KEGG   PATHWAY: lruf05200
Entry
lruf05200                   Pathway                                
Name
Pathways in cancer - Lynx rufus (bobcat)
Class
Human Diseases; Cancer: overview
Pathway map
lruf05200  Pathways in cancer
lruf05200

Organism
Lynx rufus (bobcat) [GN:lruf]
Gene
124517028  netrin receptor DCC [KO:K06765]
124520277  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
124514692  caspase-9-like [KO:K04399] [EC:3.4.22.62]
124524439  DCC-interacting protein 13-alpha [KO:K08733]
124510761  cadherin-1 [KO:K05689]
124510785  LOW QUALITY PROTEIN: cadherin-1-like [KO:K05689]
124526000  catenin beta-1 [KO:K02105]
124503525  catenin alpha-2 isoform X1 [KO:K05691]
124505812  catenin alpha-3 [KO:K05691]
124516204  catenin alpha-1 [KO:K05691]
124525491  axin-1 isoform X1 [KO:K02157]
124513498  axin-2 [KO:K04385]
124519809  adenomatous polyposis coli protein isoform X1 [KO:K02085]
124527684  adenomatous polyposis coli protein 2-like isoform X1 [KO:K02085]
124526728  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
124515627  transcription factor 7 isoform X1 [KO:K02620]
124503502  transcription factor 7-like 1 [KO:K04490]
124507146  transcription factor 7-like 2 isoform X1 [KO:K04491]
124520997  lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
124513356  baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731]
124507805  myc proto-oncogene protein [KO:K04377]
124506147  G1/S-specific cyclin-D1 [KO:K04503]
124501222  proto-oncogene Wnt-1 [KO:K03209]
124524767  protein Wnt-2 [KO:K00182]
124514758  protein Wnt-2b [KO:K00182]
124512838  proto-oncogene Wnt-3 [KO:K00312]
124520203  protein Wnt-3a [KO:K00312]
124514394  protein Wnt-4 [KO:K00408]
124524797  protein Wnt-5a [KO:K00444]
124502605  protein Wnt-5b [KO:K00444]
124514572  protein Wnt-6 [KO:K00445]
124501047  protein Wnt-7b [KO:K00572]
124522850  protein Wnt-7a [KO:K00572]
124506283  protein Wnt-8b [KO:K00714]
124509477  protein Wnt-8a [KO:K00714]
124512797  protein Wnt-9b [KO:K01064]
124520256  protein Wnt-9a [KO:K01064]
124514501  LOW QUALITY PROTEIN: protein Wnt-10a-like [KO:K01357]
124500979  protein Wnt-10b [KO:K01357]
124504623  protein Wnt-11 [KO:K01384]
124523223  protein Wnt-16 [KO:K01558]
124524898  frizzled-1 [KO:K02432]
124516209  frizzled-7 [KO:K02432]
124522257  frizzled-2 [KO:K02235]
124520701  frizzled-3 [KO:K02329]
124505762  frizzled-4 [KO:K02354]
124501774  LOW QUALITY PROTEIN: frizzled-8-like [KO:K02375]
124515634  frizzled-5 [KO:K02375]
124519080  frizzled-6 [KO:K02376]
124519329  frizzled-9 [KO:K02842]
124522028  frizzled-10 [KO:K02842]
124504910  low-density lipoprotein receptor-related protein 5 [KO:K03068]
124501748  low-density lipoprotein receptor-related protein 6 [KO:K03068]
124526346  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
124519481  segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
124514972  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
124507027  proto-oncogene FRAT1-like [KO:K03069]
124507028  GSK-3-binding protein FRAT2-like [KO:K03096]
124505518  prothrombin [KO:K01313] [EC:3.4.21.5]
124518614  angiotensinogen-like [KO:K09821]
124518259  proteinase-activated receptor 1-like [KO:K03914]
124523882  proteinase-activated receptor 4-like isoform X1 [KO:K04236]
124502841  lysophosphatidic acid receptor 1 [KO:K04289]
124524552  lysophosphatidic acid receptor 2 [KO:K04291]
124514634  lysophosphatidic acid receptor 3 [KO:K04294]
124509171  lysophosphatidic acid receptor 4 [KO:K04275]
124501374  lysophosphatidic acid receptor 5-like [KO:K08390]
124512258  lysophosphatidic acid receptor 6 [KO:K04273]
124526985  type-1 angiotensin II receptor [KO:K04166]
124519214  guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
124513497  guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
124504834  rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
124521741  rho guanine nucleotide exchange factor 11-like isoform X1 [KO:K12331]
124511074  rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
124515703  pleckstrin homology domain-containing family G member 5 isoform X1 [KO:K19464]
124523904  transforming protein RhoA [KO:K04513]
124517572  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
124504219  rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
124506687  stromal cell-derived factor 1 isoform X1 [KO:K10031]
124515642  C-X-C chemokine receptor type 4 [KO:K04189]
124514443  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
124523010  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
124524167  guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
124523241  prostaglandin E2 receptor EP1 subtype [KO:K04258]
124512192  prostaglandin E2 receptor EP2 subtype [KO:K04259]
124516345  prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
124522033  prostaglandin E2 receptor EP4 subtype [KO:K04261]
124503012  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
124503255  neuroendocrine secretory protein 55 [KO:K04632]
124524637  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
124508049  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
124503617  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
124508863  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
124526579  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
124501854  adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
124511307  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
124507481  adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
124517827  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
124514583  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
124524048  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
124514958  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
124519383  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
124502071  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
124527017  guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
124508581  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
124512197  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
124504777  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3-like [KO:K04540]
124504946  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
124518716  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
124514905  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
124524944  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
124510994  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
124503016  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
124523593  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
124516147  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
124523582  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
124525585  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
124522836  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
124513259  uncharacterized protein LOC124513259 isoform X1 [KO:K04549]
124513895  collagen alpha-5(IV) chain isoform X1 [KO:K06237]
124513959  collagen alpha-6(IV) chain-like [KO:K06237]
124515358  collagen alpha-4(IV) chain-like [KO:K06237]
124508764  collagen alpha-2(IV) chain [KO:K06237]
124516326  collagen alpha-3(IV) chain-like [KO:K06237]
124517053  collagen alpha-1(IV) chain [KO:K06237]
124519858  LOW QUALITY PROTEIN: laminin subunit alpha-1-like [KO:K05637]
124529086  laminin subunit alpha-2 [KO:K05637]
124503809  LOW QUALITY PROTEIN: laminin subunit alpha-5-like [KO:K06240]
124517646  laminin subunit alpha-3-like isoform X1 [KO:K06240]
124529047  laminin subunit alpha-4 isoform X1 [KO:K06241]
124524744  laminin subunit beta-1 [KO:K05636]
124524361  laminin subunit beta-2 [KO:K06243]
124510084  laminin subunit beta-3 isoform X1 [KO:K06244]
124524730  laminin subunit beta-4-like [KO:K06245]
124510147  laminin subunit gamma-1 [KO:K05635]
124510439  laminin subunit gamma-2 [KO:K06246]
124525641  laminin subunit gamma-3-like [KO:K06247]
124515423  fibronectin-like isoform X1 [KO:K05717]
124521689  integrin alpha-2 [KO:K06481]
124522131  integrin alpha-IIb-like [KO:K06476]
124513240  integrin alpha-3 [KO:K06482]
124516428  integrin alpha-6 isoform X1 [KO:K06485]
124515657  integrin alpha-V [KO:K06487]
124501220  integrin beta-1 [KO:K05719]
124507840  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
124525968  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
124527077  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
124514827  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
124517840  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
124514527  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
124523730  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
124518602  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
124520457  homeobox protein Nkx-3.1-like [KO:K09348]
124510270  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
124511119  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124512474  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124507057  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
124521298  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
124525847  NF-kappa-B essential modulator isoform X1 [KO:K07210]
124508912  NF-kappa-B inhibitor alpha [KO:K04734]
124520800  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
124507090  nuclear factor NF-kappa-B p100 subunit [KO:K04469]
124504954  transcription factor p65 [KO:K04735]
124510169  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
124513041  nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
124517105  apoptosis regulator Bcl-2 [KO:K02161]
124504870  baculoviral IAP repeat-containing protein 2 [KO:K16060]
124506366  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
124513901  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
124503234  baculoviral IAP repeat-containing protein 7-like [KO:K16061]
124503169  bcl-2-like protein 1 isoform X1 [KO:K04570]
124503618  TNF receptor-associated factor 1 [KO:K03172]
124522349  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
124512500  TNF receptor-associated factor 3 [KO:K03174]
124512882  TNF receptor-associated factor 4 [KO:K09848]
124510097  TNF receptor-associated factor 5 [KO:K09849]
124505383  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
124514798  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
124505103  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
124513164  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
124505120  bcl2-associated agonist of cell death-like [KO:K02158]
124511738  forkhead box protein O1 [KO:K07201]
124501378  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
124519563  cellular tumor antigen p53 isoform X1 [KO:K04451]
124500999  cyclin-dependent kinase inhibitor 1B [KO:K06624]
124528296  cyclin-dependent kinase inhibitor 1 [KO:K06625]
124518162  breakpoint cluster region protein isoform X1 [KO:K08878] [EC:2.7.11.1]
124525633  tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
124519825  crk-like protein [KO:K04438]
124512970  adapter molecule crk isoform X1 [KO:K04438]
124504852  E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
124522097  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
124522246  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
124528336  serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
124509521  serine/threonine-protein kinase pim-2 [KO:K08806] [EC:2.7.11.1]
124526765  kininogen-2-like isoform X1 [KO:K03898]
124528998  endothelin-1 [KO:K16366]
124512427  B1 bradykinin receptor-like [KO:K03915]
124512289  B2 bradykinin receptor-like [KO:K03916]
124520812  endothelin-1 receptor isoform X1 [KO:K04197]
124513142  endothelin receptor type B [KO:K04198]
124528694  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
124524235  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
124503791  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
124503878  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
124505119  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
124508712  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
124513500  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
124517730  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
124527789  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
124520662  interleukin-2 [KO:K05429]
124509424  interleukin-3-like [KO:K04736]
124523858  interleukin-4 [KO:K05430]
124523720  interleukin-5 [KO:K05428]
124524718  interleukin-6 [KO:K05405]
124507732  interleukin-7-like isoform X1 [KO:K05431]
124526682  interleukin-12 subunit alpha [KO:K05406]
124520689  interleukin-12 subunit beta [KO:K05425]
124523786  interleukin-13-like [KO:K05435]
124520617  interleukin-15 [KO:K05433]
124501368  interleukin-23 subunit alpha [KO:K05426]
124519180  erythropoietin [KO:K05437]
124524295  interferon alpha-like [KO:K05414]
124525665  interferon alpha-2-like [KO:K05414]
124525682  interferon alpha-2-like [KO:K05414]
124525697  interferon alpha [KO:K05414]
124525706  interferon alpha-like [KO:K05414]
124525727  interferon alpha-like [KO:K05414]
124502020  interferon gamma [KO:K04687]
124501580  interleukin-2 receptor subunit alpha [KO:K05068]
124501540  interleukin-2 receptor subunit beta-like [KO:K05069]
124521570  cytokine receptor common subunit gamma isoform X1 [KO:K05070]
124509311  interleukin-3 receptor subunit alpha-like isoform X1 [KO:K04737]
124517909  interleukin-4 receptor subunit alpha-like isoform X1 [KO:K05071]
124501643  cytokine receptor common subunit beta-like isoform X1 [KO:K04738]
124524268  interleukin-5 receptor subunit alpha-like [KO:K05067]
124521695  interleukin-6 receptor subunit alpha-like isoform X1 [KO:K05055]
124517290  interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
124522249  interleukin-7 receptor subunit alpha-like isoform X1 [KO:K05072]
124523112  interleukin-12 receptor subunit beta-1-like isoform X1 [KO:K05063]
124514131  interleukin-12 receptor subunit beta-2-like isoform X1 [KO:K05064]
124513869  interleukin-13 receptor subunit alpha-1 [KO:K05076]
124516127  interleukin-23 receptor-like [KO:K05065]
124524413  erythropoietin receptor isoform X1 [KO:K05079]
124527044  interferon alpha/beta receptor 1-like [KO:K05130]
124525951  interferon alpha/beta receptor 2-like isoform X1 [KO:K05131]
124527922  interferon gamma receptor 1-like [KO:K05132]
124526582  interferon gamma receptor 2-like isoform X1 [KO:K05133]
124504120  echinoderm microtubule-associated protein-like 4 isoform X1 [KO:K15420]
124503580  ALK tyrosine kinase receptor [KO:K05119] [EC:2.7.10.1]
124508723  RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
124504875  RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
124503577  ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
124511162  RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
124515396  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
124527989  tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
124523034  tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
124522098  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
124515343  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
124501367  signal transducer and activator of transcription 2-like [KO:K11221]
124515342  signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
124501154  signal transducer and activator of transcription 6 [KO:K11225]
124529172  uncharacterized protein LOC124529172 [KO:K05448]
124505127  vascular endothelial growth factor B isoform X1 [KO:K16858]
124512131  placenta growth factor-like isoform X1 [KO:K16859]
124520334  vascular endothelial growth factor C [KO:K05449]
124509365  vascular endothelial growth factor D [KO:K05449]
124503927  protransforming growth factor alpha [KO:K08774]
124520329  LOW QUALITY PROTEIN: pro-epidermal growth factor-like [KO:K04357]
124523868  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
124513327  receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
124519341  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
124502365  platelet-derived growth factor subunit B [KO:K17386]
124520247  platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
124507266  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
124502456  insulin-like growth factor I isoform X1 [KO:K05459]
124527882  insulin-like growth factor II [KO:K13769]
124517265  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
124502685  kit ligand [KO:K05461]
124520981  mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
124510912  fms-related tyrosine kinase 3 ligand-like isoform X1 [KO:K05454]
124511181  receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
124523080  hepatocyte growth factor isoform X1 [KO:K05460]
124524670  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
124517067  fibroblast growth factor 1 isoform X1 [KO:K18496]
124521134  LOW QUALITY PROTEIN: fibroblast growth factor 2-like [KO:K18497]
124510046  fibroblast growth factor 18 [KO:K04358]
124510963  fibroblast growth factor 9 [KO:K04358]
124504714  fibroblast growth factor 4 [KO:K04358]
124519959  fibroblast growth factor 5 isoform X1 [KO:K04358]
124506118  fibroblast growth factor 3-like [KO:K04358]
124527665  fibroblast growth factor 22-like [KO:K04358]
124506722  fibroblast growth factor 8 isoform X1 [KO:K04358]
124520853  fibroblast growth factor 20 [KO:K04358]
124520903  fibroblast growth factor 17 isoform X1 [KO:K04358]
124501069  fibroblast growth factor 6 [KO:K04358]
124507410  fibroblast growth factor 10 [KO:K04358]
124508605  fibroblast growth factor 7 [KO:K04358]
124509155  fibroblast growth factor 16 [KO:K04358]
124506117  fibroblast growth factor 19-like [KO:K22603]
124511571  fibroblast growth factor 21-like [KO:K22429]
124501214  fibroblast growth factor 23-like [KO:K22428]
124520453  LOW QUALITY PROTEIN: fibroblast growth factor receptor 1-like [KO:K04362] [EC:2.7.10.1]
124506756  LOW QUALITY PROTEIN: fibroblast growth factor receptor 2-like [KO:K05093] [EC:2.7.10.1]
124522669  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
124520052  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
124513422  growth factor receptor-bound protein 2 [KO:K04364]
124504040  son of sevenless homolog 1 isoform X1 [KO:K03099]
124512209  son of sevenless homolog 2 isoform X1 [KO:K03099]
124527565  GTPase HRas isoform X1 [KO:K02833]
124502703  GTPase KRas isoform X1 [KO:K07827]
124516245  GTPase NRas [KO:K07828]
124509491  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
124524722  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
124523760  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124508471  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124524782  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
124517731  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
124519861  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
124516273  transcription factor Jun [KO:K04448]
124512631  protein c-Fos [KO:K04379]
124506258  protein C-ets-1 isoform X1 [KO:K02678]
124504840  interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
124511320  72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
124503402  matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
124520198  interleukin-8 [KO:K10030]
124501159  cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
124512574  ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
124506146  proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
124506827  coiled-coil domain-containing protein 6 isoform X1 [KO:K09288]
124506961  nuclear receptor coactivator 4-like isoform X1 [KO:K09289]
124521817  high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
124521888  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
124521247  LOW QUALITY PROTEIN: tropomyosin alpha-3 chain-like [KO:K09290]
124510165  nucleoprotein TPR isoform X1 [KO:K09291]
124526571  protein TFG isoform X1 [KO:K09292]
124523107  ras association domain-containing protein 1 isoform X1 [KO:K09850]
124509963  ras association domain-containing protein 5 isoform X1 [KO:K08015]
124503353  serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
124529187  death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
124508517  death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
124523886  death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
124503060  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
124511524  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
124509494  ETS domain-containing protein Elk-1 [KO:K04375]
124503379  calmodulin-1 [KO:K02183]
124510996  calmodulin-1 [KO:K02183]
124512578  calmodulin-1 [KO:K02183]
124514424  LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
124508455  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
124502502  calmodulin-like protein 3 [KO:K02183]
124502628  calmodulin-like [KO:K02183]
124524655  calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
124520612  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
124506916  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
124521364  calcium/calmodulin-dependent protein kinase type II subunit alpha-like [KO:K04515] [EC:2.7.11.17]
124503890  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
124525632  ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
124523651  ras-related protein Ral-A [KO:K07834]
124514605  ras-related protein Ral-B [KO:K07835]
124519890  ralA-binding protein 1 isoform X1 [KO:K08773]
124519312  cell division control protein 42 homolog [KO:K04393]
124514573  cell division control protein 42 homolog [KO:K04393]
124519305  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
124501030  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
124522479  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
124525987  phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
124519573  phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
124520648  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124506951  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124514653  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
124503598  paired box protein Pax-8 [KO:K09293]
124524538  peroxisome proliferator-activated receptor gamma [KO:K08530]
124522367  retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
124528137  retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
124510372  retinoic acid receptor RXR-gamma [KO:K08526]
124527103  retinoic acid receptor beta isoform X1 [KO:K08528]
124529259  estrogen receptor [KO:K08550]
124512326  estrogen receptor beta isoform X1 [KO:K08551]
124503065  nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
124503159  nuclear receptor coactivator 3 isoform X1 [KO:K11256] [EC:2.3.1.48]
124502539  transcription factor Sp1 isoform X1 [KO:K04684]
124527932  peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
124522235  junction plakoglobin [KO:K10056]
124505157  zinc finger and BTB domain-containing protein 16 [KO:K10055]
124513342  LOW QUALITY PROTEIN: retinoic acid receptor alpha-like [KO:K08527]
124520480  cyclin-A2 [KO:K06627]
124509481  cyclin-A1 [KO:K06627]
124508418  protein PML-like isoform X1 [KO:K10054] [EC:2.3.2.-]
124526329  runt-related transcription factor 1 isoform X1 [KO:K08367]
124519045  protein CBFA2T1 [KO:K10053]
124505642  transcription factor PU.1 isoform X1 [KO:K09438]
124511262  CCAAT/enhancer-binding protein alpha [KO:K09055]
124509310  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
124509309  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X1 [KO:K05066]
124516500  granulocyte colony-stimulating factor receptor-like isoform X1 [KO:K05061]
124521466  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
124525759  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
124503500  transcription factor E2F1 [KO:K17454]
124515072  transcription factor E2F2 isoform X1 [KO:K09389]
124528848  transcription factor E2F3 isoform X1 [KO:K06620]
124512113  protein max isoform X1 [KO:K04453]
124514675  zinc finger and BTB domain-containing protein 17 [KO:K10500]
124501072  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
124523204  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
124501054  G1/S-specific cyclin-D2 [KO:K10151]
124528816  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
124527676  cyclin-dependent kinases regulatory subunit 2 [KO:K02219]
124521874  cyclin-dependent kinases regulatory subunit 1 [KO:K02219]
124515676  S-phase kinase-associated protein 1 [KO:K03094]
124524656  cullin-1 [KO:K03347]
124501699  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
124522217  S-phase kinase-associated protein 2 [KO:K03875]
124502320  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
124511276  G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
124518951  G1/S-specific cyclin-E2 [KO:K06626]
124512196  retinoblastoma-associated protein isoform X1 [KO:K06618]
124524872  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
124515398  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
124523614  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
124510927  apoptosis regulator BAX isoform X1 [KO:K02159]
124528274  bcl-2 homologous antagonist/killer [KO:K14021]
124504922  DNA damage-binding protein 2 isoform X1 [KO:K10140]
124518196  DNA polymerase kappa-like isoform X1 [KO:K03511] [EC:2.7.7.7]
124522726  LOW QUALITY PROTEIN: telomerase reverse transcriptase-like [KO:K11126] [EC:2.7.7.49]
124523039  microphthalmia-associated transcription factor isoform X1 [KO:K09455]
124511094  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
124510378  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
124512625  transforming growth factor beta-3 proprotein [KO:K13377]
124502313  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
124526598  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
124517096  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
124508465  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
124516988  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
124526640  histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
124507216  C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
124522633  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
124528271  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
124514885  histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
124526785  DNA mismatch repair protein Mlh1 [KO:K08734]
124504069  DNA mismatch repair protein Msh2 [KO:K08735]
124518549  DNA mismatch repair protein Msh3-like [KO:K08736]
124503151  DNA mismatch repair protein Msh6 [KO:K08737]
124511444  breast cancer type 2 susceptibility protein homolog [KO:K08775]
124508704  DNA repair protein RAD51 homolog 1 [KO:K04482]
124510216  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
124518681  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
124505197  FAS-associated death domain protein-like [KO:K02373]
124515468  caspase-8-like [KO:K04398] [EC:3.4.22.61]
124501306  BH3-interacting domain death agonist-like [KO:K04726]
124517009  phorbol-12-myristate-13-acetate-induced protein 1-like [KO:K10131]
124510983  bcl-2-binding component 3, isoforms 1/2 isoform X1 [KO:K10132]
124503325  bcl-2-like protein 11 isoform X1 [KO:K16341]
124524650  cytochrome c [KO:K08738]
124526642  cytochrome c-like [KO:K08738]
124526919  cytochrome c-like [KO:K08738]
124514186  cytochrome c, testis-specific-like [KO:K08738]
124501505  cytochrome c-like [KO:K08738]
124502126  cytochrome c-like [KO:K08738]
124502711  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
124507150  caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
124523929  kelch-like ECH-associated protein 1 [KO:K10456]
124514555  nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
124502305  heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
124511446  NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
124518329  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
124518330  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
124518376  glutathione S-transferase theta-3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124518377  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
124520489  microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
124506319  LOW QUALITY PROTEIN: glutathione S-transferase omega-2-like [KO:K00799] [EC:2.5.1.18]
124507125  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
124528729  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
124529260  glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
124529381  LOW QUALITY PROTEIN: glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
124515811  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
124515940  glutathione S-transferase Mu 4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124502576  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
124509923  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
124505671  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
124525715  thioredoxin reductase 2, mitochondrial isoform X1 [KO:K22182] [EC:1.8.1.9]
124523368  thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
124502653  thioredoxin reductase 1, cytoplasmic [KO:K22182] [EC:1.8.1.9]
124524316  von Hippel-Lindau disease tumor suppressor [KO:K03871]
124507724  elongin-C [KO:K03872]
124528988  elongin-C-like [KO:K03872]
124517897  elongin-B isoform X1 [KO:K03873]
124506000  elongin-B-like [KO:K03873]
124516626  elongin-B-like [KO:K03873]
124501340  cullin-2 [KO:K03870]
124511105  prolyl hydroxylase EGLN2 isoform X1 [KO:K09592] [EC:1.14.11.29]
124518601  egl nine homolog 1 isoform X1 [KO:K09592] [EC:1.14.11.29]
124508892  prolyl hydroxylase EGLN3 [KO:K09592] [EC:1.14.11.29]
124510262  fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
124512137  hypoxia-inducible factor 1-alpha [KO:K08268]
124503773  endothelial PAS domain-containing protein 1 [KO:K09095]
124516159  aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
124517207  aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
124517735  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
124501617  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
124515644  solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
124503879  protein jagged-1 [KO:K06052]
124512327  protein jagged-2 isoform X1 [KO:K21635]
124511742  LOW QUALITY PROTEIN: delta-like protein 3 [KO:K06051]
124527837  delta-like protein 1 [KO:K06051]
124508251  delta-like protein 4 [KO:K06051]
124522322  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1-like [KO:K02599]
124516604  neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
124522904  neurogenic locus notch homolog protein 3 [KO:K20995]
124529032  neurogenic locus notch homolog protein 4 [KO:K20996]
124526288  transcription factor HES-1 [KO:K06054]
124514782  transcription factor HES-5 [KO:K06055]
124507432  hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
124514860  hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
124528934  hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
124509327  vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
124523508  sonic hedgehog protein [KO:K11988]
124529241  protein patched homolog 1 [KO:K06225]
124525159  smoothened homolog [KO:K06226]
124517315  LOW QUALITY PROTEIN: kinesin-like protein KIF7 [KO:K18806]
124507098  suppressor of fused homolog isoform X1 [KO:K06229]
124501321  zinc finger protein GLI1 isoform X1 [KO:K16797]
124516485  zinc finger protein GLI2 [KO:K16798]
124524721  transcriptional activator GLI3 [KO:K06230]
124504345  bone morphogenetic protein 2 [KO:K21283]
124512337  bone morphogenetic protein 4 [KO:K04662]
124520992  hedgehog-interacting protein [KO:K06231]
124515976  protein patched homolog 2 isoform X1 [KO:K11101]
124521599  androgen receptor [KO:K08557]
124512510  heat shock protein HSP 90-alpha [KO:K04079]
124528527  heat shock protein HSP 90-beta [KO:K04079]
124501451  endoplasmin [KO:K09487]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  Superoxide
C00735  Cortisol
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
  Authors
Weinberg RA.
  Title
The biology of cancer
  Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
PMID:10647931
  Authors
Hanahan D, Weinberg RA
  Title
The hallmarks of cancer.
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Cell 100:57-70 (2000)
DOI:10.1016/S0092-8674(00)81683-9
Reference
PMID:15000146
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Grady WM.
  Title
Genomic instability and colon cancer.
  Journal
Cancer Metastasis Rev 23:11-27 (2004)
DOI:10.1023/A:1025861527711
Reference
PMID:16555243
  Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
  Title
Microsatellite instability in colorectal cancer.
  Journal
Br J Surg 93:395-406 (2006)
DOI:10.1002/bjs.5328
Reference
PMID:11078609
  Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
  Title
Hereditary non-polyposis colorectal cancer: an updated review.
  Journal
Eur J Surg Oncol 26:635-45 (2000)
DOI:10.1053/ejso.2000.0974
Reference
PMID:16699851
  Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
  Title
Colorectal cancer: genetics of development and metastasis.
  Journal
J Gastroenterol 41:185-92 (2006)
DOI:10.1007/s00535-006-1801-6
Reference
PMID:12621137
  Authors
Lynch HT, de la Chapelle A.
  Title
Hereditary colorectal cancer.
  Journal
N Engl J Med 348:919-32 (2003)
DOI:10.1056/NEJMra012242
Reference
PMID:12951588
  Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
  Title
The significance of unstable chromosomes in colorectal cancer.
  Journal
Nat Rev Cancer 3:695-701 (2003)
DOI:10.1038/nrc1165
Reference
PMID:10505543
  Authors
Behrens J.
  Title
Cadherins and catenins: role in signal transduction and tumor progression.
  Journal
Cancer Metastasis Rev 18:15-30 (1999)
DOI:10.1023/A:1006200102166
Reference
PMID:16042571
  Authors
Behrens J.
  Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
  Journal
Biochem Soc Trans 33:672-5 (2005)
DOI:10.1042/BST0330672
Reference
PMID:15349822
  Authors
Behrens J, Lustig B.
  Title
The Wnt connection to tumorigenesis.
  Journal
Int J Dev Biol 48:477-87 (2004)
DOI:10.1387/ijdb.041815jb
Reference
PMID:9196022
  Authors
Polakis P.
  Title
The adenomatous polyposis coli (APC) tumor suppressor.
  Journal
Biochim Biophys Acta 1332:F127-47 (1997)
DOI:10.1016/S0304-419X(97)00008-5
Reference
PMID:12737309
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
PMID:11459867
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
PMID:15573119
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
Reference
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Related
pathway
lruf03320  PPAR signaling pathway
lruf04010  MAPK signaling pathway
lruf04020  Calcium signaling pathway
lruf04024  cAMP signaling pathway
lruf04060  Cytokine-cytokine receptor interaction
lruf04066  HIF-1 signaling pathway
lruf04110  Cell cycle
lruf04115  p53 signaling pathway
lruf04150  mTOR signaling pathway
lruf04151  PI3K-Akt signaling pathway
lruf04210  Apoptosis
lruf04310  Wnt signaling pathway
lruf04330  Notch signaling pathway
lruf04340  Hedgehog signaling pathway
lruf04350  TGF-beta signaling pathway
lruf04370  VEGF signaling pathway
lruf04510  Focal adhesion
lruf04512  ECM-receptor interaction
lruf04520  Adherens junction
lruf04630  JAK-STAT signaling pathway
lruf04915  Estrogen signaling pathway
KO pathway
ko05200   
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