KEGG   PATHWAY: pleu04110
Entry
pleu04110                   Pathway                                
Name
Cell cycle - Peromyscus leucopus (white-footed mouse)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
pleu04110  Cell cycle
pleu04110

Other DBs
GO: 0000278
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114694498  Ccnd1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
114701440  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
114705331  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
114704814  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114688249  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114698792  Rb1; retinoblastoma-associated protein isoform X1 [KO:K06618]
114681841  Rbl1; retinoblastoma-like protein 1 [KO:K04681]
114694542  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
114703784  Abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
114683075  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
114705645  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
114696875  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
114706553  E2f1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
114697224  E2f2; transcription factor E2F2 isoform X1 [KO:K09389]
114701050  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
114681033  E2f4; transcription factor E2F4 [KO:K04682]
114704095  E2f5; transcription factor E2F5 isoform X1 [KO:K04682]
114701239  Tfdp1; transcription factor Dp-1 isoform X1 [KO:K04683]
114690972  Tfdp2; transcription factor Dp-2 isoform X1 [KO:K09392]
114701479  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114685302  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
114698210  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
114697904  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
114694883  Smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
114691539  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
114690183  Smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
114701991  Myc; myc proto-oncogene protein [KO:K04377]
114700870  Zbtb17; LOW QUALITY PROTEIN: zinc finger and BTB domain-containing protein 17 [KO:K10500]
114698355  LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 2A-like [KO:K06621]
114698354  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
114706541  Cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
114695221  Cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
114710338  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
114694167  Cdkn1c; cyclin-dependent kinase inhibitor 1C isoform X1 [KO:K09993]
114706157  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
114698889  Ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
114694576  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
114681779  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
114683050  Skp1; S-phase kinase-associated protein 1 [KO:K03094]
114699340  S-phase kinase-associated protein 1-like [KO:K03094]
114698005  Cul1; cullin-1 [KO:K03347]
114707186  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
114694298  Rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
114681382  S-phase kinase-associated protein 2-like [KO:K03875]
114697360  Skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
114707180  Ccna2; cyclin-A2 [KO:K06627]
114695883  Ccna1; cyclin-A1 [KO:K06627]
114706956  Cdc6; cell division control protein 6 homolog isoform X1 [KO:K02213]
114700974  Cdt1; DNA replication factor Cdt1 [KO:K10727]
114707615  Orc1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
114704522  Orc2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
114695441  Orc3; origin recognition complex subunit 3 isoform X2 [KO:K02605]
114700566  Orc4; origin recognition complex subunit 4 isoform X1 [KO:K02606]
114707995  Orc5; origin recognition complex subunit 5 isoform X1 [KO:K02607]
114687390  origin recognition complex subunit 6-like [KO:K02608]
114709956  Orc6; origin recognition complex subunit 6 [KO:K02608]
114681073  Mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
114692349  Mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
114709462  Mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
114681395  Mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
114696962  Mcm6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
114685024  Mcm7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
114680990  Cdc45; cell division control protein 45 homolog [KO:K06628]
114696169  Ticrr; treslin [KO:K26117]
114694833  mdm2-binding protein [KO:K26116]
114691813  Cdc7; cell division cycle 7-related protein kinase [KO:K02214] [EC:2.7.11.1]
114687657  Dbf4; protein DBF4 homolog A isoform X1 [KO:K06629]
114698532  Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
114703855  Ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
114690838  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
114709997  Ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
114699513  Cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
114705113  Cdc25c; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
114698856  Ywhaq; 14-3-3 protein theta [KO:K16197]
114692606  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
114703643  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
114691442  Ywhae; 14-3-3 protein epsilon isoform X1 [KO:K06630]
114694046  Ywhah; 14-3-3 protein eta [KO:K16198]
114710296  Ywhag; 14-3-3 protein gamma [KO:K16198]
114688632  serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
114688873  LOW QUALITY PROTEIN: serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
114692205  Plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
114700602  LOW QUALITY PROTEIN: serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
114684461  Wee2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
114710459  Wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
114680782  Pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
114710512  Ccnh; cyclin-H [KO:K06634]
114703858  Cdk7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
114709522  Anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
114692776  Anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
114702279  Cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
114690903  Anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
114704554  Anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
114701233  Cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
114704561  Anapc7; anaphase-promoting complex subunit 7 isoform X3 [KO:K03354]
114705117  Cdc23; cell division cycle protein 23 homolog [KO:K03355]
114701641  Anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
114680630  Anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
114683729  Cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
114693536  Anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
114706596  Anapc15; anaphase-promoting complex subunit 15 isoform X2 [KO:K25228]
114704732  Anapc16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
114709350  Cdc20; cell division cycle protein 20 homolog [KO:K03363]
114689839  Pttg1; securin [KO:K06635]
114704598  LOW QUALITY PROTEIN: securin-like [KO:K06635]
114707294  LOW QUALITY PROTEIN: securin-like [KO:K06635]
114696628  Espl1; separin [KO:K02365] [EC:3.4.22.49]
114683382  Smc1a; structural maintenance of chromosomes protein 1A isoform X2 [KO:K06636]
114699196  Smc1b; structural maintenance of chromosomes protein 1B [KO:K06636]
114697047  Smc3; structural maintenance of chromosomes protein 3 isoform X1 [KO:K06669]
114692254  Rad21; double-strand-break repair protein rad21 homolog [KO:K06670]
114693545  Stag1; cohesin subunit SA-1 isoform X1 [KO:K06671]
114701518  Stag2; cohesin subunit SA-2 isoform X1 [KO:K06671]
114691743  LOW QUALITY PROTEIN: transcriptional regulator ATRX-like [KO:K10779]
114704881  Atrx; transcriptional regulator ATRX isoform X1 [KO:K10779]
114696313  Ddx11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
114697355  Nipbl; nipped-B-like protein isoform X1 [KO:K06672]
114682856  LOW QUALITY PROTEIN: MAU2 chromatid cohesion factor homolog [KO:K11266]
114686690  MAU2 chromatid cohesion factor homolog isoform X3 [KO:K11266]
114708647  Hdac8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
114686151  N-acetyltransferase ESCO1-like [KO:K11268] [EC:2.3.1.-]
114698170  Esco1; LOW QUALITY PROTEIN: N-acetyltransferase ESCO1 [KO:K11268] [EC:2.3.1.-]
114707295  Esco2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
114699162  Pds5b; sister chromatid cohesion protein PDS5 homolog B isoform X2 [KO:K11267]
114702024  Pds5a; sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
114699328  Wapl; wings apart-like protein homolog isoform X1 [KO:K25163]
114682110  sororin [KO:K17390]
114693236  Aurkb; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
114707461  Sgo1; shugoshin 1 [KO:K11580]
114683042  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
114698498  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
114690258  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
114686858  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
114683665  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
114687192  Ppp2r5a; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
114682088  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
114705315  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
114703087  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
114696419  Ndc80; kinetochore protein NDC80 homolog isoform X1 [KO:K11547]
114688796  LOW QUALITY PROTEIN: kinetochore scaffold 1-like [KO:K11542]
114704599  Knl1; LOW QUALITY PROTEIN: kinetochore scaffold 1 [KO:K11542]
114682397  LOW QUALITY PROTEIN: dual specificity protein kinase TTK-like [KO:K08866] [EC:2.7.12.1]
114697267  Ttk; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
114685117  Mad1l1; LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
114700919  Mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
114709647  Mad2l2; mitotic spindle assembly checkpoint protein MAD2B isoform X3 [KO:K13728]
114705912  Bub1b; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
114692615  Bub3; mitotic checkpoint protein BUB3 [KO:K02180]
114709524  Bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X2 [KO:K02178] [EC:2.7.11.1]
114696095  Trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
114705364  MAD2L1-binding protein [KO:K26093]
114688374  Fzr1; fizzy-related protein homolog [KO:K03364]
114707485  Fbxo5; F-box only protein 5 [KO:K10292]
114707413  Cdc14a; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
114708425  Cdc14b; dual specificity protein phosphatase CDC14B isoform X2 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
114694299  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
114710614  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
114709460  Prkdc; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]
114690969  Atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
114690277  Atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
114693314  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114693171  Tp53; cellular tumor antigen p53 [KO:K04451]
114688301  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114689482  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114700921  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
114699526  Pcna; proliferating cell nuclear antigen [KO:K04802]
114706000  Sfn; 14-3-3 protein sigma [KO:K06644]
114684003  Chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
114685972  serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
114705236  Cdc25a; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
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EMBO J 18:396-410 (1999)
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Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
pleu03030  DNA replication
pleu04010  MAPK signaling pathway
pleu04120  Ubiquitin mediated proteolysis
pleu04210  Apoptosis
KO pathway
ko04110   
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