KEGG   PATHWAY: prob04814
Entry
prob04814                   Pathway                                
Name
Motor proteins - Phodopus roborovskii (desert hamster)
Class
Cellular Processes; Cell motility
Pathway map
prob04814  Motor proteins
prob04814

Organism
Phodopus roborovskii (desert hamster) [GN:prob]
Gene
127231147  Dync1h1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
127216909  Dync2h1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
127222428  Dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
127216462  Dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
127234633  Dync1li2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
127234880  Dync1li1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
127214903  Dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
127222109  LOW QUALITY PROTEIN: dynein light chain 1, cytoplasmic-like [KO:K10418]
127215994  Dynll1; dynein light chain 1, cytoplasmic [KO:K10418]
127226960  Dynll2; dynein light chain 2, cytoplasmic [KO:K10418]
127233007  dynein light chain 1, cytoplasmic [KO:K10418]
127228218  Dynlrb1; dynein light chain roadblock-type 1 [KO:K10419]
127234445  Dynlrb2; dynein light chain roadblock-type 2 [KO:K10419]
127217102  Dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
127237709  Dynlt1; dynein light chain Tctex-type 1 [KO:K10420]
127237668  Dynlt2; dynein light chain Tctex-type protein 2 [KO:K25419]
127225226  Dynlt4; dynein light chain Tctex-type 4 [KO:K25420]
127224866  Dynlt5; dynein light chain Tctex-type 5 [KO:K25421]
127228260  Dnah3; dynein axonemal heavy chain 3 [KO:K10408]
127216158  Dnah12; dynein axonemal heavy chain 12 [KO:K10408]
127223299  Dnah14; dynein axonemal heavy chain 14 [KO:K10408]
127235652  Dnah6; dynein axonemal heavy chain 6 [KO:K10408]
127216938  Dnah11; dynein axonemal heavy chain 11 [KO:K10408]
127224182  Dnah8; dynein axonemal heavy chain 8 [KO:K10408]
127236846  Dnah1; dynein axonemal heavy chain 1 [KO:K10408]
127236936  Dnah10; dynein axonemal heavy chain 10 [KO:K10408]
127219121  Dnah9; dynein axonemal heavy chain 9 [KO:K10408]
127219836  Dnah2; dynein axonemal heavy chain 2 [KO:K10408]
127219838  Dnah17; dynein axonemal heavy chain 17 [KO:K10408]
127226294  Dnah7; dynein axonemal heavy chain 7 [KO:K10408]
127220684  Dnah5; dynein axonemal heavy chain 5 [KO:K10408]
127224538  Dnai1; dynein axonemal intermediate chain 1 isoform X1 [KO:K10409]
127218866  Dnai2; dynein axonemal intermediate chain 2 isoform X1 [KO:K11143]
127229837  Dnai3; dynein axonemal intermediate chain 3 [KO:K24722]
127224991  Dnai4; dynein axonemal intermediate chain 4 [KO:K24723]
127225338  Dnali1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
127230962  Dnal1; dynein axonemal light chain 1 [KO:K10411]
127225806  Dnal4; dynein axonemal light chain 4 [KO:K10412]
127235787  Dctn1; dynactin subunit 1 isoform X1 [KO:K04648]
127215670  Dctn2; dynactin subunit 2 [KO:K10424]
127224544  Dctn3; dynactin subunit 3 [KO:K10425]
127234218  Dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
127228293  Dctn5; dynactin subunit 5 [KO:K10427]
127224896  dynactin subunit 5-like [KO:K10427]
127220414  Dctn6; dynactin subunit 6 [KO:K10428]
127236758  Actr1b; beta-centractin [KO:K16575]
127233208  Actr1a; alpha-centractin [KO:K16575]
127230665  Actr10; actin-related protein 10 [KO:K16576]
127212863  Capza3; F-actin-capping protein subunit alpha-3 [KO:K10364]
127232991  Capza1; F-actin-capping protein subunit alpha-1 [KO:K10364]
127215338  Capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
127213175  Capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
127215973  Bicdl1; BICD family-like cargo adapter 1 [KO:K16756]
127219593  Bicdl2; BICD family-like cargo adapter 2 [KO:K16756]
127220369  Hook3; protein Hook homolog 3 [KO:K16536]
127229737  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
127236145  Tuba8; tubulin alpha-8 chain [KO:K07374]
127212994  tubulin alpha-3 chain [KO:K07374]
127226045  tubulin alpha-1B chain [KO:K07374]
127226047  tubulin alpha-1A chain [KO:K07374]
127226048  tubulin alpha-1C chain [KO:K07374]
127213112  tubulin alpha-3 chain [KO:K07374]
127226461  tubulin alpha-4A chain [KO:K07374]
127234743  Tubb3; tubulin beta-3 chain [KO:K07375]
127222574  Tubb4b; tubulin beta-4B chain [KO:K07375]
127222820  Tubb1; tubulin beta-1 chain [KO:K07375]
127229353  tubulin beta-2B chain isoform X1 [KO:K07375]
127216800  Tubb4a; tubulin beta-4A chain [KO:K07375]
127224367  Tubb; tubulin beta chain [KO:K07375]
127234080  Tubb6; tubulin beta-6 chain isoform X1 [KO:K07375]
127216521  Tubg1; LOW QUALITY PROTEIN: tubulin gamma-1 chain [KO:K10389]
127216532  tubulin gamma-2 chain [KO:K10389]
127224171  Tubd1; tubulin delta chain isoform X1 [KO:K10390]
127215148  Tube1; tubulin epsilon chain [KO:K10391]
127215673  Kif5a; kinesin heavy chain [KO:K10396]
127222536  Kif5c; kinesin heavy chain [KO:K10396]
127237451  Kif5b; kinesin-1 heavy chain [KO:K10396]
127228680  Klc2; kinesin light chain 2 [KO:K10407]
127236767  Klc4; kinesin light chain 4 isoform X1 [KO:K10407]
127231172  Klc1; kinesin light chain 1 [KO:K10407]
127239043  Klc3; kinesin light chain 3 [KO:K10407]
127227511  LOW QUALITY PROTEIN: kinesin light chain 2-like [KO:K10407]
127219294  Kif3a; kinesin-like protein KIF3A isoform X1 [KO:K10394]
127228395  Kif3b; kinesin-like protein KIF3B [KO:K20196]
127223499  Kifap3; kinesin-associated protein 3 isoform X1 [KO:K25388]
127220056  Kif3c; kinesin-like protein KIF3C [KO:K20197]
127213319  Kif17; kinesin-like protein KIF17 [KO:K20198]
127218989  Kif1c; kinesin-like protein KIF1C [KO:K10392]
127213545  Kif1b; kinesin-like protein KIF1B isoform X1 [KO:K10392]
127226720  Kif1a; kinesin-like protein KIF1A [KO:K10392]
127229275  Kif13a; kinesin-like protein KIF13A isoform X1 [KO:K17914]
127230255  Kif13b; kinesin-like protein KIF13B isoform X1 [KO:K17914]
127221298  Kif14; kinesin-like protein KIF14 [KO:K17915]
127221372  Kif16b; kinesin-like protein KIF16B [KO:K17916]
127221585  Stard9; stAR-related lipid transfer protein 9 [KO:K16491]
127218012  Kif4a; chromosome-associated kinesin KIF4A isoform X1 [KO:K10395]
127231013  chromosome-associated kinesin KIF4A-like [KO:K10395]
127238154  Kif7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
127225972  Kif21a; kinesin-like protein KIF21A isoform X1 [KO:K24185]
127221313  Kif21b; kinesin-like protein KIF21B [KO:K24185]
127229165  Kif27; kinesin-like protein KIF27 [KO:K24186]
127233212  Kif11; kinesin-like protein KIF11 isoform X1 [KO:K10398]
127235186  Kif20a; kinesin-like protein KIF20A [KO:K10402]
127233488  Kif20b; kinesin-like protein KIF20B [KO:K10402]
127231852  Kif23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
127222983  Cenpe; LOW QUALITY PROTEIN: centromere-associated protein E [KO:K11498]
127221797  Kif18a; LOW QUALITY PROTEIN: kinesin-like protein KIF18A [KO:K10401]
127226462  LOW QUALITY PROTEIN: kinesin-like protein KIF18A [KO:K10401]
127217021  Kif18b; kinesin-like protein KIF18B [KO:K26156]
127237131  kinesin-like protein KIF19 [KO:K26157]
127218878  Kif19; kinesin-like protein KIF19 [KO:K26157]
127235973  Kif9; kinesin-like protein KIF9 isoform X1 [KO:K10397]
127236515  kinesin-like protein KIF6 [KO:K10397]
127228354  Kif22; kinesin-like protein KIF22 isoform X1 [KO:K10403]
127223675  Kif26b; kinesin-like protein KIF26B [KO:K10404]
127231182  Kif26a; kinesin-like protein KIF26A isoform X1 [KO:K10404]
127224773  Kif12; kinesin-like protein KIF12 [KO:K10399]
127235589  Kif15; kinesin-like protein KIF15 [KO:K10400]
127224535  Kif24; kinesin-like protein KIF24 [KO:K10393]
127230573  Kif2b; kinesin-like protein KIF2B [KO:K10393]
127225229  Kif2c; kinesin-like protein KIF2C [KO:K10393]
127220996  Kif2a; kinesin-like protein KIF2A isoform X1 [KO:K10393]
127224254  Kifc1; kinesin-like protein KIFC1 [KO:K10405]
127234879  Kifc3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
127225710  Kifc2; kinesin-like protein KIFC2 isoform X1 [KO:K10406]
127215654  Myo1a; unconventional myosin-Ia [KO:K10356]
127215896  Myo1h; unconventional myosin-Ih [KO:K10356]
127217796  Myo1f; unconventional myosin-If [KO:K10356]
127218794  Myo1d; unconventional myosin-Id [KO:K10356]
127218910  Myo1c; unconventional myosin-Ic isoform X1 [KO:K10356]
127231943  Myo1e; unconventional myosin-Ie isoform X1 [KO:K10356]
127226210  Myo1b; unconventional myosin-Ib isoform X1 [KO:K10356]
127233907  Myo1g; unconventional myosin-Ig [KO:K10356]
127221877  myosin-IIIb [KO:K08834] [EC:2.7.11.1]
127215879  LOW QUALITY PROTEIN: myosin-IIIa-like [KO:K08834] [EC:2.7.11.1]
127237452  Myo3a; LOW QUALITY PROTEIN: myosin-IIIa [KO:K08834] [EC:2.7.11.1]
127234361  Myo5b; LOW QUALITY PROTEIN: unconventional myosin-Vb [KO:K10357]
127231979  Myo5a; unconventional myosin-Va [KO:K10357]
127231980  Myo5c; unconventional myosin-Vc [KO:K10357]
127212887  Myo6; unconventional myosin-VI isoform X1 [KO:K10358]
127227929  Myo7a; unconventional myosin-VIIa [KO:K10359]
127235135  Myo7b; unconventional myosin-VIIb [KO:K21868]
127217245  Myo9b; unconventional myosin-IXb isoform X1 [KO:K10360]
127231841  Myo9a; unconventional myosin-IXa isoform X1 [KO:K10360]
127220673  Myo10; unconventional myosin-X [KO:K12559]
127219191  Myo15a; unconventional myosin-XV [KO:K10361]
127219254  Myo15b; LOW QUALITY PROTEIN: myosin XVB [KO:K10361]
127220245  Myo16; unconventional myosin-XVI [KO:K17481]
127215892  Myo18b; unconventional myosin-XVIIIb [KO:K10362]
127218857  Myo18a; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
127222398  Myo19; unconventional myosin-XIX [KO:K25838]
127219123  myosin-1 [KO:K24220]
127219124  myosin-4 [KO:K24220]
127219125  myosin-2 [KO:K24220]
127219126  Myh8; myosin-8 [KO:K24220]
127219127  myosin-3 [KO:K24220]
127219128  Myh13; myosin-13 [KO:K24220]
127226821  Myh15; myosin-15 [KO:K24220]
127227989  Myh7b; myosin-7B isoform X1 [KO:K24220]
127230396  myosin-6 [KO:K17751]
127230410  myosin-7 [KO:K17751]
127219092  Myh10; myosin-10 isoform X1 [KO:K10352]
127225735  Myh9; myosin-9 [KO:K10352]
127238219  Myh11; myosin-11 isoform X1 [KO:K10352]
127213908  Myh14; myosin-14 isoform X1 [KO:K10352]
127226398  Myl1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
127235944  Myl3; myosin light chain 3 [KO:K12749]
127221500  Myl4; myosin light chain 4 [KO:K12750]
127215625  Myl6b; myosin light chain 6B [KO:K12751]
127215626  Myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
127216106  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
127233878  Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
127224759  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
127236944  Myl10; LOW QUALITY PROTEIN: myosin regulatory light chain 10 [KO:K12756]
127226782  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
127226784  myosin regulatory light chain 12B [KO:K12757]
127228373  Myl11; myosin regulatory light chain 11 [KO:K12758]
127234740  Acta1; actin, alpha skeletal muscle [KO:K10354]
127233248  Acta2; actin, aortic smooth muscle [KO:K12313]
127221770  Actc1; actin, alpha cardiac muscle 1 [KO:K12314]
127235578  Actg2; actin, gamma-enteric smooth muscle [KO:K12315]
127234394  uncharacterized protein LOC127234394 [KO:K05692]
127234395  uncharacterized protein LOC127234395 [KO:K05692]
127234396  uncharacterized protein LOC127234396 [KO:K05692]
127217780  uncharacterized protein LOC127217780 [KO:K05692]
127237213  Actb; actin, cytoplasmic 1 isoform X1 [KO:K05692]
127237366  uncharacterized protein LOC127237366 [KO:K05692]
127220241  Actg1; actin, cytoplasmic 2 [KO:K05692]
127214100  uncharacterized protein LOC127214100 [KO:K05692]
127214101  uncharacterized protein LOC127214101 [KO:K05692]
127236854  Tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
127221308  Tnni1; troponin I, slow skeletal muscle [KO:K10371]
127238680  Tnnt1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
127223763  Tnnc2; troponin C, skeletal muscle [KO:K12042]
127227816  Tnni2; troponin I, fast skeletal muscle [KO:K12043]
127228560  Tnnt3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
127238799  Tnni3; troponin I, cardiac muscle [KO:K12044]
127221319  Tnnt2; troponin T, cardiac muscle [KO:K12045]
127231930  Tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
127227426  tropomyosin alpha-1 chain-like [KO:K10373]
127224597  Tpm2; tropomyosin beta chain isoform X1 [KO:K10374]
127233030  Tpm3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
127217265  Tpm4; tropomyosin alpha-4 chain [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
LinkDB

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