KEGG   PATHWAY: pleu04010
Entry
pleu04010                   Pathway                                
Name
MAPK signaling pathway - Peromyscus leucopus (white-footed mouse)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pleu04010  MAPK signaling pathway
pleu04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680645  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
114680686  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
114680692  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
114680695  Rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
114680696  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
114680857  Tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
114681035  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114681076  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
114681114  Pla2g4e; LOW QUALITY PROTEIN: cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
114681118  Pla2g4b; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
114681139  Pla2g4d; cytosolic phospholipase A2 delta isoform X2 [KO:K16342] [EC:3.1.1.4]
114681142  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
114681218  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X2 [KO:K04855]
114681241  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
114681341  Fgfr1; fibroblast growth factor receptor 1 isoform X4 [KO:K04362] [EC:2.7.10.1]
114681424  [KO:K04460] [EC:3.1.3.16]
114681497  Flt4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
114681520  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681542  Map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X2 [KO:K04418] [EC:2.7.11.25]
114681621  Sos1; son of sevenless homolog 1 [KO:K03099]
114681623  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
114681754  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
114681888  Mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
114682069  Map3k11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
114682099  Rela; transcription factor p65 [KO:K04735]
114682214  Pdgfa; platelet-derived growth factor subunit A [KO:K04359]
114682503  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
114682692  Egf; pro-epidermal growth factor [KO:K04357]
114682714  Crkl; crk-like protein [KO:K04438]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114682885  Jund; transcription factor jun-D [KO:K04449]
114683184  Insr; insulin receptor isoform X3 [KO:K04527] [EC:2.7.10.1]
114683205  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114683255  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114683276  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
114683277  Mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
114683299  Cacna1s; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
114683314  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
114683361  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
114683479  Fgf18; fibroblast growth factor 18 [KO:K04358]
114683507  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
114683608  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
114683759  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
114683828  Ppm1a; protein phosphatase 1A isoform X2 [KO:K04457] [EC:3.1.3.16]
114683909  Vegfc; vascular endothelial growth factor C [KO:K05449]
114684105  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
114684134  Efna2; ephrin-A2 [KO:K05462]
114684152  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114684157  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
114684224  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
114684252  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
114684652  Ntf4; neurotrophin-4 [KO:K12457]
114684727  Fgf21; fibroblast growth factor 21 [KO:K22429]
114684979  Rasgrp4; RAS guanyl-releasing protein 4 [KO:K12363]
114684980  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
114685127  [KO:K02833]
114685302  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
114685631  Ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
114686066  Map2k7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
114686204  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
114686371  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
114686515  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
114686570  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
114686934  [KO:K03283]
114687177  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X2 [KO:K05454]
114687180  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
114687327  Hgf; LOW QUALITY PROTEIN: hepatocyte growth factor [KO:K05460]
114687339  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X3 [KO:K04858]
114687520  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
114687522  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
114687523  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
114687528  Cacng6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
114687553  Arrb2; beta-arrestin-2 [KO:K04439]
114687652  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
114687916  Pspn; LOW QUALITY PROTEIN: persephin [KO:K25416]
114687991  [KO:K04374]
114688121  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114688301  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114688488  [KO:K02833]
114688557  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
114688893  Nrtn; LOW QUALITY PROTEIN: neurturin [KO:K25414]
114689359  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
114689482  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114689636  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114689662  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
114689971  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
114690029  Hspa6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
114690404  Map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X3 [KO:K04421] [EC:2.7.11.25]
114690437  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
114690438  Cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
114690439  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114690458  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
114690478  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114690811  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X4 [KO:K04407] [EC:2.7.11.1]
114690812  Il1r1; interleukin-1 receptor type 1 [KO:K04386]
114690920  [KO:K04674] [EC:2.7.11.30]
114690942  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
114690976  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
114691135  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
114691309  [KO:K04393]
114691347  Rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
114691364  Map3k4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
114691441  Crk; adapter molecule crk isoform X1 [KO:K04438]
114691474  Taok1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114691513  Nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
114691525  Nf1; neurofibromin isoform X1 [KO:K08052]
114691596  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
114691643  Map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
114691745  [KO:K04674] [EC:2.7.11.30]
114691777  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114692203  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114692206  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
114692385  Fgfr2; fibroblast growth factor receptor 2 isoform X2 [KO:K05093] [EC:2.7.10.1]
114692609  Stk4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
114692733  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
114692795  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
114692885  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
114692912  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
114693019  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114693020  Mapk11; mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
114693034  Mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
114693067  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
114693118  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
114693171  Tp53; cellular tumor antigen p53 [KO:K04451]
114693311  Rap1b; ras-related protein Rap-1b [KO:K07836]
114693493  [KO:K02833]
114693556  Mras; ras-related protein M-Ras isoform X2 [KO:K07831]
114693595  Hras; GTPase HRas isoform X1 [KO:K02833]
114693631  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
114693768  Jun; transcription factor AP-1 [KO:K04448]
114693771  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
114693817  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
114693842  Fgf9; fibroblast growth factor 9 [KO:K04358]
114693931  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
114694021  Dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114694056  Fgfr3; fibroblast growth factor receptor 3 isoform X4 [KO:K05094] [EC:2.7.10.1]
114694075  [KO:K13769]
114694218  Cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
114694231  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114694276  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
114694280  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
114694285  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
114694287  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I isoform X3 [KO:K04856]
114694721  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
114694913  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
114695166  Fgf20; fibroblast growth factor 20 [KO:K04358]
114695174  Ins; insulin [KO:K04526]
114695227  Fgf3; fibroblast growth factor 3 [KO:K04358]
114695229  Fgf4; fibroblast growth factor 4 [KO:K04358]
114695237  Fgf19; fibroblast growth factor 19 [KO:K22603]
114695257  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
114695325  Mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
114695419  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
114695462  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
114695719  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
114695787  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
114695916  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
114696332  Efna5; ephrin-A5 isoform X1 [KO:K05462]
114696553  [KO:K02833]
114696615  Map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
114696655  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
114696755  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
114696773  Pla2g4a; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
114697046  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114697095  [KO:K04723]
114697206  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
114697350  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
114697392  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
114697520  [KO:K04350]
114697601  Rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
114697754  Max; protein max isoform X1 [KO:K04453]
114697904  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
114698038  Fos; proto-oncogene c-Fos [KO:K04379]
114698053  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
114698071  Elk4; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-4 [KO:K04376]
114698087  Pgf; placenta growth factor isoform X1 [KO:K16859]
114698119  Ptpn7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
114698210  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
114698264  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114698330  [KO:K04457] [EC:3.1.3.16]
114698446  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
114698577  Ngf; beta-nerve growth factor [KO:K02582]
114698582  Nras; GTPase NRas [KO:K07828]
114698668  Map3k9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
114698679  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
114698703  Arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
114698768  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
114698782  Fgf17; fibroblast growth factor 17 [KO:K04358]
114698806  [KO:K04348] [EC:3.1.3.16]
114699036  Ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
114699133  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
114699134  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
114699348  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114699472  [KO:K04370]
114699513  Cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
114699656  Taok3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
114699711  Mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
114699932  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
114700000  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
114700198  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114700477  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
114700491  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
114700619  Igf1; insulin-like growth factor I isoform X2 [KO:K05459]
114700759  Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
114700762  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X8 [KO:K04850]
114700827  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
114700875  Epha2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
114700920  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114700921  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
114701196  Dusp6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
114701275  [KO:K04393]
114701281  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
114701407  Fgf6; fibroblast growth factor 6 [KO:K04358]
114701473  Fgf23; fibroblast growth factor 23 [KO:K22428]
114701725  Ereg; proepiregulin [KO:K09784]
114701727  Areg; amphiregulin [KO:K09782]
114701876  Angpt2; angiopoietin-2 [KO:K05466]
114701991  Myc; myc proto-oncogene protein [KO:K04377]
114702098  Bdnf; brain-derived neurotrophic factor [KO:K04355]
114702139  Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
114702210  Dusp3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
114702264  Map3k14; mitogen-activated protein kinase kinase kinase 14 isoform X2 [KO:K04466] [EC:2.7.11.25]
114702276  Mapt; microtubule-associated protein tau isoform X2 [KO:K04380]
114702344  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
114702950  Map3k1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703630  Stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
114703714  Rps6ka6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
114703899  Pla2g4c; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
114703900  Araf; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
114703932  Elk1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
114704240  Fgf10; fibroblast growth factor 10 [KO:K04358]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704341  Taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
114704475  Map3k20; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
114704800  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
114704897  Fgf16; fibroblast growth factor 16 [KO:K04358]
114704977  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
114705023  Rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
114705140  Cd14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391]
114705300  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
114705333  Srf; serum response factor isoform X1 [KO:K04378]
114705518  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
114705519  Ppp3r1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
114705532  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114705549  Angpt4; angiopoietin-4 [KO:K05467]
114705711  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
114705738  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114705817  Tnf; tumor necrosis factor [KO:K03156]
114705867  Hspa1a; heat shock 70 kDa protein 1A [KO:K03283]
114705868  [KO:K03283]
114705870  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
114705910  [KO:K04350]
114705943  Map3k6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
114705974  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
114705993  [KO:K04381]
114706145  Daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
114706162  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
114706165  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114706175  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114706205  Irak1; interleukin-1 receptor-associated kinase 1 isoform X3 [KO:K04730] [EC:2.7.11.1]
114706242  Dusp9; LOW QUALITY PROTEIN: dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
114706253  Flna; filamin-A isoform X1 [KO:K04437]
114706431  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114706806  Mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
114706830  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
114706913  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X3 [KO:K04862]
114706940  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
114707024  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
114707161  Map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
114707170  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
114707256  Rap1a; ras-related protein Rap-1A [KO:K04353]
114707287  Kitlg; kit ligand isoform X1 [KO:K05461]
114707365  Pdgfrb; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
114707382  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
114707535  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114707913  Efna4; LOW QUALITY PROTEIN: ephrin-A4 [KO:K05462]
114707937  Efna1; ephrin-A1 isoform X1 [KO:K05462]
114707941  Efna3; ephrin-A3 isoform X1 [KO:K05462]
114708007  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
114708042  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
114708136  Fgf8; fibroblast growth factor 8 isoform X2 [KO:K04358]
114708354  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114708477  Kras; GTPase KRas isoform X2 [KO:K07827]
114708536  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
114708775  Ntf3; neurotrophin-3 [KO:K04356]
114708799  Tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114709012  Ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
114709068  Fgf7; fibroblast growth factor 7 [KO:K04358]
114709081  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114709386  Artn; artemin isoform X1 [KO:K25415]
114709487  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
114709520  Il1b; interleukin-1 beta [KO:K04519]
114709525  Il1a; interleukin-1 alpha [KO:K04383]
114709874  Relb; transcription factor RelB isoform X1 [KO:K09253]
114710030  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
114710308  Hspb1; heat shock protein beta-1 [KO:K04455]
114710367  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114710416  Dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
114710510  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
114710523  [KO:K04371] [EC:2.7.11.24]
114710754  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
114710954  Cacna2d2; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
114710975  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114710980  Mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
119088838  [KO:K04438]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
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Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pleu04070  Phosphatidylinositol signaling system
pleu04110  Cell cycle
pleu04115  p53 signaling pathway
pleu04210  Apoptosis
pleu04310  Wnt signaling pathway
pleu04668  TNF signaling pathway
KO pathway
ko04010   

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