KEGG   PATHWAY: sasa04914
Entry
sasa04914                   Pathway                                
Name
Progesterone-mediated oocyte maturation - Salmo salar (Atlantic salmon)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
sasa04914  Progesterone-mediated oocyte maturation
sasa04914

Other DBs
GO: 0001556
Organism
Salmo salar (Atlantic salmon) [GN:sasa]
Gene
100846969  nuclear progesterone receptor [KO:K08556]
106600405  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106567700  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
106599005  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
106560529  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106613635  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106569403  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106568949  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
106573900  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106563018  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
106584012  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
106587034  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
106598808  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
106568747  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
106572046  pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
106581359  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
106613931  pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
106613172  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
106604288  mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
106560362  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
106604910  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
106568502  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
106576863  mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
106579004  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
106563760  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
106589346  mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
106609456  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
106609457  MK12; mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106561402  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106566975  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106566983  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
106573286  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106572737  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106572761  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106566105  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106566106  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106576243  MK12; mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106576244  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
100137046  p38b; mitogen activated protein kinase p38b [KO:K04441] [EC:2.7.11.24]
100196619  mk13; Mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100136932  p38a; mitogen activated protein kinase p38a [KO:K04441] [EC:2.7.11.24]
106609493  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
106565669  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
106566064  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
106573324  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
106572859  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
106576428  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
100380647  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
106566384  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
100217348  gnai2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [KO:K04630]
100196762  gnai3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 [KO:K04630]
106583193  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
106582753  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
106599721  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
106569164  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
106584068  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
106560395  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
106570343  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
106588693  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
106584132  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
106605024  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
106607897  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
106608969  adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
106582348  adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
106586396  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
106566714  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
106572701  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
106571946  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
106567013  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
106562384  adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
106587576  adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
106611404  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
106568630  adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
106590289  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106590466  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106601887  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106601890  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106606489  adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
106564461  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106564466  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106592286  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
106564260  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
106569146  KAPCB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106613442  prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106599750  KAPCB; cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
106606839  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100196609  stk6; Serine/threonine-protein kinase 6 [KO:K11481] [EC:2.7.11.1]
106604870  cytoplasmic polyadenylation element-binding protein 3-like [KO:K02602]
106604296  cytoplasmic polyadenylation element-binding protein 4-like [KO:K02602]
106603870  cytoplasmic polyadenylation element-binding protein 4-like [KO:K02602]
106560740  cytoplasmic polyadenylation element-binding protein 1-A-like [KO:K02602]
106612156  cytoplasmic polyadenylation element-binding protein 4-like [KO:K02602]
106567449  cytoplasmic polyadenylation element-binding protein 4-like [KO:K02602]
106560248  cytoplasmic polyadenylation element-binding protein 2-like [KO:K02602]
106562788  cytoplasmic polyadenylation element-binding protein 1-like [KO:K02602]
106576796  cytoplasmic polyadenylation element-binding protein 3-like [KO:K02602]
106584219  cytoplasmic polyadenylation element-binding protein 2-like [KO:K02602]
106587658  cytoplasmic polyadenylation element-binding protein 1-like [KO:K02602]
106561877  spdya; speedy/RINGO cell cycle regulator family member A [KO:K08694]
106565437  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
100196712  cdk2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
106607826  cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100196122  cdc2; Cell division control protein 2 homolog [KO:K02087] [EC:2.7.11.22 2.7.11.23]
106611545  cyclin-A2-like [KO:K06627]
106563854  ccna1; cyclin A1 [KO:K06627]
100195170  ccna2; cyclin A2 [KO:K06627]
106590218  mos; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1]
106608136  heat shock protein HSP 90-alpha-like [KO:K04079]
106608137  heat shock protein HSP 90-alpha 1 [KO:K04079]
106571588  heat shock protein HSP 90-alpha 1-like [KO:K04079]
100136360  hsp90ab1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
100380418  hs90a; Heat shock protein HSP 90-alpha [KO:K04079]
106584829  map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106570952  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106600714  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
106592057  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
100380511  mk03; Mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
106612640  ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
106612512  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
106603065  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
106604080  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
106610660  ribosomal protein S6 kinase 2 alpha-like [KO:K04373] [EC:2.7.11.1]
106563584  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
106579471  ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
106589820  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
106590479  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
106579073  pkmyt1; protein kinase, membrane associated tyrosine/threonine 1 [KO:K06633] [EC:2.7.11.1]
106566708  CCNB1; G2/mitotic-specific cyclin-B1-like [KO:K05868]
106562137  G2/mitotic-specific cyclin-B1-like [KO:K05868]
106563318  ccnb1; cyclin B1 [KO:K05868]
106587173  G2/mitotic-specific cyclin-B1-like [KO:K05868]
106587338  ccnb2; cyclin B2 [KO:K21770]
100195267  ccnb3; cyclin B3 [KO:K21771]
106563680  G2/mitotic-specific cyclin-B3-like [KO:K21771]
106603843  serine/threonine-protein kinase 10-like [KO:K08837] [EC:2.7.11.1]
106567511  serine/threonine-protein kinase 10-like [KO:K08837] [EC:2.7.11.1]
106592455  plk1; polo like kinase 1 [KO:K06631] [EC:2.7.11.21]
106590979  serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
106561325  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
106611433  cdc25b; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
106593289  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
106563618  M-phase inducer phosphatase 1-B-like [KO:K05867] [EC:3.1.3.48]
106603941  INS; insulin-like [KO:K04526]
106567474  INS; insulin [KO:K04526]
106612054  insulin-like [KO:K04526]
106609475  insulin-like growth factor I [KO:K05459]
100136517  insulin-like growth factor I [KO:K05459]
106573762  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
106588078  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100194499  igf1r; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
106582637  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106585772  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106602915  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106607890  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106610858  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106564869  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106613111  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106581334  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106571474  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100194605  akt2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
106589689  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106562335  cGMP-inhibited 3',5'-cyclic phosphodiesterase B-like [KO:K13296] [EC:3.1.4.17]
106587530  pde3b; phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
106601908  GTPase HRas-like [KO:K07827]
106606379  GTPase HRas-like [KO:K07827]
106561428  GTPase KRas [KO:K07827]
100380437  rask; GTPase KRas [KO:K07827]
106580530  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
106585138  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
106571905  RAF1b; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
106566757  RAF1a; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
100136351  raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
106607702  mitotic checkpoint serine/threonine-protein kinase BUB1-like [KO:K02178] [EC:2.7.11.1]
100306849  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
106564124  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
106564137  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
106592232  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
106594579  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
106594581  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
106595452  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
106577502  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
100195682  md2l1; Mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
106566888  mad2l2; MAD2 mitotic arrest deficient-like 2 (yeast) [KO:K13728]
106599985  fizzy-related protein homolog [KO:K03364]
106569402  FZR; fizzy-related protein homolog [KO:K03364]
106569538  fizzy-related protein homolog [KO:K03364]
106613917  FZR; fizzy-related protein homolog [KO:K03364]
106608142  anaphase-promoting complex subunit 1-like [KO:K03348]
106566731  anaphase-promoting complex subunit 2-like [KO:K03349]
106563313  anaphase-promoting complex subunit 2-like [KO:K03349]
106600875  CDC27; cell division cycle protein 27 homolog [KO:K03350]
100194929  cdc27; cell division cycle 27 [KO:K03350]
106560255  anapc4; anaphase promoting complex subunit 4 [KO:K03351]
100306794  anapc5; anaphase promoting complex subunit 5 [KO:K03352]
106581643  cell division cycle protein 16 homolog [KO:K03353]
106586025  cell division cycle protein 16 homolog [KO:K03353]
100286578  anapc7; anaphase promoting complex subunit 7 [KO:K03354]
106585471  anaphase-promoting complex subunit 7-like [KO:K03354]
106603039  cell division cycle protein 23 homolog [KO:K03355]
100380698  cdc23; cell division cycle protein 23 homolog [KO:K03355]
106578198  anapc10; anaphase promoting complex subunit 10 [KO:K03357]
106588092  anaphase-promoting complex subunit 11 [KO:K03358]
106564932  anaphase-promoting complex subunit 11-like [KO:K03358]
106567795  anaphase-promoting complex subunit CDC26-like [KO:K03359]
100195816  cdc26; cell division cycle 26 [KO:K03359]
106603647  anaphase-promoting complex subunit 13-like [KO:K12456]
100286719  anc13; Anaphase-promoting complex subunit 13 [KO:K12456]
106613224  anapc15; anaphase promoting complex subunit 15 [KO:K25228]
106594499  anaphase-promoting complex subunit 16 [KO:K25229]
106594500  anaphase-promoting complex subunit 16 [KO:K25229]
106560840  anaphase-promoting complex subunit 16 [KO:K25229]
106579399  kif22; kinesin family member 22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
sasa04010  MAPK signaling pathway
sasa04110  Cell cycle
KO pathway
ko04914   
LinkDB

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