KEGG    Network variation - MAPK signaling
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ENTRYnt06526
NameMAPK signaling
CategoryPathway view; Signal transduction
Pathwayhsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
DiseaseH00523 Noonan syndrome and related disorders
H02541 Juvenile myelomonocytic leukemia
Display drug-target relation   disease type
N01592    GFRTKGRB2SOSRASRAFMEKERK
    Many cancers GF*
    Many cancers   RTK*
    Many cancers         RAS*
    Many cancers           BRAF*
    HH6 FGF8*
    HH20 FGF17*
    IMD125 FLT3LG*
    HH2   FGFR1*
    Pfeiffer/JWS   FGFR1*
    Pfeiffer/Apert/CS/JWS/BSTVS/SCS/ABS   FGFR2*
    CS/Muenke   FGFR3*
    PGS/MTC   RET*
    HSCR1   RET*
    NS4/GINGF1       SOS1*
    NS9       SOS2*
    CS         HRAS*
    NS3/JMML/MTC/CFC2         KRAS*
    NS11         MRAS*
    NS6/JMML         NRAS*
    NS12         RRAS2*
    NS7/CFC1/LPRD3           BRAF*
    NS5/LPRD2           RAF1*
    CFC3/MEL             MAP2K1*
    CFC4             MAP2K2*
    NS13               MAPK1*
N01599    CBLRTK
    JMML/CBL CBL*
N01595        (PTPN11,SHC,GAB,GR..SOS
    NS1/JMML/LPRD1     PTPN11*
N01596          (LZTR1+CUL3)(RAS,RIT1)
    NS10       LZTR1*
    NS8         RIT1*
N01597          (SPRED+NF1)RAS
    LS       SPRED1*
    JMML/NF1/PGS/NFNS/WTSN       NF1*
N01600          RasGAPRAS
    CMAVM1/PWS       RASA1*
N01598            (MRAS+SHOC2+PP1)RAF
    NSLH1         SHOC2*
    NSLH2         PPP1CB*
N01593                (PTP,MKP)(ERK,JNK,MAPK14)
    HH19             DUSP6*
N01601                  ERKRSK
    CLS                 RPS6KA3*
N01602                  ERK(MAX+MYC)
    PGS                 MAX*
 
N01594    MLKMKK4/7JNK
    SFMMP MAP3K20*
 
N00542    EGFEGFRGRB2SOSRASMEKK1MKK4JNK
N00186    IL1IL1RMYD88IRAK1/4TRAF6TAB1/2/3TAK1MKK3/6MAPK14MK2TTP
N00188    IL1IL1RMYD88IRAK1/4TRAF6TAB1/2/3TAK1MKK4/7JNKAP1

Disease nameDisease category
HH6H00255Hypogonadotropic hypogonadismEndocrine and metabolic disease
HH20H00255Hypogonadotropic hypogonadismEndocrine and metabolic disease
IMD125H01725Primary immunodeficiency diseaseImmune system disease
HH2H00255Hypogonadotropic hypogonadismEndocrine and metabolic disease
Pfeiffer/JWSH01756Pfeiffer syndromeCongenital malformation
H01988Jackson-Weiss syndromeCongenital malformation
Pfeiffer/Apert/CS/JWS/BSTVS/SCS/ABSH01756Pfeiffer syndromeCongenital malformation
H01755Apert syndromeCongenital malformation
H01754Crouzon syndromeCongenital malformation
H01988Jackson-Weiss syndromeCongenital malformation
H01989Beare-Stevenson syndromeCongenital malformation
H01991Saethre-Chotzen syndromeCongenital malformation
H01753Antley-Bixler syndromeCongenital malformation
CS/MuenkeH01754Crouzon syndromeCongenital malformation
H01990Muenke syndromeCongenital malformation
PGS/MTCH01510Malignant paragangliomaCancer
H01592Medullary thyroid cancerCancer
HSCR1H00910Hirschsprung diseaseCongenital malformation
NS4/GINGF1H01738Noonan syndromeCongenital malformation
H01250Hereditary gingival fibromatosisDigestive system disease
NS9H01738Noonan syndromeCongenital malformation
CSH01747Costello syndromeCongenital malformation
NS3/JMML/MTC/CFC2H01738Noonan syndromeCongenital malformation
H02541Juvenile myelomonocytic leukemiaCancer
H01592Medullary thyroid cancerCancer
H01745Cardiofaciocutaneous syndromeCongenital malformation
NS11H01738Noonan syndromeCongenital malformation
NS6/JMMLH01738Noonan syndromeCongenital malformation
H02541Juvenile myelomonocytic leukemiaCancer
NS12H01738Noonan syndromeCongenital malformation
NS7/CFC1/LPRD3H01738Noonan syndromeCongenital malformation
H01745Cardiofaciocutaneous syndromeCongenital malformation
H01984Leopard syndromeCongenital malformation
NS5/LPRD2H01738Noonan syndromeCongenital malformation
H01984Leopard syndromeCongenital malformation
CFC3/MELH01745Cardiofaciocutaneous syndromeCongenital malformation
H02631MelorheostosisMusculoskeletal disease
CFC4H01745Cardiofaciocutaneous syndromeCongenital malformation
NS13H01738Noonan syndromeCongenital malformation
JMML/CBLH02541Juvenile myelomonocytic leukemiaCancer
H02190CBL syndromeCongenital malformation
NS1/JMML/LPRD1H01738Noonan syndromeCongenital malformation
H02541Juvenile myelomonocytic leukemiaCancer
H01984Leopard syndromeCongenital malformation
NS10H01738Noonan syndromeCongenital malformation
NS8H01738Noonan syndromeCongenital malformation
LSH01986Legius syndromeCongenital malformation
JMML/NF1/PGS/NFNS/WTSNH02541Juvenile myelomonocytic leukemiaCancer
H01437Neurofibromatosis type 1Congenital malformation
H01510Malignant paragangliomaCancer
H02189Neurofibromatosis-Noonan syndromeCongenital malformation
H02188Watson syndromeCongenital malformation
CMAVM1/PWSH02043Capillary malformation-arteriovenous malformationCongenital malformation
H00532Parkes Weber syndromeCongenital malformation
NSLH1H02191Noonan-like syndrome with loose anagen hairCongenital malformation
NSLH2H02191Noonan-like syndrome with loose anagen hairCongenital malformation
HH19H00255Hypogonadotropic hypogonadismEndocrine and metabolic disease
CLSH00574Coffin-Lowry syndromeCongenital malformation
PGSH01510Malignant paragangliomaCancer
SFMMPH00471Split-hand/foot malformationCongenital malformation