KEGG   PATHWAY: tpai04010
Entry
tpai04010                   Pathway                                
Name
MAPK signaling pathway - Tympanuchus pallidicinctus (lesser prairie-chicken)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
tpai04010  MAPK signaling pathway
tpai04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Tympanuchus pallidicinctus (lesser prairie-chicken) [GN:tpai]
Gene
128071797  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
128071805  [KO:K04386]
128071868  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
128072158  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
128072298  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
128072399  ARTN; artemin isoform X1 [KO:K25415]
128072448  JUN; transcription factor Jun [KO:K04448]
128072523  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
128072581  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
128072661  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
128072770  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
128072774  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
128072854  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
128073080  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
128073122  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
128073142  [KO:K04849]
128073173  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
128073209  [KO:K04441] [EC:2.7.11.24]
128073210  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
128073241  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
128073387  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
128073475  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
128073511  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
128073514  KITLG; kit ligand isoform X1 [KO:K05461]
128073537  IGF1; insulin-like growth factor I [KO:K05459]
128073578  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
128073584  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
128073589  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
128073591  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
128073655  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
128073796  PTPRR; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
128073883  RAP1B; ras-related protein Rap-1b [KO:K07836]
128074177  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
128074235  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
128074443  FGF10; fibroblast growth factor 10 [KO:K04358]
128074489  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
128074502  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
128074814  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
128074883  FGF9; fibroblast growth factor 9 [KO:K04358]
128074996  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
128074997  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
128075267  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
128075282  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
128075328  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
128075443  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
128075567  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
128075754  [KO:K05096] [EC:2.7.10.1]
128075775  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
128075914  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
128075925  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
128076008  FGF16; fibroblast growth factor 16 isoform X1 [KO:K04358]
128076240  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
128076303  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
128076448  VEGFD; vascular endothelial growth factor D [KO:K05449]
128076633  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
128076663  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
128076670  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
128076846  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
128076880  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
128076915  [KO:K04388] [EC:2.7.11.30]
128076995  MRAS; ras-related protein M-Ras [KO:K07831]
128077633  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
128077678  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
128077706  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
128077841  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128077909  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
128077983  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128078052  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
128078153  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
128078201  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
128078363  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128078381  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
128078384  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
128078544  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
128078545  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
128078635  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
128078774  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128078817  [KO:K04452]
128078918  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
128078963  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
128078993  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
128079041  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
128079133  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
128079172  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
128079308  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
128079400  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
128079548  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
128079558  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
128079775  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
128079870  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
128079938  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
128079966  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
128080113  FGF20; fibroblast growth factor 20 [KO:K04358]
128080125  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
128080166  VEGFC; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
128080206  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
128080230  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
128080248  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128080350  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
128080378  EREG; proepiregulin [KO:K09784]
128080422  AREG; amphiregulin [KO:K09782]
128080445  FGF2; fibroblast growth factor 2 [KO:K18497]
128080541  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
128080542  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
128080543  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
128080580  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
128080591  FGF5; fibroblast growth factor 5 [KO:K04358]
128080681  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
128080741  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
128080898  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
128080949  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
128081129  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
128081147  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
128081270  SRF; serum response factor isoform X1 [KO:K04378]
128081364  CD14; monocyte differentiation antigen CD14 [KO:K04391]
128081503  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
128081569  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
128081597  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
128081599  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
128081637  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
128081672  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
128081756  TRADD; LOW QUALITY PROTEIN: tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
128081780  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
128081918  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
128082135  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
128082295  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
128082674  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
128082766  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
128082822  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
128083026  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
128083050  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
128083108  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128083117  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
128083143  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
128083145  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
128083148  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
128083179  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
128083202  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
128083340  NF1; neurofibromin isoform X1 [KO:K08052]
128083403  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
128083625  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
128083633  HSPB1; heat shock protein beta-1 [KO:K04455]
128083660  CRK; adapter molecule crk isoform X1 [KO:K04438]
128083796  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
128083876  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
128083930  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
128084062  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
128084151  CRKL; crk-like protein [KO:K04438]
128084359  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
128084384  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
128084429  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128084480  NTF3; neurotrophin-3 [KO:K04356]
128084481  FGF23; fibroblast growth factor 23 [KO:K22428]
128084483  FGF6; fibroblast growth factor 6 [KO:K04358]
128084496  KRAS; GTPase KRas isoform X1 [KO:K07827]
128084585  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128084724  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
128085079  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
128085113  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
128085307  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
128085633  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
128085676  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
128085705  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
128085740  [KO:K16342] [EC:3.1.1.4]
128085743  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
128085777  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128085789  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
128085876  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128085982  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
128085996  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
128086102  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
128086352  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
128086364  HRAS; GTPase HRas [KO:K02833]
128086480  [KO:K16342] [EC:3.1.1.4]
128086481  [KO:K16342] [EC:3.1.1.4]
128086482  [KO:K16342] [EC:3.1.1.4]
128086510  FGF19; fibroblast growth factor 19 [KO:K22603]
128086511  FGF3; fibroblast growth factor 3 [KO:K04358]
128086513  FGF4; fibroblast growth factor 4 [KO:K04358]
128086622  INS; insulin [KO:K04526]
128086648  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
128086784  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128086814  IGF2; insulin-like growth factor II [KO:K13769]
128086826  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
128086858  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
128086877  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
128086966  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
128086968  FOS; protein c-Fos [KO:K04379]
128086972  PGF; placenta growth factor isoform X1 [KO:K16859]
128087044  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
128087126  MAX; protein max [KO:K04453]
128087173  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
128087323  [KO:K04421] [EC:2.7.11.25]
128087396  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
128087419  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
128087420  [KO:K16342] [EC:3.1.1.4]
128087421  [KO:K16342] [EC:3.1.1.4]
128087422  [KO:K16342] [EC:3.1.1.4]
128087642  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
128087681  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
128087782  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
128087895  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
128087957  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
128087993  NGF; beta-nerve growth factor [KO:K02582]
128088024  RAP1A; ras-related protein Rap-1A [KO:K04353]
128088076  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
128088187  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
128088218  NRAS; GTPase NRas [KO:K07828]
128088306  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
128088328  STMN1; stathmin isoform X1 [KO:K04381]
128088438  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
128088475  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
128088498  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
128088698  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
128088727  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
128088784  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
128088788  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
128088836  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
128088943  EFNA2; ephrin-A2 [KO:K05462]
128088947  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
128088984  JUND; transcription factor JunD [KO:K04449]
128089037  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
128089042  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
128089272  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
128089273  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
128089435  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
128089516  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
128089621  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
128089780  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
128089796  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
128089959  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
128090046  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
128090186  [KO:K04519]
128090190  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
128090271  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
128090273  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
128090290  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
128090314  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
128090350  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
128090367  NRTN; neurturin isoform X1 [KO:K25414]
128090440  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
128090447  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
128090579  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
128091367  STK3; serine/threonine-protein kinase 3 [KO:K04412]
128091493  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
128091562  MYC; myc proto-oncogene protein [KO:K04377]
128091763  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
128091773  DUSP3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
tpai04070  Phosphatidylinositol signaling system
tpai04110  Cell cycle
tpai04115  p53 signaling pathway
tpai04210  Apoptosis
tpai04310  Wnt signaling pathway
KO pathway
ko04010   

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