KEGG   PATHWAY: uah00830
Entry
uah00830                    Pathway                                
Name
Retinol metabolism - Ursus arctos (brown bear)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
uah00830  Retinol metabolism
uah00830

Other DBs
GO: 0006776
Organism
Ursus arctos (brown bear) [GN:uah]
Gene
113252529  BCO1; beta,beta-carotene 15,15'-dioxygenase [KO:K00515] [EC:1.13.11.63]
113263118  alcohol dehydrogenase E chain [KO:K13951] [EC:1.1.1.1]
113263120  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
113263121  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
113263119  ADH6; alcohol dehydrogenase 6 isoform X2 [KO:K13952] [EC:1.1.1.1]
113270489  DHRS3; short-chain dehydrogenase/reductase 3 isoform X1 [KO:K11146] [EC:1.1.1.300]
113246025  dehydrogenase/reductase SDR family member 4 isoform X2 [KO:K11147] [EC:1.1.-.-]
113250804  DHRS9; dehydrogenase/reductase SDR family member 9 [KO:K11149] [EC:1.1.-.-]
113242646  RDH8; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
113253048  RDH10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
113248305  RDH11; retinol dehydrogenase 11 [KO:K11152] [EC:1.1.1.300]
113248293  RDH12; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
113247404  RDH13; retinol dehydrogenase 13 [KO:K11161] [EC:1.1.1.300]
113256401  SDR9C7; short-chain dehydrogenase/reductase family 9C member 7 isoform X3 [KO:K11154] [EC:1.1.1.-]
113268084  SDR16C5; epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
113256406  HSD17B6; 17-beta-hydroxysteroid dehydrogenase type 6 isoform X3 [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
113255775  LRAT; lecithin retinol acyltransferase isoform X2 [KO:K00678] [EC:2.3.1.135]
113247638  DGAT1; diacylglycerol O-acyltransferase 1 isoform X1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
113245600  AWAT2; acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.75 2.3.1.76]
113240758  patatin-like phospholipase domain-containing protein 4 isoform X2 [KO:K11157] [EC:3.1.1.-]
130541805  PNPLA4; patatin-like phospholipase domain-containing protein 4 isoform X1 [KO:K11157] [EC:3.1.1.-]
113254543  RPE65; retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
113256460  RDH5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
113250605  aldehyde oxidase 2 isoform X2 [KO:K00157] [EC:1.2.3.1]
113250606  AOX1; aldehyde oxidase isoform X2 [KO:K00157] [EC:1.2.3.1]
113250607  aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
113269676  ALDH1A2; retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
113269854  aldehyde dehydrogenase 1A1 isoform X1 [KO:K07249] [EC:1.2.1.36]
113263632  ALDH1A3; aldehyde dehydrogenase family 1 member A3 [KO:K07249] [EC:1.2.1.36]
125282684  aldehyde dehydrogenase 1A1-like [KO:K07249] [EC:1.2.1.36]
130542350  ALDH1A1; aldehyde dehydrogenase 1A1 isoform X1 [KO:K07249] [EC:1.2.1.36]
113243079  cytochrome P450 26A1 [KO:K07437] [EC:1.14.14.-]
113244073  cytochrome P450 26B1 [KO:K12664] [EC:1.14.14.-]
113243078  cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
113240972  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
113240971  cytochrome P450 1A2 isoform X2 [KO:K07409] [EC:1.14.14.1]
113243545  cytochrome P450 2B11 [KO:K07412] [EC:1.14.14.1]
113243547  cytochrome P450 2B4-like isoform X1 [KO:K07412] [EC:1.14.14.1]
113251748  cytochrome P450 2C21 isoform X3 [KO:K07413] [EC:1.14.14.1]
113243099  cytochrome P450 2C41-like [KO:K07413] [EC:1.14.14.1]
125282749  cytochrome P450 2C41-like [KO:K07413] [EC:1.14.14.1]
113243544  cytochrome P450 2S1 [KO:K07420] [EC:1.14.14.1]
113267901  cytochrome P450 3A12-like isoform X1 [KO:K07424] [EC:1.14.14.1]
113267902  cytochrome P450 3A12-like [KO:K07424] [EC:1.14.14.1]
113249444  cytochrome P450 3A12 [KO:K07424] [EC:1.14.14.1]
113249757  cytochrome P450 3A12-like [KO:K07424] [EC:1.14.14.1]
113247722  cytochrome P450 2W1 [KO:K07423] [EC:1.14.14.-]
113249623  cytochrome P450 4A6 isoform X1 [KO:K07425] [EC:1.14.14.80]
130543466  cytochrome P450 4A6-like [KO:K07425] [EC:1.14.14.80]
130543468  cytochrome P450 4A6-like isoform X1 [KO:K07425] [EC:1.14.14.80]
130543470  cytochrome P450 4A6-like [KO:K07425] [EC:1.14.14.80]
125280889  cytochrome P450 4A6-like isoform X1 [KO:K07425] [EC:1.14.14.80]
113250325  UDP-glucuronosyltransferase 1A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
113262548  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
113262550  UDP-glucuronosyltransferase 2A2 isoform X2 [KO:K00699] [EC:2.4.1.17]
113262552  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
125283434  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
125280979  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125283091  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125283092  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125283435  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125283436  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125281344  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
130542426  UDP-glucuronosyltransferase 1A10-like [KO:K00699] [EC:2.4.1.17]
130542430  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
125283093  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
130543210  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
113243209  RETSAT; all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
113263376  cytochrome P450 27C1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
LinkDB

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