KEGG   PATHWAY: tpai04350
Entry
tpai04350                   Pathway                                
Name
TGF-beta signaling pathway - Tympanuchus pallidicinctus (lesser prairie-chicken)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
tpai04350  TGF-beta signaling pathway
tpai04350

Other DBs
GO: 0007179
Organism
Tympanuchus pallidicinctus (lesser prairie-chicken) [GN:tpai]
Gene
128071628  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
128072204  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
128072397  TMEM53; transmembrane protein 53 [KO:K28359]
128073176  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
128073404  DCN; decorin [KO:K04660]
128073421  IFNG; interferon gamma [KO:K04687]
128073610  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
128073950  LEMD3; inner nuclear membrane protein Man1 isoform X1 [KO:K19410]
128074252  [KO:K04501]
128074324  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
128074328  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
128074415  FST; follistatin isoform X1 [KO:K04661]
128074835  SMAD9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
128074897  LRRC32; transforming growth factor beta activator LRRC32 [KO:K26316]
128075232  THSD4; thrombospondin type-1 domain-containing protein 4 [KO:K23377]
128075233  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
128075308  FBN1; fibrillin-1 isoform X1 [KO:K06825]
128075448  NEO1; neogenin isoform X1 [KO:K06766]
128075477  BMP2; bone morphogenetic protein 2 [KO:K21283]
128075506  RGMA; repulsive guidance molecule A [KO:K23096]
128075633  SMAD6; mothers against decapentaplegic homolog 6 [KO:K04677]
128075634  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
128076074  [KO:K26316]
128076915  [KO:K04388] [EC:2.7.11.30]
128076923  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
128077003  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
128077078  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
128077291  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
128077330  INHBB; inhibin beta B chain [KO:K22687]
128077468  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
128077564  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
128077695  [KO:K21283]
128078777  RHOA; transforming protein RhoA [KO:K04513]
128078806  [KO:K04677]
128078936  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
128078939  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
128079067  [KO:K04658]
128079383  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
128080184  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
128080407  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
128080909  TGIF2; homeobox protein TGIF2 isoform X1 [KO:K19553]
128080934  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
128080972  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
128081025  BMP7; bone morphogenetic protein 7 [KO:K16621]
128081082  GDF5; growth/differentiation factor 5 [KO:K04664]
128081093  LTBP1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
128081780  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
128081835  CHRD; chordin isoform X1 [KO:K04657]
128082007  [KO:K14736]
128082128  NRROS; transforming growth factor beta activator LRRC33 [KO:K26317]
128082175  SKIL; ski-like protein [KO:K18499]
128082218  E2F4; transcription factor E2F4 [KO:K04682]
128082454  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
128082606  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
128083007  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
128083296  NOG; noggin [KO:K04658]
128083440  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
128083528  GDF7; growth/differentiation factor 7 [KO:K20013]
128083585  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
128083845  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
128083942  SMAD5; mothers against decapentaplegic homolog 5 [KO:K16790]
128083975  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
128084233  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
128084585  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128084855  SKI; ski oncogene isoform X1 [KO:K26503]
128084997  NBL1; neuroblastoma suppressor of tumorigenicity 1 isoform X1 [KO:K19558]
128085557  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
128086467  BAMBI; BMP and activin membrane-bound inhibitor homolog isoform X1 [KO:K10162]
128086613  THBS1; thrombospondin-1 [KO:K16857]
128086653  GREM1; gremlin-1 [KO:K23318]
128086785  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
128086877  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
128086966  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
128087220  BMP4; bone morphogenetic protein 4 [KO:K04662]
128087775  CUL1; cullin-1 isoform X1 [KO:K03347]
128087782  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
128087892  ID4; DNA-binding protein inhibitor ID-4 isoform X1 [KO:K17695]
128087911  BMP6; bone morphogenetic protein 6 [KO:K16620]
128088046  FMOD; fibromodulin [KO:K08121]
128088338  [KO:K16622]
128088402  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
128088443  INHBA; inhibin beta A chain isoform X1 [KO:K04667]
128088516  ID3; LOW QUALITY PROTEIN: DNA-binding protein inhibitor ID-3 [KO:K17694]
128089299  ZFYVE16; LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 16 [KO:K04679]
128089594  RGMB; repulsive guidance molecule B isoform X1 [KO:K06847]
128089766  [KO:K04685]
128089960  GREM2; gremlin-2 [KO:K23318]
128089989  NODAL; nodal homolog [KO:K04666]
128090376  AMH; muellerian-inhibiting factor [KO:K04665]
128090506  [KO:K22689]
128090507  [KO:K22688]
128090580  [KO:K04501]
128090727  E2F5; transcription factor E2F5 [KO:K04682]
128090747  GDF6; growth/differentiation factor 6 [KO:K20012]
128090812  TGIF1; homeobox protein TGIF1 isoform X1 [KO:K19383]
128091426  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
128091562  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
tpai04010  MAPK signaling pathway
tpai04110  Cell cycle
tpai04120  Ubiquitin mediated proteolysis
tpai04210  Apoptosis
KO pathway
ko04350   

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