KEGG   PATHWAY: pleu04510
Entry
pleu04510                   Pathway                                
Name
Focal adhesion - Peromyscus leucopus (white-footed mouse)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pleu04510  Focal adhesion
pleu04510

Other DBs
GO: 0005925
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680598  Actg1; LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
114680645  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
114680676  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
114680692  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
114680721  Flnb; filamin-B isoform X1 [KO:K27392]
114680796  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
114680916  Itga10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
114681270  Ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
114681429  Arhgap35; rho GTPase-activating protein 35 [KO:K05732]
114681497  Flt4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
114681520  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681621  Sos1; son of sevenless homolog 1 [KO:K03099]
114681739  Itga7; integrin alpha-7 isoform X9 [KO:K06583]
114681835  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114681851  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
114682147  [KO:K04659]
114682214  Pdgfa; platelet-derived growth factor subunit A [KO:K04359]
114682499  Itga9; integrin alpha-9 [KO:K06585]
114682605  Pxn; paxillin isoform X1 [KO:K05760]
114682692  Egf; pro-epidermal growth factor [KO:K04357]
114682714  Crkl; crk-like protein [KO:K04438]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114682753  Parvb; beta-parvin isoform X1 [KO:K06275]
114682762  Parvg; gamma-parvin [KO:K06275]
114682847  [KO:K04659]
114683196  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
114683507  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
114683759  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
114683843  Ilk; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
114683897  Shc4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449]
114683909  Vegfc; vascular endothelial growth factor C [KO:K05449]
114683953  [KO:K06269] [EC:3.1.3.16]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684102  Shc2; SHC-transforming protein 2 [KO:K17447]
114684216  Vav2; guanine nucleotide exchange factor VAV2 isoform X4 [KO:K05730]
114684224  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
114684256  [KO:K05692]
114684418  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
114684638  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
114684682  Actn4; alpha-actinin-4 isoform X3 [KO:K05699]
114685127  [KO:K02833]
114685987  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
114686543  Vav1; proto-oncogene vav [KO:K05730]
114687327  Hgf; LOW QUALITY PROTEIN: hepatocyte growth factor [KO:K05460]
114687523  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
114688360  Pip5k1c; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
114688364  [KO:K19719]
114688488  [KO:K02833]
114688889  [KO:K06236]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689078  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
114689488  Shc3; SHC-transforming protein 3 [KO:K17448]
114689585  Cav3; caveolin-3 [KO:K12959]
114689636  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114689981  Tln2; talin-2 [KO:K06271]
114690439  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114690942  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
114691309  [KO:K04393]
114691337  Thbs2; thrombospondin-2 [KO:K04659]
114691441  Crk; adapter molecule crk isoform X1 [KO:K04438]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114691507  Vtn; vitronectin [KO:K06251]
114691660  Itga11; integrin alpha-11 [KO:K06587]
114691777  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114691790  Spp1; osteopontin isoform X1 [KO:K06250]
114691862  [KO:K06253]
114692203  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114692317  Col9a1; collagen alpha-1(IX) chain isoform X2 [KO:K08131]
114692435  Itgb6; integrin beta-6 isoform X1 [KO:K06589]
114692892  Chad; chondroadherin [KO:K06248]
114692897  Col1a1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
114692902  Dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
114692904  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
114693311  Rap1b; ras-related protein Rap-1b [KO:K07836]
114693361  Arhgap5; rho GTPase-activating protein 5 [KO:K13709]
114693444  Col1a2; LOW QUALITY PROTEIN: collagen alpha-2(I) chain [KO:K06236]
114693493  [KO:K02833]
114693506  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693565  [KO:K06238]
114693566  Col6a6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
114693595  Hras; GTPase HRas isoform X1 [KO:K02833]
114693605  Fn1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
114693768  Jun; transcription factor AP-1 [KO:K04448]
114693946  Itga8; LOW QUALITY PROTEIN: integrin alpha-8 [KO:K06584]
114694098  Myl7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
114694231  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114694276  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
114694498  Ccnd1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
114694721  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
114694722  Cav1; caveolin-1 [KO:K06278]
114694723  Cav2; caveolin-2 [KO:K12958]
114695018  Emp1; epithelial membrane protein 1 [KO:K26255]
114695104  Col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
114695105  Col4a1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114695462  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
114695536  Emp2; epithelial membrane protein 2 [KO:K26256]
114695636  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
114696284  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
114696413  [KO:K12757]
114696416  [KO:K12757]
114696435  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
114696436  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
114696517  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
114696519  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
114696553  [KO:K02833]
114696602  Itga5; integrin alpha-5 [KO:K06484]
114696632  Itgb7; integrin beta-7 isoform X1 [KO:K06590]
114696878  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
114696882  Fyn; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
114697206  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
114697593  Parva; alpha-parvin [KO:K06275]
114697781  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
114698012  Zyx; zyxin isoform X1 [KO:K06273]
114698087  Pgf; placenta growth factor isoform X1 [KO:K16859]
114698113  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
114698155  Lama3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
114698172  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
114698321  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
114698332  Col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
114698334  Col4a6; collagen alpha-6(IV) chain [KO:K06237]
114698613  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
114698679  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
114698838  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
114699134  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
114699348  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114699957  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
114700210  Vcl; vinculin isoform X1 [KO:K05700]
114700491  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
114700619  Igf1; insulin-like growth factor I isoform X2 [KO:K05459]
114700691  Col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
114700910  [KO:K04513]
114701036  Itgb8; integrin beta-8 [KO:K06591]
114701275  [KO:K04393]
114701440  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
114701479  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114701517  [KO:K04725] [EC:2.3.2.27]
114702188  Mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
114702233  Itga2b; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
114702284  Itgb3; integrin beta-3 [KO:K06493]
114702393  Lamb3; laminin subunit beta-3 [KO:K06244]
114702763  Rapgef1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
114702810  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
114703016  Itga2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703205  Tln1; LOW QUALITY PROTEIN: talin-1 [KO:K06271]
114703598  Itgav; integrin alpha-V isoform X1 [KO:K06487]
114703664  Pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
114703730  Itga4; integrin alpha-4 [KO:K06483]
114703745  Itga1; integrin alpha-1 [KO:K06480]
114703788  Lamc3; laminin subunit gamma-3 [KO:K06247]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114703932  Elk1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
114704074  Lama1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
114704195  Col9a3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
114704204  Lama5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704363  Mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
114704479  Itga6; LOW QUALITY PROTEIN: integrin alpha-6 [KO:K06485]
114704570  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
114704572  [KO:K10351]
114704659  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
114704843  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
114704849  Itgb5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
114704893  [KO:K13709]
114704920  Col9a2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
114705208  Lamb2; LOW QUALITY PROTEIN: laminin subunit beta-2 [KO:K06243]
114705216  Rhoa; transforming protein RhoA [KO:K04513]
114705300  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
114705331  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
114705499  Actb; actin, cytoplasmic 1 [KO:K05692]
114705532  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114705574  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
114705711  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
114705780  Itgb1; integrin beta-1 isoform X1 [KO:K05719]
114705857  Tnxb; tenascin-X isoform X12 [KO:K06252]
114705915  Thbs1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
114705916  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
114706253  Flna; filamin-A isoform X1 [KO:K04437]
114706830  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114706940  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
114707024  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
114707063  Itgb4; integrin beta-4 isoform X2 [KO:K06525]
114707256  Rap1a; ras-related protein Rap-1A [KO:K04353]
114707365  Pdgfrb; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
114707535  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114707889  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
114707893  Thbs3; LOW QUALITY PROTEIN: thrombospondin-3 [KO:K04659]
114707992  Reln; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
114708003  [KO:K16060]
114708004  [KO:K16060]
114708007  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
114708454  Lamb1; laminin subunit beta-1 [KO:K05636]
114708534  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
114708777  Vwf; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
114709027  Tnc; LOW QUALITY PROTEIN: tenascin [KO:K06252]
114709099  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
114709186  Thbs4; LOW QUALITY PROTEIN: thrombospondin-4 [KO:K04659]
114709870  [KO:K06274]
114709967  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
114710028  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
114710030  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
114710330  Myl10; LOW QUALITY PROTEIN: myosin regulatory light chain 10 [KO:K12756]
114710523  [KO:K04371] [EC:2.7.11.24]
119088838  [KO:K04438]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pleu04010  MAPK signaling pathway
pleu04060  Cytokine-cytokine receptor interaction
pleu04070  Phosphatidylinositol signaling system
pleu04110  Cell cycle
pleu04151  PI3K-Akt signaling pathway
pleu04310  Wnt signaling pathway
pleu04512  ECM-receptor interaction
pleu04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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