KEGG   PATHWAY: rno00760
Entry
rno00760                    Pathway                                
Name
Nicotinate and nicotinamide metabolism - Rattus norvegicus (rat)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
rno00760  Nicotinate and nicotinamide metabolism
rno00760

Module
rno_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:rno00760]
Other DBs
UMBBD: nic
GO: 0046497 0006769
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100125370  Nadk; NAD kinase [KO:K00858] [EC:2.7.1.23]
100360582  Nt5c; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
100363253  Nt5c2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
100912521  Nmrk2; nicotinamide riboside kinase 2 [KO:K10524] [EC:2.7.1.22 2.7.1.173]
25668  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
287368  Nt5m; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
287545  Sarm1; NAD(+) hydrolase SARM1 [KO:K27536]
289095  Nmnat2; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
290029  Pnp; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
292875  Aspdh; aspartate dehydrogenase domain-containing protein [KO:K06989] [EC:1.4.1.21]
293152  Art2b; T-cell ecto-ADP-ribosyltransferase 2 precursor [KO:K19980] [EC:2.4.2.31 3.2.2.5]
293504  Qprt; nicotinate-nucleotide pyrophosphorylase [carboxylating] [KO:K00767] [EC:2.4.2.19]
293615  Sirt3; NAD-dependent protein deacetylase sirtuin-3, mitochondrial [KO:K11413] [EC:2.3.1.286]
297508  Nampt; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
298653  Nmnat1; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
298881  Nt5c1b; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
299638  Sirt6; NAD-dependent protein deacylase sirtuin-6 [KO:K11416] [EC:2.3.1.286]
300691  Nnmt; nicotinamide N-methyltransferase [KO:K00541] [EC:2.1.1.1]
303745  Sirt7; NAD-dependent protein deacetylase sirtuin-7 [KO:K11417] [EC:2.3.1.286]
304539  Sirt4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial [KO:K11414] [EC:2.3.1.286 2.3.1.313]
306840  Sirt5; NAD-dependent protein deacylase sirtuin-5, mitochondrial [KO:K11415] [EC:2.3.1.286]
309757  Sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
310378  Nnt; NAD(P) transhydrogenase, mitochondrial [KO:K00323] [EC:7.1.1.1]
313574  Nt5c1a; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
315085  Naprt; nicotinate phosphoribosyltransferase [KO:K00763] [EC:6.3.4.21]
316421  Aox2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
316424  Aox4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
353255  Nadsyn1; glutamine-dependent NAD(+) synthetase [KO:K01950] [EC:6.3.5.1]
361532  Sirt2; NAD-dependent protein deacetylase sirtuin-2 isoform 1 [KO:K11412] [EC:2.3.1.286]
363118  Nmnat3; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
365699  Nadk2; NAD kinase 2, mitochondrial [KO:K00858] [EC:2.7.1.23]
367323  Nudt12; NAD-capped RNA hydrolase NUDT12 [KO:K03426] [EC:3.6.1.22]
493909  Aox3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
499330  Nmrk1; nicotinamide riboside kinase 1 [KO:K10524] [EC:2.7.1.22 2.7.1.173]
54349  Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
54410  Enpp3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
58813  Nt5e; 5'-nucleotidase precursor [KO:K19970] [EC:3.1.3.5]
682978  Nudt13; NAD(P)H pyrophosphatase NUDT13, mitochondrial [KO:K03426] [EC:3.6.1.22]
81506  Bst1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor [KO:K18152] [EC:3.2.2.6 2.4.99.20]
85496  Enpp1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00745  Nicotine
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16386  (R)-Nicotine
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C21154  N-Methylmyosmine
Reference
PMID:13475371
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
PMID:16894175
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
PMID:11514508
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
PMID:16321959
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
PMID:21953451
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
Related
pathway
rno00020  Citrate cycle (TCA cycle)
rno00250  Alanine, aspartate and glutamate metabolism
rno00380  Tryptophan metabolism
rno00620  Pyruvate metabolism
KO pathway
ko00760   

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