Entry Name Bacterial invasion of epithelial cells - Peromyscus leucopus (white-footed mouse)
Description Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map pleu05100 Bacterial invasion of epithelial cells
Organism Peromyscus leucopus (white-footed mouse) [GN:
pleu ]
Gene 114681031 Elmo3; engulfment and cell motility protein 3 isoform X1 [KO:K19241 ]
114682062 Elmo1; LOW QUALITY PROTEIN: engulfment and cell motility protein 1 [KO:K12366 ]
114682779 Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
114683897 Shc4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449 ]
114684032 Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
114688966 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
114692640 Elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
114693559 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
114695335 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
114695594 Wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612 ]
114697206 Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
114703850 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
114705950 Wasf2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748 ]
114706924 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
114707507 Wasf1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753 ]
114707535 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
114709099 Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726 ]
114709647 Mad2l2; mitotic spindle assembly checkpoint protein MAD2B isoform X3 [KO:K13728 ]
114710730 Hcls1; LOW QUALITY PROTEIN: hematopoietic lineage cell-specific protein [KO:K06106 ]
Reference Authors Mostowy S, Cossart P
Title Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.
Journal Reference Authors Hauck CR, Ohlsen K
Title Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.
Journal Reference Authors Wang B, Li S, Dedhar S, Cleary PP
Title Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.
Journal Reference Authors Matsumoto H, Young GM
Title Translocated effectors of Yersinia.
Journal Reference Authors McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title Salmonella takes control: effector-driven manipulation of the host.
Journal Reference Authors Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C
Title A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.
Journal Related KO pathway
