KEGG   PATHWAY: zvi04350
Entry
zvi04350                    Pathway                                
Name
TGF-beta signaling pathway - Zootoca vivipara (common lizard)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
zvi04350  TGF-beta signaling pathway
zvi04350

Other DBs
GO: 0007179
Organism
Zootoca vivipara (common lizard) [GN:zvi]
Gene
118093878  CHRD; chordin isoform X1 [KO:K04657]
118081458  NOG; noggin [KO:K04658]
118093270  noggin-2-like [KO:K04658]
118091155  noggin-like [KO:K04658]
118087990  NBL1; neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
118082729  GREM2; gremlin-2 [KO:K23318]
118082836  GREM1; gremlin-1 [KO:K23318]
118082968  THBS1; thrombospondin-1 [KO:K16857]
118090898  DCN; decorin [KO:K04660]
118089348  FMOD; fibromodulin [KO:K08121]
118083222  left-right determination factor 2-like [KO:K04668]
118077143  FST; follistatin isoform X1 [KO:K04661]
118085958  bone morphogenetic protein 2-like [KO:K21283]
118082499  BMP2; bone morphogenetic protein 2 [KO:K21283]
118086063  bone morphogenetic protein 2-A-like [KO:K21283]
118077290  BMP4; bone morphogenetic protein 4 [KO:K04662]
118089785  BMP6; bone morphogenetic protein 6 [KO:K16620]
118091930  INHBB; inhibin beta B chain [KO:K22687]
118094079  ovotransferrin-like [KO:K14736]
118082357  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
118088620  BMP7; bone morphogenetic protein 7 [KO:K16621]
118086764  bone morphogenetic protein 8B-like [KO:K16622]
118088490  GDF5; growth/differentiation factor 5 [KO:K04664]
118090437  GDF6; growth/differentiation factor 6 [KO:K20012]
118082871  GDF7; growth/differentiation factor 7 [KO:K20013]
118087957  AMH; muellerian-inhibiting factor [KO:K04665]
118091505  interferon gamma-like [KO:K04687]
118076151  TNF; tumor necrosis factor [KO:K03156]
118092768  THSD4; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
118093304  FBN1; fibrillin-1 isoform X1 [KO:K06825]
118081797  LTBP1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
118086683  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
118076237  transforming growth factor beta-2 proprotein-like [KO:K13376]
118083182  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
118081749  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
118092223  INHBA; inhibin beta A chain [KO:K04667]
118097317  NODAL; nodal homolog [KO:K04666]
118096082  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
118083897  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
118093081  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
118096116  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
118092702  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
118075863  hemojuvelin-like [KO:K23100]
118097477  hemojuvelin-like [KO:K23100]
118092461  NEO1; neogenin [KO:K06766]
118095097  TFR2; transferrin receptor protein 2 isoform X1 [KO:K23910]
118093631  TFRC; transferrin receptor protein 1 [KO:K06503]
118092806  RGMA; repulsive guidance molecule A [KO:K23096]
118076983  RGMB; RGM domain family member B [KO:K06847]
118081440  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
118094733  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
118091951  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
118092373  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118094336  EMP3; epithelial membrane protein 3 [KO:K26257]
118085647  LRRC32; transforming growth factor beta activator LRRC32 isoform X1 [KO:K26316]
118084262  transforming growth factor beta activator LRRC32-like [KO:K26316]
118093709  NRROS; transforming growth factor beta activator LRRC33 [KO:K26317]
118079300  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
118092384  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
118093089  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
118079203  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
118091891  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
118083354  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
118080376  SMAD5; mothers against decapentaplegic homolog 5 isoform X1 [KO:K16790]
118085372  SMAD9; mothers against decapentaplegic homolog 9 [KO:K16791]
118077093  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
118093281  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
118083703  mothers against decapentaplegic homolog 3-like [KO:K23605]
118076190  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
118077059  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
118075617  mothers against decapentaplegic homolog 6-like [KO:K04677]
118092649  SMAD6; mothers against decapentaplegic homolog 6 [KO:K04677]
118077108  SMAD7; mothers against decapentaplegic homolog 7 [KO:K19631]
118079628  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
118093240  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
118076809  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
118089461  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
118091458  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
118077678  CUL1; cullin-1 isoform X1 [KO:K03347]
118081788  S-phase kinase-associated protein 1-like [KO:K03094]
118080358  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
118075832  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118094794  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118080560  RHOA; transforming protein RhoA [KO:K04513]
118097793  transforming protein RhoA-like [KO:K04513]
118089797  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
118086500  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
118097627  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
118090279  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
118096774  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
118087766  HAMP; hepcidin [KO:K23106]
118088775  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
118082405  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
118087758  ID3; DNA-binding protein inhibitor ID-3 [KO:K17694]
118090391  ID4; DNA-binding protein inhibitor ID-4 [KO:K17695]
118089009  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
118087424  E2F4; transcription factor E2F4 [KO:K04682]
118090259  E2F5; transcription factor E2F5 [KO:K04682]
118084836  TFDP1; transcription factor Dp-1 [KO:K04683]
118090622  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
118092437  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
118077160  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
118093691  SKIL; ski-like protein [KO:K18499]
118086609  SKI; ski oncogene isoform X1 [KO:K26503]
118096172  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
118082135  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
118086612  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
118097120  NCOR1; nuclear receptor corepressor 1 [KO:K04650]
118089642  TGIF1; homeobox protein TGIF1 isoform X1 [KO:K19383]
118089545  TGIF2; homeobox protein TGIF2 isoform X1 [KO:K19553]
118090392  MYC; myc proto-oncogene protein [KO:K04377]
118075361  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
118087356  pituitary homeobox 2-like [KO:K04686]
118084342  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
zvi04010  MAPK signaling pathway
zvi04110  Cell cycle
zvi04120  Ubiquitin mediated proteolysis
zvi04210  Apoptosis
KO pathway
ko04350   
LinkDB

DBGET integrated database retrieval system