Network variation - Pancreatic cancer
[
Network menu
|
Network entry
|
Help
]
ENTRY
nt06262
Name
Pancreatic cancer
Category
Disease view; Cancer
Pathway
hsa05212
Pancreatic cancer
Disease
H00019
Pancreatic cancer
Display
drug-target relation
disease type
ERK signaling
N00216
HGF
→
MET
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00012
(
KRAS*
,
NRAS*
)
→
RAF
→
MEK
→
ERK
→
CCND1
Other RAS signaling
N00103
EGF
→
EGFR
→
GRB2
→
SOS
→
RAS
→
RALGDS
→
RAL
N00104
KRAS*
→
RALGDS
→
RAL
PI3K signaling
N00284
AREG
→
EGFR
→
PI3K
→
PIP3
→
AKT
→
MTOR
→
S6K
N00034
EGF
→
(
ERBB2*
+
EGFR
)
→
PI3K
→
PIP3
→
AKT
→
MTOR
→
S6K
N00218
FLT3LG
→
FLT3
→
GRB2
→
SOS
→
RAS
→
PI3K
→
PIP3
→
AKT
→
MTOR
N00032
(
KRAS*
,
NRAS*
)
→
PI3K
→
PIP3
→
AKT
⊣
BAD
JAK-STAT signaling
N00094
EGF
→
EGFR
→
JAK1
→
STAT1/3/5
N00095
EGF
→
(
ERBB2*
+
EGFR
)
→
JAK1
→
STAT1/3
⇒
VEGFA
Cell cycle
N00069
CDKN2A
⊣
(CCND+CDK4/6)
→
RB1
⌿
E2F
N00070
CDKN2A*
⌿
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00071
CDKN2A*
⌿
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
Transcription
N00115
TP53*
⌿
(
CDKN1A
,
GADD45
,
BAX..