KEGG   PATHWAY: pteh04120
Entry
pteh04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Piliocolobus tephrosceles (Ugandan red Colobus)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
pteh04120  Ubiquitin mediated proteolysis
pteh04120

Other DBs
GO: 0016567
Organism
Piliocolobus tephrosceles (Ugandan red Colobus) [GN:pteh]
Gene
113225158  polyubiquitin-like [KO:K04551]
111526445  UBB; polyubiquitin-B [KO:K04551]
111527493  polyubiquitin-like [KO:K04551]
111554206  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
111522653  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
111534944  ubiquitin-40S ribosomal protein S27a [KO:K02977]
111536381  UBA1; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
111519931  SAE1; SUMO-activating enzyme subunit 1 isoform X2 [KO:K10684] [EC:6.2.1.45]
111520808  SUMO-activating enzyme subunit 1-like isoform X1 [KO:K10684] [EC:6.2.1.45]
111553904  UBA2; SUMO-activating enzyme subunit 2 isoform X1 [KO:K10685] [EC:6.2.1.45]
111533449  UBA3; NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
111555440  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
111555793  UBA6; ubiquitin-like modifier-activating enzyme 6 isoform X1 [KO:K10699] [EC:6.2.1.45]
111531453  UBE2A; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
111529159  UBE2B; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
111549969  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
111530024  UBE2C; ubiquitin-conjugating enzyme E2 C isoform X1 [KO:K06688] [EC:2.3.2.23]
111528414  ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
113219495  ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
111552308  UBE2D4; ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
111521925  UBE2D1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
111545552  ubiquitin-conjugating enzyme E2 D3-like [KO:K06689] [EC:2.3.2.23]
111547975  UBE2D3; ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
111542788  UBE2E3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
111539471  UBE2E1; ubiquitin-conjugating enzyme E2 E1 isoform X1 [KO:K20217] [EC:2.3.2.23]
111554632  NEDD8-conjugating enzyme UBE2F-like isoform X1 [KO:K10687] [EC:2.3.2.34]
111553786  UBE2F; NEDD8-conjugating enzyme UBE2F isoform X1 [KO:K10687] [EC:2.3.2.34]
111521243  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
111526916  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
111539864  UBE2H; ubiquitin-conjugating enzyme E2 H isoform X1 [KO:K10576] [EC:2.3.2.23]
111528900  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
113221709  SUMO-conjugating enzyme UBC9-B-like isoform X1 [KO:K10577]
111538078  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
111526852  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
111527369  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
111550940  UBE2K; ubiquitin-conjugating enzyme E2 K isoform X1 [KO:K04649] [EC:2.3.2.23]
111530653  UBE2L3; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
111554781  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
111523794  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
111544865  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
111530372  UBE2M; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
111541210  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
111541382  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
111550896  UBE2N; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
111521424  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
111553911  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
111554673  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
111547100  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
113220490  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
111542385  UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1 [KO:K10581] [EC:2.3.2.24]
111530421  UBE2Q2; ubiquitin-conjugating enzyme E2 Q2 isoform X1 [KO:K10582] [EC:2.3.2.23]
111546770  UBE2QL1; ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
111543724  UBE2Q1; ubiquitin-conjugating enzyme E2 Q1 [KO:K10582] [EC:2.3.2.23]
111530527  CDC34; ubiquitin-conjugating enzyme E2 R1 [KO:K02207] [EC:2.3.2.23]
111536809  UBE2R2; ubiquitin-conjugating enzyme E2 R2 isoform X1 [KO:K02207] [EC:2.3.2.23]
111521104  UBE2S; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
111539757  UBE2U; ubiquitin-conjugating enzyme E2 U isoform X4 [KO:K10584] [EC:2.3.2.23]
111520972  UBE2W; ubiquitin-conjugating enzyme E2 W isoform X3 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
111537540  UBE2Z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
111545411  BIRC6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
111525102  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
111532607  UBE3B; ubiquitin-protein ligase E3B isoform X1 [KO:K10588] [EC:2.3.2.26]
111551418  UBE3C; ubiquitin-protein ligase E3C isoform X1 [KO:K10589] [EC:2.3.2.26]
111542523  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
111526389  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
111548161  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
111549658  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
111541414  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 [KO:K05630] [EC:2.3.2.26]
111527551  TRIP12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
111553677  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
111546863  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
111536181  HUWE1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
111551572  UBR5; E3 ubiquitin-protein ligase UBR5 isoform X1 [KO:K10593] [EC:2.3.2.26]
111521749  HERC1; probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
111530630  HERC2; E3 ubiquitin-protein ligase HERC2 isoform X1 [KO:K10595] [EC:2.3.2.26]
111528670  HERC3; probable E3 ubiquitin-protein ligase HERC3 isoform X1 [KO:K10614] [EC:2.3.2.26]
111537938  HERC4; probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
111540207  UBE4A; ubiquitin conjugation factor E4 A isoform X1 [KO:K10596] [EC:2.3.2.27]
111544655  UBE4B; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
111524029  STUB1; E3 ubiquitin-protein ligase CHIP isoform X1 [KO:K09561] [EC:2.3.2.27]
111530674  PPIL2; RING-type E3 ubiquitin-protein ligase PPIL2 isoform X1 [KO:K10598] [EC:5.2.1.8]
111544829  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
111548078  UBOX5; RING finger protein 37 [KO:K10600]
111528609  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
111540239  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
111542832  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
111527900  CBLC; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
111550282  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
111536575  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
111524432  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X2 [KO:K04506] [EC:2.3.2.27]
111526997  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
111521878  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
111541624  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
111539371  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
111524565  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
111540065  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
111540066  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
111532918  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
111520493  BIRC7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
111548338  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
111539686  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
111531395  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
111521986  PIAS4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
111522389  SYVN1; E3 ubiquitin-protein ligase synoviolin isoform X1 [KO:K10601] [EC:2.3.2.27]
111541037  NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
111526706  AIRE; autoimmune regulator [KO:K10603]
111551725  MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
111537329  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
111553447  FANCL; E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
111531478  MID1; E3 ubiquitin-protein ligase Midline-1 [KO:K08285] [EC:2.3.2.27]
111550318  TRIM32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
111537640  TRIM37; E3 ubiquitin-protein ligase TRIM37 isoform X2 [KO:K10608] [EC:2.3.2.27]
111532697  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
111548968  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
111551417  CUL1; cullin-1 [KO:K03347]
111529166  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
111538928  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
111547216  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
111545519  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
111553047  FBXW7; F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
111526300  FBXO2; F-box only protein 2 [KO:K10099]
111545482  FBXO4; F-box only protein 4 [KO:K10291]
111546668  CUL2; cullin-2 [KO:K03870]
111520953  ELOC; elongin-C [KO:K03872]
111530698  ELOB; elongin-B isoform X1 [KO:K03873]
111546933  VHL; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
113221554  VHLL; LOW QUALITY PROTEIN: von Hippel-Lindau-like protein [KO:K03871]
111549233  CUL3; cullin-3 isoform X1 [KO:K03869]
111527757  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
111536096  KLHL13; kelch-like protein 13 isoform X1 [KO:K10447]
111537206  KLHL9; kelch-like protein 9 [KO:K10447]
111521936  RHOBTB1; rho-related BTB domain-containing protein 1 [KO:K07868]
111545696  RHOBTB2; rho-related BTB domain-containing protein 2 [KO:K07868]
111535923  CUL4B; cullin-4B isoform X1 [KO:K10609]
111546375  CUL4A; cullin-4A isoform X1 [KO:K10609]
111524303  DDB1; DNA damage-binding protein 1 [KO:K10610]
111544893  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
111541606  ERCC8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
111522859  DET1; DET1 homolog isoform X1 [KO:K10571]
111526425  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
111540099  CUL5; LOW QUALITY PROTEIN: cullin-5 [KO:K10612]
111555212  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
111542349  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
111543062  CUL7; cullin-7 isoform X1 [KO:K10613]
111537450  FBXW8; F-box/WD repeat-containing protein 8 isoform X1 [KO:K10264]
111542291  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
111553089  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
111548724  CDC20; cell division cycle protein 20 homolog [KO:K03363]
111520673  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
111524276  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
111525408  LYZL6; lysozyme-like protein 6 isoform X1 [KO:K03350]
111526563  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
111549830  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
111537907  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
111546351  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
111536080  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
111528687  CDC23; cell division cycle protein 23 homolog [KO:K03355]
111522570  ANAPC10; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 10 [KO:K03357]
111550344  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
111523382  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
111540902  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
111537876  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
pteh03050  Proteasome
KO pathway
ko04120   
LinkDB

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