KEGG   PATHWAY: ssco03460
Entry
ssco03460                   Pathway                                
Name
Fanconi anemia pathway - Scomber scombrus (Atlantic mackerel)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
Pathway map
ssco03460  Fanconi anemia pathway
ssco03460

Other DBs
GO: 0043240
Organism
Scomber scombrus (Atlantic mackerel) [GN:ssco]
Gene
133977483  fancd2; Fanconi anemia group D2 protein [KO:K10891]
133977625  cenps; centromere protein S [KO:K11511]
133977964  atrip; ATR-interacting protein [KO:K10905]
133978490  rmi1; recQ-mediated genome instability protein 1 [KO:K10990]
133978898  poli; DNA polymerase iota isoform X1 [KO:K03510] [EC:2.7.7.7]
133978911  fancg; Fanconi anemia group G protein [KO:K10894]
133979023  top3b; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
133979151  fancc; Fanconi anemia group C protein [KO:K10890]
133979571  polk; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
133980425  brip1; Fanconi anemia group J protein [KO:K15362] [EC:5.6.2.3]
133980781  rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
133981002  brca2; breast cancer type 2 susceptibility protein [KO:K08775]
133981673  faap24; Fanconi anemia core complex-associated protein 24 [KO:K10898]
133981804  blm; recQ-like DNA helicase BLM [KO:K10901] [EC:5.6.2.4]
133981847  fan1; fanconi-associated nuclease 1 [KO:K15363] [EC:3.1.21.- 3.1.4.1]
133981902  fanci; Fanconi anemia group I protein [KO:K10895]
133981957  [KO:K10888]
133982495  fancf; Fanconi anemia group F protein [KO:K10893]
133984049  rpa2; replication protein A 32 kDa subunit [KO:K10739]
133984719  her6; hairy-related 6 [KO:K06054]
133984969  usp1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1 [KO:K11832] [EC:3.4.19.12]
133986470  palb2; partner and localizer of BRCA2 [KO:K10897]
133987460  ube2t; ubiquitin-conjugating enzyme E2 T [KO:K13960] [EC:2.3.2.23]
133987521  her9; hairy-related 9 isoform X1 [KO:K06054]
133987738  rad51c; DNA repair protein RAD51 homolog 3 [KO:K10870]
133988250  fance; Fanconi anemia group E protein isoform X1 [KO:K10892]
133990339  [KO:K15361]
133990743  [KO:K06054]
133991368  slx4; structure-specific endonuclease subunit SLX4 isoform X1 [KO:K10484]
133991622  mlh1; DNA mismatch repair protein Mlh1 [KO:K08734]
133991902  polh; DNA polymerase eta [KO:K03509] [EC:2.7.7.7]
133991998  fancl; E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
133992711  ercc1; DNA excision repair protein ERCC-1 [KO:K10849]
133992862  fancb; Fanconi anemia group B protein [KO:K10889]
133993195  rev1; DNA repair protein REV1 isoform X1 [KO:K03515] [EC:2.7.7.-]
133993953  [KO:K07466]
133995960  [KO:K10739]
133996608  rpa3; replication protein A 14 kDa subunit [KO:K10740]
133997508  rad51; DNA repair protein RAD51 homolog 1 [KO:K04482]
133998082  rev3l; DNA polymerase zeta catalytic subunit isoform X1 [KO:K02350] [EC:2.7.7.7]
133999134  top3a; DNA topoisomerase 3-alpha isoform X1 [KO:K03165] [EC:5.6.2.1]
133999691  cenpx; centromere protein X [KO:K15360]
134000131  rmi2; recQ-mediated genome instability protein 2 [KO:K15365]
134000413  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
134001301  fancm; Fanconi anemia group M protein [KO:K10896]
134003047  pms2; mismatch repair endonuclease PMS2 [KO:K10858]
134003110  [KO:K10605] [EC:2.3.2.27]
134003340  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
134003378  faap100; Fanconi anemia core complex-associated protein 100 [KO:K10993]
134003449  ercc4; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
134003692  eme1; crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
134005523  poln; DNA polymerase nu [KO:K16618] [EC:2.7.7.7]
134005805  slx1b; structure-specific endonuclease subunit SLX1 [KO:K15078] [EC:3.6.1.-]
134005919  mus81; crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
Reference
PMID:18047734
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
PMID:19805513
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
PMID:21701511
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
PMID:20064461
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
PMID:20039786
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
PMID:18518821
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
Related
pathway
ssco03430  Mismatch repair
ssco03440  Homologous recombination
KO pathway
ko03460   

DBGET integrated database retrieval system