KEGG   PATHWAY: zvi04010
Entry
zvi04010                    Pathway                                
Name
MAPK signaling pathway - Zootoca vivipara (common lizard)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
zvi04010  MAPK signaling pathway
zvi04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Zootoca vivipara (common lizard) [GN:zvi]
Gene
118075207  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
118075210  FLNA; filamin-A isoform X1 [KO:K04437]
118075247  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
118075337  PSPN; persephin [KO:K25416]
118075358  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118075410  SOS2; son of sevenless homolog 2 [KO:K03099]
118075436  [KO:K16342] [EC:3.1.1.4]
118075494  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
118075568  [KO:K03283]
118075569  [KO:K03283]
118075687  RELA; transcription factor p65 [KO:K04735]
118075832  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118075897  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
118075939  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
118076085  EFNA4; ephrin-A4 [KO:K05462]
118076102  [KO:K03173] [EC:2.3.2.27]
118076151  TNF; tumor necrosis factor [KO:K03156]
118076237  [KO:K13376]
118076297  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
118076306  EFNA1; ephrin-A1 [KO:K05462]
118076307  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
118076311  VEGFB; vascular endothelial growth factor B [KO:K16858]
118076480  CRKL; crk-like protein [KO:K04438]
118076516  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
118076522  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
118076532  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
118076691  RASA1; ras GTPase-activating protein 1 [KO:K04352]
118076712  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
118076765  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
118076788  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
118076813  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
118076992  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
118077087  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
118077090  FGF10; fibroblast growth factor 10 [KO:K04358]
118077295  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
118077342  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
118077483  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
118077655  [KO:K03173] [EC:2.3.2.27]
118077665  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
118077690  [KO:K06268]
118078041  DAXX; death domain-associated protein 6 [KO:K02308]
118078177  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
118078263  [KO:K05094] [EC:2.7.10.1]
118078298  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
118078403  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118078499  [KO:K03173] [EC:2.3.2.27]
118078524  DDIT3; LOW QUALITY PROTEIN: DNA damage-inducible transcript 3 protein [KO:K04452]
118078861  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118078982  [KO:K18019] [EC:3.1.3.48]
118079324  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
118079501  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
118079615  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
118079636  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
118079637  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
118079638  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
118079639  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118079658  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118079705  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
118079760  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
118079785  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
118079827  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118079904  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
118079980  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
118079984  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118079987  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118079990  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
118080296  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
118080327  FGF1; fibroblast growth factor 1 [KO:K18496]
118080395  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118080415  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
118080418  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
118080419  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118080501  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
118080594  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
118080598  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
118080623  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118080671  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118080704  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
118080709  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
118081749  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
118081774  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
118081795  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
118081801  FOS; proto-oncogene c-Fos [KO:K04379]
118081845  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118081879  PGF; placenta growth factor [KO:K16859]
118081881  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
118081939  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
118081954  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
118082025  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
118082069  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
118082247  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
118082440  ANGPT2; angiopoietin-2 [KO:K05466]
118082516  FGF18; LOW QUALITY PROTEIN: fibroblast growth factor 18 [KO:K04358]
118082582  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
118082777  [KO:K04364]
118082795  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
118083027  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
118083028  SOS1; son of sevenless homolog 1 [KO:K03099]
118083086  SRF; serum response factor isoform X1 [KO:K04378]
118083106  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
118083182  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
118083197  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
118083321  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
118083339  PDGFC; platelet-derived growth factor C [KO:K05450]
118083370  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
118083396  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118083408  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
118083493  [KO:K16342] [EC:3.1.1.4]
118083513  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
118083517  FGF2; fibroblast growth factor 2 [KO:K18497]
118083547  [KO:K16342] [EC:3.1.1.4]
118083562  [KO:K16342] [EC:3.1.1.4]
118083572  [KO:K16342] [EC:3.1.1.4]
118083576  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
118083582  [KO:K16342] [EC:3.1.1.4]
118083588  [KO:K16342] [EC:3.1.1.4]
118083590  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118083601  [KO:K16342] [EC:3.1.1.4]
118083607  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
118083713  EGF; pro-epidermal growth factor [KO:K04357]
118083754  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118083834  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
118083927  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
118083971  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
118084047  NRK; nik-related protein kinase [KO:K04407] [EC:2.7.11.1]
118084069  FGF20; fibroblast growth factor 20 [KO:K04358]
118084127  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
118084130  FGF5; fibroblast growth factor 5 [KO:K04358]
118084151  [KO:K05096] [EC:2.7.10.1]
118084180  FGF16; fibroblast growth factor 16 isoform X1 [KO:K04358]
118084391  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
118084634  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
118084843  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
118084973  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
118084996  [KO:K04386]
118085080  FGF3; fibroblast growth factor 3 [KO:K04358]
118085083  [KO:K04439]
118085232  PDGFD; platelet-derived growth factor D [KO:K05450]
118085249  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
118085281  VEGFD; vascular endothelial growth factor D [KO:K05449]
118085511  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
118085540  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
118085775  FGF9; fibroblast growth factor 9 [KO:K04358]
118085901  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
118085950  FGF19; fibroblast growth factor 19 [KO:K22603]
118085966  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118085969  PPM1N; probable protein phosphatase 1N [KO:K04457] [EC:3.1.3.16]
118085986  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
118086153  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
118086319  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
118086362  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
118086488  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
118086555  STMN1; stathmin isoform X1 [KO:K04381]
118086581  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
118086608  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
118086683  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
118086854  [KO:K04519]
118086883  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
118086896  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
118087021  [KO:K05466]
118087118  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
118087137  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118087169  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
118087171  [KO:K04460] [EC:3.1.3.16]
118087182  [KO:K16342] [EC:3.1.1.4]
118087251  [KO:K16342] [EC:3.1.1.4]
118087289  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
118087328  IL1B; interleukin-1 beta [KO:K04519]
118087372  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
118087476  RELB; transcription factor RelB isoform X1 [KO:K09253]
118087532  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
118087734  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118087771  FGF22; fibroblast growth factor 22 [KO:K04358]
118087777  EFNA2; ephrin-A2 [KO:K05462]
118087829  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118087859  JUND; transcription factor jun-D [KO:K04449]
118087959  IGF2; insulin-like growth factor II [KO:K13769]
118087977  NRTN; neurturin isoform X1 [KO:K25414]
118087979  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
118088010  [KO:K03283]
118088107  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
118088152  FGF4; fibroblast growth factor 4 [KO:K04358]
118088174  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
118088233  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118088249  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
118088250  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118088252  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118088479  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
118088497  STK4; serine/threonine-protein kinase 4 [KO:K04411]
118088554  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
118088567  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
118088586  HRAS; GTPase HRas [KO:K02833]
118088633  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
118088787  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
118088847  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
118088941  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
118089037  NGF; beta-nerve growth factor [KO:K02582]
118089100  JUN; transcription factor AP-1 [KO:K04448]
118089245  NRAS; GTPase NRas [KO:K07828]
118089274  [KO:K04526]
118089344  ANGPT4; angiopoietin-4 [KO:K05467]
118089490  RAP1A; ras-related protein Rap-1A [KO:K04353]
118089529  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
118089565  ARTN; artemin [KO:K25415]
118089981  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
118090045  ANGPT1; angiopoietin-1 [KO:K05465]
118090392  MYC; myc proto-oncogene protein [KO:K04377]
118090400  MAX; protein max isoform X1 [KO:K04453]
118090424  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
118090569  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118090617  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118090625  RAP1B; ras-related protein Rap-1b [KO:K07836]
118090655  KRAS; GTPase KRas isoform X1 [KO:K07827]
118090716  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
118090805  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
118090901  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
118090907  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
118090918  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
118090932  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118090963  KITLG; kit ligand isoform X1 [KO:K05461]
118090974  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
118091017  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
118091073  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
118091179  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
118091266  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
118091269  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
118091282  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
118091334  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
118091357  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
118091365  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
118091391  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
118091403  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118091508  MRAS; ras-related protein M-Ras [KO:K07831]
118091571  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
118091861  [KO:K04421] [EC:2.7.11.25]
118091890  [KO:K02583]
118091951  [KO:K04388] [EC:2.7.11.30]
118091971  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
118092114  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
118092232  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
118092373  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118092483  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
118092541  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
118092573  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118092590  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
118092637  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
118092639  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
118092682  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
118092693  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
118092724  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118092785  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
118092919  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
118092935  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
118092954  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
118092994  FGF7; fibroblast growth factor 7 [KO:K04358]
118093285  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
118093405  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
118093425  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
118093483  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
118093520  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118093525  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
118093688  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
118093802  FGF8; fibroblast growth factor 8 [KO:K04358]
118094142  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
118094147  [KO:K16342] [EC:3.1.1.4]
118094148  [KO:K16342] [EC:3.1.1.4]
118094149  [KO:K16342] [EC:3.1.1.4]
118094183  [KO:K05454]
118094194  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
118094199  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118094231  RRAS; ras-related protein R-Ras [KO:K07830]
118094234  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
118094387  [KO:K04438]
118094447  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
118094461  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
118094470  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
118094598  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
118094616  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
118094733  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
118094736  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
118094741  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
118094794  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118094799  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
118094849  [KO:K07827]
118094938  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
118094978  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
118095060  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
118095128  EREG; proepiregulin [KO:K09784]
118095173  FGF21; fibroblast growth factor 21 [KO:K22429]
118095178  NTF4; neurotrophin-4 [KO:K12457]
118095188  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
118095230  [KO:K04468] [EC:2.7.11.24]
118095321  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
118095827  AREG; amphiregulin [KO:K09782]
118095898  [KO:K04355]
118095909  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
118096151  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
118096206  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118096210  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
118096231  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118096297  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
118096313  FGF6; fibroblast growth factor 6 [KO:K04358]
118096328  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
118096357  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118096361  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
118096480  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118096518  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
118096699  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
118096713  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
118096717  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
118096728  CRK; adapter molecule crk isoform X1 [KO:K04438]
118096839  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
118096895  NF1; neurofibromin isoform X1 [KO:K08052]
118097100  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118097182  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118097183  HSPB1; heat shock protein beta-1 [KO:K04455]
118097569  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
118097605  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
118097632  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
118097807  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
118097922  [KO:K03158]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
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Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
zvi04070  Phosphatidylinositol signaling system
zvi04110  Cell cycle
zvi04115  p53 signaling pathway
zvi04210  Apoptosis
zvi04310  Wnt signaling pathway
KO pathway
ko04010   

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