KEGG ORTHOLOGY: K10896

ORTHOLOGY: K10896

Entry

K10896                      KO

Symbol

FANCM

Name

fanconi anemia group M protein

Pathway

map03460

Fanconi anemia pathway

Disease

H00238

Fanconi anemia

H00627

Premature ovarian failure

H01282

Spermatogenic failure

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03460 Fanconi anemia pathway
    K10896  FANCM; fanconi anemia group M protein
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K10896  FANCM; fanconi anemia group M protein
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  DSBR (double strand breaks repair)
   FA (Fanconi anemia) pathway
    FA core complex
     K10896  FANCM; fanconi anemia group M protein

Genes

HSA:	57697(FANCM)

PTR:	452885(FANCM)

PPS:	100988683(FANCM)

GGO:	101153685(FANCM)

PON:	100453260(FANCM)

NLE:	100584150(FANCM)

HMH:	116484723(FANCM)

MCC:	702513(FANCM)

MCF:	102119275(FANCM)

MTHB:

126957874

MNI:	105481893(FANCM)

CSAB:

103228909(FANCM)

CATY:

105598174(FANCM)

PANU:

101020933(FANCM)

TGE:	112629048(FANCM)

MLEU:

105551084(FANCM)

RRO:	104682586(FANCM)

RBB:	108537060(FANCM)

TFN:	117069696(FANCM)

PTEH:

111549508(FANCM)

CANG:

105515286(FANCM)

CJC:	100397303(FANCM)

SBQ:	101028397(FANCM)

CIMI:

108290121(FANCM)

CSYR:

103276017(FANCM)

MMUR:

105881217(FANCM)

LCAT:

123649708(FANCM)

PCOQ:

105809203(FANCM)

OGA:	100948521(FANCM)

MMU:	104806(Fancm)

MCAL:

110307393(Fancm)

MPAH:

110324038(Fancm)

MCOC:

116079662(Fancm)

CGE:	100768967(Fancm)

MAUA:

101844734(Fancm)

PROB:

127230632(Fancm)

PLEU:

114684374(Fancm)

MORG:

121452569(Fancm)

MFOT:

126493709

AAMP:

119818943(Fancm)

NGI:	103751929(Fancm)

HGL:	101713730(Fancm)

CPOC:

100715324(Fancm)

CCAN:

109697840(Fancm)

DORD:

105982579(Fancm)

DSP:	122106552(Fancm)

PLOP:

125362879

NCAR:

124976885

MMMA:

107146851(Fancm)

OCU:

100354209

OPI:	101527300(FANCM)

TUP:	102499114(FANCM)

GVR:	103587247(FANCM)

CFA:	480307(FANCM)

CLUD:

112657593(FANCM)

VVP:	112921475(FANCM)

VLG:	121493445(FANCM)

NPO:	129499571(FANCM)

AML:	100471058(FANCM)

UMR:	103665654(FANCM)

UAH:	113266177(FANCM)

UAR:	123793500(FANCM)

LLV:

125104074

MPUF:

101691988(FANCM)

MNP:	131999917(FANCM)

MLK:	131836516(FANCM)

NVS:	122893295(FANCM)

ORO:	101376111(FANCM)

EJU:	114208736(FANCM)

ZCA:	113908520(FANCM)

MLX:	118002193(FANCM)

LWW:	102734110(FANCM)

FCA:	101086570(FANCM)

PYU:	121031712(FANCM)

PBG:	122469042(FANCM)

PVIV:

125168628(FANCM)

LRUF:

124508935

PTG:	102954921(FANCM)

PPAD:

109268528(FANCM)

PUC:

125909542

AJU:

106975093

HHV:	120248954(FANCM)

BTA:	513626(FANCM)

BOM:	102278142(FANCM)

BIU:	109575366(FANCM)

BBUB:

102407395(FANCM)

BBIS:

104985781(FANCM)

CHX:	102179326(FANCM)

OAS:	101106113(FANCM)

BTAX:

128066822(FANCM)

ODA:	120875028(FANCM)

CCAD:

122455094(FANCM)

MBEZ:

129550557(FANCM)

SSC:	100155917(FANCM)

CFR:	102518664(FANCM)

CBAI:

105078451(FANCM)

CDK:	105086459(FANCM)

VPC:	102535556(FANCM)

BACU:

103007875(FANCM)

BMUS:

118890348(FANCM)

LVE:	103070968(FANCM)

OOR:	101278559(FANCM)

DLE:	111173198(FANCM)

PCAD:

102977098(FANCM)

PSIU:

116748679(FANCM)

NASI:

112398721(FANCM)

ECB:	100063761(FANCM)

EPZ:	103560703(FANCM)

EAI:	106827708(FANCM)

MYB:	102251343(FANCM)

MYD:	102764229(FANCM)

MMYO:

118674848(FANCM)

MLF:	102430215(FANCM)

PKL:	118730238(FANCM)

EFUS:

103304100(FANCM)

MNA:	107540573(FANCM)

DRO:

112316992

SHON:

118987813(FANCM)

AJM:	119058815(FANCM)

PDIC:

114491724(FANCM)

PHAS:

123825189(FANCM)

MMF:	118639666(FANCM)

PPAM:

129073867

HAI:	109371998(FANCM)

RFQ:	117024172(FANCM)

PALE:

102886782(FANCM)

PGIG:

120597797(FANCM)

MJV:	108396570(FANCM)

TOD:	119239049(FANCM)

SARA:

105943137

SETR:

126001135(FANCM)

LAV:	100672225(FANCM)

TMU:

101343731

ETF:	101662940(FANCM)

DNM:	101444879(FANCM)

MDO:	100025437(FANCM)

GAS:	123235832(FANCM)

SHR:	100927042(FANCM)

AFZ:

127549550

PCW:	110208388(FANCM)

OAA:	100084161(FANCM)

GGA:	100857997(FANCM)

PCOC:

116234612(FANCM)

MGP:	100544656(FANCM)

CJO:	107315485(FANCM)

TPAI:

128087169(FANCM)

LMUT:

125695061(FANCM)

NMEL:

110401678(FANCM)

APLA:

101804655(FANCM)

ACYG:

106047771(FANCM)

CATA:

118250399(FANCM)

AFUL:

116489442(FANCM)

TGU:	100226778(FANCM)

LSR:	110473483(FANCM)

PMOA:

120497076(FANCM)

OTC:	121339052(FANCM)

PRUF:

121348699(FANCM)

FAB:	101806820(FANCM)

OMA:	130254343(FANCM)

PHI:	102104896(FANCM)

PMAJ:

107205393(FANCM)

CCAE:

111929509(FANCM)

CCW:	104695916(FANCM)

CBRC:

103618919(FANCM)

ETL:	114069133(FANCM)

ZAB:	102069734(FANCM)

ACHL:

103806235(FANCM)

SVG:	106858935(FANCM)

HRT:	120754552(FANCM)

FPG:	101924413(FANCM)

FCH:	102059127(FANCM)

CLV:	102089824(FANCM)

EGZ:	104131708(FANCM)

NNI:	104019501(FANCM)

PCRI:

104032630(FANCM)

PLET:

104628240(FANCM)

PCAO:

104045167(FANCM)

ACUN:

113480375(FANCM)

TALA:

104368566(FANCM)

PADL:

103914910(FANCM)

AFOR:

103907700(FANCM)

ACHC:

115338659(FANCM)

HALD:

104325100(FANCM)

HLE:	104839514(FANCM)

AGEN:

126050506

GCL:

127016758

CCRI:

104161749(FANCM)

CSTI:

104554486(FANCM)

CMAC:

104476185

MUI:	104541839(FANCM)

FGA:	104077803(FANCM)

LDI:

104341269

OHA:	104337438(FANCM)

NNT:	104406143(FANCM)

SHAB:

115607536(FANCM)

DPUB:

104297297(FANCM)

PGUU:

104472127(FANCM)

ACAR:

104529834

CPEA:

104391857(FANCM)

CVF:	104294328(FANCM)

RTD:	128908372(FANCM)

CUCA:

104059607(FANCM)

TEO:	104373091(FANCM)

BRHI:

104490035(FANCM)

AROW:

112961205(FANCM)

NPD:	112957770(FANCM)

DNE:	112994083(FANCM)

SCAM:

104145446(FANCM)

ASN:	102380413(FANCM)

AMJ:	102564352(FANCM)

CPOO:

109324577(FANCM)

GGN:	109288596(FANCM)

PSS:	102448405(FANCM)

CMY:	102940185(FANCM)

CCAY:

125638214(FANCM)

DCC:	119857396(FANCM)

CPIC:

101943242(FANCM)

TST:	117876155(FANCM)

CABI:

116818613

MRV:	120403928(FANCM)

ACS:	103279881(fancm)

ASAO:

132762163(FANCM)

PVT:	110091046(FANCM)

SUND:

121919335(FANCM)

PMUR:

107290155(FANCM)

CTIG:

120314988(FANCM)

TSR:	106543839(FANCM)

PGUT:

117674999

APRI:

131188126(FANCM)

PTEX:

113435159(FANCM)

NSS:	113414147(FANCM)

VKO:	123026543(FANCM)

PRAF:

128410174(FANCM)

ZVI:	118094815(FANCM)

HCG:	128332896(FANCM)

GJA:	107123405(FANCM)

EMC:	129324453(FANCM)

XLA:	100286772(fancm.L)

XTR:	100494932(fancm)

NPR:	108797909(FANCM)

RTEM:

120920343(FANCM)

BBUF:

120981711(FANCM)

BGAR:

122921566(FANCM)

MUO:	115477175(FANCM)

GSH:	117363593(FANCM)

DRE:	100006685(fancm)

SRX:	107719692(fancm)

SANH:

107687205(fancm)

SGH:	107568489(fancm)

CAUA:

113080962 113094963

CGIB:

127976790

PTET:

122334497(fancm)

LROH:

127179398(fancm)

OMC:	131523637(fancm)

PPRM:

120477694(fancm)

RKG:	130071820(fancm)

MAMB:

125269206(fancm)

CIDE:

127498158 127498501

MASI:

127455159

TROS:

130560187(fancm)

TDW:	130436641(fancm)

MANU:

129417008(fancm)

IPU:

108269866

IFU:	128612341(fancm)

PHYP:

113533929(fancm)

SMEO:

124390183(fancm)

TFD:	113651228(fancm)

TVC:	132852867(fancm)

AMEX:

103045299(fancm)

CMAO:

118823323(fancm)

EEE:

113567581

CHAR:

105908171(fancm)

TRU:	101070270(fancm)

TFS:	130513235(fancm)

TNG:	GSTEN00032103G001

LCO:	104940415(fancm)

NCC:

104955675

TBEN:

117479400(fancm)

CGOB:

115027641(fancm)

PGEO:

117467430(fancm)

GACU:

117556415(fancm)

EMAC:

134881336(fancm)

ELY:	117267351(fancm)

EFO:	125900426(fancm)

PLEP:

121953557(fancm)

SLUC:

116037711(fancm)

ECRA:

117936224(fancm)

ESP:	116670269(fancm)

PFLV:

114547341(fancm)

GAT:	120832712(fancm)

PPUG:

119227642(fancm)

AFB:	129104006(fancm)

CLUM:

117751406(fancm)

PSWI:

130191208(fancm)

MSAM:

119910054(fancm)

SCHU:

122862333(fancm)

CUD:	121526135(fancm)

ALAT:

119004360(fancm)

MZE:	101479658(fancm)

ONL:	100693459(fancm)

OAU:	116334790(fancm)

OLA:	101171121(fancm)

OML:	112137588(fancm)

CSAI:

133462785(fancm)

XMA:	102226650(fancm)

XCO:	114134554(fancm)

XHE:	116709357(fancm)

PRET:

103458841(fancm)

PFOR:

103144212(fancm)

PLAI:

106962737(fancm)

PMEI:

106915680(fancm)

GAF:	122845705(fancm)

PPRL:

129374641(fancm)

CVG:	107088066(fancm)

CTUL:

119778799(fancm)

GMU:	124855245(fancm)

NFU:	107392037(fancm)

KMR:	108234629(fancm)

ALIM:

106522259(fancm)

NWH:	119427690(fancm)

AOCE:

111586009(fancm)

MCEP:

125023558(fancm)

CSEM:

103377868(fancm)

SSEN:

122782969(fancm)

HHIP:

117756052(fancm)

HSP:	118116688(fancm)

SMAU:

118285890(fancm)

LCF:

108874912

SDU:	111225867(fancm)

SLAL:

111649835(fancm)

XGL:	120795295(fancm)

HCQ:	109526736(fancm)

SSCV:

125980469

SBIA:

133513009(fancm)

PEE:	133413008(fancm)

PTAO:

133488174(fancm)

BPEC:

110155436(fancm)

MALB:

109955122(fancm)

BSPL:

114848808(fancm)

SJO:	128374924(fancm)

SASA:

106610649(fancm)

STRU:

115162594(fancm)

OTW:	112256445(fancm)

OMY:	110505258(fancm)

OGO:	124046252(fancm)

ONE:	115138275(fancm)

OKI:	109878127(fancm)

OKE:	118368542(fancm)

SALP:

112080452(fancm)

SNH:	120023612(fancm)

CCLU:

121545137(fancm)

ELS:	105016002(fancm)

SFM:	108941450(fancm)

PKI:	111852479(fancm)

AANG:

118227432(fancm)

LOC:	102694611(fancm)

PSPA:

121324113(fancm)

ARUT:

117410622 117422574

PSEX:

120518531(fancm)

LCM:	102366771(FANCM)

CMK:	103185355(fancm)

RTP:

109928837

CPLA:

122553493(fancm)

HOC:	132818351(fancm)

LERI:

129700143(fancm)

PMRN:

116948372(FANCM)

LRJ:	133352815(FANCM)

BFO:

BBEL:

SCLV:

SPU:

LPIC:

APLC:

AJC:

DME:	Dmel_CG7922(Fancm)

DER:

6553406

DSE:

6614342

DSI:	Dsimw501_GD19428(Dsim_GD19428)

DYA:	Dyak_GE11154 Dyak_GE25739

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16508 Dmoj_GI18468

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:	101889475 131806398

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AAG:

AALB:

CQU:	CpipJ_CPIJ020191

CPII:

CNS:

BCOO:

SOY:

CSET:

AGB:

LDC:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

BANY:

PMAC:

PPOT:

PXU:

PRAP:

PNAP:

ZCE:

AAGE:

HAW:

HZE:

HHAL:

FOC:

TPAL:

CSEC:

DMK:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

EAF:

LSM:

DSV:

RSAN:

RMP:

VJA:

PTEP:

SDM:

LGI:	LOTGIDRAFT_127429

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OSN:

LAK:

NVE:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

ATH:	AT1G35530(FANCM)

ALY:

9327251

CRB:

17897201

CSAT:

104742059 104757860 104777475

EUS:	EUTSA_v10001810mg EUTSA_v10002370mg

BRP:

103868821

BNA:	106423789 106451832

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10000033mg

PVY:

MINC:

TCC:

GRA:

GHI:	107895100 107948805

GAB:

HSYR:

DZI:

EGR:

GMX:

GSJ:

PVU:	PHAVU_011G000500g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:	131628586 131643486

ADU:

107477607

AIP:

107629773

AHF:	112737441 112789513

LANG:

109363659

PCIN:

129313758

QSA:	O6P43_030010

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119286515 119295265

TAES:

123086669 123091290 123096268

TUA:

125550758

LPER:

127294162

LRD:	124696467 124696694

SBI:

ZMA:

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:	122009705 122014928

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

PPP:

OLU:	OSTLU_35638

MIS:	MICPUN_56202

CME:	CYME_CML313C

MBR:	MONBRDRAFT_30349

DDI:	DDB_G0274841

DFA:

DFA_04537

ACAN:

ACA1_376610

TET:	TTHERM_00535470

PTI:	PHATRDRAFT_47619

TPS:	THAPSDRAFT_264868

TVA:	TVAG_2v0877280

TKM:

POL:

MPT:

Reference

PMID:18285517

Authors

Xue Y, Li Y, Guo R, Ling C, Wang W

Title

FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair.

Journal

Hum Mol Genet 17:1641-52 (2008)
DOI:10.1093/hmg/ddn054

Sequence

[hsa:57697]

Reference

PMID:16116422

Authors

Meetei AR, Medhurst AL, Ling C, Xue Y, Singh TR, Bier P, Steltenpool J, Stone S, Dokal I, Mathew CG, Hoatlin M, Joenje H, de Winter JP, Wang W

Title

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.

Journal

Nat Genet 37:958-63 (2005)
DOI:10.1038/ng1626

Sequence

[hsa:57697]

Reference

PMID:20667794

Authors

Lestini R, Duan Z, Allers T

Title

The archaeal Xpf/Mus81/FANCM homolog Hef and the Holliday junction resolvase Hjc define alternative pathways that are essential for cell viability in Haloferax volcanii.

Journal

DNA Repair (Amst) 9:994-1002 (2010)
DOI:10.1016/j.dnarep.2010.06.012

LinkDB

DBGET integrated database retrieval system