KEGG   PATHWAY: yro00270
Entry
yro00270                    Pathway                                
Name
Cysteine and methionine metabolism - Yersinia rohdei
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
yro00270  Cysteine and methionine metabolism
yro00270

Module
yro_M00017  Methionine biosynthesis, aspartate => homoserine => methionine [PATH:yro00270]
yro_M00021  Cysteine biosynthesis, serine => cysteine [PATH:yro00270]
yro_M00034  Methionine salvage pathway [PATH:yro00270]
yro_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:yro00270]
Other DBs
GO: 0006534 0006555
Organism
Yersinia rohdei [GN:yro]
Gene
CH64_2669  cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]
CH64_1358  cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]
CH64_3588  pyridoxal-phosphate dependent enzyme family protein [KO:K01738] [EC:2.5.1.47]
CH64_1105  beta-eliminating lyase family protein [KO:K01758] [EC:4.4.1.1]
CH64_2024  metC; cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]
CH64_556  C-S lyase family protein [KO:K14155] [EC:4.4.1.13]
CH64_1104  CBS domain protein [KO:K01697] [EC:4.2.1.22]
CH64_2291  metH; methionine synthase [KO:K00548] [EC:2.1.1.13]
CH64_2840  metE; 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase [KO:K00549] [EC:2.1.1.14]
CH64_1808  metK; methionine adenosyltransferase [KO:K00789] [EC:2.5.1.6]
CH64_3330  speD; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
CH64_3331  speE; spermidine synthase [KO:K00797] [EC:2.5.1.16]
CH64_970  esaI; acyl-homoserine-lactone synthase [KO:K22956] [EC:2.3.1.184]
CH64_3356  mtnN; MTA/SAH nucleosidase [KO:K01243] [EC:3.2.2.9]
CH64_3499  mtnK; S-methyl-5-thioribose kinase [KO:K00899] [EC:2.7.1.100]
CH64_3471  multi-copper polyphenol oxidoreductase laccase family protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
CH64_3498  mtnA; S-methyl-5-thioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
CH64_3495  mtnB; methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
CH64_3496  mtnC; 2,3-diketo-5-methylthio-1-phosphopentane phosphatase [KO:K09880] [EC:3.1.3.77]
CH64_3497  mtnD; acireductone dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
CH64_2266  tyrB; aromatic-amino-acid aminotransferase [KO:K00832] [EC:2.6.1.57]
CH64_792  GAF domain protein [KO:K08968] [EC:1.8.4.14]
CH64_3657  bspRIM; modification methylase BspRI [KO:K00558] [EC:2.1.1.37]
CH64_3454  luxS; S-ribosylhomocysteine lyase [KO:K07173] [EC:4.4.1.21]
CH64_2290  aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
CH64_3222  aspartate kinase domain protein [KO:K12524] [EC:2.7.2.4 1.1.1.3]
CH64_2701  aspartate kinase domain protein [KO:K12525] [EC:2.7.2.4 1.1.1.3]
CH64_2431  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CH64_2296  metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]
CH64_2700  metB; O-succinylhomoserine (thiol)-lyase [KO:K01739] [EC:2.5.1.48]
CH64_886  O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein [KO:K01740] [EC:2.5.1.49]
CH64_2741  ilvE; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
CH64_3453  gshA; glutamate--cysteine ligase [KO:K01919] [EC:6.3.2.2]
CH64_1815  gshB; glutathione synthase [KO:K01920] [EC:6.3.2.3]
CH64_1011  aspC; aspartate aminotransferase [KO:K00813] [EC:2.6.1.1]
CH64_3860  rhodanese-like domain protein [KO:K01011] [EC:2.8.1.1 2.8.1.2]
CH64_1253  aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
CH64_256  dcyD; D-cysteine desulfhydrase [KO:K05396] [EC:4.4.1.15]
CH64_3042  mdh; malate dehydrogenase, NAD-dependent [KO:K00024] [EC:1.1.1.37]
CH64_1102  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
CH64_846  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
CH64_1366  cysM; cysteine synthase B [KO:K12339] [EC:2.5.1.144]
CH64_1794  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CH64_1034  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
yro00010  Glycolysis / Gluconeogenesis
yro00250  Alanine, aspartate and glutamate metabolism
yro00260  Glycine, serine and threonine metabolism
yro00290  Valine, leucine and isoleucine biosynthesis
yro00430  Taurine and hypotaurine metabolism
yro00480  Glutathione metabolism
yro00620  Pyruvate metabolism
yro00640  Propanoate metabolism
yro00770  Pantothenate and CoA biosynthesis
yro00900  Terpenoid backbone biosynthesis
yro00920  Sulfur metabolism
KO pathway
ko00270   
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