 isoform X1 [KO:K02154]
120509688  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
120501700  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
120496566  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
120495771  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
120507943  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
120499274  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
120513333  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
120503206  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
120510765  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
120514066  RAB7A; ras-related protein Rab-7a [KO:K07897]
120497640  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
120507581  rab-interacting lysosomal protein isoform X1 [KO:K13883]
120503702  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
120506591  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
120500244  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
120514164  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
120503197  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
120497787  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
120497296  tubulin alpha-8 chain [KO:K07374]
120503465  tubulin alpha-3 chain [KO:K07374]
120504435  tubulin alpha-3 chain isoform X1 [KO:K07374]
120499491  tubulin alpha-1A chain [KO:K07374]
120499499  tubulin alpha-3 chain-like [KO:K07374]
120501562  TUBA8; tubulin alpha-8 chain [KO:K07374]
120496796  TUBA4A; LOW QUALITY PROTEIN: tubulin alpha-4A chain [KO:K07374]
120497243  tubulin beta-2 chain isoform X1 [KO:K07375]
120505740  TUBB; tubulin beta chain [KO:K07375]
120500837  TUBB6; tubulin beta-6 chain [KO:K07375]
120507135  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
120507394  TUBB4B; tubulin beta-4B chain [KO:K07375]
120496240  TUBB3; tubulin beta-3 chain [KO:K07375]
120504532  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
120506104  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
120497393  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
120497760  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
120510300  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
120513449  myeloperoxidase-like isoform X1 [KO:K10789] [EC:1.11.2.2]
120511953  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
120514087  procathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]
120502604  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
120512493  SEC61A2; protein transport protein Sec61 subunit alpha [KO:K10956]
120514174  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
120502986  SEC61B; protein transport protein Sec61 subunit beta isoform X1 [KO:K09481]
120505039  SEC61G; protein transport protein Sec61 subunit gamma isoform X1 [KO:K07342]
120503661  antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
120503659  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
120505887  calreticulin-like [KO:K08057]
120505888  calreticulin-like [KO:K08057]
120498463  CANX; calnexin [KO:K08054]
120504147  low affinity immunoglobulin gamma Fc region receptor II-like [KO:K06498]
120506099  low affinity immunoglobulin gamma Fc region receptor II-like [KO:K12560]
120506298  low affinity immunoglobulin gamma Fc region receptor II-like [KO:K12560]
120512175  LOW QUALITY PROTEIN: immunoglobulin superfamily member 3-like [KO:K06856]
120506470  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
120511553  ITGB2; integrin beta-2 [KO:K06464]
120505096  C3; complement C3 [KO:K03990]
120505261  COLEC11; collectin-11 isoform X1 [KO:K10066]
120500812  COLEC12; collectin-12 [KO:K10062]
120507264  pulmonary surfactant-associated protein A-like [KO:K10067]
120507294  pulmonary surfactant-associated protein A-like [KO:K10067]
120511498  ITGAV; integrin alpha-V [KO:K06487]
120502329  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
120504832  LOW QUALITY PROTEIN: integrin alpha-5-like [KO:K06484]
120502076  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
120498400  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
120498892  ITGB5; integrin beta-5 [KO:K06588]
120500320  THBS1; thrombospondin-1 [KO:K16857]
120498934  THBS3; thrombospondin-3 [KO:K04659]
120499021  cartilage oligomeric matrix protein isoform X1 [KO:K04659]
120501393  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
120502375  THBS4; thrombospondin-4 [KO:K04659]
120497936  toll-like receptor 2 type-1 [KO:K10159]
120497937  toll-like receptor 2 type-2 [KO:K10159]
120497454  toll-like receptor 1 [KO:K10169]
120507511  TLR4; toll-like receptor 4 [KO:K10160]
120498150  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
120498398  MRC2; C-type mannose receptor 2 [KO:K06560]
120501346  macrophage mannose receptor 1-like isoform X1 [KO:K06560]
120501352  macrophage mannose receptor 1-like isoform X1 [KO:K06560]
120501370  macrophage mannose receptor 1-like isoform X1 [KO:K06560]
120501646  MRC1; macrophage mannose receptor 1 isoform X1 [KO:K06560]
120501657  macrophage mannose receptor 1-like [KO:K06560]
120503678  hepatic lectin-like isoform X1 [KO:K06563]
120511125  MARCO; macrophage receptor MARCO [KO:K13884]
120509678  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
120509247  CD36; platelet glycoprotein 4 [KO:K06259]
120496262  cytochrome b-245 light chain [KO:K08009]
120511868  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
120512867  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120513483  NCF1; neutrophil cytosol factor 1 [KO:K08011]
120510455  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
120510036  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
pmoa04142  Lysosome
pmoa04144  Endocytosis
pmoa04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
LinkDB

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