KEGG   PATHWAY: pleu05010
Entry
pleu05010                   Pathway                                
Name
Alzheimer disease - Peromyscus leucopus (white-footed mouse)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
pleu05010  Alzheimer disease
pleu05010

Disease
H00056  Alzheimer disease
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680667  Rtn3; reticulon-3 isoform X1 [KO:K20723]
114680674  Plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
114680676  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
114680703  [KO:K02273]
114680800  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
114681169  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
114681270  Ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
114681319  Wnt7a; protein Wnt-7a [KO:K00572]
114681332  [KO:K02266]
114681418  Calm3; calmodulin-3 [KO:K02183]
114681520  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681547  Psmc4; 26S proteasome regulatory subunit 6B [KO:K03063]
114681638  [KO:K02270]
114681644  [KO:K02267]
114681660  Psenen; gamma-secretase subunit PEN-2 [KO:K06170]
114681741  [KO:K00237]
114681809  Slc39a5; zinc transporter ZIP5 [KO:K14711]
114681917  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
114681926  [KO:K00418]
114682020  Tubb1; tubulin beta-1 chain isoform X1 [KO:K07375]
114682022  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
114682085  Atg2a; LOW QUALITY PROTEIN: autophagy-related protein 2 homolog A [KO:K17906]
114682091  Capn1; LOW QUALITY PROTEIN: calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
114682099  Rela; transcription factor p65 [KO:K04735]
114682244  [KO:K14709]
114682270  [KO:K14709]
114682357  Tubb6; tubulin beta-6 chain [KO:K07375]
114682377  Aph1a; gamma-secretase subunit APH-1A [KO:K06172]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114682737  Grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
114682741  Nox4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
114682782  Psmb7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
114682800  Becn1; beclin-1 isoform X1 [KO:K08334]
114682891  Dkk2; dickkopf-related protein 2 [KO:K02165]
114682897  Ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
114682960  Ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
114682971  Wnt3a; protein Wnt-3a [KO:K00312]
114683006  Wnt9a; protein Wnt-9a [KO:K01064]
114683045  [KO:K02135]
114683079  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
114683087  Ryr3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
114683184  Insr; insulin receptor isoform X3 [KO:K04527] [EC:2.7.10.1]
114683197  Psmd4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
114683205  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114683212  Slc39a8; metal cation symporter ZIP8 [KO:K14714]
114683237  Psmb4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
114683255  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114683299  Cacna1s; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
114683308  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
114683312  Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
114683399  [KO:K08683] [EC:1.1.1.35 1.1.1.178]
114683623  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
114683812  Apbb1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684038  [KO:K17589]
114684041  Psma3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
114684081  Apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
114684114  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
114684126  Atp5f1d; ATP synthase subunit delta, mitochondrial [KO:K02134]
114684418  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
114684579  [KO:K03062]
114684718  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
114684877  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
114684987  Psmd8; 26S proteasome non-ATPase regulatory subunit 8 isoform X1 [KO:K03031]
114685023  Chrm3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
114685127  [KO:K02833]
114685169  [KO:K21246]
114685317  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
114685345  Psma2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
114685415  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
114685431  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
114685753  Fzd7; frizzled-7 [KO:K02432]
114685872  [KO:K03967]
114686016  Fzd9; frizzled-9 [KO:K02842]
114686066  Map2k7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
114686204  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
114686266  [KO:K07374]
114686355  Slc39a7; zinc transporter SLC39A7 [KO:K14713]
114686525  [KO:K00420]
114686570  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
114686643  Psma8; LOW QUALITY PROTEIN: proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
114686672  Atp2a1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
114686683  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
114686777  [KO:K17445]
114686852  [KO:K04741] [EC:3.4.22.-]
114686928  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
114686999  Tubb; tubulin beta chain [KO:K07375]
114687555  Psmb6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
114687713  [KO:K02267]
114687911  Tubb4a; LOW QUALITY PROTEIN: tubulin beta-4A chain [KO:K07375]
114687963  Fzd1; frizzled-1 [KO:K02432]
114687991  [KO:K04374]
114688121  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114688125  Slc39a3; zinc transporter ZIP3 [KO:K14709]
114688226  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
114688434  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
114688488  [KO:K02833]
114688857  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689420  [KO:K02727] [EC:3.4.25.1]
114689636  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114689745  [KO:K08738]
114689756  Il6; interleukin-6 [KO:K05405]
114689804  [KO:K00417]
114689841  [KO:K02271]
114689894  Atf6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
114690246  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
114690300  Psma4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
114690344  [KO:K02264]
114690413  Psmc5; 26S proteasome regulatory subunit 8 [KO:K03066]
114690416  Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
114690433  Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
114690442  Axin2; axin-2 [KO:K04385]
114690448  Wipi1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
114690465  Slc39a11; zinc transporter ZIP11 [KO:K14717]
114690605  Becn2; beclin-2 [KO:K08334]
114690634  Psen2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114690700  Ncstn; nicastrin [KO:K06171]
114690723  [KO:K02271]
114690776  Adam10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
114690777  [KO:K02265]
114690973  [KO:K02264]
114691045  [KO:K06172]
114691055  [KO:K06172]
114691205  Bace1; beta-secretase 1 isoform X1 [KO:K04521] [EC:3.4.23.46]
114691328  Psmb1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114691518  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
114691544  Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
114691546  Cdk5r1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
114691595  Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
114691640  Calml4; calmodulin-like protein 4 isoform X2 [KO:K02183]
114691662  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
114691675  Slc39a6; zinc transporter ZIP6 isoform X1 [KO:K14712]
114691777  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114691928  [KO:K05862]
114691978  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
114692176  [KO:K00415]
114692200  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
114692767  Tubb4b; tubulin beta-4B chain [KO:K07375]
114692778  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
114692795  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
114692923  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
114692965  Psmb3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
114693209  Dvl2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
114693377  Psma6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
114693426  Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
114693469  [KO:K02273]
114693493  [KO:K02833]
114693507  Pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693595  Hras; GTPase HRas isoform X1 [KO:K02833]
114693690  Fzd10; frizzled-10 [KO:K02842]
114693817  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
114693819  [KO:K08738]
114693920  [KO:K02266]
114693933  Slc39a12; zinc transporter ZIP12 [KO:K14718]
114693991  Xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
114694084  [KO:K05853] [EC:7.2.2.10]
114694100  [KO:K00419]
114694169  [KO:K00413]
114694261  [KO:K08960] [EC:2.7.11.1]
114694285  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
114694322  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
114694345  Slc39a4; zinc transporter ZIP4 [KO:K14710]
114694438  Fadd; FAS-associated death domain protein [KO:K02373]
114694445  [KO:K05863]
114694482  Csnk2a2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
114694590  Lrp5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
114694672  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
114694673  [KO:K02268]
114694717  Wnt2; protein Wnt-2 [KO:K00182]
114694740  [KO:K03063]
114694751  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
114694791  [KO:K02271]
114694811  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
114694895  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
114695020  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
114695106  Irs2; insulin receptor substrate 2 [KO:K07187]
114695174  Ins; insulin [KO:K04526]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114695345  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
114695408  [KO:K08738]
114695505  Chrna7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
114695532  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
114695599  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
114695609  Wnt16; protein Wnt-16 [KO:K01558]
114695621  Kif5b; kinesin-1 heavy chain [KO:K10396]
114695763  Fzd8; frizzled-8 [KO:K02375]
114695816  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
114695853  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
114696032  Atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
114696051  Psmc6; 26S proteasome regulatory subunit 10B [KO:K03064]
114696086  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
114696107  Ndufs6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
114696316  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
114696438  Irs1; insulin receptor substrate 1 [KO:K16172]
114696553  [KO:K02833]
114696614  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
114696654  Atg101; autophagy-related protein 101 [KO:K19730]
114696672  Slc11a2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
114696775  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
114696911  [KO:K04634]
114697006  Nox1; NADPH oxidase 1 [KO:K08008]
114697038  [KO:K00417]
114697063  Casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
114697207  Wnt4; protein Wnt-4 [KO:K00408]
114697493  [KO:K04133]
114697603  Psma1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
114697622  [KO:K00134] [EC:1.2.1.12]
114697683  [KO:K04520]
114697686  Atp5pf; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
114697766  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
114697787  Slc39a9; zinc transporter ZIP9 [KO:K14715]
114697868  Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
114697928  [KO:K08738]
114698331  Irs4; insulin receptor substrate 4 [KO:K17446]
114698423  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
114698444  Psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
114698522  Nrbf2; nuclear receptor-binding factor 2 isoform X2 [KO:K21246]
114698582  Nras; GTPase NRas [KO:K07828]
114698667  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
114698691  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
114698768  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
114698769  Slc39a14; metal cation symporter ZIP14 isoform X1 [KO:K14720]
114698806  [KO:K04348] [EC:3.1.3.16]
114698857  Adam17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
114699199  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
114699348  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114699651  Nos1; nitric oxide synthase, brain isoform X2 [KO:K13240] [EC:1.14.13.39]
114699672  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
114699678  Psmc3; 26S proteasome regulatory subunit 6A [KO:K03065]
114699679  Slc39a13; zinc transporter ZIP13 isoform X1 [KO:K14719]
114699698  Atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
114699701  Ambra1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
114699830  [KO:K03937]
114699911  Fzd6; frizzled-6 [KO:K02376]
114699928  Kif5c; kinesin heavy chain [KO:K10396]
114699980  Psma5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
114700000  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
114700086  Cdk5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
114700198  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114700220  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
114700271  [KO:K02270]
114700348  Bace2; beta-secretase 2 isoform X1 [KO:K07747] [EC:3.4.23.45]
114700482  Ppid; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
114700550  Apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
114700572  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
114700676  Ndufa10; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
114700704  [KO:K03064]
114700731  Tuba8; tubulin alpha-8 chain isoform X2 [KO:K07374]
114700736  Bid; BH3-interacting domain death agonist [KO:K04726]
114700757  Wnt5b; protein Wnt-5b [KO:K00444]
114700762  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X8 [KO:K04850]
114700813  [KO:K08738]
114700826  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
114700859  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
114700886  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
114700935  [KO:K07375]
114700949  [KO:K02263]
114701092  [KO:K00411] [EC:7.1.1.8]
114701179  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
114701281  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
114701310  [KO:K07375]
114701319  [KO:K21421] [EC:1.-.-.-]
114701331  Tubb2b; tubulin beta-2B chain [KO:K07375]
114701446  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
114701479  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114701507  [KO:K02128]
114701855  [KO:K00411] [EC:7.1.1.8]
114701889  Atg2b; LOW QUALITY PROTEIN: autophagy-related protein 2 homolog B [KO:K17906]
114701979  [KO:K00417]
114702120  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
114702202  Wnt9b; protein Wnt-9b [KO:K01064]
114702239  Fzd2; frizzled-2 [KO:K02235]
114702271  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
114702276  Mapt; microtubule-associated protein tau isoform X2 [KO:K04380]
114702447  Ide; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
114702631  [KO:K03945]
114702840  Hsd17b10; LOW QUALITY PROTEIN: 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703061  Klc1; kinesin light chain 1 isoform X1 [KO:K10407]
114703117  Lpl; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
114703266  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
114703543  Nae1; NEDD8-activating enzyme E1 regulatory subunit isoform X1 [KO:K04532]
114703574  [KO:K08738]
114703635  [KO:K02268]
114703666  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
114703672  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
114703694  [KO:K03944]
114703705  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
114703739  [KO:K07375]
114703831  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114703900  Araf; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
114703999  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
114704190  [KO:K02268]
114704207  Adrm1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
114704212  Psma7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
114704267  Psmb2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704407  [KO:K02266]
114704425  [KO:K03957]
114704437  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
114704485  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
114704543  Psmd9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
114704560  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
114704715  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
114704792  Lrp1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
114704795  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
114704800  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
114704803  Kif5a; kinesin heavy chain [KO:K10396]
114704883  [KO:K02271]
114704952  Slc39a10; zinc transporter ZIP10 isoform X2 [KO:K14716]
114705017  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
114705020  Calm1; calmodulin-1 [KO:K02183]
114705069  Fzd5; frizzled-5 [KO:K02375]
114705083  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
114705120  Apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
114705144  Wnt8a; protein Wnt-8a [KO:K00714]
114705194  [KO:K00414]
114705314  Klc4; kinesin light chain 4 isoform X1 [KO:K10407]
114705416  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
114705437  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
114705494  Wipi2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
114705519  Ppp3r1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
114705570  [KO:K02263]
114705599  Csnk2a1; LOW QUALITY PROTEIN: casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
114705738  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114705743  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
114705751  Dkk4; dickkopf-related protein 4 [KO:K02165]
114705813  Ager; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
114705817  Tnf; tumor necrosis factor [KO:K03156]
114705884  Csnk2b; casein kinase II subunit beta isoform X1 [KO:K03115]
114705921  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
114705971  [KO:K00417]
114706041  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
114706046  [KO:K02273]
114706123  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
114706175  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114706333  Atp2a3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
114706431  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114706728  Psmd7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
114706785  Snca; alpha-synuclein [KO:K04528]
114706830  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
114706832  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
114706860  [KO:K00416]
114706884  [KO:K03069]
114706894  [KO:K03096]
114706920  Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114707044  Grin2c; glutamate receptor ionotropic, NMDA 2C isoform X2 [KO:K05211]
114707050  Atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138]
114707249  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
114707263  Wnt2b; protein Wnt-2b [KO:K00182]
114707293  Fzd3; frizzled-3 isoform X1 [KO:K02329]
114707394  Csnk1a1; casein kinase I isoform X2 [KO:K08957] [EC:2.7.11.1]
114707771  [KO:K02127]
114707908  Slc39a1; zinc transporter ZIP1 [KO:K14709]
114707943  [KO:K03097] [EC:2.7.11.1]
114707978  Psmc2; 26S proteasome regulatory subunit 7 [KO:K03061]
114708034  [KO:K17589]
114708122  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
114708149  Wnt8b; protein Wnt-8b [KO:K00714]
114708203  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
114708251  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
114708260  Calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
114708306  Atp5f1c; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
114708326  Rtn4; LOW QUALITY PROTEIN: reticulon-4 [KO:K20720]
114708393  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
114708408  [KO:K02272]
114708475  [KO:K07374]
114708477  Kras; GTPase KRas isoform X2 [KO:K07827]
114708546  Wnt10b; protein Wnt-10b [KO:K01357]
114708557  [KO:K07374]
114708572  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
114708577  [KO:K07374]
114708578  Tuba1b; tubulin alpha-1B chain [KO:K07374]
114708599  [KO:K03941] [EC:7.1.1.2]
114708619  [KO:K02268]
114708722  Psmb5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
114708754  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
114708768  [KO:K02183]
114708779  Calml3; calmodulin-like protein 3 [KO:K02183]
114708781  Gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
114708793  [KO:K07374]
114708799  Tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114708890  Mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
114708910  [KO:K02270]
114709020  [KO:K08738]
114709194  Klc2; kinesin light chain 2 [KO:K10407]
114709209  Calm2; calmodulin-2 [KO:K02183]
114709307  Wnt10a; LOW QUALITY PROTEIN: protein Wnt-10a [KO:K01357]
114709311  Wnt6; protein Wnt-6 [KO:K00445]
114709335  Tuba4a; LOW QUALITY PROTEIN: tubulin alpha-4A chain [KO:K07374]
114709380  [KO:K00134] [EC:1.2.1.12]
114709466  Axin1; axin-1 isoform X1 [KO:K02157]
114709520  Il1b; interleukin-1 beta [KO:K04519]
114709525  Il1a; interleukin-1 alpha [KO:K04383]
114709626  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
114709670  Mtor; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
114709796  [KO:K00417]
114709849  Apoe; apolipoprotein E [KO:K04524]
114709863  Klc3; kinesin light chain 3 isoform X1 [KO:K10407]
114710174  [KO:K00417]
114710215  [KO:K02138]
114710287  [KO:K08738]
114710353  Lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
114710373  Psmd6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
114710383  Mme; neprilysin [KO:K01389] [EC:3.4.24.11]
114710475  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
114710523  [KO:K04371] [EC:2.7.11.24]
114710708  Fzd4; frizzled-4 [KO:K02354]
114710722  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
114710781  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
114710919  Dkk1; dickkopf-related protein 1 [KO:K02165]
114711016  [KO:K05863]
119088668  [KO:K02272]
36275531  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
36275532  COX3; cytochrome c oxidase subunit III [KO:K02262]
36275535  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
36275537  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
36275544  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
36275547  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
36275552  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
36275554  COX2; cytochrome c oxidase subunit II [KO:K02261]
36275555  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
36275556  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
36275557  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
36275560  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
36275561  CYTB; cytochrome b [KO:K00412]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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PMID:12805290
  Authors
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J
  Title
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
  Journal
J Neurosci 23:4499-508 (2003)
DOI:10.1523/JNEUROSCI.23-11-04499.2003
Reference
PMID:15645263
  Authors
Roy S, Zhang B, Lee VM, Trojanowski JQ
  Title
Axonal transport defects: a common theme in neurodegenerative diseases.
  Journal
Acta Neuropathol 109:5-13 (2005)
DOI:10.1007/s00401-004-0952-x
Reference
PMID:26074767
  Authors
Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG
  Title
Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.
  Journal
Front Cell Neurosci 9:191 (2015)
DOI:10.3389/fncel.2015.00191
Reference
PMID:24529521
  Authors
De Felice FG, Lourenco MV, Ferreira ST
  Title
How does brain insulin resistance develop in Alzheimer's disease?
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Alzheimers Dement 10:S26-32 (2014)
DOI:10.1016/j.jalz.2013.12.004
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PMID:26136647
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Bedse G, Di Domenico F, Serviddio G, Cassano T
  Title
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
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Front Neurosci 9:204 (2015)
DOI:10.3389/fnins.2015.00204
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PMID:20101724
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Funderburk SF, Marcellino BK, Yue Z
  Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
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Mt Sinai J Med 77:59-68 (2010)
DOI:10.1002/msj.20161
Related
pathway
pleu00190  Oxidative phosphorylation
pleu03050  Proteasome
pleu04020  Calcium signaling pathway
pleu04140  Autophagy - animal
pleu04141  Protein processing in endoplasmic reticulum
pleu04210  Apoptosis
pleu04310  Wnt signaling pathway
pleu04910  Insulin signaling pathway
pleu04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

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