KEGG   PATHWAY: setr04727
Entry
setr04727                   Pathway                                
Name
GABAergic synapse - Suncus etruscus (white-toothed pygmy shrew)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
setr04727  GABAergic synapse
setr04727

Other DBs
GO: 0051932
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
126022859  SLC38A1; sodium-coupled neutral amino acid symporter 1 [KO:K14990]
126022858  SLC38A2; sodium-coupled neutral amino acid symporter 2 [KO:K14207]
126022970  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
126008914  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
126014468  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
126009074  GAD1; glutamate decarboxylase 1 [KO:K01580] [EC:4.1.1.15]
126017336  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
126001248  ABAT; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
126012225  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
126012226  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
126021832  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 isoform X1 [KO:K05175]
126032455  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 isoform X1 [KO:K05175]
126032458  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
125999440  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 isoform X1 [KO:K05175]
126012223  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
126021830  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 [KO:K05181]
126032460  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
126011917  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 [KO:K05186]
126021831  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
126032121  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
126007243  LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit gamma-1-like [KO:K05186]
126011537  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
125998944  GABRE; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
125998946  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
126012230  GABRP; gamma-aminobutyric acid receptor subunit pi [KO:K05189]
126030328  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
126005939  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
126017330  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
126017297  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
126030861  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126027978  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126022272  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
125998017  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
126027464  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
126027540  EMCN; LOW QUALITY PROTEIN: endomucin [KO:K08341]
126016984  NSF; vesicle-fusing ATPase isoform X1 [KO:K06027] [EC:3.6.4.6]
126008903  TRAK2; trafficking kinesin-binding protein 2 [KO:K15374]
126008904  PLCL1; inactive phospholipase C-like protein 1 [KO:K15375]
126003982  GPHN; gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
126017278  SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967]
126006726  LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit rho-2-like [KO:K05190]
126006733  LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit rho-1-like [KO:K05190]
126030243  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
126020490  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
126022196  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
126013230  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
125999147  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
126004344  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
125996385  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
126023323  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
126014071  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
126022872  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
125997317  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
126027101  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
126011605  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
126031035  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
126006589  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
126012077  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
126002081  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
125999572  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
126017910  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
126030791  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
126005956  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126026239  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126031195  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
126028279  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
126020263  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
126003829  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126023960  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126024701  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126033760  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
125999484  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126000312  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
126010869  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126010895  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
126020118  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126024681  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
126030830  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
126010822  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
126001569  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
126024671  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
126020139  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
126029834  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
126000769  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
126024026  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
126001049  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
126026247  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
126022668  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
126027080  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
125997104  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
126001221  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
126025599  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
125998050  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
126022335  SLC6A13; sodium- and chloride-dependent GABA transporter 2 [KO:K05046]
125998047  SLC6A11; sodium- and chloride-dependent GABA transporter 3 isoform X1 [KO:K05044]
126022333  SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045]
126013439  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
126014048  SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576]
125999332  SLC38A5; sodium-coupled neutral amino acid transporter 5 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
setr00020  Citrate cycle (TCA cycle)
setr00250  Alanine, aspartate and glutamate metabolism
setr04144  Endocytosis
setr04721  Synaptic vesicle cycle
KO pathway
ko04727   
LinkDB

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