KEGG   PATHWAY: rro04914
Entry
rro04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
rro04914  Progesterone-mediated oocyte maturation
rro04914

Other DBs
GO: 0001556
Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104658433  PGR; progesterone receptor isoform X3 [KO:K08556]
104662124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104675620  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104680672  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104663050  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104665061  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104670605  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104676194  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104678447  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104668007  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104660767  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
104660769  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104682867  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
104682868  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
104655987  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
104667102  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
104673307  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
104671165  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
104674083  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
104658457  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
104662674  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
104668142  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
104654871  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
104672569  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
104675683  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
104672288  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
104662061  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
104677489  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104661051  LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
104663263  aurora kinase A-like isoform X1 [KO:K11481] [EC:2.7.11.1]
104673294  aurora kinase A [KO:K11481] [EC:2.7.11.1]
104656978  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
104660476  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
104670143  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
104676497  CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform X4 [KO:K02602]
104658161  CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X2 [KO:K02602]
104666112  putative speedy protein E7 [KO:K08694]
104662823  SPDYC; speedy protein C isoform X1 [KO:K08694]
104668463  SPDYA; speedy protein A isoform X1 [KO:K08694]
104672954  speedy protein E5-like [KO:K08694]
104676333  speedy protein E4 isoform X1 [KO:K08694]
115898167  speedy protein E3-like [KO:K08694]
115894900  SPDYE4; speedy protein E4 [KO:K08694]
104673700  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
104663679  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
104661791  CCNA2; cyclin-A2 [KO:K06627]
104677942  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
104661778  proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
115899586  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
104667373  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
104654438  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
104682584  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
104662575  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104676897  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104681150  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104658904  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
104675232  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
104675748  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
104657930  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
104672324  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
104675626  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
104670890  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
115896370  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
104670125  STK10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
104658253  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
104671299  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
104674594  CDC25B; M-phase inducer phosphatase 2 isoform X2 [KO:K05866] [EC:3.1.3.48]
104681726  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
104677102  INS; insulin [KO:K04526]
104657459  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
104677192  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
104673041  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104676121  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104654186  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115893905  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104681940  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
104670041  KRAS; GTPase KRas isoform X1 [KO:K07827]
104664593  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
104659700  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
104673299  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
104672448  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
104664955  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X2 [KO:K06679]
104663595  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
104654352  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
104665446  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
104680409  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
104669632  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
104662521  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
104679571  LOW QUALITY PROTEIN: cell division cycle protein 27 homolog [KO:K03350]
104662078  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
104666274  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
104671361  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
104674806  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
104681723  CDC23; cell division cycle protein 23 homolog [KO:K03355]
104660768  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
104654968  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
104667867  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
104663569  ANAPC13; anaphase-promoting complex subunit 13 isoform X2 [KO:K12456]
104665156  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
104669939  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
104681470  KIF22; kinesin-like protein KIF22 isoform X1 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
rro04010  MAPK signaling pathway
rro04110  Cell cycle
KO pathway
ko04914   
LinkDB

DBGET integrated database retrieval system