KEGG    Network variation - Ferroptosis
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ENTRYnt06525
NameFerroptosis
CategoryPathway view; Cellular process
Pathwayhsa04216 Ferroptosis
Display drug-target relation   disease type
N01589    Cys+Glu−(GCLC+GCLM)⇉GSS→GSH−GPX→GSSG
    GCSD   GCLC*
    GCSD/GSD     GSS*
    SMDS         GPX4*
N01590    AA+CoA−ACSL4⇉LPCAT3⇉ALOX15→PE-AA-O-OH
    XLID   ACSL4*
 
N01587    Fe2+−CP→Fe3+−(TF+TFR1)→Fe3+(endosome)−STEAP3→Fe2+−(DMT1,ZIP8/14)→Fe2+
    ACP   CP*
    Atransferrinemia       TF*
    AHMIO2           STEAP3*
    AHMIO1               SLC11A2*
    HMNDYT2               SLC39A14*
N01591    (Fe2++PCBP2)−Ferroportin→Fe2+(extracellular..
    HFE4   SLC40A1*
N01588    ATG5/7→NCOA4−(Fe3++(FTH1+FTL))
    HFE5     FTH1*
    NBIA9     FTH1*↗
    NBIA3/NF     FTL*↗

Disease nameDisease category
GCSDH00668Anemia due to disorders of glutathione metabolismHematologic disease
GCSD/GSDH00668Anemia due to disorders of glutathione metabolismHematologic disease
H02312Glutathione synthetase deficiencyInherited metabolic disorder
SMDSH01825Spondylometaphyseal dysplasia, Sedaghatian typeCongenital malformation
XLIDH00480X-linked intellectual developmental disorderMental and behavioural disorder
ACPH02206AceruloplasminemiaNervous system disease
AtransferrinemiaH01145AtransferrinemiaCardiovascular disease
AHMIO2H01196Hypochromic microcytic anemiaHematologic disease
AHMIO1H01196Hypochromic microcytic anemiaHematologic disease
HMNDYT2H01938Hypermanganesemia with dystoniaHematologic disease
HFE4H00211HemochromatosisInherited metabolic disorder
HFE5H00211HemochromatosisInherited metabolic disorder
NBIA9H00833Neurodegeneration with brain iron accumulationNervous system disease
NBIA3/NFH00833Neurodegeneration with brain iron accumulationNervous system disease