KEGG   PATHWAY: rtem04141
Entry
rtem04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Rana temporaria (common frog)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
rtem04141  Protein processing in endoplasmic reticulum
rtem04141

Other DBs
GO: 0030433 0034976
Organism
Rana temporaria (common frog) [GN:rtem]
Gene
120945103  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
120940467  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
120940363  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
120936738  SEC62; translocation protein SEC62 [KO:K12275]
120937184  SEC63; translocation protein SEC63 homolog [KO:K09540]
120945096  RPN1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
120918768  RPN2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1 [KO:K12667]
120930312  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad1 [KO:K12668]
120940642  DAD1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
120924138  DDOST; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
120940314  STT3B; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
120915701  STT3A; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
120921903  MAGT1; magnesium transporter protein 1 isoform X1 [KO:K19478]
120922416  TUSC3; tumor suppressor candidate 3 isoform X1 [KO:K19478]
120917869  OSTC; oligosaccharyltransferase complex subunit OSTC [KO:K26501]
120917262  TMEM258; transmembrane protein 258 [KO:K26502]
120917150  MOGS; mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
120932672  CKAP4; cytoskeleton-associated protein 4 [KO:K13999]
120937738  RRBP1; ribosome-binding protein 1 isoform X1 [KO:K14000]
120915158  HYOU1; hypoxia up-regulated protein 1 [KO:K09486]
120914259  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
120943672  DNAJB11; dnaJ homolog subfamily B member 11 [KO:K09517]
120940000  DNAJC1; dnaJ homolog subfamily C member 1 [KO:K09521]
120926312  DNAJC3; dnaJ homolog subfamily C member 3 [KO:K09523]
120933617  dnaJ homolog subfamily C member 3-like isoform X1 [KO:K09523]
120943944  DNAJC10; dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
120932108  HSP90B1; endoplasmin [KO:K09487]
120917559  GANAB; neutral alpha-glucosidase AB isoform X1 [KO:K05546] [EC:3.2.1.207]
120933347  PRKCSH; glucosidase 2 subunit beta [KO:K08288]
120932528  CANX; calnexin isoform X1 [KO:K08054]
120931255  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
120933333  CALR; calreticulin [KO:K08057]
120944872  calreticulin-like [KO:K08057]
120937260  MAN1A1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
120926862  MAN1C1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IC [KO:K01230] [EC:3.2.1.113]
120928114  MAN1A2; mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [KO:K01230] [EC:3.2.1.113]
120914028  MAN1B1; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1 [KO:K23741] [EC:3.2.1.209]
120932176  LMAN2; vesicular integral-membrane protein VIP36 [KO:K10082]
120931471  LMAN1L; protein ERGIC-53-like [KO:K10080]
120927301  LMAN1; protein ERGIC-53 [KO:K10080]
120935948  PREB; prolactin regulatory element-binding protein [KO:K14003]
120947199  SAR1A; GTP-binding protein SAR1a [KO:K07953] [EC:3.6.5.-]
120932422  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
120945018  SEC13; protein SEC13 homolog [KO:K14004]
120947209  SEC31B; protein transport protein Sec31B isoform X1 [KO:K14005]
120914230  SEC31A; protein transport protein Sec31A isoform X1 [KO:K14005]
120937748  SEC23B; protein transport protein Sec23B [KO:K14006]
120920983  SEC23A; protein transport protein Sec23A isoform X1 [KO:K14006]
120908935  SEC24C; protein transport protein Sec24C isoform X1 [KO:K14007]
120917812  SEC24B; protein transport protein Sec24B isoform X1 [KO:K14007]
120918511  SEC24D; protein transport protein Sec24D isoform X1 [KO:K14007]
120932419  SEC24A; LOW QUALITY PROTEIN: protein transport protein Sec24A [KO:K14007]
120926313  UGGT2; UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1 [KO:K11718] [EC:2.4.1.-]
120936396  UGGT1; UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [KO:K11718] [EC:2.4.1.-]
120944892  EDEM1; ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
120919520  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
120945551  EDEM3; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
120918924  P4HB; protein disulfide-isomerase isoform X1 [KO:K09580] [EC:5.3.4.1]
120940488  PDIA4; protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
120936337  PDIA6; protein disulfide-isomerase A6 isoform X1 [KO:K09584] [EC:5.3.4.1]
120933175  ERP29; endoplasmic reticulum resident protein 29 [KO:K09586]
120940700  TXNDC5; thioredoxin domain-containing protein 5 [KO:K13984] [EC:5.3.4.1]
120921059  ERO1A; ERO1-like protein alpha isoform X1 [KO:K10950] [EC:1.8.4.-]
120929451  OS9; protein OS-9 isoform X1 [KO:K10088]
120938003  ERLEC1; endoplasmic reticulum lectin 1 [KO:K14008]
120940689  SSR1; translocon-associated protein subunit alpha isoform X1 [KO:K13249]
120920290  translocon-associated protein subunit beta [KO:K13250]
120942680  LOW QUALITY PROTEIN: translocon-associated protein subunit beta-like [KO:K13250]
120936687  SSR3; translocon-associated protein subunit gamma [KO:K13251]
120913227  SSR4; translocon-associated protein subunit delta [KO:K04571]
120913149  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
120941116  TRAM1; translocating chain-associated membrane protein 1 [KO:K14010]
120941488  DERL1; derlin-1 [KO:K11519]
120926612  DERL2; derlin-2 isoform X1 [KO:K13989]
120936600  DERL3; derlin-3 isoform X1 [KO:K13989]
120944148  UBXN4; UBX domain-containing protein 4 [KO:K24348]
120917554  UBXN1; UBX domain-containing protein 1 [KO:K24348]
120936285  UBXN2A; UBX domain-containing protein 2A [KO:K24349]
120911331  UBXN6; UBX domain-containing protein 6 isoform X1 [KO:K14011]
120914878  UBXN8; UBX domain-containing protein 8 isoform X1 [KO:K24351]
120919613  NSFL1C; NSFL1 cofactor p47 [KO:K14012]
120916960  small VCP/p97-interacting protein isoform X1 [KO:K14014]
120925562  transitional endoplasmic reticulum ATPase [KO:K13525]
120919024  NPLOC4; nuclear protein localization protein 4 homolog [KO:K14015]
120936123  UFD1; ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
120915681  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
120916435  heat shock cognate 71 kDa protein-like [KO:K03283]
120913507  heat shock 70 kDa protein [KO:K03283]
120928800  heat shock 70 kDa protein-like [KO:K03283]
120915182  DNAJA1; dnaJ homolog subfamily A member 1 [KO:K09502]
120917882  DNAJA2; dnaJ homolog subfamily A member 2 [KO:K09503]
120933241  DNAJB1; dnaJ homolog subfamily B member 1 [KO:K09507]
120944190  DNAJB2; dnaJ homolog subfamily B member 2 [KO:K09508]
120947192  DNAJB12; dnaJ homolog subfamily B member 12 [KO:K09518]
120918437  DNAJC5; dnaJ homolog subfamily C member 5 isoform X1 [KO:K09525]
120941070  DNAJC5B; dnaJ homolog subfamily C member 5B isoform X1 [KO:K09525]
120935964  DNAJC5G; dnaJ homolog subfamily C member 5G [KO:K09525]
120938091  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
120920750  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
120921071  heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
120929179  HSPH1; heat shock protein 105 kDa [KO:K09485]
120940560  BAG1; BAG family molecular chaperone regulator 1 [KO:K09555]
120936996  BAG2; BAG family molecular chaperone regulator 2 [KO:K09556]
120915323  HSPBP1; hsp70-binding protein 1 [KO:K09562]
120924197  alpha-crystallin A chain [KO:K09541]
120915144  CRYAB; alpha-crystallin B chain isoform X1 [KO:K09542]
120916235  HSPB6; heat shock protein beta-6 [KO:K09542]
120927095  YOD1; ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
120944891  PLAA; phospholipase A-2-activating protein [KO:K14018]
120945185  RAD23B; UV excision repair protein RAD23 homolog B isoform X1 [KO:K10839]
120920224  UBQLN4; ubiquilin-4 [KO:K04523]
120942595  UBQLN1; ubiquilin-1 isoform X1 [KO:K04523]
120940265  NGLY1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
120921147  ATXN3; ataxin-3 [KO:K11863] [EC:3.4.22.-]
120915695  UBE4B; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
120924480  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
120921192  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
120943971  NFE2L2; nuclear factor erythroid 2-related factor 2 [KO:K05638]
120928311  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
120945302  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
120945303  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
120929463  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
120940635  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
120945523  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
120913240  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
120924432  WFS1; wolframin isoform X1 [KO:K14020]
120917646  MBTPS1; membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
120927517  MBTPS2; membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
120932778  XBP1; X-box-binding protein 1 [KO:K09027]
120919295  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
120943312  ERN2; serine/threonine-protein kinase/endoribonuclease IRE2 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
120914048  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
120937349  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
120933221  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
120909277  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120915815  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120916527  BAX; apoptosis regulator BAX [KO:K02159]
120927258  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
120938079  CAPN11; calpain-11 isoform X1 [KO:K01367] [EC:3.4.22.52]
120921949  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
120917378  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
120937867  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
120913392  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
120939554  MARCHF6; E3 ubiquitin-protein ligase MARCHF6 isoform X1 [KO:K10661] [EC:2.3.2.27]
120937112  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
120915386  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
120926603  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
120933486  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
120943846  UBE2G2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
120917325  SYVN1; E3 ubiquitin-protein ligase synoviolin isoform X1 [KO:K10601] [EC:2.3.2.27]
120913232  RNF5; E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
120937042  RNF185; E3 ubiquitin-protein ligase RNF185 isoform X1 [KO:K10666] [EC:2.3.2.27]
120931141  SELENOS; selenoprotein S [KO:K14025]
120920600  SEL1L; protein sel-1 homolog 1 isoform X1 [KO:K14026]
120917700  HERPUD1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
120917680  AMFR; E3 ubiquitin-protein ligase AMFR [KO:K10636] [EC:2.3.2.36]
120943166  STUB1; E3 ubiquitin-protein ligase CHIP isoform X1 [KO:K09561] [EC:2.3.2.27]
120909052  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
120918353  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
120947091  UBE2D1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
120933070  UBE2D4; ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
120945492  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
120940358  CUL1; cullin-1 isoform X1 [KO:K03347]
120932428  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
120915646  F-box only protein 2-like [KO:K10099]
120943004  F-box only protein 6-like [KO:K10100]
120915508  F-box only protein 6-like isoform X1 [KO:K10100]
120915509  F-box only protein 6-like [KO:K10100]
120915645  F-box only protein 6-like [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
rtem00510  N-Glycan biosynthesis
rtem03050  Proteasome
rtem03060  Protein export
rtem04210  Apoptosis
KO pathway
ko04141   
LinkDB

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