KEGG   PATHWAY: pviv04350
Entry
pviv04350                   Pathway                                
Name
TGF-beta signaling pathway - Prionailurus viverrinus (fishing cat)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
pviv04350  TGF-beta signaling pathway
pviv04350

Other DBs
GO: 0007179
Organism
Prionailurus viverrinus (fishing cat) [GN:pviv]
Gene
125146802  LRRC32; transforming growth factor beta activator LRRC32 isoform X1 [KO:K26316]
125147134  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
125147429  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
125148439  NODAL; nodal homolog [KO:K04666]
125148629  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
125148749  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
125148757  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
125149069  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125149158  TGIF1; homeobox protein TGIF1 [KO:K19383]
125149476  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
125150521  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
125150881  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
125151143  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
125151670  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
125151683  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
125151724  NOG; noggin [KO:K04658]
125151867  RHOA; transforming protein RhoA [KO:K04513]
125152756  E2F4; transcription factor E2F4 [KO:K04682]
125152868  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
125153618  HAMP; hepcidin [KO:K23106]
125153715  EMP3; epithelial membrane protein 3 [KO:K26257]
125153770  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
125154001  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
125154129  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
125154314  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
125154374  TFR2; transferrin receptor protein 2 isoform X1 [KO:K23910]
125154521  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
125155525  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
125155536  GREM2; gremlin-2 isoform X1 [KO:K23318]
125155757  FMOD; fibromodulin [KO:K08121]
125156455  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
125156689  MYC; myc proto-oncogene protein [KO:K04377]
125156759  GDF6; growth/differentiation factor 6 [KO:K20012]
125157247  CUL1; cullin-1 [KO:K03347]
125157444  IGSF1; immunoglobulin superfamily member 1 isoform X1 [KO:K26168]
125158346  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
125159630  [KO:K04668]
125159631  [KO:K04668]
125160766  AMH; muellerian-inhibiting factor [KO:K04665]
125161033  INHBA; inhibin beta A chain [KO:K04667]
125161738  TGIF2; homeobox protein TGIF2 [KO:K19553]
125161913  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
125162076  LTBP1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
125162242  GDF5; growth/differentiation factor 5 [KO:K04664]
125162550  BMP2; bone morphogenetic protein 2 [KO:K21283]
125162737  BMP7; bone morphogenetic protein 7 [KO:K16621]
125162810  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
125163089  GDF7; growth/differentiation factor 7 [KO:K20013]
125163895  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
125164090  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
125164370  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
125164655  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
125165327  TNF; tumor necrosis factor [KO:K03156]
125165417  TFDP1; transcription factor Dp-1 [KO:K04683]
125165524  BMP6; bone morphogenetic protein 6 [KO:K16620]
125165735  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
125166046  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
125166544  BMP5; bone morphogenetic protein 5 [KO:K04663]
125166578  HFE; hereditary hemochromatosis protein isoform X1 [KO:K26535]
125166728  ID4; DNA-binding protein inhibitor ID-4 [KO:K17695]
125167855  GREM1; gremlin-1 [KO:K23318]
125167893  FBN1; fibrillin-1 [KO:K06825]
125168224  RGMA; repulsive guidance molecule A [KO:K23096]
125168227  THBS1; thrombospondin-1 [KO:K16857]
125168330  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
125168385  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
125168386  NEO1; neogenin isoform X1 [KO:K06766]
125168446  THSD4; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
125168589  SMAD6; mothers against decapentaplegic homolog 6 [KO:K04677]
125168683  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
125168869  SMAD5; mothers against decapentaplegic homolog 5 [KO:K16790]
125168872  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
125169541  INHBC; inhibin beta C chain [KO:K22688]
125169758  SP1; transcription factor Sp1 [KO:K04684]
125169759  AMHR2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
125170078  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
125170145  LEMD3; inner nuclear membrane protein Man1 [KO:K19410]
125170327  DCN; decorin [KO:K04660]
125170397  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
125170497  IFNG; interferon gamma [KO:K04687]
125170911  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
125171206  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
125171322  INHBE; inhibin beta E chain [KO:K22689]
125171575  ID3; DNA-binding protein inhibitor ID-3 [KO:K17694]
125171995  BMP8A; bone morphogenetic protein 8A isoform X1 [KO:K16622]
125172001  SKI; ski oncogene isoform X1 [KO:K26503]
125172179  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
125172537  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
125172633  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
125172646  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
125172698  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
125172951  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
125173047  HJV; hemojuvelin [KO:K23100]
125173312  NBL1; neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
125173449  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
125173868  INHBB; inhibin beta B chain [KO:K22687]
125173894  TMEM53; transmembrane protein 53 isoform X1 [KO:K28359]
125173951  BMP8B; bone morphogenetic protein 8B isoform X1 [KO:K16622]
125174367  RGMB; repulsive guidance molecule B isoform X1 [KO:K06847]
125174424  [KO:K14736]
125174572  CHRD; chordin isoform X1 [KO:K04657]
125174624  TFRC; transferrin receptor protein 1 [KO:K06503]
125174809  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
125174825  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
125174858  [KO:K14736]
125175063  SMAD9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
125175231  SKIL; ski-like protein [KO:K18499]
125175262  NRROS; transforming growth factor beta activator LRRC33 [KO:K26317]
125176421  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
125176609  FST; follistatin isoform X1 [KO:K04661]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
pviv04010  MAPK signaling pathway
pviv04110  Cell cycle
pviv04120  Ubiquitin mediated proteolysis
pviv04210  Apoptosis
KO pathway
ko04350   

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