KEGG   PATHWAY: tfs04530
Entry
tfs04530                    Pathway                                
Name
Tight junction - Takifugu flavidus (sansaifugu)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
tfs04530  Tight junction
tfs04530

Other DBs
GO: 0005923
Organism
Takifugu flavidus (sansaifugu) [GN:tfs]
Gene
130513019  [KO:K07374]
130513021  [KO:K05702]
130513246  cldn23l; claudin-23 [KO:K06087]
130513317  ezra; ezrin a [KO:K08007]
130513661  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
130513696  [KO:K07200]
130513702  scrib; protein scribble homolog isoform X1 [KO:K16175]
130513723  [KO:K04237]
130514064  [KO:K05719]
130514077  cldn11b; claudin-11b [KO:K06087]
130514204  [KO:K20479]
130514318  [KO:K18584]
130514439  llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
130514576  marveld3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
130514682  [KO:K10352]
130514712  actb2; actin, cytoplasmic 2 [KO:K05692]
130514755  nherf1b; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
130514889  arhgap17b; rho GTPase-activating protein 17b isoform X1 [KO:K20638]
130514924  [KO:K04392]
130514978  micall2a; MICAL-like protein 2a [KO:K21068]
130515305  cldni; claudin i [KO:K06087]
130515581  [KO:K10352]
130515585  [KO:K10352]
130515587  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
130515820  [KO:K08007]
130515843  [KO:K17388] [EC:2.7.11.39]
130515978  gata4; transcription factor GATA-4 [KO:K09183]
130516047  [KO:K06087]
130516275  afdna; LOW QUALITY PROTEIN: afadin [KO:K05702]
130516277  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
130516436  llgl2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
130516655  pals1b; MAGUK p55 subfamily member 5b isoform X1 [KO:K06091]
130516785  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
130516838  cldn23.1; claudin 23a [KO:K06087]
130516989  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
130517030  tjp2a; tight junction protein ZO-2a isoform X1 [KO:K06098]
130517193  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
130517245  cldn5b; claudin-5b [KO:K06087]
130517429  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
130517466  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
130517479  cgnl1; cingulin-like protein 1 isoform X1 [KO:K21110]
130517499  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
130517616  marveld2a; LOW QUALITY PROTEIN: uncharacterized protein marveld2a [KO:K17291]
130517759  ppp2r2ab; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
130517805  cldn35; claudin-4 [KO:K06087]
130517828  [KO:K12791]
130518686  pard6gb; par-6 family cell polarity regulator gamma b [KO:K06093]
130518786  cgnb; cingulin isoform X1 [KO:K06102]
130519125  hcls1; src substrate protein p85-like [KO:K06106]
130520283  [KO:K07902]
130520579  tjp1a; tight junction protein ZO-1 isoform X1 [KO:K05701]
130521525  [KO:K06106]
130521943  nedd4a; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
130522041  [KO:K07374]
130522265  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
130522278  [KO:K06087]
130522285  [KO:K21109]
130522319  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
130522361  jam2a; junctional adhesion molecule 2A isoform X1 [KO:K06735]
130522533  cldn7a; claudin-7-A [KO:K06087]
130522659  [KO:K06087]
130522690  runx1; runt-related transcription factor 1 isoform X1 [KO:K08367]
130522700  zgc:101810; actin-related protein 2 [KO:K17260]
130522786  cldn10e; claudin-10 isoform X1 [KO:K06087]
130522787  cldn10d; claudin-10 [KO:K06087]
130522813  sympk; symplekin [KO:K06100]
130522890  [KO:K06095]
130522906  [KO:K07374]
130522914  [KO:K18584]
130523291  [KO:K07374]
130523300  cldn15a; claudin-15a [KO:K06087]
130523547  [KO:K04353]
130523775  magi1b; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1b isoform X1 [KO:K05631]
130523844  [KO:K04513]
130523882  [KO:K05704] [EC:2.7.10.2]
130524047  [KO:K04393]
130524094  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
130524113  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
130524200  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
130524329  myl2a; myosin regulatory light chain 2a [KO:K10351]
130524335  myl6; myosin light polypeptide 6 [KO:K12751]
130524404  [KO:K04513]
130524422  cldn19; claudin-19 isoform X1 [KO:K06087]
130524612  [KO:K02089] [EC:2.7.11.22]
130524671  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
130524683  [KO:K05755]
130524887  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
130525264  myl2b; myosin, light chain 2b, regulatory, cardiac, slow isoform X1 [KO:K10351]
130525362  [KO:K04354]
130525934  nf2a; NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor a isoform X1 [KO:K16684]
130525969  [KO:K05692]
130526000  [KO:K04382] [EC:3.1.3.16]
130526014  [KO:K17291]
130526054  cldn26; putative claudin-24 [KO:K06087]
130526063  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
130526236  cldn5a; claudin 5a [KO:K06087]
130526244  pcna; proliferating cell nuclear antigen [KO:K04802]
130526544  [KO:K06098]
130526817  micall2b; protein-methionine sulfoxide oxidase mical2b isoform X1 [KO:K21068]
130526868  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
130526869  actb1; actin, cytoplasmic 1 [KO:K05692]
130526870  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
130527122  [KO:K06087]
130527227  [KO:K04345] [EC:2.7.11.11]
130527270  [KO:K10352]
130527346  si:dkey-92j12.5; LOW QUALITY PROTEIN: multiple PDZ domain protein [KO:K06095]
130527640  ppp2r2ca; protein phosphatase 2, regulatory subunit B, gamma a [KO:K04354]
130527867  [KO:K10352]
130527894  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
130527956  myh11a; myosin-11a isoform X1 [KO:K10352]
130528158  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
130528453  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
130528455  patj; LOW QUALITY PROTEIN: inaD-like protein [KO:K06092]
130528565  arhgef18b; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 18 [KO:K21066]
130528807  cldn34a; claudin-34 [KO:K06087]
130528808  [KO:K06087]
130528969  [KO:K05762]
130529110  tjp3; tight junction protein ZO-3 isoform X1 [KO:K06097]
130529127  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
130529159  jun; transcription factor AP-1 [KO:K04448]
130529243  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
130529252  si:ch211-191a24.4; uncharacterized protein si:ch211-191a24.4 [KO:K21099]
130529306  [KO:K12076]
130529319  si:ch73-61d6.3; occludin [KO:K06088]
130529356  [KO:K07901]
130529524  [KO:K06087]
130529528  [KO:K06087]
130529534  cldn10b; claudin-10 isoform X1 [KO:K06087]
130529563  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
130529737  [KO:K07374]
130529759  [KO:K07374]
130529760  [KO:K07374]
130529761  [KO:K07374]
130529776  [KO:K07374]
130529777  [KO:K07374]
130529864  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
130529929  [KO:K05747]
130530017  [KO:K05631]
130530090  zgc:153867; myosin light polypeptide 6 isoform X1 [KO:K12751]
130530472  arhgap17a; rho GTPase-activating protein 17a isoform X1 [KO:K20638]
130530521  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
130530552  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
130530615  [KO:K04513]
130530616  [KO:K04513]
130530696  [KO:K04393]
130530702  pard6b; partitioning defective 6 homolog beta [KO:K06093]
130530730  tuba5; tubulin alpha 5 [KO:K07374]
130530732  [KO:K04353]
130530872  rap2c; ras-related protein Rap-2c [KO:K07839]
130530888  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
130530920  [KO:K21112]
130530925  hspa4b; heat shock 70 kDa protein 4b [KO:K09489]
130530943  ppp2r2ba; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
130530988  dlg3; disks large homolog 3 isoform X1 [KO:K21098]
130531009  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
130531174  [KO:K21109]
130531201  [KO:K04354]
130531780  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
130531906  [KO:K05763]
130532050  cldn12; claudin-12 [KO:K06087]
130532123  arhgef2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
130532213  [KO:K06102]
130532312  rab13; ras-related protein Rab-13 [KO:K06109]
130532364  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
130532779  bves; blood vessel epicardial substance [KO:K21108]
130533045  cdc42l; cell division cycle 42, like [KO:K04393]
130533199  epb41l4b; band 4.1-like protein 4B isoform X1 [KO:K21111]
130533229  prkcea; LOW QUALITY PROTEIN: protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
130533300  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
130533601  [KO:K17260]
130533632  tjap1; tight junction-associated protein 1 [KO:K06105]
130533643  [KO:K07374]
130533649  [KO:K07374]
130533656  [KO:K07374]
130533690  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
130534076  [KO:K18050] [EC:2.7.11.13]
130534319  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
130534463  [KO:K06087]
130534580  tiam1b; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
130534584  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
130534638  cldn8.2; claudin-8 [KO:K06087]
130534643  [KO:K06087]
130534647  cldn8.1; claudin-8 [KO:K06087]
130534649  [KO:K06087]
130534652  [KO:K06087]
130534654  [KO:K06087]
130534655  cldnj; claudin j [KO:K06087]
130534657  [KO:K06087]
130534661  [KO:K06087]
130534662  [KO:K06087]
130534699  [KO:K06274]
130534802  jam3a; junctional adhesion molecule 3B [KO:K06785]
130535368  [KO:K06786]
130535582  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
130535888  tjp1b; tight junction protein ZO-1 isoform X1 [KO:K05701]
130535893  [KO:K21110]
130535948  cftr; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
130536034  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
130536194  jam2b; junctional adhesion molecule 2b [KO:K06735]
130536276  [KO:K07902]
130536537  pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
130537049  cldn2; claudin-2 [KO:K06087]
130537066  f11r.1; F11 receptor, tandem duplicate 1 [KO:K06089]
130537233  dlg2; disks large homolog 2 isoform X1 [KO:K12075]
130537246  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
130537281  [KO:K06087]
130537347  hspa4a; heat shock 70 kDa protein 4a [KO:K09489]
130537352  tiam1a; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
130537456  msna; moesin a [KO:K05763]
130537551  nf2b; NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor b [KO:K16684]
130537617  [KO:K06087]
130537621  [KO:K06087]
130537622  [KO:K06087]
130537623  [KO:K06087]
130537624  cldnb; claudin b [KO:K06087]
130537625  [KO:K06087]
130537626  cldn29; claudin 29 [KO:K06087]
130537628  [KO:K06087]
130537661  amot; angiomotin [KO:K16819]
130537885  [KO:K06087]
130538091  [KO:K06785]
130538112  rapgef6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
130538214  [KO:K06274]
130538229  [KO:K06786]
130538298  arhgef18a; rho guanine nucleotide exchange factor 18a isoform X1 [KO:K21066]
130538313  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
130538327  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
130538339  [KO:K12076]
130538358  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
130538377  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
130538505  cldn18; claudin-18 isoform X1 [KO:K06087]
130538517  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
130538573  amotl2b; angiomotin-like protein 2b [KO:K06104]
130538624  [KO:K04237]
130538817  [KO:K07901]
130538932  [KO:K04448]
130539006  [KO:K13365]
130539172  cldn15la; claudin 15-like a [KO:K06087]
130539219  cldn1; claudin-1 [KO:K06087]
130539311  [KO:K05754]
130539422  [KO:K07200]
130539508  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
130539555  [KO:K05719]
130539651  pals1a; protein PALS1 [KO:K06091]
130539701  [KO:K07374]
130539781  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
130539864  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
130540269  [KO:K07374]
130540340  cldn11a; claudin-11a [KO:K06087]
130540347  [KO:K06087]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
tfs04520  Adherens junction
tfs04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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