KEGG    Network variation - Hormone/cytokine signaling
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ENTRYnt06325
NameHormone/cytokine signaling
CategoryPathway view; Endocrine system
Display drug-target relation   disease type
 D3,D4
 |
      
N00920    PRLPRLRJAK2STAT5
    HPRL   PRLR*
 
N01800    LEPLEPRJAK2STAT3/5
    LEPD LEP*
    LEPRD   LEPR*
 
N01788    ADIPOQADIPORAPPL1
    ADPOD ADIPOQ*
    MODY14     APPL1*
 
N01708    INSINSRIRSPI3K
    T1D2/MODY10/PNDM4 INS*
    DS/RMS/IRAN/HHF5   INSR*
    CHNG9     IRS4*
 
N01783    NPPANPR1cGMPPRKG1/2
    ATFB6/ATRST2 NPPA*
    ATT8       PRKG1*
    AMD4/SMDP       PRKG2*
N01787    NPPCNPR2cGMPPRKG1/2
    AMD1/SNSK   NPR2*
    ECDM   NPR2*
 
   D1,D2
 |
          
N00915    AVPAVPR2GNASADCY3/6/9cAMPPKAAQP2
    NPDI AVP*
    NSIAD   AVPR2*
 
N00879    PROK1/2PROKR1/2GNAIERK
    HH4 PROK2*
    HH3   PROKR2*
 
N01792    EDN1/2/3EDNRA/BGNAQ,GNA11
    ARCND3 EDN1*
    HSCR4/WS4B EDN3*
    MFDA   EDNRA*
    HSCR2/WS4A/ABCDS   EDNRB*
 
N01793    GALGALRGNAO1,GNAI,GNA11/1..
    ETL8 GAL*
 
N01794    HCRTHCRTR1/2GNAQ,GNA11/14/15,G..
    NRCLP1 HCRT*
 
N01823    FGF23(FGFR1+KL)ERKSGK1WNK1/4NCC(Na+,CL-)(cyto)
N01824          SGK1(NHERF1+NPT)(Na+,Pi)(cyto)
    ADHR FGF23*
    HFTC2 FGF23*
    HFTC3   KL*
    PHA2C         WNK1*
    HSAN2A         WNK1*
    PHA2B         WNK4*
    NPHLOP2         NHERF1*
    NPHLOP1/FRTS2/HCINF2         SLC34A1*
    HHRH         SLC34A3*
    GTLMNS           SLC12A3*

Disease nameDisease category
HPRLH01388HyperprolactinemiaEndocrine and metabolic disease
LEPDH02059Leptin deficiencyEndocrine and metabolic disease
LEPRDH02060Leptin receptor deficiencyEndocrine and metabolic disease
ADPODH00967Adiponectin deficiencyInherited metabolic disorder
MODY14H00410Maturity onset diabetes of the young (MODY)Endocrine and metabolic disease
T1D2/MODY10/PNDM4H00408Type 1 diabetes mellitusMetabolic disease
H00410Maturity onset diabetes of the young (MODY)Endocrine and metabolic disease
H00512Permanent neonatal diabetes mellitusEndocrine and metabolic disease
DS/RMS/IRAN/HHF5H00719LeprechaunismEndocrine and metabolic disease
H00942Rabson-Mendenhall syndromeEndocrine and metabolic disease
H01228Insulin-resistant diabetes mellitus with acanthosis nigricansMetabolic disease
H01267Familial hyperinsulinemic hypoglycemiaInherited metabolic disorder
CHNG9H00250Congenital nongoitrous hypothyroidism (CHNG)Endocrine and metabolic disease
ATFB6/ATRST2H00731Atrial fibrillationCardiovascular disease
H02674Atrial standstillCardiovascular disease
ATT8H00801Familial thoracic aortic aneurysm and dissectionCardiovascular disease
AMD4/SMDPH02543Acromesomelic dysplasiaCongenital malformation
H02185Spondylometaphyseal dysplasiaCongenital malformation
AMD1/SNSKH02543Acromesomelic dysplasiaCongenital malformation
H02681Short stature with nonspecific skeletal abnormalitiesCongenital malformation
ECDMH02679Miura-type epiphyseal chondrodysplasiaCongenital malformation
NPDIH00253Neurohypophyseal diabetes insipidusEndocrine and metabolic disease
NSIADH01294Nephrogenic syndrome of inappropriate antidiuresisEndocrine and metabolic disease
HH4H00255Hypogonadotropic hypogonadismEndocrine and metabolic disease
HH3H00255Hypogonadotropic hypogonadismEndocrine and metabolic disease
ARCND3H01884Auriculocondylar syndromeCongenital malformation
HSCR4/WS4BH00910Hirschsprung diseaseCongenital malformation
H00759Waardenburg syndromeInherited metabolic disorder
MFDAH02126Mandibulofacial dysostosis with alopeciaCongenital malformation
HSCR2/WS4A/ABCDSH00910Hirschsprung diseaseCongenital malformation
H00759Waardenburg syndromeInherited metabolic disorder
H00823ABCD syndromeCongenital malformation
ETL8H00809Familial epilepsy temporal lobe (ETL)Nervous system disease
NRCLP1H01293NarcolepsyNervous system disease
ADHRH00214Hypophosphatemic ricketsInherited metabolic disorder
HFTC2H01193Familial tumoral calcinosisInherited metabolic disorder
HFTC3H01193Familial tumoral calcinosisInherited metabolic disorder
PHA2CH00243Hyperkalemic distal renal tubular acidosis (RTA type 4)Urinary system disease
HSAN2AH00265Hereditary sensory and autonomic neuropathyNervous system disease
PHA2BH00243Hyperkalemic distal renal tubular acidosis (RTA type 4)Urinary system disease
NPHLOP2H00888Nephrolithiasis/osteoporosis, hypophosphatemicUrinary system disease
NPHLOP1/FRTS2/HCINF2H00888Nephrolithiasis/osteoporosis, hypophosphatemicUrinary system disease
H01198Fanconi renotubular syndromeInherited metabolic disorder
H01371Hypercalcemia infantileInherited metabolic disorder
HHRHH00214Hypophosphatemic ricketsInherited metabolic disorder
GTLMNSH00240Gitelman syndromeEndocrine and metabolic disease


Drug name
D1D00101Vasopressin (JP18/USP)
D2D02235Desmopressin acetate (USP)
D3D00780Bromocriptine mesylate (USP)
D4D00987Cabergoline (JP18/USP/INN)