KEGG   PATHWAY: sluc00260
Entry
sluc00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Sander lucioperca (pikeperch)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sluc00260  Glycine, serine and threonine metabolism
sluc00260

Module
sluc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sluc00260]
sluc_M00047  Creatine pathway [PATH:sluc00260]
sluc_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sluc00260]
sluc_M00555  Betaine biosynthesis, choline => betaine [PATH:sluc00260]
sluc_M00621  Glycine cleavage system [PATH:sluc00260]
sluc_M00974  Betaine metabolism, animals, betaine => glycine [PATH:sluc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Sander lucioperca (pikeperch) [GN:sluc]
Gene
116034003  gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
116034803  si:ch211-127i16.2; probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
116034954  sardh; sarcosine dehydrogenase, mitochondrial isoform X2 [KO:K00314] [EC:1.5.8.3]
116036328  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
116038699  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
116039427  [KO:K01754] [EC:4.3.1.19]
116040490  grhprb; glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]
116040627  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
116040731  alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
116040773  [KO:K00600] [EC:2.1.2.1]
116040842  amt; aminomethyltransferase, mitochondrial isoform X2 [KO:K00605] [EC:2.1.2.10]
116041160  pipox; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
116042433  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
116042526  tdh2; L-threonine dehydrogenase 2 [KO:K15789] [EC:1.1.1.103]
116042531  sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
116042937  pgam1b; phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]
116044613  [KO:K01697] [EC:4.2.1.22]
116044747  [KO:K15789] [EC:1.1.1.103]
116045713  [KO:K02437]
116046104  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
116047995  psph; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
116048770  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
116048910  pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
116050658  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
116051286  glyctk; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
116051347  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial isoform X2 [KO:K00643] [EC:2.3.1.37]
116051378  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
116053066  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
116053988  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
116054035  [KO:K01834] [EC:5.4.2.11]
116054167  [KO:K00544] [EC:2.1.1.5]
116054168  [KO:K00544] [EC:2.1.1.5]
116054267  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
116054482  [KO:K17989] [EC:4.3.1.17 4.3.1.19]
116054650  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
116055105  zgc:162816; D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]
116055256  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
116055346  cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
116055480  [KO:K00613] [EC:2.1.4.1]
116056739  [KO:K00273] [EC:1.4.3.3]
116056791  [KO:K00544] [EC:2.1.1.5]
116059043  cbsb; cystathionine beta-synthase b [KO:K01697] [EC:4.2.1.22]
116061532  tha1; threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
116062215  [KO:K00643] [EC:2.3.1.37]
116062799  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
116062805  aoc2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
116062809  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
116062994  bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
116063288  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
116064385  grhpra; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
116065269  shmt1; serine hydroxymethyltransferase, cytosolic isoform X3 [KO:K00600] [EC:2.1.2.1]
116065459  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
116065996  tdh; L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sluc00010  Glycolysis / Gluconeogenesis
sluc00020  Citrate cycle (TCA cycle)
sluc00230  Purine metabolism
sluc00250  Alanine, aspartate and glutamate metabolism
sluc00270  Cysteine and methionine metabolism
sluc00290  Valine, leucine and isoleucine biosynthesis
sluc00330  Arginine and proline metabolism
sluc00470  D-Amino acid metabolism
sluc00564  Glycerophospholipid metabolism
sluc00600  Sphingolipid metabolism
sluc00620  Pyruvate metabolism
sluc00630  Glyoxylate and dicarboxylate metabolism
sluc00640  Propanoate metabolism
sluc00860  Porphyrin metabolism
sluc00920  Sulfur metabolism
KO pathway
ko00260   

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