KEGG   PATHWAY: mthb05200
Entry
mthb05200                   Pathway                                
Name
Pathways in cancer - Macaca thibetana thibetana (Pere David's macaque)
Class
Human Diseases; Cancer: overview
Pathway map
mthb05200  Pathways in cancer
mthb05200

Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126941361  netrin receptor DCC isoform X1 [KO:K06765]
126954341  caspase-3 [KO:K02187] [EC:3.4.22.56]
126929188  LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
126948801  DCC-interacting protein 13-alpha isoform X1 [KO:K08733]
126944055  cadherin-1 [KO:K05689]
126948505  catenin beta-1 isoform X1 [KO:K02105]
126963368  catenin alpha-3 isoform X1 [KO:K05691]
126957275  catenin alpha-1 isoform X1 [KO:K05691]
126933368  catenin alpha-2 isoform X1 [KO:K05691]
126944825  axin-1 isoform X1 [KO:K02157]
126938336  axin-2 isoform X1 [KO:K04385]
126942456  LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
126956213  adenomatous polyposis coli protein isoform X1 [KO:K02085]
126949239  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
126955989  transcription factor 7 isoform X1 [KO:K02620]
126933391  transcription factor 7-like 1 isoform X1 [KO:K04490]
126962827  transcription factor 7-like 2 isoform X1 [KO:K04491]
126954934  lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
126963345  baculoviral IAP repeat-containing protein 5-like [KO:K08731]
126939275  baculoviral IAP repeat-containing protein 5 [KO:K08731]
126960612  myc proto-oncogene protein [KO:K04377]
126935963  G1/S-specific cyclin-D1 [KO:K04503]
126930178  proto-oncogene Wnt-1 [KO:K03209]
126930501  protein Wnt-2b [KO:K00182]
126951195  protein Wnt-2 [KO:K00182]
126936033  protein Wnt-3a [KO:K00312]
126938314  proto-oncogene Wnt-3 [KO:K00312]
126956796  protein Wnt-4 [KO:K00408]
126930247  protein Wnt-5b [KO:K00444]
126947624  protein Wnt-5a isoform X1 [KO:K00444]
126933008  protein Wnt-6 isoform X1 [KO:K00445]
126949140  protein Wnt-7a [KO:K00572]
126963624  protein Wnt-7b isoform X1 [KO:K00572]
126963076  protein Wnt-8b [KO:K00714]
126957556  protein Wnt-8a [KO:K00714]
126938932  protein Wnt-9b isoform X1 [KO:K01064]
126935947  protein Wnt-9a isoform X1 [KO:K01064]
126930177  protein Wnt-10b [KO:K01357]
126933003  protein Wnt-10a [KO:K01357]
126935098  protein Wnt-11 isoform X1 [KO:K01384]
126950813  protein Wnt-16 [KO:K01558]
126932182  frizzled-7 [KO:K02432]
126949919  frizzled-1 [KO:K02432]
126938678  frizzled-2 [KO:K02235]
126961767  frizzled-3 isoform X1 [KO:K02329]
126934903  frizzled-4 isoform X1 [KO:K02354]
126962319  LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
126933089  frizzled-5 [KO:K02375]
126960879  frizzled-6 isoform X1 [KO:K02376]
126930546  frizzled-10 [KO:K02842]
126950358  frizzled-9 [KO:K02842]
126930738  low-density lipoprotein receptor-related protein 6 [KO:K03068]
126935940  low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
126939681  segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
126951679  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
126948407  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
126962089  proto-oncogene FRAT1 [KO:K03069]
126962094  GSK-3-binding protein FRAT2 [KO:K03096]
126935772  LOW QUALITY PROTEIN: prothrombin [KO:K01313] [EC:3.4.21.5]
126942065  angiotensinogen isoform X1 [KO:K09821]
126957589  proteinase-activated receptor 1 [KO:K03914]
126942286  proteinase-activated receptor 4 [KO:K04236]
126937741  lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
126935655  lysophosphatidic acid receptor 1-like isoform X1 [KO:K04289]
126942297  lysophosphatidic acid receptor 2 [KO:K04291]
126963632  lysophosphatidic acid receptor 3 [KO:K04294]
126946250  lysophosphatidic acid receptor 4 [KO:K04275]
126930445  lysophosphatidic acid receptor 5 [KO:K08390]
126940444  lysophosphatidic acid receptor 6 [KO:K04273]
126947490  type-1 angiotensin II receptor [KO:K04166]
126951492  guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
126938356  guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
126936572  rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
126948045  rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
126941747  LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 1 [KO:K12330]
126952446  pleckstrin homology domain-containing family G member 5 isoform X1 [KO:K19464]
126948741  transforming protein RhoA [KO:K04513]
126941287  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
126933801  rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
126962810  stromal cell-derived factor 1 isoform X1 [KO:K10031]
126932241  C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
126929846  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
126949885  guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
126948709  guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
126942434  prostaglandin E2 receptor EP1 subtype [KO:K04258]
126958526  prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04259]
126962978  prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
126956451  prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
126929358  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
126929369  neuroendocrine secretory protein 55 [KO:K04632]
126950155  adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
126956053  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
126933644  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
126958798  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
126949094  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
126930150  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
126944901  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
126961343  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
126944580  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
126942437  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
126937647  cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
126963591  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
126952008  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
126950415  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
126930448  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
126947562  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
126959042  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
126958548  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
126935530  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1 [KO:K04540]
126942604  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
126955333  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126963646  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126951422  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126935723  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126942881  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
126943523  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
126937751  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126949943  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
126942836  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
126939573  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
126944893  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
126949942  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
126939894  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
126932884  collagen alpha-4(IV) chain isoform X1 [KO:K06237]
126932960  collagen alpha-3(IV) chain isoform X1 [KO:K06237]
126946614  collagen alpha-6(IV) chain isoform X1 [KO:K06237]
126946615  collagen alpha-5(IV) chain isoform X1 [KO:K06237]
126940592  collagen alpha-1(IV) chain [KO:K06237]
126940593  collagen alpha-2(IV) chain [KO:K06237]
126940995  laminin subunit alpha-1 isoform X1 [KO:K05637]
126953024  laminin subunit alpha-2 isoform X1 [KO:K05637]
126941333  laminin subunit alpha-3 isoform X1 [KO:K06240]
126929064  laminin subunit alpha-5 [KO:K06240]
126953585  laminin subunit alpha-4 isoform X1 [KO:K06241]
126951221  laminin subunit beta-1 [KO:K05636]
126948619  laminin subunit beta-2 [KO:K06243]
126949026  laminin subunit beta-3 [KO:K06244]
126951219  laminin subunit beta-4 isoform X1 [KO:K06245]
126950143  laminin subunit gamma-1 isoform X1 [KO:K05635]
126940264  laminin subunit gamma-2 [KO:K06246]
126936881  laminin subunit gamma-3 [KO:K06247]
126932417  fibronectin isoform X1 [KO:K05717]
126956842  integrin alpha-2 [KO:K06481]
126938666  integrin alpha-IIb [KO:K06476]
126939866  integrin alpha-3 isoform X1 [KO:K06482]
126932479  integrin alpha-6 isoform X1 [KO:K06485]
126933042  integrin alpha-V isoform X1 [KO:K06487]
126962945  integrin beta-1 isoform X1 [KO:K05719]
126961367  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
126947557  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126952893  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126948170  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126961422  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126956531  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126942202  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
126963336  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
126960732  homeobox protein Nkx-3.1 [KO:K09348]
126943096  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126959416  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126942032  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126963067  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
126960750  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
126945470  NF-kappa-B essential modulator isoform X1 [KO:K07210]
126959170  NF-kappa-B inhibitor alpha [KO:K04734]
126955390  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
126962742  nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
126935358  transcription factor p65 isoform X1 [KO:K04735]
126950108  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
126938749  nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
126941201  apoptosis regulator Bcl-2 [KO:K02161]
126936001  baculoviral IAP repeat-containing protein 2 [KO:K16060]
126936002  baculoviral IAP repeat-containing protein 3 [KO:K16060]
126946702  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
126929820  baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
126964283  bcl-2-like protein 1 isoform X1 [KO:K04570]
126936852  TNF receptor-associated factor 1 [KO:K03172]
126936973  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
126959960  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
126956100  TNF receptor-associated factor 4-like [KO:K09848]
126938725  TNF receptor-associated factor 4 isoform X1 [KO:K09848]
126948771  TNF receptor-associated factor 5 isoform X1 [KO:K09849]
126936615  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
126952739  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
126939388  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
126935360  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
126935617  bcl2-associated agonist of cell death [KO:K02158]
126940335  forkhead box protein O1 [KO:K07201]
126931704  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
126939707  cellular tumor antigen p53 isoform X1 [KO:K04451]
126930782  cyclin-dependent kinase inhibitor 1B [KO:K06624]
126952813  cyclin-dependent kinase inhibitor 1 [KO:K06625]
126929594  breakpoint cluster region protein [KO:K08878] [EC:2.7.11.1]
126936893  tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
126938875  adapter molecule crk isoform X1 [KO:K04438]
126929691  crk-like protein [KO:K04438]
126936575  E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
126938428  signal transducer and activator of transcription 5A [KO:K11223]
126938430  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
126952784  serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
126945605  serine/threonine-protein kinase pim-2 isoform X1 [KO:K08806] [EC:2.7.11.1]
126946400  kininogen-1 [KO:K03898]
126952027  endothelin-1 [KO:K16366]
126959680  B1 bradykinin receptor isoform X1 [KO:K03915]
126959675  B2 bradykinin receptor [KO:K03916]
126955379  endothelin-1 receptor [KO:K04197]
126940512  endothelin receptor type B [KO:K04198]
126937577  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
126942698  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
126964414  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
126959796  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
126964415  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
126935554  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
126938340  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
126944386  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126943319  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126955754  interleukin-2 [KO:K05429]
126956031  interleukin-3 [KO:K04736]
126956021  interleukin-4 isoform X1 [KO:K05430]
126956041  interleukin-5 [KO:K05428]
126950025  interleukin-6 isoform X1 [KO:K05405]
126961637  interleukin-7 [KO:K05431]
126949358  interleukin-12 subunit alpha isoform X1 [KO:K05406]
126957215  interleukin-12 subunit beta [KO:K05425]
126956018  interleukin-13 [KO:K05435]
126954296  interleukin-15 isoform X1 [KO:K05433]
126931219  interleukin-23 subunit alpha isoform X1 [KO:K05426]
126950416  erythropoietin isoform X1 [KO:K05437]
126937598  interferon alpha-14 [KO:K05414]
126937600  interferon alpha-4-like [KO:K05414]
126937601  interferon alpha-17 [KO:K05414]
126937602  interferon alpha-17-like [KO:K05414]
126937603  interferon alpha-17-like [KO:K05414]
126937604  interferon alpha-17-like [KO:K05414]
126937605  LOW QUALITY PROTEIN: interferon alpha-10-like [KO:K05414]
126937606  interferon alpha-10-like [KO:K05414]
126937607  interferon alpha-1/13-like [KO:K05414]
126937608  interferon alpha-1/13 [KO:K05414]
126937609  interferon alpha-1/13-like [KO:K05414]
126937610  interferon alpha-6 [KO:K05414]
126937611  interferon alpha-4 [KO:K05414]
126937612  interferon alpha-8 [KO:K05414]
126937613  interferon alpha-2 [KO:K05414]
126937615  interferon alpha-21 [KO:K05414]
126947451  interferon alpha-10-like [KO:K05414]
126930989  interferon gamma [KO:K04687]
126962923  interleukin-2 receptor subunit alpha [KO:K05068]
126963717  interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
126946182  cytokine receptor common subunit gamma isoform X1 [KO:K05070]
126946851  interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
126947139  interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
126944434  interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
126963701  cytokine receptor common subunit beta isoform X1 [KO:K04738]
126948981  interleukin-5 receptor subunit alpha [KO:K05067]
126934004  interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
126957544  interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
126956291  interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
126942203  interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
126939056  interleukin-12 receptor subunit beta-2 [KO:K05064]
126946102  interleukin-13 receptor subunit alpha-1 [KO:K05076]
126962924  interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
126938995  interleukin-23 receptor [KO:K05065]
126942618  erythropoietin receptor [KO:K05079]
126951662  interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
126951665  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
126952034  interferon gamma receptor 1 isoform X1 [KO:K05132]
126951668  interferon gamma receptor 2 [KO:K05133]
126934196  echinoderm microtubule-associated protein-like 4 isoform X1 [KO:K15420]
126933845  LOW QUALITY PROTEIN: ALK tyrosine kinase receptor [KO:K05119] [EC:2.7.10.1]
126960104  RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
126935564  RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
126934266  ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
126942141  RAS guanyl-releasing protein 4 [KO:K12363]
126935739  tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
126937558  tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
126942179  tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
126938424  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
126932637  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
126931203  signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
126932635  signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
126930369  signal transducer and activator of transcription 6 [KO:K11225]
126952424  vascular endothelial growth factor A isoform X1 [KO:K05448]
126935608  vascular endothelial growth factor B isoform X1 [KO:K16858]
126959573  placenta growth factor isoform X1 [KO:K16859]
126955710  vascular endothelial growth factor C isoform X1 [KO:K05449]
126946911  vascular endothelial growth factor D isoform X1 [KO:K05449]
126934085  protransforming growth factor alpha isoform X1 [KO:K08774]
126954925  pro-epidermal growth factor isoform X1 [KO:K04357]
126950202  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
126938415  receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
126950578  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
126963759  platelet-derived growth factor subunit B [KO:K17386]
126954734  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
126956582  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
126931779  insulin-like growth factor I isoform X1 [KO:K05459]
126935883  insulin-like growth factor II [KO:K13769]
126959327  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
126929998  kit ligand isoform X1 [KO:K05461]
126954735  mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
126943138  fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
126940719  receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
126949900  hepatocyte growth factor isoform X1 [KO:K05460]
126951204  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
126957258  LOW QUALITY PROTEIN: fibroblast growth factor 1 [KO:K18496]
126954986  fibroblast growth factor 2 [KO:K18497]
126942993  fibroblast growth factor 22 [KO:K04358]
126962737  fibroblast growth factor 8 isoform X1 [KO:K04358]
126931752  fibroblast growth factor 6 [KO:K04358]
126956981  fibroblast growth factor 18 [KO:K04358]
126957199  fibroblast growth factor 10 [KO:K04358]
126946335  fibroblast growth factor 16 [KO:K04358]
126958707  fibroblast growth factor 7 [KO:K04358]
126940532  fibroblast growth factor 9 [KO:K04358]
126935967  fibroblast growth factor 3 [KO:K04358]
126935973  fibroblast growth factor 4 [KO:K04358]
126960920  fibroblast growth factor 20 [KO:K04358]
126961295  fibroblast growth factor 17 isoform X1 [KO:K04358]
126935968  fibroblast growth factor 19 [KO:K22603]
126943598  fibroblast growth factor 21 [KO:K22429]
126931744  fibroblast growth factor 23 [KO:K22428]
126961189  fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
126962662  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
126955560  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
126956321  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
126939255  growth factor receptor-bound protein 2 [KO:K04364]
126933534  son of sevenless homolog 1 isoform X1 [KO:K03099]
126958499  son of sevenless homolog 2 isoform X1 [KO:K03099]
126935869  GTPase HRas isoform X1 [KO:K02833]
126931572  GTPase KRas [KO:K07827]
126930824  GTPase NRas [KO:K07828]
126945567  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
126949633  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
126949054  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126957976  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
126942673  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
126944456  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
126929669  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126962798  transcription factor Jun [KO:K04448]
126959543  protein c-Fos [KO:K04379]
126936554  protein C-ets-1 isoform X1 [KO:K02678]
126936364  interstitial collagenase [KO:K01388] [EC:3.4.24.7]
126945112  72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
126963805  matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
126954919  interleukin-8 [KO:K10030]
126930400  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
126959645  ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
126962192  proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
126962147  coiled-coil domain-containing protein 6 [KO:K09288]
126963212  nuclear receptor coactivator 4 isoform X1 [KO:K09289]
126948042  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
126934335  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
126950086  nucleoprotein TPR [KO:K09291]
126949302  protein TFG isoform X1 [KO:K09292]
126948713  ras association domain-containing protein 1 isoform X1 [KO:K09850]
126938008  ras association domain-containing protein 5 isoform X1 [KO:K08015]
126963827  serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
126942600  death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
126937490  death-associated protein kinase 1 isoform X1 [KO:K08803] [EC:2.7.11.1]
126957970  death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
126963902  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
126943961  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
126944416  LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1-like [KO:K04375]
126945587  ETS domain-containing protein Elk-1 [KO:K04375]
126934689  LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1-like [KO:K04375]
126961592  calmodulin-1-like [KO:K02183]
126962311  calmodulin-like protein 5 [KO:K02183]
126962328  calmodulin-like protein 3 [KO:K02183]
126943484  calmodulin-3 isoform X1 [KO:K02183]
126958173  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
126951481  calmodulin-1-like [KO:K02183]
126934255  calmodulin-2 [KO:K02183]
126952282  calmodulin-like protein 6 [KO:K02183]
126959699  calmodulin-1 isoform X1 [KO:K02183]
126962427  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
126955622  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
126956598  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
126950160  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
126929778  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929779  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929780  ral-GDS-related protein-like [KO:K08732]
126936899  ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
126964069  ral-GDS-related protein-like [KO:K08732]
126947346  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929238  ral-GDS-related protein-like [KO:K08732]
126929502  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929506  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929550  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929580  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929584  ral-GDS-related protein-like [KO:K08732]
126929625  ral-GDS-related protein-like [KO:K08732]
126950131  ras-related protein Ral-A [KO:K07834]
126933156  ras-related protein Ral-B [KO:K07835]
126941117  ralA-binding protein 1 isoform X1 [KO:K08773]
126956242  cell division control protein 42 homolog isoform X1 [KO:K04393]
126953277  cell division control protein 42 homolog [KO:K04393]
126954326  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
126950508  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126963767  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
126939124  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
126939667  phospholipase D2 [KO:K01115] [EC:3.1.4.4]
126948354  phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
126954697  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126963142  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126956917  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126933492  paired box protein Pax-8 isoform X1 [KO:K09293]
126949058  peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
126936987  retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
126952745  retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
126941840  retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
126948091  retinoic acid receptor beta isoform X1 [KO:K08528]
126952370  estrogen receptor isoform X1 [KO:K08550]
126959022  estrogen receptor beta isoform X1 [KO:K08551]
126933643  nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
126929087  nuclear receptor coactivator 3 isoform X1 [KO:K11256] [EC:2.3.1.48]
126931105  transcription factor Sp1 isoform X1 [KO:K04684]
126952758  peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
126938435  junction plakoglobin [KO:K10056]
126935921  zinc finger and BTB domain-containing protein 16 [KO:K10055]
126938478  retinoic acid receptor alpha isoform X1 [KO:K08527]
126955746  cyclin-A2 [KO:K06627]
126940304  cyclin-A1 isoform X1 [KO:K06627]
126958947  protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
126950720  runt-related transcription factor 1 isoform X1 [KO:K08367]
126961644  protein CBFA2T1 isoform X1 [KO:K10053]
126936391  transcription factor PU.1 [KO:K09438]
126941775  CCAAT/enhancer-binding protein alpha [KO:K09055]
126946850  granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
126947138  granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
126959228  granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
126956584  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
126937619  cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
126964352  transcription factor E2F1 [KO:K17454]
126955302  transcription factor E2F2 [KO:K09389]
126953853  transcription factor E2F3 isoform X1 [KO:K06620]
126959765  protein max isoform X1 [KO:K04453]
126953902  zinc finger and BTB domain-containing protein 17 [KO:K10500]
126937616  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
126951304  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
126931745  G1/S-specific cyclin-D2 [KO:K10151]
126953804  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
126943414  cyclin-dependent kinases regulatory subunit 1 [KO:K02219]
126937672  cyclin-dependent kinases regulatory subunit 2 [KO:K02219]
126940472  cyclin-dependent kinases regulatory subunit 1-like [KO:K02219]
126934933  cyclin-dependent kinases regulatory subunit 1-like [KO:K02219]
126935238  cyclin-dependent kinases regulatory subunit 1 [KO:K02219]
126941134  cyclin-dependent kinases regulatory subunit 1-like [KO:K02219]
126956019  S-phase kinase-associated protein 1 [KO:K03094]
126941022  S-phase kinase-associated protein 1-like [KO:K03094]
126951000  cullin-1 [KO:K03347]
126957088  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
126931216  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
126943618  G1/S-specific cyclin-E1 [KO:K06626]
126960826  G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
126940411  retinoblastoma-associated protein isoform X1 [KO:K06618]
126942832  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
126937334  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
126939469  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
126943600  apoptosis regulator BAX isoform X1 [KO:K02159]
126952802  bcl-2 homologous antagonist/killer [KO:K14021]
126936385  DNA damage-binding protein 2 isoform X1 [KO:K10140]
126957066  DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
126957402  telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
126947639  microphthalmia-associated transcription factor isoform X1 [KO:K09455]
126941768  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
126948495  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
126959539  transforming growth factor beta-3 proprotein [KO:K13377]
126938052  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
126946646  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
126941494  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
126957972  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
126941313  mothers against decapentaplegic homolog 4 [KO:K04501]
126948321  histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
126954828  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
126962565  C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
126964086  LOW QUALITY PROTEIN: C-terminal-binding protein 2-like [KO:K04496] [EC:1.1.1.428]
126957492  histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
126952258  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
126948474  DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
126934240  DNA mismatch repair protein Msh2 isoform X1 [KO:K08735]
126957572  DNA mismatch repair protein Msh3 isoform X1 [KO:K08736]
126934239  DNA mismatch repair protein Msh6 [KO:K08737]
126940709  breast cancer type 2 susceptibility protein [KO:K08775]
126959857  DNA repair protein RAD51 homolog 1 isoform X1 [KO:K04482]
126941397  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
126963192  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
126935972  FAS-associated death domain protein [KO:K02373]
126932110  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
126929772  BH3-interacting domain death agonist [KO:K04726]
126941403  phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
126943534  bcl-2-binding component 3 [KO:K10132]
126933423  bcl-2-like protein 11 isoform X1 [KO:K16341]
126949081  cytochrome c-like [KO:K08738]
126961774  cytochrome c-like [KO:K08738]
126936610  cytochrome c-like [KO:K08738]
126937973  cytochrome c-like [KO:K08738]
126944405  cytochrome c-like [KO:K08738]
126932751  cytochrome c-like [KO:K08738]
126951393  cytochrome c [KO:K08738]
126947125  cytochrome c-like [KO:K08738]
126941401  cytochrome c-like [KO:K08738]
126952962  cytochrome c-like [KO:K08738]
126942126  cytochrome c-like [KO:K08738]
126931282  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
126962014  caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
126932076  nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
126964018  heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
126944082  NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
126930060  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126930154  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
126930168  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
126954620  microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
126931359  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
126963047  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
126963049  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
126946285  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
126952227  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
126941935  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
126929522  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
126929523  glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
126929524  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
126929525  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126953690  glutathione S-transferase A1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126953691  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
126953692  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
126949123  thioredoxin reductase 3 isoform X1 [KO:K22182] [EC:1.8.1.9]
126930901  thioredoxin reductase 1, cytoplasmic isoform X1 [KO:K22182] [EC:1.8.1.9]
126929633  thioredoxin reductase 2, mitochondrial isoform X1 [KO:K22182] [EC:1.8.1.9]
126947727  von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
126952946  LOW QUALITY PROTEIN: von Hippel-Lindau-like protein [KO:K03871]
126961707  elongin-C [KO:K03872]
126963960  elongin-C-like [KO:K03872]
126951410  elongin-C-like [KO:K03872]
126934987  elongin-B-like [KO:K03873]
126962982  cullin-2 isoform X1 [KO:K03870]
126942488  egl nine homolog 1 [KO:K09592] [EC:1.14.11.29]
126959176  prolyl hydroxylase EGLN3 [KO:K09592] [EC:1.14.11.29]
126942051  prolyl hydroxylase EGLN2 [KO:K09592] [EC:1.14.11.29]
126942798  fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
126958962  hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
126934183  endothelial PAS domain-containing protein 1 isoform X1 [KO:K09095]
126931516  aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
126960044  aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
126963565  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
126944569  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
126959708  solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
126964413  protein jagged-1 isoform X1 [KO:K06052]
126958623  protein jagged-2 isoform X1 [KO:K21635]
126952479  delta-like protein 1 [KO:K06051]
126959819  delta-like protein 4 [KO:K06051]
126942003  delta-like protein 3 isoform X1 [KO:K06051]
126936867  neurogenic locus notch homolog protein 1 [KO:K02599]
126931272  neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
126942169  neurogenic locus notch homolog protein 3 [KO:K20995]
126953209  neurogenic locus notch homolog protein 4 [KO:K20996]
126947977  transcription factor HES-1 [KO:K06054]
126961434  transcription factor HES-5 [KO:K06055]
126961663  hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
126953267  hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
126960300  hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
126956306  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
126951534  sonic hedgehog protein [KO:K11988]
126937986  protein patched homolog 1 isoform X1 [KO:K06225]
126949757  smoothened homolog isoform X1 [KO:K06226]
126958899  kinesin-like protein KIF7 [KO:K18806]
126962750  suppressor of fused homolog isoform X1 [KO:K06229]
126930363  zinc finger protein GLI1 [KO:K16797]
126932004  zinc finger protein GLI2 [KO:K16798]
126951434  transcriptional activator GLI3 isoform X1 [KO:K06230]
126964143  bone morphogenetic protein 2 [KO:K21283]
126959339  bone morphogenetic protein 4 isoform X1 [KO:K04662]
126955317  hedgehog-interacting protein isoform X1 [KO:K06231]
126958883  protein patched homolog 2 isoform X1 [KO:K11101]
126946491  androgen receptor isoform X1 [KO:K08557]
126955457  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
126958418  heat shock protein HSP 90-alpha [KO:K04079]
126952392  heat shock protein HSP 90-beta [KO:K04079]
126930897  endoplasmin [KO:K09487]
126943121  prostate-specific antigen isoform X1 [KO:K01351] [EC:3.4.21.77]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  Superoxide
C00735  Cortisol
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
  Authors
Weinberg RA.
  Title
The biology of cancer
  Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
PMID:10647931
  Authors
Hanahan D, Weinberg RA
  Title
The hallmarks of cancer.
  Journal
Cell 100:57-70 (2000)
DOI:10.1016/S0092-8674(00)81683-9
Reference
PMID:15000146
  Authors
Grady WM.
  Title
Genomic instability and colon cancer.
  Journal
Cancer Metastasis Rev 23:11-27 (2004)
DOI:10.1023/A:1025861527711
Reference
PMID:16555243
  Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
  Title
Microsatellite instability in colorectal cancer.
  Journal
Br J Surg 93:395-406 (2006)
DOI:10.1002/bjs.5328
Reference
PMID:11078609
  Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
  Title
Hereditary non-polyposis colorectal cancer: an updated review.
  Journal
Eur J Surg Oncol 26:635-45 (2000)
DOI:10.1053/ejso.2000.0974
Reference
PMID:16699851
  Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
  Title
Colorectal cancer: genetics of development and metastasis.
  Journal
J Gastroenterol 41:185-92 (2006)
DOI:10.1007/s00535-006-1801-6
Reference
PMID:12621137
  Authors
Lynch HT, de la Chapelle A.
  Title
Hereditary colorectal cancer.
  Journal
N Engl J Med 348:919-32 (2003)
DOI:10.1056/NEJMra012242
Reference
PMID:12951588
  Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
  Title
The significance of unstable chromosomes in colorectal cancer.
  Journal
Nat Rev Cancer 3:695-701 (2003)
DOI:10.1038/nrc1165
Reference
PMID:10505543
  Authors
Behrens J.
  Title
Cadherins and catenins: role in signal transduction and tumor progression.
  Journal
Cancer Metastasis Rev 18:15-30 (1999)
DOI:10.1023/A:1006200102166
Reference
PMID:16042571
  Authors
Behrens J.
  Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
  Journal
Biochem Soc Trans 33:672-5 (2005)
DOI:10.1042/BST0330672
Reference
PMID:15349822
  Authors
Behrens J, Lustig B.
  Title
The Wnt connection to tumorigenesis.
  Journal
Int J Dev Biol 48:477-87 (2004)
DOI:10.1387/ijdb.041815jb
Reference
PMID:9196022
  Authors
Polakis P.
  Title
The adenomatous polyposis coli (APC) tumor suppressor.
  Journal
Biochim Biophys Acta 1332:F127-47 (1997)
DOI:10.1016/S0304-419X(97)00008-5
Reference
PMID:12737309
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
PMID:11459867
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
PMID:15573119
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
Reference
PMID:15310786
  Authors
Mehlen P, Fearon ER.
  Title
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
  Journal
J Clin Oncol 22:3420-8 (2004)
DOI:10.1200/JCO.2004.02.019
Reference
PMID:11223406
  Authors
Peltomaki P.
  Title
DNA mismatch repair and cancer.
  Journal
Mutat Res 488:77-85 (2001)
DOI:10.1016/S1383-5742(00)00058-2
Reference
PMID:15711891
  Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
  Title
TGF-beta signaling in colon cancer cells.
  Journal
World J Surg 29:306-11 (2005)
DOI:10.1007/s00268-004-7813-6
Reference
PMID:11170304
  Authors
Roman C, Saha D, Beauchamp R.
  Title
TGF-beta and colorectal carcinogenesis.
  Journal
Microsc Res Tech 52:450-7 (2001)
DOI:10.1002/1097-0029(20010215)52:4<450::AID-JEMT1030>3.0.CO;2-O
Reference
PMID:16326109
  Authors
Watson AJ.
  Title
An overview of apoptosis and the prevention of colorectal cancer.
  Journal
Crit Rev Oncol Hematol 57:107-21 (2006)
DOI:10.1016/j.critrevonc.2005.06.005
Reference
PMID:15479695
  Authors
Watson AJ.
  Title
Apoptosis and colorectal cancer.
  Journal
Gut 53:1701-9 (2004)
DOI:10.1136/gut.2004.052704
Reference
PMID:11477132
  Authors
Houlston RS.
  Title
What we could do now: molecular pathology of colorectal cancer.
  Journal
Mol Pathol 54:206-14 (2001)
DOI:10.1136/mp.54.4.206
Reference
  Authors
Von Hoff D, Evans D, Hruban R (ed).
  Title
Pancreatic cancer
  Journal
Jones and Bartlett publishers (2005)
Reference
  Authors
Niitsu Y, Yokota J (ed).
  Title
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese)
  Journal
Nankodo (1999)
Reference
PMID:12459728
  Authors
Bardeesy N, DePinho RA.
  Title
Pancreatic cancer biology and genetics.
  Journal
Nat Rev Cancer 2:897-909 (2002)
DOI:10.1038/nrc949
Reference
PMID:11407945
  Authors
Bardeesy N, Sharpless NE, DePinho RA, Merlino G.
  Title
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
  Journal
Semin Cancer Biol 11:201-18 (2001)
DOI:10.1006/scbi.2000.0371
Reference
PMID:12946833
  Authors
Cowgill SM, Muscarella P.
  Title
The genetics of pancreatic cancer.
  Journal
Am J Surg 186:279-86 (2003)
DOI:10.1016/S0002-9610(03)00226-5
Reference
PMID:16702400
  Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
  Title
Genetics and biology of pancreatic ductal adenocarcinoma.
  Journal
Genes Dev 20:1218-49 (2006)
DOI:10.1101/gad.1415606
Reference
PMID:10740269
  Authors
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ.
  Title
Understanding Ras: 'it ain't over 'til it's over'.
  Journal
Trends Cell Biol 10:147-54 (2000)
DOI:10.1016/S0962-8924(00)01740-2
Reference
PMID:12648469
  Authors
Holbro T, Civenni G, Hynes NE.
  Title
The ErbB receptors and their role in cancer progression.
  Journal
Exp Cell Res 284:99-110 (2003)
DOI:10.1016/S0014-4827(02)00099-X
Reference
PMID:14967450
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
PMID:14586404
  Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
  Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
  Journal
Oncogene 22:7781-95 (2003)
DOI:10.1038/sj.onc.1206966
Reference
PMID:12545153
  Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
  Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
  Journal
Oncogene 22:319-29 (2003)
DOI:10.1038/sj.onc.1206122
Reference
PMID:14580692
  Authors
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M.
  Title
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
  Journal
Cancer Lett 201:107-16 (2003)
DOI:10.1016/S0304-3835(03)00482-8
Reference
PMID:12079267
  Authors
Schmid RM.
  Title
Genetic basis of pancreatic cancer.
  Journal
Best Pract Res Clin Gastroenterol 16:421-33 (2002)
DOI:10.1053/bega.2002.0316
Reference
PMID:15774796
  Authors
Elliott RL, Blobe GC.
  Title
Role of transforming growth factor Beta in human cancer.
  Journal
J Clin Oncol 23:2078-93 (2005)
DOI:10.1200/JCO.2005.02.047
Reference
PMID:15823750
  Authors
Rudkin TM, Foulkes WD.
  Title
BRCA2: breaks, mistakes and failed separations.
  Journal
Trends Mol Med 11:145-8 (2005)
DOI:10.1016/j.molmed.2005.02.003
Reference
PMID:11707511
  Authors
Venkitaraman AR.
  Title
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
  Journal
J Cell Sci 114:3591-8 (2001)
Reference
PMID:15639402
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
PMID:12154354
  Authors
Zhu Y, Parada LF.
  Title
The molecular and genetic basis of neurological tumours.
  Journal
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
Reference
PMID:11253051
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
PMID:16700615
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Tabuchi K (ed).
  Title
[Gliomas: Research and therapy] (In Japanese)
  Journal
Springer-Verlag Tokyo (2006)
Reference
PMID:12762887
  Authors
Kapoor GS, O'Rourke DM.
  Title
Mitogenic signaling cascades in glial tumors.
  Journal
Neurosurgery 52:1425-34; discussion 1434-5 (2003)
DOI:10.1227/01.NEU.0000065135.28143.39
Reference
PMID:16095998
  Authors
Hulleman E, Helin K.
  Title
Molecular mechanisms in gliomagenesis.
  Journal
Adv Cancer Res 94:1-27 (2005)
DOI:10.1016/S0065-230X(05)94001-3
Reference
PMID:11057895
  Authors
Schlessinger J.
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 103:211-25 (2000)
DOI:10.1016/S0092-8674(00)00114-8
Reference
PMID:9643506
  Authors
Ng HK, Lam PY.
  Title
The molecular genetics of central nervous system tumors.
  Journal
Pathology 30:196-202 (1998)
DOI:10.1080/00313029800169236
Reference
PMID:12084351
  Authors
Knobbe CB, Merlo A, Reifenberger G.
  Title
Pten signaling in gliomas.
  Journal
Neuro-oncol 4:196-211 (2002)
DOI:10.1093/neuonc/4.3.196
Reference
PMID:16557281
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
PMID:16551846
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
PMID:16946003
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
PMID:17062879
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
PMID:16242838
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
PMID:16189702
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
PMID:11165748
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
PMID:12094241
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Reference
PMID:16236521
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
PMID:12563308
  Authors
Tenen DG.
  Title
Disruption of differentiation in human cancer: AML shows the way.
  Journal
Nat Rev Cancer 3:89-101 (2003)
DOI:10.1038/nrc989
Reference
PMID:16146838
  Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
  Title
Signal transduction of oncogenic Flt3.
  Journal
Int J Hematol 82:93-9 (2005)
DOI:10.1532/IJH97.05090
Reference
PMID:12951584
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
PMID:16642045
  Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
  Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
  Journal
Leukemia 20:911-28 (2006)
DOI:10.1038/sj.leu.2404245
Reference
PMID:15625120
  Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
  Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
  Journal
Stem Cells 23:16-43 (2005)
DOI:10.1634/stemcells.2004-0117
Reference
PMID:11721960
  Authors
Lorsbach RB, Downing JR.
  Title
The role of the AML1 transcription factor in leukemogenesis.
  Journal
Int J Hematol 74:258-65 (2001)
DOI:10.1007/BF02982058
Reference
PMID:12468433
  Authors
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H.
  Title
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
  Journal
Blood 101:3164-73 (2003)
DOI:10.1182/blood-2002-06-1677
Reference
PMID:17554387
  Authors
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C.
  Title
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
  Journal
Leukemia 21:1638-47 (2007)
DOI:10.1038/sj.leu.2404732
Reference
PMID:16352814
  Authors
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.
  Title
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
  Journal
Blood 107:3330-8 (2006)
DOI:10.1182/blood-2005-07-3068
Reference
PMID:15719031
  Authors
Ren R.
  Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
  Journal
Nat Rev Cancer 5:172-83 (2005)
DOI:10.1038/nrc1567
Reference
PMID:11071626
  Authors
Deininger MW, Goldman JM, Melo JV.
  Title
The molecular biology of chronic myeloid leukemia.
  Journal
Blood 96:3343-56 (2000)
Reference
PMID:14982876
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
PMID:10403855
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
PMID:15156182
  Authors
Mitani K.
  Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
  Journal
Oncogene 23:4263-9 (2004)
DOI:10.1038/sj.onc.1207777
Reference
PMID:16484590
  Authors
Dong M, Blobe GC.
  Title
Role of transforming growth factor-beta in hematologic malignancies.
  Journal
Blood 107:4589-96 (2006)
DOI:10.1182/blood-2005-10-4169
Reference
PMID:9834202
  Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
  Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
  Journal
Blood 92:4003-12 (1998)
Reference
PMID:12801837
  Authors
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA.
  Title
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
  Journal
Haematologica 88:622-30 (2003)
Reference
PMID:11160144
  Authors
Baldwin AS.
  Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
  Journal
J Clin Invest 107:241-6 (2001)
DOI:10.1172/JCI11991
Reference
PMID:12244301
  Authors
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL.
  Title
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
  Journal
Nat Med 8:1145-52 (2002)
DOI:10.1038/nm759
Reference
PMID:15948971
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
PMID:12588368
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
PMID:15978322
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
PMID:15468170
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
PMID:16881963
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
PMID:16306523
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
PMID:11276000
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
J Pathol 193:427-32 (2001)
DOI:10.1002/1096-9896(2000)9999:9999<::AID-PATH815>3.0.CO;2-N
Reference
PMID:15270885
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
PMID:14737121
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
PMID:15656799
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
PMID:14556242
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
PMID:11736900
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
PMID:16054233
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
PMID:11130178
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
PMID:16822996
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
PMID:12894244
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
Reference
PMID:16750612
  Authors
Takata M, Saida T.
  Title
Genetic alterations in melanocytic tumors.
  Journal
J Dermatol Sci 43:1-10 (2006)
DOI:10.1016/j.jdermsci.2006.05.002
Reference
PMID:15841168
  Authors
Chudnovsky Y, Khavari PA, Adams AE.
  Title
Melanoma genetics and the development of rational therapeutics.
  Journal
J Clin Invest 115:813-24 (2005)
DOI:10.1172/JCI24808
Reference
PMID:16001050
  Authors
Merlino G.
  Title
Cancer biology: the weakest link?
  Journal
Nature 436:33-5 (2005)
DOI:10.1038/436033a
Reference
PMID:16001072
  Authors
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.
  Title
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
  Journal
Nature 436:117-22 (2005)
DOI:10.1038/nature03664
Reference
PMID:16899407
  Authors
Levy C, Khaled M, Fisher DE.
  Title
MITF: master regulator of melanocyte development and melanoma oncogene.
  Journal
Trends Mol Med 12:406-14 (2006)
DOI:10.1016/j.molmed.2006.07.008
Reference
PMID:15009714
  Authors
Tsao H, Goel V, Wu H, Yang G, Haluska FG.
  Title
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
  Journal
J Invest Dermatol 122:337-41 (2004)
DOI:10.1046/j.0022-202X.2004.22243.x
Reference
PMID:11224709
  Authors
Gruss C, Herlyn M.
  Title
Role of cadherins and matrixins in melanoma.
  Journal
Curr Opin Oncol 13:117-23 (2001)
DOI:10.1097/00001622-200103000-00006
Reference
PMID:15721476
  Authors
Thompson JF, Scolyer RA, Kefford RF.
  Title
Cutaneous melanoma.
  Journal
Lancet 365:687-701 (2005)
DOI:10.1016/S0140-6736(05)17951-3
Reference
PMID:14695152
  Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
  Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
  Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
PMID:15557758
  Authors
Hussein MR.
  Title
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
  Journal
Tumour Biol 25:200-7 (2004)
DOI:10.1159/000081103
Reference
PMID:10843728
  Authors
Lazar-Molnar E, Hegyesi H, Toth S, Falus A.
  Title
Autocrine and paracrine regulation by cytokines and growth factors in melanoma.
  Journal
Cytokine 12:547-54 (2000)
DOI:10.1006/cyto.1999.0614
Reference
PMID:16339096
  Authors
Cohen HT, McGovern FJ.
  Title
Renal-cell carcinoma.
  Journal
N Engl J Med 353:2477-90 (2005)
DOI:10.1056/NEJMra043172
Reference
PMID:15122209
  Authors
Pavlovich CP, Schmidt LS.
  Title
Searching for the hereditary causes of renal-cell carcinoma.
  Journal
Nat Rev Cancer 4:381-93 (2004)
DOI:10.1038/nrc1364
Reference
PMID:14634372
  Authors
Linehan WM, Walther MM, Zbar B.
  Title
The genetic basis of cancer of the kidney.
  Journal
J Urol 170:2163-72 (2003)
DOI:10.1097/01.ju.0000096060.92397.ed
Reference
PMID:14685170
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
PMID:15611513
  Authors
Kim WY, Kaelin WG.
  Title
Role of VHL gene mutation in human cancer.
  Journal
J Clin Oncol 22:4991-5004 (2004)
DOI:10.1200/JCO.2004.05.061
Reference
PMID:17211469
  Authors
Sudarshan S, Linehan WM, Neckers L.
  Title
HIF and fumarate hydratase in renal cancer.
  Journal
Br J Cancer 96:403-7 (2007)
DOI:10.1038/sj.bjc.6603547
Reference
PMID:17287871
  Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
  Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
  Journal
Nat Clin Pract Urol 4:104-10 (2007)
DOI:10.1038/ncpuro0711
Reference
PMID:12351585
  Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
  Title
Understanding familial and non-familial renal cell cancer.
  Journal
Hum Mol Genet 11:2489-98 (2002)
DOI:10.1093/hmg/11.20.2489
Reference
PMID:17158541
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
PMID:16474624
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
PMID:16110317
  Authors
Wu XR.
  Title
Urothelial tumorigenesis: a tale of divergent pathways.
  Journal
Nat Rev Cancer 5:713-25 (2005)
DOI:10.1038/nrc1697
Reference
PMID:11103787
  Authors
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R.
  Title
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
  Journal
Cancer Res 60:6298-302 (2000)
Reference
PMID:12850530
  Authors
Bellmunt J, Hussain M, Dinney CP.
  Title
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.
  Journal
Crit Rev Oncol Hematol 46 Suppl:S85-104 (2003)
DOI:10.1016/S1040-8428(03)00067-2
Reference
PMID:17149381
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
PMID:15746962
  Authors
Dunn KL, Espino PS, Drobic B, He S, Davie JR.
  Title
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling.
  Journal
Biochem Cell Biol 83:1-14 (2005)
DOI:10.1139/o04-121
Reference
PMID:15551095
  Authors
Williams SG, Stein JP.
  Title
Molecular pathways in bladder cancer.
  Journal
Urol Res 32:373-85 (2004)
DOI:10.1007/s00240-003-0345-y
Reference
PMID:12878745
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
PMID:15724144
  Authors
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC.
  Title
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
  Journal
Prostate Cancer Prostatic Dis 8:108-18 (2005)
DOI:10.1038/sj.pcan.4500776
Reference
PMID:16551847
  Authors
Pienta KJ, Bradley D.
  Title
Mechanisms underlying the development of androgen-independent prostate cancer.
  Journal
Clin Cancer Res 12:1665-71 (2006)
DOI:10.1158/1078-0432.CCR-06-0067
Reference
PMID:11900250
  Authors
Feldman BJ, Feldman D.
  Title
The development of androgen-independent prostate cancer.
  Journal
Nat Rev Cancer 1:34-45 (2001)
DOI:10.1038/35094009
Reference
PMID:15082523
  Authors
Heinlein CA, Chang C.
  Title
Androgen receptor in prostate cancer.
  Journal
Endocr Rev 25:276-308 (2004)
DOI:10.1210/er.2002-0032
Reference
PMID:9422516
  Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
  Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
  Journal
Am J Pathol 152:1-9 (1998)
Reference
PMID:10835690
  Authors
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D.
  Title
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
  Journal
Nat Med 6:703-6 (2000)
DOI:10.1038/76287
Reference
PMID:10453277
  Authors
Macri E, Loda M.
  Title
Role of p27 in prostate carcinogenesis.
  Journal
Cancer Metastasis Rev 17:337-44 (1998)
DOI:10.1023/A:1006133620914
Reference
PMID:11750244
  Authors
Steers WD.
  Title
5alpha-reductase activity in the prostate.
  Journal
Urology 58:17-24; discussion 24 (2001)
DOI:10.1016/S0090-4295(01)01299-7
Reference
PMID:8069858
  Authors
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF.
  Title
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
  Journal
Cancer Res 54:4920-6 (1994)
Reference
PMID:11527574
  Authors
Grimes CA, Jope RS.
  Title
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
  Journal
Prog Neurobiol 65:391-426 (2001)
DOI:10.1016/S0301-0082(01)00011-9
Reference
PMID:15947972
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
PMID:14747944
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
PMID:16508724
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
PMID:17028294
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
PMID:11431710
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
PMID:15284264
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12711111
  Authors
Sanchez-Cespedes M.
  Title
Dissecting the genetic alterations involved in lung carcinogenesis.
  Journal
Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3
Reference
PMID:11720739
  Authors
Kaye FJ.
  Title
Molecular biology of lung cancer.
  Journal
Lung Cancer 34 Suppl 2:S35-41 (2001)
DOI:10.1016/S0169-5002(01)00342-7
Reference
PMID:12616528
  Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
  Title
Apoptosis and lung cancer: a review.
  Journal
J Cell Biochem 88:885-98 (2003)
DOI:10.1002/jcb.10440
Reference
PMID:11807782
  Authors
Sartorius UA, Krammer PH.
  Title
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
  Journal
Int J Cancer 97:584-92 (2002)
DOI:10.1002/ijc.10096
Reference
PMID:16064138
  Authors
Adhikary S, Eilers M.
  Title
Transcriptional regulation and transformation by Myc proteins.
  Journal
Nat Rev Mol Cell Biol 6:635-45 (2005)
DOI:10.1038/nrm1703
Reference
PMID:11463388
  Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
  Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
  Journal
Mol Cell 7:639-50 (2001)
DOI:10.1016/S1097-2765(01)00210-6
Reference
PMID:15109562
  Authors
Buttery RC, Rintoul RC, Sethi T.
  Title
Small cell lung cancer: the importance of the extracellular matrix.
  Journal
Int J Biochem Cell Biol 36:1154-60 (2004)
DOI:10.1016/S1357-2725(03)00261-9
Reference
PMID:11559746
  Authors
Yamada KM, Araki M.
  Title
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
  Journal
J Cell Sci 114:2375-82 (2001)
Reference
PMID:11905738
  Authors
Rintoul RC, Sethi T.
  Title
The role of extracellular matrix in small-cell lung cancer.
  Journal
Lancet Oncol 2:437-42 (2001)
DOI:10.1016/S1470-2045(00)00421-6
Reference
PMID:12243753
  Authors
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
  Title
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
  Journal
Exp Cell Res 279:277-90 (2002)
DOI:10.1006/excr.2002.5608
Reference
PMID:12379883
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
PMID:12741677
  Authors
Yokota J, Nishioka M, Tani M, Kohno T.
  Title
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
  Journal
Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215
Reference
PMID:16870043
  Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
  Title
K-ras mutations in non-small-cell lung carcinoma: a review.
  Journal
Clin Lung Cancer 8:30-8 (2006)
DOI:10.3816/CLC.2006.n.030
Reference
PMID:15948711
  Authors
Pfeifer GP, Dammann R.
  Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
  Journal
Biochemistry (Mosc) 70:576-83 (2005)
DOI:10.1007/s10541-005-0151-y
Reference
PMID:11902573
  Authors
Altucci L, Gronemeyer H.
  Title
The promise of retinoids to fight against cancer.
  Journal
Nat Rev Cancer 1:181-93 (2001)
DOI:10.1038/35106036
Reference
PMID:10944551
  Authors
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
  Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
  Journal
J Natl Cancer Inst 92:1303-7 (2000)
DOI:10.1093/jnci/92.16.1303
Reference
PMID:12867060
  Authors
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA.
  Title
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
  Journal
Lung Cancer 41 Suppl 1:S29-42 (2003)
DOI:10.1016/S0169-5002(03)00137-5
Reference
PMID:16112428
  Authors
Panani AD, Roussos C.
  Title
Cytogenetic and molecular aspects of lung cancer.
  Journal
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
Reference
PMID:12407699
  Authors
Mitsuuchi Y, Testa JR.
  Title
Cytogenetics and molecular genetics of lung cancer.
  Journal
Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692
Reference
PMID:15942304
  Authors
Breuer RH, Postmus PE, Smit EF.
  Title
Molecular pathology of non-small-cell lung cancer.
  Journal
Respiration 72:313-30 (2005)
DOI:10.1159/000085376
Reference
PMID:11895903
  Authors
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.
  Title
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung.
  Journal
Clin Cancer Res 8:734-44 (2002)
Reference
PMID:16189154
  Authors
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K.
  Title
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  Journal
J Clin Pathol 58:1076-80 (2005)
DOI:10.1136/jcp.2004.025585
Reference
PMID:21193867
  Authors
Lappano R, Maggiolini M
  Title
G protein-coupled receptors: novel targets for drug discovery in cancer.
  Journal
Nat Rev Drug Discov 10:47-60 (2011)
DOI:10.1038/nrd3320
Reference
PMID:24508914
  Authors
O'Hayre M, Degese MS, Gutkind JS
  Title
Novel insights into G protein and G protein-coupled receptor signaling in cancer.
  Journal
Curr Opin Cell Biol 27:126-35 (2014)
DOI:10.1016/j.ceb.2014.01.005
Reference
PMID:17251915
  Authors
Dorsam RT, Gutkind JS
  Title
G-protein-coupled receptors and cancer.
  Journal
Nat Rev Cancer 7:79-94 (2007)
DOI:10.1038/nrc2069
Related
pathway
mthb03320  PPAR signaling pathway
mthb04010  MAPK signaling pathway
mthb04020  Calcium signaling pathway
mthb04024  cAMP signaling pathway
mthb04060  Cytokine-cytokine receptor interaction
mthb04066  HIF-1 signaling pathway
mthb04110  Cell cycle
mthb04115  p53 signaling pathway
mthb04150  mTOR signaling pathway
mthb04151  PI3K-Akt signaling pathway
mthb04210  Apoptosis
mthb04310  Wnt signaling pathway
mthb04330  Notch signaling pathway
mthb04340  Hedgehog signaling pathway
mthb04350  TGF-beta signaling pathway
mthb04370  VEGF signaling pathway
mthb04510  Focal adhesion
mthb04512  ECM-receptor interaction
mthb04520  Adherens junction
mthb04630  JAK-STAT signaling pathway
mthb04915  Estrogen signaling pathway
KO pathway
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