KEGG   PATHWAY: pvp04810
Entry
pvp04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Pteropus vampyrus (large flying fox)
Class
Cellular Processes; Cell motility
Pathway map
pvp04810  Regulation of actin cytoskeleton
pvp04810

Other DBs
GO: 0030036
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288337  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
105288356  ACTR3; actin-related protein 3 [KO:K18584]
105288600  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
105288737  FGF7; fibroblast growth factor 7 [KO:K04358]
105288745  ITGA9; integrin alpha-9 [KO:K06585]
105288780  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
105288842  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
105288870  VCL; vinculin isoform X1 [KO:K05700]
105289211  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
105289220  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105289221  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
105289271  [KO:K05760]
105289311  CRKL; crk-like protein [KO:K04438]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105289673  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
105289768  PFN4; profilin-4 [KO:K05759]
105289793  FAM49A; protein FAM49A [KO:K27976]
105289956  [KO:K05749]
105290017  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
105290023  F2; prothrombin isoform X2 [KO:K01313] [EC:3.4.21.5]
105290166  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
105290414  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105290433  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105290506  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
105290514  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
105291072  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
105291118  ITGB6; integrin beta-6 isoform X4 [KO:K06589]
105291123  FN1; fibronectin [KO:K05717]
105291259  MYH10; myosin-10 isoform X1 [KO:K10352]
105291404  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
105291441  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105291625  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105291659  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105291766  PFN1; profilin-1 [KO:K05759]
105291866  CRK; adapter molecule crk isoform X1 [KO:K04438]
105291887  SSH2; protein phosphatase Slingshot homolog 2 isoform X5 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
105291891  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
105291902  NCKAP1; nck-associated protein 1 [KO:K05750]
105291916  ITGA4; integrin alpha-4 [KO:K06483]
105291990  ITGAE; LOW QUALITY PROTEIN: integrin alpha-E [KO:K06524]
105292122  FGF9; fibroblast growth factor 9 [KO:K04358]
105292199  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105292284  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
105292386  FGF5; fibroblast growth factor 5 [KO:K04358]
105292586  ENAH; protein enabled homolog isoform X7 [KO:K05746]
105292665  C5; complement C5 [KO:K03994]
105292693  GSN; gelsolin [KO:K05768]
105292949  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105293045  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105293259  FGF6; fibroblast growth factor 6 [KO:K04358]
105293279  FGF23; fibroblast growth factor 23 [KO:K22428]
105293281  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
105293425  ITGB4; integrin beta-4 [KO:K06525]
105293508  PFN3; profilin-3 [KO:K05759]
105293516  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
105293808  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105293829  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105293982  TMSB4X; thymosin beta-4 [KO:K05764]
105294059  KRAS; GTPase KRas isoform X2 [KO:K07827]
105294560  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
105294565  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
105294593  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105294623  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105294862  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
105294931  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X3 [KO:K00920] [EC:2.7.1.149]
105295039  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
105295067  SCIN; adseverin [KO:K05768]
105295263  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
105295316  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
105295411  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
105295461  ROCK2; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
105295478  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
105295548  FGF20; fibroblast growth factor 20 [KO:K04358]
105295655  RDX; radixin [KO:K05762]
105295886  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105295963  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105296333  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
105296421  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
105296470  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
105296513  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105296547  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105296550  NRAS; GTPase NRas isoform X1 [KO:K07828]
105296556  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105296949  [KO:K12329]
105297028  DIAPH1; protein diaphanous homolog 1 isoform X2 [KO:K05740]
105297044  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105297140  [KO:K02649]
105297228  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
105297317  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
105297442  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105297528  ITGB5; integrin beta-5 [KO:K06588]
105297614  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
105297699  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
105297781  ITGA10; integrin alpha-10 [KO:K06586]
105297824  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105297915  CFL1; cofilin-1 [KO:K05765]
105298078  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105298133  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
105298393  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X2 [KO:K00921] [EC:2.7.1.150]
105298425  ABI2; abl interactor 2 isoform X1 [KO:K05751]
105298474  RGCC; regulator of cell cycle RGCC [KO:K26108]
105298571  C8G; complement component C8 gamma chain isoform X3 [KO:K03999]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105298795  BDKRB1; B1 bradykinin receptor [KO:K03915]
105298796  BDKRB2; B2 bradykinin receptor [KO:K03916]
105298945  C8A; complement component C8 alpha chain [KO:K03997]
105298995  C8B; complement component C8 beta chain [KO:K03998]
105299021  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105299036  BRK1; protein BRICK1 [KO:K05752]
105299048  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X2 [KO:K05755]
105299092  C6; complement component C6 [KO:K03995]
105299106  C7; complement component C7 [KO:K03996]
105299112  C9; complement component C9 [KO:K04000]
105299132  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
105299317  FGF18; fibroblast growth factor 18 [KO:K04358]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105299414  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
105299436  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105299451  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
105299770  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
105299781  MYL10; LOW QUALITY PROTEIN: myosin regulatory light chain 10 [KO:K12756]
105300159  [KO:K04456] [EC:2.7.11.1]
105300174  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
105300184  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
105300315  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105300480  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
105301110  VAV1; proto-oncogene vav [KO:K05730]
105301137  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105301152  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105301185  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
105301197  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
105301240  FAM49B; protein FAM49B [KO:K27976]
105301274  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
105301286  FGF10; fibroblast growth factor 10 [KO:K04358]
105301337  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
105301479  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105301523  PFN2; profilin-2 isoform X2 [KO:K05759]
105301596  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
105301735  RRAS; ras-related protein R-Ras [KO:K07829]
105301782  MYH14; myosin-14 [KO:K10352]
105301799  FGF21; fibroblast growth factor 21 [KO:K22429]
105301871  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
105301889  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X3 [KO:K06270]
105302193  F2R; proteinase-activated receptor 1 [KO:K03914]
105302195  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
105302250  FGF22; fibroblast growth factor 22 [KO:K04358]
105302259  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
105302383  RHOA; transforming protein RhoA [KO:K04513]
105302613  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105302623  NCKAP1L; nck-associated protein 1-like isoform X3 [KO:K05750]
105302663  ITGB7; integrin beta-7 [KO:K06590]
105302702  ITGA5; integrin alpha-5 [KO:K06484]
105302874  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
105302942  [KO:K05730]
105302989  EZR; ezrin [KO:K08007]
105303008  ITGB1; integrin beta-1 [KO:K05719]
105303028  ITGB2; integrin beta-2 [KO:K06464]
105303269  CFL2; cofilin-2 isoform X1 [KO:K05765]
105303446  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105303529  ITGA2B; integrin alpha-IIb [KO:K06476]
105303767  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
105303834  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105303955  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
105304170  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
105304500  ITGAX; integrin alpha-X [KO:K06462]
105304501  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
105304532  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
105304537  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105304647  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105304679  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
105304953  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
105305015  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
105305242  [KO:K12757]
105305243  [KO:K12757]
105305354  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X4 [KO:K05726]
105305459  ARAF; serine/threonine-protein kinase A-Raf isoform X8 [KO:K08845] [EC:2.7.11.1]
105305528  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
105305785  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105306123  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
105306141  [KO:K04361] [EC:2.7.10.1]
105306687  ACTR2; actin-related protein 2 [KO:K17260]
105306731  KNG1; kininogen-1 isoform X1 [KO:K03898]
105306744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105307049  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X3 [KO:K05729]
105307100  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105307123  [KO:K22603]
105307127  [KO:K22603]
105307133  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
105307158  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307342  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
105307385  KIF5A; kinesin heavy chain isoform X8 [KO:K00920] [EC:2.7.1.149]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105307680  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
105307748  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105307771  MSN; moesin [KO:K05763]
105307779  [KO:K05759]
105307819  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
105307927  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
105307929  ITGA1; integrin alpha-1 [KO:K06480]
105308049  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
105308212  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
105308348  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
105308370  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
105308760  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
105308889  FGF16; fibroblast growth factor 16 [KO:K04358]
105308953  [KO:K07831]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105309437  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
105309438  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
105309511  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
105309535  SOS2; son of sevenless homolog 2 [KO:K03099]
105309827  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105309865  MYL5; myosin light chain 5 isoform X2 [KO:K12753]
105309888  [KO:K04358]
105309919  SSH3; protein phosphatase Slingshot homolog 3 isoform X3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
105309924  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105310172  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
105310261  ITGA11; integrin alpha-11 [KO:K06587]
105311212  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
105311327  MYH9; myosin-9 isoform X1 [KO:K10352]
105311363  FGF4; fibroblast growth factor 4 [KO:K04358]
105311532  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
pvp04010  MAPK signaling pathway
pvp04510  Focal adhesion
pvp04520  Adherens junction
KO pathway
ko04810   

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