KEGG   PATHWAY: rmd04148
Entry
rmd04148                    Pathway                                
Name
Efferocytosis - Rhopalosiphum maidis (corn leaf aphid)
Class
Cellular Processes; Transport and catabolism
Pathway map
rmd04148  Efferocytosis
rmd04148

Organism
Rhopalosiphum maidis (corn leaf aphid) [GN:rmd]
Gene
113550549  caspase-1-like [KO:K04397] [EC:3.4.22.60]
113553186  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
113560473  85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
113559354  ADAM 17-like protease isoform X1 [KO:K06059] [EC:3.4.24.86]
113551419  disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
113549234  disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
113550613  LOW QUALITY PROTEIN: hypoxia-inducible factor 1-alpha-like [KO:K08268]
113555788  aryl hydrocarbon receptor nuclear translocator homolog isoform X1 [KO:K09097]
113555292  tyrosine-protein kinase hopscotch [KO:K04447] [EC:2.7.10.2]
113551251  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113559425  retinoic acid receptor RXR-alpha-B [KO:K08524]
113560464  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
113560820  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
113555004  calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X1 [KO:K05853] [EC:7.2.2.10]
113556511  calcium/calmodulin-dependent protein kinase type II delta chain isoform X1 [KO:K04515] [EC:2.7.11.17]
113548140  mitogen-activated protein kinase p38b-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113556474  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
113561190  dual specificity protein phosphatase Mpk3 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113555673  anoctamin-5-like [KO:K19499]
113549790  XK-related protein 6 [KO:K26811]
113556170  probable phospholipid-transporting ATPase IA [KO:K14802] [EC:7.6.2.1]
113560208  probable phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
113561134  cell cycle control protein 50A [KO:K26935]
113554034  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
113559781  adapter molecule Crk [KO:K04438]
113560416  engulfment and cell motility protein 1 [KO:K12366]
113551394  dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
113549643  ras-related protein Rac1 [KO:K04392]
113553520  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113553116  ras-like GTP-binding protein RhoL [KO:K04392]
113554524  calreticulin-like [KO:K08057]
113555570  calreticulin-like [KO:K08057]
113550219  low-density lipoprotein receptor-related protein 1 [KO:K04550]
113550177  protein draper-like [KO:K24068]
113559662  ras-related protein Rab-5C [KO:K07889]
113554411  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
113551162  vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
113561149  vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
113557346  vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
113555282  vacuolar protein sorting-associated protein 33A [KO:K20182]
113555876  ras-related protein Rab-14 [KO:K07881]
113548566  vam6/Vps39-like protein [KO:K20183]
113550169  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
113555965  ras-related protein Rab-7a-like [KO:K07897]
113548069  ras-related protein rab7-like [KO:K07897]
113549949  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
113553702  carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
113560474  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
113556630  NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
113560548  homeobox protein extradenticle isoform X1 [KO:K09355]
113558190  LOW QUALITY PROTEIN: lipase 3-like [KO:K01052] [EC:3.1.1.13]
113555480  lipase 3-like [KO:K01052] [EC:3.1.1.13]
113555482  lipase 3-like [KO:K01052] [EC:3.1.1.13]
113560725  lipase 3-like [KO:K01052] [EC:3.1.1.13]
113559777  group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]
113549432  glucose transporter type 1-like isoform X1 [KO:K07299]
113553272  solute carrier family 2, facilitated glucose transporter member 1-like isoform X1 [KO:K07299]
113550465  solute carrier family 2, facilitated glucose transporter member 1-like isoform X1 [KO:K07299]
113550141  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
rmd00010  Glycolysis / Gluconeogenesis
rmd04140  Autophagy - animal
rmd04145  Phagosome
KO pathway
ko04148   
LinkDB

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