KEGG   PATHWAY: sita04141
Entry
sita04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Setaria italica (foxtail millet)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
sita04141  Protein processing in endoplasmic reticulum
sita04141

Other DBs
GO: 0030433 0034976
Organism
Setaria italica (foxtail millet) [GN:sita]
Gene
101779598  protein transport protein Sec61 subunit alpha [KO:K10956]
101755524  protein transport protein Sec61 subunit alpha [KO:K10956]
101784537  protein transport protein Sec61 subunit beta-like [KO:K09481]
101782655  protein transport protein Sec61 subunit beta-like [KO:K09481]
101774408  protein transport protein Sec61 subunit beta-like [KO:K09481]
111256968  protein transport protein Sec61 subunit beta-like [KO:K09481]
101770322  uncharacterized protein LOC101770322 [KO:K12275]
101774248  dnaJ protein ERDJ2 [KO:K09540]
101775893  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
101755009  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
101774093  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
101784437  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
101759933  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
101763138  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
101773201  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
101773622  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
101774710  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3 [KO:K19478]
101753024  oligosaccharyltransferase complex subunit ostc [KO:K26501]
101775136  transmembrane protein 258 [KO:K26502]
101769927  heat shock 70 kDa protein 17 [KO:K09486]
101775309  luminal-binding protein 3 [KO:K09490] [EC:3.6.4.10]
101771729  heat shock 70 kDa protein BIP4-like [KO:K09490] [EC:3.6.4.10]
101777746  heat shock 70 kDa protein BIP4 [KO:K09490] [EC:3.6.4.10]
101774199  heat shock 70 kDa protein BIP2 [KO:K09490] [EC:3.6.4.10]
101782647  heat shock 70 kDa protein BIP4 [KO:K09490] [EC:3.6.4.10]
101766033  luminal-binding protein 4 [KO:K09490] [EC:3.6.4.10]
101774899  heat shock 70 kDa protein BIP4 [KO:K09490] [EC:3.6.4.10]
101784122  uncharacterized protein LOC101784122 isoform X1 [KO:K09490] [EC:3.6.4.10]
101765851  dnaJ protein ERDJ3B [KO:K09517]
101756561  dnaJ protein ERDJ3B [KO:K09517]
101777610  dnaJ protein P58IPK homolog B [KO:K09523]
101763050  heat shock protein 90-5, chloroplastic [KO:K09487]
101786826  heat shock protein 90-6, mitochondrial [KO:K09487]
101762306  endoplasmin homolog [KO:K09487]
101769528  heat shock protein 90-5, chloroplastic [KO:K09487]
101767458  probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
101777457  glucosidase 2 subunit beta [KO:K08288]
101770357  calnexin homolog [KO:K08054]
101761253  calreticulin-3 [KO:K08057]
101777678  calreticulin-3 [KO:K08057]
101762276  calreticulin [KO:K08057]
101774614  calreticulin [KO:K08057]
101786918  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
101756133  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 isoform X1 [KO:K01230] [EC:3.2.1.113]
101773458  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 [KO:K23741] [EC:3.2.1.209]
101757762  SEC12-like protein 1 [KO:K14003]
101759979  SEC12-like protein 1 isoform X2 [KO:K14003]
101785744  SEC12-like protein 2 [KO:K14003]
101772664  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
101766651  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
101768489  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
101769633  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
101779222  protein transport protein SEC13 homolog B [KO:K14004]
101767121  protein transport protein SEC13 homolog B [KO:K14004]
101763445  protein transport protein SEC13 homolog B [KO:K14004]
101758457  protein transport protein SEC31 homolog B isoform X4 [KO:K14005]
101756446  protein transport protein SEC23 [KO:K14006]
101769397  protein transport protein SEC23 isoform X1 [KO:K14006]
101784695  protein transport protein sec23-1 [KO:K14006]
101766492  protein transport protein SEC23 isoform X1 [KO:K14006]
101776179  protein transport protein Sec24-like CEF [KO:K14007]
101763317  protein transport protein Sec24-like At3g07100 [KO:K14007]
101773615  LOW QUALITY PROTEIN: protein transport protein Sec24-like At4g32640 [KO:K14007]
101769191  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
101759781  alpha-mannosidase I MNS5 [KO:K10084]
101775557  alpha-mannosidase I MNS4 isoform X2 [KO:K10085]
101753416  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
101777615  protein disulfide isomerase-like 1-2 [KO:K09580] [EC:5.3.4.1]
101785685  protein disulfide isomerase-like 5-3 [KO:K09580] [EC:5.3.4.1]
101752568  protein disulfide isomerase-like 1-5 [KO:K09580] [EC:5.3.4.1]
101780630  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
101766300  protein disulfide isomerase-like 5-2 [KO:K09580] [EC:5.3.4.1]
101773724  protein disulfide isomerase-like 1-2 [KO:K09580] [EC:5.3.4.1]
101781145  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
101772042  protein disulfide isomerase-like 2-2 [KO:K09584] [EC:5.3.4.1]
101755755  protein disulfide isomerase-like 2-1 [KO:K09584] [EC:5.3.4.1]
101774705  endoplasmic reticulum oxidoreductin-1 [KO:K10950] [EC:1.8.4.-]
101755822  protein OS-9 homolog [KO:K10088]
101758382  translocon-associated protein subunit alpha [KO:K13249]
101782934  translocon-associated protein subunit beta [KO:K13250]
101761860  uncharacterized protein LOC101761860 [KO:K13250]
101761516  B-cell receptor-associated protein 31 [KO:K14009]
101755796  B-cell receptor-associated protein 31 [KO:K14009]
101775823  uncharacterized protein LOC101775823 [KO:K14009]
101785469  derlin-1 [KO:K13989]
101774838  derlin-2 [KO:K13989]
101755503  plant UBX domain-containing protein 11 [KO:K24348]
101761288  plant UBX domain-containing protein 2 [KO:K14011]
101778656  plant UBX domain-containing protein 4 [KO:K14012]
101754142  plant UBX domain-containing protein 4 [KO:K14012]
101783353  cell division cycle protein 48 homolog [KO:K13525]
101783641  cell division cycle protein 48 homolog [KO:K13525]
101756101  cell division cycle protein 48 homolog [KO:K13525]
101773946  NPL4-like protein [KO:K14015]
101754231  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
101784888  ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
101772854  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
101752645  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
101762782  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
101770657  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
101774685  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
101785219  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
101756252  heat shock 70 kDa protein [KO:K03283]
101777821  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
101764302  heat shock cognate 70 kDa protein 2 [KO:K03283]
101764060  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
101765676  heat shock cognate 70 kDa protein [KO:K03283]
101775632  heat shock cognate 70 kDa protein [KO:K03283]
111258244  heat shock cognate 70 kDa protein 2-like [KO:K03283]
101783812  chaperone protein dnaJ A6 [KO:K09503]
101762146  dnaJ protein homolog [KO:K09503]
101762103  chaperone protein dnaJ A6 [KO:K09503]
101776188  dnaJ protein homolog [KO:K09503]
101769904  chaperone protein dnaJ 49 [KO:K09518]
101769312  chaperone protein dnaJ 49 [KO:K09518]
101760053  heat shock protein 81-1 [KO:K04079]
101782212  heat shock protein 82 [KO:K04079]
101766980  LOW QUALITY PROTEIN: heat shock protein 81-3 [KO:K04079]
111256397  LOW QUALITY PROTEIN: heat shock protein 81-1-like [KO:K04079]
101770154  uncharacterized protein LOC101770154 [KO:K09562]
101758232  hsp70-binding protein 1 [KO:K09562]
101753323  hsp70 nucleotide exchange factor FES1 [KO:K09562]
101784921  hsp70 nucleotide exchange factor FES1 [KO:K09562]
101757734  18.9 kDa heat shock protein [KO:K13993]
101759760  19.0 kDa class II heat shock protein [KO:K13993]
101766952  23.6 kDa heat shock protein, mitochondrial [KO:K13993]
101772869  17.8 kDa heat shock protein [KO:K13993]
101758975  24.1 kDa heat shock protein, mitochondrial isoform X1 [KO:K13993]
101753155  18.6 kDa class III heat shock protein [KO:K13993]
101775696  16.9 kDa class I heat shock protein 1 [KO:K13993]
101776097  16.9 kDa class I heat shock protein 1 [KO:K13993]
101776503  16.9 kDa class I heat shock protein 3 [KO:K13993]
101776908  16.9 kDa class I heat shock protein 3 [KO:K13993]
101777313  17.9 kDa heat shock protein 2 [KO:K13993]
101777729  16.6 kDa heat shock protein [KO:K13993]
101773385  17.5 kDa class II heat shock protein [KO:K13993]
101771867  16.0 kDa heat shock protein, peroxisomal [KO:K13993]
101769739  26.2 kDa heat shock protein, mitochondrial [KO:K13993]
101766359  26.2 kDa heat shock protein, mitochondrial [KO:K13993]
101764644  small heat shock protein, chloroplastic [KO:K13993]
101772922  21.9 kDa heat shock protein [KO:K13993]
101770955  17.4 kDa class I heat shock protein [KO:K13993]
101771349  17.9 kDa class I heat shock protein [KO:K13993]
101773099  17.9 kDa class I heat shock protein [KO:K13993]
101770422  26.7 kDa heat shock protein, chloroplastic [KO:K13993]
101781216  26.2 kDa heat shock protein, mitochondrial [KO:K13993]
101773804  17.5 kDa class II heat shock protein [KO:K13993]
101766163  23.2 kDa heat shock protein [KO:K13993]
111255650  18.8 kDa class V heat shock protein [KO:K13993]
101765577  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
101767650  phospholipase A-2-activating protein [KO:K14018]
101761391  ubiquitin receptor RAD23b [KO:K10839]
101786843  ubiquitin receptor RAD23d isoform X1 [KO:K10839]
101764257  probable ubiquitin receptor RAD23 [KO:K10839]
101770540  ubiquitin domain-containing protein DSK2b [KO:K04523]
101779075  ubiquitin domain-containing protein DSK2a [KO:K04523]
101784520  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
101785401  putative ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
101777433  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
101784261  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
101782825  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
101786320  subtilisin-like protease SBT6.1 [KO:K08653] [EC:3.4.21.112]
101783039  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101769615  probable E3 ubiquitin ligase SUD1 [KO:K10661] [EC:2.3.2.27]
101767236  probable E3 ubiquitin ligase SUD1 isoform X1 [KO:K10661] [EC:2.3.2.27]
101783763  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
101754991  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
101784150  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
101754620  ubiquitin-conjugating enzyme E2 7 isoform X1 [KO:K10575] [EC:2.3.2.23]
101774761  ERAD-associated E3 ubiquitin-protein ligase HRD1 isoform X2 [KO:K10601] [EC:2.3.2.27]
101761751  ERAD-associated E3 ubiquitin-protein ligase HRD1 isoform X1 [KO:K10601] [EC:2.3.2.27]
101757151  uncharacterized protein LOC101757151 [KO:K10666] [EC:2.3.2.27]
101757988  uncharacterized protein LOC101757988 [KO:K10666] [EC:2.3.2.27]
101754403  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
101755974  E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
101782523  E3 ubiquitin-protein ligase RNF5 isoform X2 [KO:K10666] [EC:2.3.2.27]
101761597  E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
101764890  ERAD-associated E3 ubiquitin-protein ligase component HRD3 [KO:K14026]
101766024  E3 ubiquitin protein ligase RIN2 [KO:K10636] [EC:2.3.2.36]
101762127  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
101760049  E3 ubiquitin-protein ligase CHIP isoform X2 [KO:K09561] [EC:2.3.2.27]
101785004  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
101769713  ubiquitin-conjugating enzyme E2 11 isoform X2 [KO:K06689] [EC:2.3.2.23]
101781812  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
101778020  ubiquitin-conjugating enzyme E2 5A [KO:K06689] [EC:2.3.2.23]
101784577  ubiquitin-conjugating enzyme E2 5B [KO:K06689] [EC:2.3.2.23]
101781975  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
111258067  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
101761659  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
101778950  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
101779959  cullin-1 [KO:K03347]
101760842  cullin-1 [KO:K03347]
101760424  cullin-1 [KO:K03347]
101756927  SKP1-like protein 1A [KO:K03094]
101778521  SKP1-like protein 1A [KO:K03094]
101778932  SKP1-like protein 1A [KO:K03094]
101783437  SKP1-like protein 1A [KO:K03094]
101752945  SKP1-like protein 1A [KO:K03094]
101753761  SKP1-like protein 1B [KO:K03094]
101752686  SKP1-like protein 18 [KO:K03094]
101760358  SKP1-like protein 1B [KO:K03094]
101767110  SKP1-like protein 11 [KO:K03094]
101763393  SKP1-like protein 13 [KO:K03094]
101761705  SKP1-like protein 1A [KO:K03094]
111256418  SKP1-like protein 11 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
sita00510  N-Glycan biosynthesis
sita03050  Proteasome
sita03060  Protein export
KO pathway
ko04141   
LinkDB

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