KEGG   PATHWAY: sbq04145
Entry
sbq04145                    Pathway                                
Name
Phagosome - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
sbq04145  Phagosome
sbq04145

Other DBs
GO: 0045335
Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101049642  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
101048369  STX12; syntaxin-12 [KO:K13813]
101040691  STX7; syntaxin-7 isoform X1 [KO:K08488]
101037287  ACTB; actin, cytoplasmic 1 [KO:K05692]
101050060  actin, cytoplasmic 2-like isoform X1 [KO:K05692]
101049910  ACTG1; actin, cytoplasmic 2 [KO:K05692]
104651678  actin, cytoplasmic 1-like [KO:K05692]
101039705  CORO1A; coronin-1A [KO:K13882]
101037189  STX18; syntaxin-18 isoform X1 [KO:K08492]
101041226  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
101042893  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101043856  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101046108  HLA class I histocompatibility antigen, B-27 alpha chain-like [KO:K06751]
104650390  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
104650398  putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
101032412  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101040674  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101041111  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101033054  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
101040568  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101040877  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like isoform X1 [KO:K06751]
101044935  LOW QUALITY PROTEIN: popy class I histocompatibility antigen, alpha chain E [KO:K06751]
101050220  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101050865  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101053828  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X2 [KO:K06752]
101054155  HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752]
101053201  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X4 [KO:K06752]
101054478  HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X1 [KO:K06752]
101052879  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
101034517  HLA class II histocompatibility antigen, DRB1-4 beta chain-like isoform X1 [KO:K06752]
101041326  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
101034208  HLA class II histocompatibility antigen, DRB1-9 beta chain-like [KO:K06752]
101041640  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
101038711  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
104650606  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101039757  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
101039220  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
101040088  HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752]
101052651  HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
101052977  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
101034494  RAB5A; ras-related protein Rab-5A [KO:K07887]
101046115  ras-related protein Rab-5B [KO:K07888]
101045231  RAB5C; ras-related protein Rab-5C [KO:K07889]
101049276  EEA1; early endosome antigen 1 [KO:K12478]
101045444  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101030435  TFRC; transferrin receptor protein 1 [KO:K06503]
101048011  HGS; LOW QUALITY PROTEIN: hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
101041261  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
101051309  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
101043270  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
101042857  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
101046103  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
101033128  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
101050200  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
101052229  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
101044983  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
101048930  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
101035408  ATP6V1G3; LOW QUALITY PROTEIN: V-type proton ATPase subunit G 3 [KO:K02152]
101032939  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
101029359  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
101042407  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
101053813  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform 3 isoform X1 [KO:K02154]
101037096  ATP6V0A2; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a isoform 2 [KO:K02154]
101049040  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 [KO:K02154]
101045262  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 isoform X1 [KO:K02154]
101028542  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
101053174  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
101047328  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101047790  LOW QUALITY PROTEIN: V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
101030201  LOW QUALITY PROTEIN: V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
101053104  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
101039958  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
101041102  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
101041825  RAB7A; ras-related protein Rab-7a [KO:K07897]
101046682  RAB7B; ras-related protein Rab-7b [KO:K07898]
101042377  RILP; rab-interacting lysosomal protein [KO:K13883]
101035437  DYNC1H1; LOW QUALITY PROTEIN: cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
101050061  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X2 [KO:K10414]
101049825  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X2 [KO:K10415]
101048157  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
101036323  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
101045403  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
101046265  tubulin alpha-1B chain [KO:K07374]
101047200  tubulin alpha-1A chain [KO:K07374]
101046886  tubulin alpha-1C chain [KO:K07374]
101039362  TUBA8; tubulin alpha-8 chain [KO:K07374]
101040729  TUBAL3; tubulin alpha chain-like 3 isoform X2 [KO:K07374]
101027836  TUBA4A; LOW QUALITY PROTEIN: tubulin alpha-4A chain [KO:K07374]
101045575  tubulin beta-2A chain [KO:K07375]
101051381  tubulin beta chain-like [KO:K07375]
101041752  TUBB1; tubulin beta-1 chain [KO:K07375]
101036523  tubulin beta-8 chain-like [KO:K07375]
101043702  TUBB4A; tubulin beta-4A chain [KO:K07375]
101052549  tubulin beta chain [KO:K07375]
101052315  TUBB6; tubulin beta-6 chain [KO:K07375]
101034943  TUBB; tubulin beta chain [KO:K07375]
101034100  TUBB3; tubulin beta-3 chain [KO:K07375]
101054187  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
101043758  LAMP1; LOW QUALITY PROTEIN: lysosome-associated membrane glycoprotein 1 [KO:K06528]
101028683  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X2 [KO:K00921] [EC:2.7.1.150]
101032728  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
101034544  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
101046117  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
101030077  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
101051131  LOW QUALITY PROTEIN: putative cathepsin L-like protein 6 [KO:K01365] [EC:3.4.22.15]
101044698  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
101041434  SEC61A2; protein transport protein Sec61 subunit alpha isoform 2 [KO:K10956]
101038739  SEC61A1; protein transport protein Sec61 subunit alpha isoform 1 [KO:K10956]
101031213  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
101046824  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
101050206  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
101052015  TAP2; LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
101043082  CALR; calreticulin [KO:K08057]
101030099  CANX; calnexin [KO:K08054]
101052887  FCAR; immunoglobulin alpha Fc receptor [KO:K06513]
101027415  LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
101040113  FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a isoform X1 [KO:K06472]
101039367  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X2 [KO:K12560]
101040447  low affinity immunoglobulin gamma Fc region receptor III isoform X2 [KO:K06463]
101040997  LOW QUALITY PROTEIN: putative V-set and immunoglobulin domain-containing protein 7 [KO:K06856]
101054381  putative V-set and immunoglobulin domain-containing-like protein IGHV1OR21-1 [KO:K06856]
101033685  uncharacterized protein LOC101033685 [KO:K06856]
101041646  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
101033061  C1R; complement C1r subcomponent isoform X2 [KO:K01330] [EC:3.4.21.41]
101035688  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
101053620  ITGB2; integrin beta-2 [KO:K06464]
101044671  C3; complement C3 [KO:K03990]
101027810  COLEC11; collectin-11 isoform X2 [KO:K10066]
101053922  COLEC12; collectin-12 [KO:K10062]
101029843  mannose-binding protein A-like [KO:K03991]
101045108  MBL2; mannose-binding protein C [KO:K03991]
101030163  pulmonary surfactant-associated protein A1 [KO:K10067]
101029520  SFTPD; pulmonary surfactant-associated protein D [KO:K10068]
101032614  ITGAV; integrin alpha-V [KO:K06487]
101041311  ITGA2; integrin alpha-2 [KO:K06481]
101043820  ITGA5; integrin alpha-5 [KO:K06484]
101040620  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
101049562  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
101029859  ITGB5; integrin beta-5 [KO:K06588]
101029602  THBS1; thrombospondin-1 [KO:K16857]
101040437  COMP; cartilage oligomeric matrix protein [KO:K04659]
101043743  THBS2; thrombospondin-2 [KO:K04659]
101046556  THBS4; thrombospondin-4 [KO:K04659]
101039744  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101045472  TLR2; toll-like receptor 2 [KO:K10159]
101034209  TLR6; toll-like receptor 6 [KO:K10169]
101043935  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
101051835  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101046372  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
101032818  MRC2; LOW QUALITY PROTEIN: C-type mannose receptor 2 [KO:K06560]
101047591  MRC1; macrophage mannose receptor 1 [KO:K06560]
101034477  CD209 antigen-like protein 2 isoform X1 [KO:K06563]
101043670  CLEC7A; C-type lectin domain family 7 member A isoform X2 [KO:K10074]
101031394  MSR1; macrophage scavenger receptor types I and II [KO:K06558]
101045374  MARCO; macrophage receptor MARCO [KO:K13884]
101044203  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
101047508  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
101043591  CD36; platelet glycoprotein 4 [KO:K06259]
101045425  cytochrome b-245 light chain [KO:K08009]
101052306  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101042808  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101054407  NCF1; LOW QUALITY PROTEIN: neutrophil cytosol factor 1 [KO:K08011]
101034817  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
101034334  NCF4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
sbq04142  Lysosome
sbq04144  Endocytosis
sbq04610  Complement and coagulation cascades
sbq04612  Antigen processing and presentation
sbq04620  Toll-like receptor signaling pathway
sbq04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
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